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1. 发明授权

US06304771B1 Systems and methods for imaging fluorophores 失效
标题翻译：荧光团成像系统和方法
公开(公告)号：US06304771B1
公开(公告)日：2001-10-16
申请号：US08783682
申请日：1997-01-15
申请人： Arjun G. Yodh , Britton Chance , David A. Boas , Maureen O'Leary , Xingde Li
发明人： Arjun G. Yodh , Britton Chance , David A. Boas , Maureen O'Leary , Xingde Li
IPC分类号： A61B600
CPC分类号： G01N21/6456 , A61B5/0059 , G01N21/4795 , G01N21/6428
摘要： The systems comprise source means for illuminating the fluorophores with diffuse photon density waves of a first specified wavelength, whereby the fluorophores will fluoresce re-radiated diffuse photon density waves of a second wavelength after being illuminated with the diffuse photon density waves of the first specified wavelength; detection means for detecting the re-radiated diffuse photon density waves of the second wavelength, wherein there is a phase shift between the diffuse photon density waves of the first wavelength and the diffuse photon density waves of the second wavelength; and processing means interfaced with the detection means for processing data corresponding to the phase shift and the amplitude of the re-radiated waves to determine concentration and lifetime of the fluorophores as a function of spatial position of the fluorophores in the turbid medium.
摘要翻译：这些系统包括用于用第一特定波长的漫射光子密度波照射荧光团的源装置，由此荧光团将在用第一指定波长的漫射光子密度波照射之后发出第二波长的再辐射扩散光子密度波 ; 检测装置，用于检测第二波长的再辐射漫射光子密度波，其中在第一波长的漫射光子密度波与第二波长的漫射光子密度波之间存在相移; 以及处理装置，与所述检测装置接口，用于处理对应于所述相移和所述再辐射波幅度的数据，以确定所述荧光团的浓度和寿命作为所述浑浊介质中所述荧光团的空间位置的函数。

2. 发明授权

US5917190A Object imaging using diffuse light 失效
标题翻译：对象成像使用漫射光
公开(公告)号：US5917190A
公开(公告)日：1999-06-29
申请号：US637645
申请日：1996-07-25
申请人： Arjun G. Yodh , Britton Chance , David A. Boas , Maureen O'Leary
发明人： Arjun G. Yodh , Britton Chance , David A. Boas , Maureen O'Leary
IPC分类号： A61B10/00 , G01N21/17 , G01N21/47 , G01N21/64 , G01S17/87 , G01S17/89
CPC分类号： G01N21/6428 , G01N21/4795 , G01S17/87 , G01S17/89 , A61B5/0091
摘要： Imaging tumors using diffuse light. An imaging system includes a source of diffuse light for generating oscillatory diffuse photon density waves to illuminate an object, a detector for detecting diffuse photon density waves interacting with the object, and a computer interfaced with the detector for processing data corresponding to the photon density waves detected to determine at least a position of the object. In one embodiment, the turbid medium and the object have associated therewith at least one diffusion coefficient and the diffuse photon density waves which illuminate the object refract around the object as a result of their interaction with it, thereby producing a distorted wavefront that allows the computer to construct an image of the object. In another embodiment, a fluorescent object produces re-radiated diffuse photon density waves which allow the object to be imaged.
摘要翻译： PCT No.PCT / US94 / 12486 Sec。 371日期：1996年7月25日 102（e）日期1996年7月25日PCT 1994年10月31日PCT PCT。出版物WO95 / 12132 日期1995年5月4日使用漫射光照射肿瘤。成像系统包括用于产生振荡漫射光子密度波以照射物体的漫射光源，用于检测与物体相互作用的漫射光子密度波的检测器和与检测器接口的计算机，用于处理对应于光子密度波的数据检测到以至少确定对象的位置。在一个实施例中，混浊介质和物体具有至少一个扩散系数，并且由于它们与其相互作用而照射物体折射物体的扩散光子密度波折射，从而产生允许计算机构建对象的图像。在另一个实施例中，荧光物体产生允许物体成像的再辐射漫射光子密度波。

3. 发明授权

US07983741B2 Examination and imaging of brain cognitive functions 有权
标题翻译：大脑认知功能的检查和成像
公开(公告)号：US07983741B2
公开(公告)日：2011-07-19
申请号：US12157185
申请日：2008-06-07
申请人： Britton Chance
发明人： Britton Chance
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/0035 , A61B5/0042 , A61B5/6834
摘要： A system and method for examining or imaging brain functions of a subject includes a light source and a light detector located on the exterior surface of the subject's head. The light source introduces transcranially optical radiation into the brain of a subject, and the light detector detects radiation that has migrated in a brain region from the light source to the detector. The system also provides brain stimulation and evaluates the detected radiation to determine a brain cognitive function of the subject. One embodiment of the system can detect a brain disorder. Another embodiment of the system can detect “deceit.” In addition to the optical module, the system may include other optional modules such as an EEG module, an MEG module, a thermography module, a respiratory module, a skin conductivity module, and a blood pressure module.
摘要翻译：用于检查或成像对象的脑功能的系统和方法包括位于受检者头部的外表面上的光源和光检测器。光源将经射线的光辐射引入到受试者的脑中，并且光检测器检测已经在脑区域中从光源迁移到检测器的辐射。该系统还提供脑刺激并评估检测到的辐射以确定受试者的脑认知功能。该系统的一个实施例可以检测脑障碍。该系统的另一实施例可以检测“欺骗”。除了光学模块之外，系统还可以包括其他可选模块，例如EEG模块，MEG模块，热成像模块，呼吸模块，皮肤电导率模块和血压模块

4. 发明申请

US20100174160A1 Detection, imaging and characterization of brain tissue 审中-公开
标题翻译：脑组织的检测，成像和表征
公开(公告)号：US20100174160A1
公开(公告)日：2010-07-08
申请号：US12589636
申请日：2009-10-26
申请人： Britton Chance
发明人： Britton Chance
IPC分类号： A61B5/1455 , A61B6/00
CPC分类号： A61B5/14553 , A61B5/0042 , A61B5/0073 , A61B5/4064 , A61B2562/0233 , A61B2562/0242 , A61B2562/046
摘要： An optical examination technique employs an optical system for in vivo non-invasive transcranial examination of brain tissue of a subject. The optical system includes an optical module arranged for placement on the exterior of the head, a controller and a processor. The optical module includes an array of optical input ports and optical detection ports located in a selected geometrical pattern to provide a multiplicity of photon migration paths inside the biological tissue. Each optical input port is constructed to introduce into the examined tissue visible or infrared light emitted from a light source. Each optical detection port is constructed to provide light from the tissue to a light detector. The controller is constructed and arranged to activate one or several light sources and light detectors so that the light detector detects light that has migrated over at least one of the photon migration paths. The processor receives signals corresponding to the detected light and forms at least two data sets, a first of said data sets representing blood volume in the examined tissue region and a second of said data sets representing blood oxygenation of the examined tissue. The processor is arranged to correlate the first and second data sets to detect abnormal tissue in the examined tissue.
摘要翻译：光学检查技术采用光学系统用于受试者脑组织的体内非侵入性经颅检查。光学系统包括布置成放置在头部外部的光学模块，控制器和处理器。光学模块包括位于选定几何图案中的光学输入端口和光学检测端口的阵列，以在生物组织内部提供多个光子迁移路径。每个光学输入端口构造成将被检查的组织引入可见光或从光源发射的红外光。每个光学检测端口被构造成将来自组织的光提供给光检测器。控制器被构造和布置成激活一个或多个光源和光检测器，使得光检测器检测已经通过至少一个光子迁移路径迁移的光。所述处理器接收对应于检测到的光的信号并形成至少两个数据集，所述数据集中的第一个表示所检查的组织区域中的血液体积，所述数据集中的第二个表示所检查的组织的血氧。处理器被布置成使第一和第二数据集相关联，以检测检查的组织中的异常组织。

5. 发明申请

US20060058683A1 Optical examination of biological tissue using non-contact irradiation and detection 失效
标题翻译：使用非接触式照射和检测对生物组织进行光学检查
公开(公告)号：US20060058683A1
公开(公告)日：2006-03-16
申请号：US11203826
申请日：2005-08-13
申请人： Britton Chance
发明人： Britton Chance
IPC分类号： A61B5/05 , A61B6/00
CPC分类号： A61B5/0059 , A61B5/0037 , A61B5/0068 , A61B5/0091 , A61B5/415 , A61B5/418 , A61B5/4312 , A61B5/6834 , A61B5/7285
摘要： An optical system for examination of biological tissue includes a light source, a light detector, optics and electronics. The light source generates a light beam, transmitted to the biological tissue, spaced apart from the source. The light detector is located away (i.e., in a non-contact position) from the examined biological tissue and is constructed to detect light that has migrated in the examined tissue. The electronics controls the light source and the light detector, and a system separates the reflected photons (e.g., directly reflected or scattered from the surface or superficial photons) from the photons that have migrated in the examined tissue. The system prevents detection of the “noise” photons by the light detector or, after detection, eliminates the “noise” photons in the detected optical data used for tissue examination.
摘要翻译：用于生物组织检查的光学系统包括光源，光检测器，光学器件和电子器件。光源产生一个光束，传输到生物组织，与光源隔开。光检测器位于被检查的生物组织的远离（即处于非接触位置）的位置，并被构造成检测在被检查的组织中迁移的光。电子装置控制光源和光检测器，并且系统将已反射的光子（例如，从表面或表面光子直接反射或散射）与已检查组织中迁移的光子分离。该系统防止光检测器检测“噪声”光子，或者在检测之后，消除用于组织检查的检测到的光学数据中的“噪声”光子。

6. 发明授权

US06949081B1 Sensing and interactive drug delivery 失效
标题翻译：感应和互动药物递送
公开(公告)号：US06949081B1
公开(公告)日：2005-09-27
申请号：US09383476
申请日：1999-08-26
申请人： Britton Chance
发明人： Britton Chance
IPC分类号： A61B5/00 , A61M31/00 , A61M37/00 , A61N1/08 , A61N1/30 , A61N1/32 , F04B53/00
CPC分类号： A61N1/0428 , A61B5/0022 , A61B5/0059 , A61M37/00 , A61N1/08 , A61N1/30 , A61N1/327
摘要： An interactive drug delivery system includes a drug delivery module, an optical probe, a local controller, and an optional central controller. The drug delivery module is constructed and arranged to deliver selected amounts of a drug into a subject. The optical probe is constructed and arranged to detect in a selected tissue region of the subject a manifestation caused by the delivered drug. The local controller is constructed and arranged to receive data from or transmit data to the optical probe and the drug delivery module. The local controller is arranged to correlate optical data, received from the optical probe, to selected data and provide signals to the drug delivery module for adjusting the amounts of the drug to be delivered into the subject.
摘要翻译：交互式药物递送系统包括药物递送模块，光学探针，本地控制器和可选的中央控制器。药物递送模块被构造和布置成将选定量的药物递送到受试者中。光学探针被构造和布置成在对象的选定组织区域中检测由递送的药物引起的表现。本地控制器被构造和布置成从光学探针和药物传递模块接收数据或传输数据。本地控制器被布置成将从光学探针接收的光学数据与所选择的数据相关联，并向药物递送模块提供信号，以调整要递送到受试者的药物的量。

7. 发明申请

US20050197583A1 Detection, imaging and characterization of breast tumors 失效
标题翻译：乳腺肿瘤的检测，成像和表征
公开(公告)号：US20050197583A1
公开(公告)日：2005-09-08
申请号：US10983371
申请日：2004-11-08
申请人： Britton Chance
发明人： Britton Chance
IPC分类号： G01N21/17 , A61B5/00 , A61B5/145 , A61B5/1455 , A61B10/00 , A61B6/00
CPC分类号： A61B5/0091 , A61B5/0073 , A61B5/14552 , A61B5/4312 , A61B2562/0233 , A61B2562/0242 , A61B2562/046
摘要： An optical examination technique employs an optical system for in vivo non-invasive examination of breast tissue of a subject. The optical system includes an optical module, a controller and a processor. The optical module includes an array of optical input ports and optical detection ports located in a selected geometrical pattern to provide a multiplicity of photon migration paths inside the biological tissue. Each optical input port is constructed to introduce into the examined tissue visible or infrared light emitted from a light source. Each optical detection port is constructed to provide light from the tissue to a light detector. The controller is constructed and arranged to activate one or several light sources and light detectors so that the light detector detects light that has migrated over at least one of the photon migration paths. The processor receives signals corresponding to the detected light and forms at least two data sets, a first of said data sets representing blood volume in the examined tissue region and a second of said data sets representing blood oxygenation of the examined tissue. The processor is arranged to correlate the first and second data sets to detect abnormal tissue in the examined tissue.
摘要翻译：光学检查技术采用光学系统用于体内非侵入性检查受试者的乳腺组织。光学系统包括光学模块，控制器和处理器。光学模块包括位于选定几何图案中的光学输入端口和光学检测端口的阵列，以在生物组织内部提供多个光子迁移路径。每个光学输入端口构造成将被检查的组织引入可见光或从光源发射的红外光。每个光学检测端口被构造成将来自组织的光提供给光检测器。控制器被构造和布置成激活一个或多个光源和光检测器，使得光检测器检测已经通过至少一个光子迁移路径迁移的光。所述处理器接收对应于检测到的光的信号并形成至少两个数据集，所述数据集中的第一个表示所检查的组织区域中的血液体积，所述数据集中的第二个表示所检查的组织的血氧。处理器被布置成使第一和第二数据集相关联，以检测检查的组织中的异常组织。

8. 发明授权

US06785568B2 Transcranial examination of the brain 有权
标题翻译：经颅脑检查
公开(公告)号：US06785568B2
公开(公告)日：2004-08-31
申请号：US10184528
申请日：2002-06-27
申请人： Britton Chance
发明人： Britton Chance
IPC分类号： A61B500
CPC分类号： A61B5/14553 , A61B5/14551 , A61B5/14552 , A61B5/1459 , A61B5/6824 , A61B5/7257
摘要： A cognition spectrophotometer system for transcranial brain examination using electromagnetic radiation of a visible or infrared wavelength includes an optical unit, a stimulation module, a remote communication unit, and a processor. The optical unit includes a light source adapted to introduce transcranially from an input port, placed at a input location on the exterior of the head, electromagnetic radiation of the wavelength into the brain, and a light detector adapted to detect, at a detection port placed at a detection location on the exterior of the head, radiation that has migrated in the brain. The stimulation module is constructed and arranged to cause stimulation of a brain activity while introducing the radiation at the input port. The remote communication unit includes a transmitter and a receiver. The processor adapted to process signals of the detected radiation that has migrated in the brain to create processed data and determine a characteristic of the brain activity by correlating the processed data to the caused stimulation of the brain activity, wherein the processor is constructed to provide the processed data reflecting a difference between stimulated and non-stimulated tissue.
摘要翻译：使用可见光或红外波长的电磁辐射的经颅脑检查的认知分光光度计系统包括光学单元，刺激模块，远程通信单元和处理器。所述光学单元包括光源，其适于从放置在所述头部的外部的输入位置处的输入端口经颅导入，将所述波长的电磁辐射放入脑中;以及光检测器，适于在放置的检测端口处检测在头部外部的检测位置，已经在大脑中迁移的辐射。刺激模块被构造和布置成在输入端口处引入辐射时引起大脑活动的刺激。远程通信单元包括发射机和接收机。所述处理器适于处理已经在大脑中迁移的检测到的辐射的信号以产生经处理的数据，并且通过将所处理的数据与所引起的大脑活动的刺激相关联来确定大脑活动的特征，其中所述处理器被构造为提供处理的数据反映了刺激组织和非刺激组织之间的差异。

9. 发明授权

US06263221B1 Quantitative analyses of biological tissue using phase modulation spectroscopy 失效
标题翻译：使用相位调制光谱对生物组织进行定量分析
公开(公告)号：US06263221B1
公开(公告)日：2001-07-17
申请号：US08799206
申请日：1997-02-13
申请人： Britton Chance , Vasilis Ntziachristos
发明人： Britton Chance , Vasilis Ntziachristos
IPC分类号： A61B500
CPC分类号： G01N21/3151 , A61B5/0075 , A61B5/0084 , A61B5/14551 , A61B5/14552 , A61B5/14553 , A61B5/1459 , A61B5/6828 , A61B5/7228 , A61B2562/0233 , A61B2562/0242 , A61B2562/043 , G01N21/47 , G01N21/4795 , G01N21/49 , G01N2021/1789 , G01N2021/3181 , G01N2201/0696
摘要： A spectroscopic system for quantifying in vivo concentration of an absorptive pigment in biological tissue includes an oscillator for generating a first carrier waveform of a first frequency on the order of 108 Hz, a light source for generating light of a selected wavelengths modulated by the carrier waveform, and a detector for detecting radiation that has migrated over photon migration paths in the tissue from an input port to a detection port spaced several centimeters apart. The wavelength is sensitive to concentration of an absorptive pigment present in the tissue. A phase detector compares the detected radiation with the introduced radiation and determines therefrom the phase shift of the detected radiation. A processor quantifies the concentration of the absorptive pigment by calculating a value of the absorption coefficient.
摘要翻译：用于定量生物组织中吸收性颜料的体内浓度的光谱系统包括用于产生大约108Hz的第一频率的第一载流子波形的振荡器，用于产生由载波波形调制的所选波长的光的光源以及用于检测已经从组织中的光子迁移路径迁移到辐射的检测器，其从输入端口到间隔几厘米的检测端口。该波长对存在于组织中的吸收性颜料的浓度敏感。相位检测器将检测到的辐射与引入的辐射进行比较，并由此确定检测到的辐射的相移。处理器通过计算吸收系数的值来量化吸收性颜料的浓度。

10. 发明授权

US5987351A Optical coupler for in vivo examination of biological tissue 失效
标题翻译：用于体内检查生物组织的光耦合器
公开(公告)号：US5987351A
公开(公告)日：1999-11-16
申请号：US860789
申请日：1997-10-06
申请人： Britton Chance
发明人： Britton Chance
IPC分类号： G01N21/64 , A61B5/00 , A61B5/145 , A61B5/1455 , A61B5/1459 , A61B5/1464 , G01N21/01 , G01N21/27 , G01N21/49 , A61B6/00
CPC分类号： A61B5/6814 , A61B5/0042 , A61B5/0077 , A61B5/0091 , A61B5/1455 , A61B5/14551 , A61B5/14552 , A61B5/14553 , A61B5/1459 , A61B5/4312 , A61B5/6853 , A61B2562/0233 , A61B2562/046 , A61B2562/146 , A61B5/0035 , A61B5/14532
摘要： For in vivo examination using a spectrophotometer that generates optical radiation and characterizes biological tissue by detecting photons that have migrated in the tissue, an array of optical fibers that transmit radiation between the spectrophotometer and biological tissue, the fibers including distal ends freely protruding from a support in the manner of bristles from a hairbrush, forming an array of optical ports to couple photons to a contiguous tissue region or to collect photons from the tissue region, the optical fibers including proximal ends arranged to optically couple the radiation with the spectrophotometer. Also shown are: fibers sized and distributed to penetrate freely extending hair on the subject's head to make optical contact over an array of points with the scalp or skin; the array of fibers constructed as a handheld probe moved and placed against the head; optical matching material coupling between the fibers and the biological tissue region; and an irradiation array with the proximal fiber ends coupled to a light source, e.g. for brain tissue examination. Also shown are fibers as a detection array, e.g. for brain tissue examination or for imaging of the brain or for use in a magnet used for magnetic resonance imaging. The spectrophotometer is shown as a continuous wave spectrophotometer, phase modulation spectrophotometer, time resolved spectrophotometer and a phased array spectrophotometer.
摘要翻译：对于使用分光光度计产生光学辐射并通过检测在组织中迁移的光子来表征生物组织的体内检查，在分光光度计和生物组织之间传输辐射的光纤阵列，包括从支撑体自由突出的远端的纤维以来自发刷的刷毛的方式，形成光学孔的阵列以将光子耦合到连续的组织区域或从组织区域收集光子，所述光纤包括被配置为将辐射与分光光度计光学耦合的近端。还示出了：尺寸和分布的纤维，以穿透受试者头部上的自由延伸的头发，以使与头皮或皮肤的点阵列发生光学接触; 被构造为手持探针的纤维阵列移动并放置在头部上; 纤维与生物组织区域之间的光学匹配材料耦合; 以及近端光纤末端耦合到光源的照射阵列，例如光源。用于脑组织检查。还示出了作为检测阵列的光纤，例如。用于脑组织检查或用于脑的成像或用于磁共振成像的磁体中。分光光度计显示为连续波分光光度计，相位调制分光光度计，时间分辨分光光度计和相控阵分光光度计。

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