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    • 1. 发明授权
    • Systems and methods for imaging fluorophores
    • 荧光团成像系统和方法
    • US06304771B1
    • 2001-10-16
    • US08783682
    • 1997-01-15
    • Arjun G. YodhBritton ChanceDavid A. BoasMaureen O'LearyXingde Li
    • Arjun G. YodhBritton ChanceDavid A. BoasMaureen O'LearyXingde Li
    • A61B600
    • G01N21/6456A61B5/0059G01N21/4795G01N21/6428
    • The systems comprise source means for illuminating the fluorophores with diffuse photon density waves of a first specified wavelength, whereby the fluorophores will fluoresce re-radiated diffuse photon density waves of a second wavelength after being illuminated with the diffuse photon density waves of the first specified wavelength; detection means for detecting the re-radiated diffuse photon density waves of the second wavelength, wherein there is a phase shift between the diffuse photon density waves of the first wavelength and the diffuse photon density waves of the second wavelength; and processing means interfaced with the detection means for processing data corresponding to the phase shift and the amplitude of the re-radiated waves to determine concentration and lifetime of the fluorophores as a function of spatial position of the fluorophores in the turbid medium.
    • 这些系统包括用于用第一特定波长的漫射光子密度波照射荧光团的源装置,由此荧光团将在用第一指定波长的漫射光子密度波照射之后发出第二波长的再辐射扩散光子密度波 ; 检测装置,用于检测第二波长的再辐射漫射光子密度波,其中在第一波长的漫射光子密度波与第二波长的漫射光子密度波之间存在相移; 以及处理装置,与所述检测装置接口,用于处理对应于所述相移和所述再辐射波幅度的数据,以确定所述荧光团的浓度和寿命作为所述浑浊介质中所述荧光团的空间位置的函数。
    • 2. 发明授权
    • Object imaging using diffuse light
    • 对象成像使用漫射光
    • US5917190A
    • 1999-06-29
    • US637645
    • 1996-07-25
    • Arjun G. YodhBritton ChanceDavid A. BoasMaureen O'Leary
    • Arjun G. YodhBritton ChanceDavid A. BoasMaureen O'Leary
    • A61B10/00G01N21/17G01N21/47G01N21/64G01S17/87G01S17/89
    • G01N21/6428G01N21/4795G01S17/87G01S17/89A61B5/0091
    • Imaging tumors using diffuse light. An imaging system includes a source of diffuse light for generating oscillatory diffuse photon density waves to illuminate an object, a detector for detecting diffuse photon density waves interacting with the object, and a computer interfaced with the detector for processing data corresponding to the photon density waves detected to determine at least a position of the object. In one embodiment, the turbid medium and the object have associated therewith at least one diffusion coefficient and the diffuse photon density waves which illuminate the object refract around the object as a result of their interaction with it, thereby producing a distorted wavefront that allows the computer to construct an image of the object. In another embodiment, a fluorescent object produces re-radiated diffuse photon density waves which allow the object to be imaged.
    • PCT No.PCT / US94 / 12486 Sec。 371日期:1996年7月25日 102(e)日期1996年7月25日PCT 1994年10月31日PCT PCT。 出版物WO95 / 12132 日期1995年5月4日使用漫射光照射肿瘤。 成像系统包括用于产生振荡漫射光子密度波以照射物体的漫射光源,用于检测与物体相互作用的漫射光子密度波的检测器和与检测器接口的计算机,用于处理对应于光子密度波的数据 检测到以至少确定对象的位置。 在一个实施例中,混浊介质和物体具有至少一个扩散系数,并且由于它们与其相互作用而照射物体折射物体的扩散光子密度波折射,从而产生允许计算机 构建对象的图像。 在另一个实施例中,荧光物体产生允许物体成像的再辐射漫射光子密度波。