专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09390522B2 System for creating a tomographic object image based on multiple imaging modalities 有权
标题翻译：用于基于多个成像模式创建断层图像对象图像的系统
公开(公告)号：US09390522B2
公开(公告)日：2016-07-12
申请号：US14358037
申请日：2011-11-18
申请人： Vasilis Ntziachristos , Angelica Ale
发明人： Vasilis Ntziachristos , Angelica Ale
IPC分类号： G06K9/00 , G06T11/00
CPC分类号： G06T11/006 , G06T2210/41 , G06T2211/40
摘要： A system for creating an object image of an object under investigation, comprises a computing device being configured for creating the object image by using first tomography data of the object provided by a first tomography system and second tomography data of the object provided by a second tomography system, wherein the computing device is configured for calculating a first forward model describing the first tomography data using the second tomography data, performing a first inversion of the first forward model, calculating a parameter set using the first inversion, and performing a second inversion using the parameter set to obtain the object image to be created. Furthermore, a method of imaging an object under investigation is described, wherein the system for creating an object image is used.
摘要翻译：一种用于创建被调查对象的对象图像的系统，包括：计算设备，被配置为通过使用由第一层析摄影系统提供的对象的第一层析成像数据和由第二层析成像仪提供的对象的第二层析成像数据来创建对象图像系统，其中所述计算设备被配置为使用所述第二断层摄影数据来计算描述所述第一断层摄影数据的第一前向模型，执行所述第一正向模型的第一倒置，使用所述第一倒置来计算参数集合，以及使用该参数设置为获取要创建的对象图像。此外，描述了一种对待调查对象进行成像的方法，其中使用用于创建对象图像的系统。

2. 发明申请

US20140114187A1 ULTRASOUND DETECTOR AND DETECTING DEVICE FOR OPTOACOUSTIC OR THERMOACOUSTIC IMAGING 有权
标题翻译：超声波检测器和用于光学或热成像的检测装置
公开(公告)号：US20140114187A1
公开(公告)日：2014-04-24
申请号：US13982019
申请日：2011-02-04
申请人： Amir Rozental , Daniel Razansky , Vasilis Ntziachristos
发明人： Amir Rozental , Daniel Razansky , Vasilis Ntziachristos
IPC分类号： A61B8/00
CPC分类号： A61B8/44 , A61B5/0095 , A61B5/0097 , G01H9/004
摘要： An ultrasound detector adapted for ultrasound detection with medical applications includes an optical waveguide, and at least one Bragg grating, created with a predetermined refractive index modulation amplitude in the optical waveguide, wherein the at least one Bragg grating includes a localized defect in periodicity so that a localized-light resonance portion is formed around the defect, and the localized-light resonance portion has spectral properties capable of being modulated in response to an ultrasound oscillation, wherein the optical waveguide is a non-amplifying optical medium, and the refractive index modulation amplitude is selected such that the localized-light resonance portion is concentrated at the defect in periodicity and the ultrasound oscillation can be sensed by the at least one Bragg grating with an acoustic sensitivity most of which being obtained over the localized-light resonance portion.
摘要翻译：适用于医疗应用的超声波检测的超声波检测器包括光波导和在光波导中以预定的折射率调制幅度产生的至少一个布拉格光栅，其中所述至少一个布拉格光栅包括周期性的局部缺陷，使得局部光共振部分形成在缺陷周围，并且局部光共振部分具有能够响应于超声波振荡而被调制的光谱特性，其中光波导是非放大光学介质，并且折射率调制选择振幅使得局部光共振部分集中在周期性的缺陷，并且可以通过至少一个具有声敏感的布拉格光栅来感测超声波振荡，其大部分是通过局部光共振部分获得的。

3. 发明授权

US10292593B2 Imaging device and method for optoacoustic imaging of small animals 有权
公开(公告)号：US10292593B2
公开(公告)日：2019-05-21
申请号：US13386491
申请日：2010-07-23
申请人： Daniel Razansky , Vasilis Ntziachristos
发明人： Daniel Razansky , Vasilis Ntziachristos
IPC分类号： A61B5/00 , A61B6/00 , A61B8/13 , G01N21/17 , G01N21/39
摘要： An imaging device configured for optoacoustic imaging of an object, including an illumination device including optical components arranged to illuminate the object, a detector device comprising an array of detector elements arranged in a tank and arranged to detect acoustic signals created in the object, and a container device including a tank arranged to accommodate the detector device, the object and a matching transmission medium, a holding device adapted to position and move the object relative to the illumination device and the detector device, wherein the optical components are arranged in the tank to illuminate the object from different directions.

4. 发明授权

US09332942B2 Systems, processes and computer-accessible medium for providing hybrid flourescence and optical coherence tomography imaging 有权
标题翻译：用于提供混合荧光和光学相干断层扫描成像的系统，过程和计算机可访问介质
公开(公告)号：US09332942B2
公开(公告)日：2016-05-10
申请号：US12020765
申请日：2008-01-28
申请人： Farouc A. Jaffer , Vasilis Ntziachristos
发明人： Farouc A. Jaffer , Vasilis Ntziachristos
IPC分类号： A61B5/00 , G01N21/47 , G01N21/64
CPC分类号： A61B5/6852 , A61B5/0066 , A61B5/0073 , G01N21/4795 , G01N21/6456
摘要： Apparatus and method can be provided for obtaining information regarding at least one portion of a biological structure. For example, using a first arrangement, it is possible to generate a first electro-magnetic radiation to be forwarded to the portion and receive, from the portion, a second fluorescent radiation associated with the first electro-magnetic radiation Further, using a second arrangement, it is possible to obtain information associated with the second fluorescent radiation, and generate at least one image of the portion as a function of the second fluorescent radiation. According to an exemplary embodiment of the present invention, the first arrangement can be inserted into at least one lumen, and the image of the portion may be associated with the at least one lumen.
摘要翻译：可以提供装置和方法来获得关于生物结构的至少一部分的信息。例如，使用第一布置，可以产生要转发到该部分并且从该部分接收与第一电磁辐射相关联的第二荧光辐射的第一电磁辐射。此外，使用第二布置，可以获得与第二荧光辐射相关的信息，并且产生作为第二荧光辐射的函数的该部分的至少一个图像。根据本发明的示例性实施例，第一布置可以插入至少一个内腔中，并且该部分的图像可以与至少一个内腔相关联。

5. 发明申请

US20150366458A1 APPARATUS AND METHOD FOR FREQUENCY-DOMAIN THERMO-ACOUSTIC TOMOGRAPHIC IMAGING 审中-公开
标题翻译：频域热声成像的装置和方法
公开(公告)号：US20150366458A1
公开(公告)日：2015-12-24
申请号：US14399272
申请日：2012-05-07
申请人： Stephan Kellnberger , Vasilis Ntziachristos , George Sergiadis , Nikolaos Deliolanis , Murad Omar
发明人： Stephan Kellnberger , Vasilis Ntziachristos , George Sergiadis , Nikolaos Deliolanis , Murad Omar
IPC分类号： A61B5/00 , A61B19/00 , G01N21/17
CPC分类号： A61B5/0095 , A61B5/6852 , A61B90/39 , A61B2503/40 , A61B2503/42 , A61B2560/0406 , A61B2562/14 , A61B2562/143 , G01N21/1702 , G01N29/2418 , G01N2021/1706 , G01N2201/06113 , G01N2201/08 , G01N2201/12 , G01N2291/02466 , G01N2291/02475
摘要： An imaging apparatus (100), configured for thermoacoustic tomographic imaging a region of interest (2) in an object (1), comprises a source device (10) being arranged for emitting an electromagnetic energy input into the region of interest (2), a detector device (20) being arranged for detecting mechanical wave response signals generated in the region of interest (2) along multiple angular projection directions in response to the electromagnetic energy input, and an image data acquisition and processing device (30) being arranged for providing tomographic image data representing the image of the region of interest (2) on the basis of the mechanical wave response signals, wherein the source device (10) is adapted for continuously emitting the electromagnetic energy input with a predetermined input modulation, and the image data acquisition and processing device (30) is adapted for converting the mechanical wave response signals into the frequency domain and for performing data processing and image reconstruction in the frequency domain or in the time domain. Furthermore, an imaging method for thermoacoustic tomographic imaging a region of interest (2) in an object (1) is described.
摘要翻译：一种成像设备（100），被配置用于对象（1）中的感兴趣区域（2）的热声层析成像，包括：源装置（10），被布置成用于发射输入到所述感兴趣区域（2）的电磁能量; 检测器装置（20）被布置成响应于电磁能输入，沿着多个角度投影方向检测在感兴趣区域（2）中产生的机械波响应信号，以及图像数据采集和处理装置（30）基于所述机械波响应信号，提供表示所述感兴趣区域（2）的图像的断层图像数据，其中所述源装置（10）适于以预定输入调制连续发射所述电磁能量输入，并且所述图像数据采集和处理装置（30）适用于将机械波响应信号转换成频域并执行数据处理 g和频域或时域中的图像重建。此外，描述了用于对象（1）中的感兴趣区域（2）的热声层析成像的成像方法。

6. 发明授权

US08326406B2 Method and system for free space optical tomography of diffuse media 有权
标题翻译：漫射介质的自由空间光学层析成像方法与系统
公开(公告)号：US08326406B2
公开(公告)日：2012-12-04
申请号：US13099929
申请日：2011-05-03
申请人： Vasilis Ntziachristos , Jorge Ripoll
发明人： Vasilis Ntziachristos , Jorge Ripoll
IPC分类号： A61B6/00
CPC分类号： A61B5/0066 , A61B5/0071 , A61B5/0073 , A61B5/1076 , A61B5/1077
摘要： A method and a system for free space optical tomography provides one or more light source and one or more light sensors spaced, which in one embodiment are spaced apart from and object to be imaged. A surface capture system coupled to a variety of optical models provides the method and system with the ability to render accurate tomographic images though the light has propagated both through a diffuse medium and, in on embodiment, also through free space to the one or more light sensors.
摘要翻译：用于自由空间光学断层摄影的方法和系统提供了一个或多个光源和一个或多个间隔开的光传感器，在一个实施例中，光传感器与要成像的物体间隔开。耦合到各种光学模型的表面捕获系统为方法和系统提供了能够呈现精确的断层图像的能力，尽管光已经通过漫射介质传播，并且在实施例中也通过自由空间传播到一个或多个光传感器。

7. 发明申请

US20110306857A1 QUANTITATIVE MULTI-SPECTRAL OPTO-ACOUSTIC TOMOGRAPHY (MSOT) OF TISSUE BIOMARKERS 有权
标题翻译：组织生物标志物的定量多光谱光学成像（MSOT）
公开(公告)号：US20110306857A1
公开(公告)日：2011-12-15
申请号：US13055552
申请日：2008-07-25
申请人： Daniel Razansky , Vasilis Ntziachristos
发明人： Daniel Razansky , Vasilis Ntziachristos
IPC分类号： A61B6/00 , A61B5/1455
CPC分类号： A61B5/0073 , A61B5/0095
摘要： A method of multi-spectral opto-acoustic tomography (MSOT) imaging of a target tissue including a target tissue biomarker includes illuminating the target tissue with an illumination device emitting at least one pulsed illumination pattern at several illumination wavelengths, detecting pressure signals from the target tissue biomarker with a detector device, wherein the pressure signals being produced in the target tissue are in response to the illumination, and reconstructing a quantitative tomographic image of a distribution of the target tissue biomarker in the target tissue, wherein the pressure signals are analyzed using a photon propagation model which depends on an illuminating light fluence in the target tissue and on the illumination wavelengths, at least one spectral processing scheme, and an inversion scheme providing the tomographic image.
摘要翻译：包括靶组织生物标志物的靶组织的多光谱光声层析成像（MSOT）的方法包括用照射装置照射目标组织，所述照明装置在几个照射波长处发射至少一个脉冲照明图案，检测来自目标的压力信号具有检测器装置的组织生物标志物，其中在靶组织中产生的压力信号响应于照明，并且重建靶组织中靶组织生物标志物分布的定量断层图像，其中使用取决于目标组织中的照明光注量和照明波长的光子传播模型，至少一个光谱处理方案和提供该断层图像的反演方案。

8. 发明申请

US20110087111A1 System and Method for Normalized Diffuse Emission Epi-illumination Imaging and Normalized Diffuse Emission Transillumination Imaging 有权
标题翻译：用于归一化散射发射Epi照明成像和归一化扩散发射透射成像的系统和方法
公开(公告)号：US20110087111A1
公开(公告)日：2011-04-14
申请号：US12973075
申请日：2010-12-20
申请人： Vasilis Ntziachristos
发明人： Vasilis Ntziachristos
IPC分类号： A61B6/00
CPC分类号： A61B1/00009 , A61B1/043 , A61B5/0064 , A61B5/0071 , A61B5/0084 , A61B5/0088 , A61B5/415 , A61B5/418
摘要： A system and method provide normalized fluorescence epi-illumination images and normalized fluorescence transillumination images. The normalization can be used to improve two-dimensional (planar) fluorescence epi-illumination images and two-dimensional (planar) fluorescence transillumination images. The system and method can also provide normalized bioluminescence epi-illumination images and normalized bioluminescence transillumination images. In some arrangements, the system and method can provide imaging of small animals, intro-operative imaging, endoscopic imaging, and/or imaging of hollow organs.
摘要翻译：系统和方法提供标准化的荧光外照明图像和标准化的荧光透照图像。标准化可以用于改进二维（平面）荧光环境照明图像和二维（平面）荧光透照图像。该系统和方法还可以提供归一化的生物发光背景照明图像和归一化的生物发光透照图像。在一些布置中，系统和方法可以提供小动物的成像，内窥镜成像，内窥镜成像和/或中空器官的成像。

9. 发明申请

US20090192358A1 SYSTEMS, PROCESSES AND COMPUTER-ACCESSIBLE MEDIUM FOR PROVIDING HYBRID FLOURESCENCE AND OPTICAL COHERENCE TOMOGRAPHY IMAGING 有权
标题翻译：用于提供混合动画和光学相干图像成像的系统，过程和计算机可访问媒体
公开(公告)号：US20090192358A1
公开(公告)日：2009-07-30
申请号：US12020765
申请日：2008-01-28
申请人： Farouc A. Jaffer , Vasilis Ntziachristos
发明人： Farouc A. Jaffer , Vasilis Ntziachristos
IPC分类号： A61B1/07
CPC分类号： A61B5/6852 , A61B5/0066 , A61B5/0073 , G01N21/4795 , G01N21/6456
摘要： Apparatus and method can be provided for obtaining information regarding at least one portion of a biological structure. For example, using a first arrangement, it is possible to generate a first electro-magnetic radiation to be forwarded to the portion and receive, from the portion, a second fluorescent radiation associated with the first electro-magnetic radiation Further, using a second arrangement, it is possible to obtain information associated with the second fluorescent radiation, and generate at least one image of the portion as a function of the second fluorescent radiation. According to an exemplary embodiment of the present invention, the first arrangement can be inserted into at least one lumen, and the image of the portion may be associated with the at least one lumen.
摘要翻译：可以提供装置和方法来获得关于生物结构的至少一部分的信息。例如，使用第一布置，可以产生要转发到该部分并且从该部分接收与第一电磁辐射相关联的第二荧光辐射的第一电磁辐射。此外，使用第二布置，可以获得与第二荧光辐射相关的信息，并且产生作为第二荧光辐射的函数的该部分的至少一个图像。根据本发明的示例性实施例，第一布置可以插入至少一个内腔中，并且该部分的图像可以与至少一个内腔相关联。

10. 发明申请

US20070274580A1 Method and system for tomographic imaging using fluorescent proteins 失效
标题翻译：使用荧光蛋白的断层成像的方法和系统
公开(公告)号：US20070274580A1
公开(公告)日：2007-11-29
申请号：US10598703
申请日：2005-03-10
申请人： Vasilis Ntziachristos , Jorge Ripoll , Giannis Zacharakis
发明人： Vasilis Ntziachristos , Jorge Ripoll , Giannis Zacharakis
IPC分类号： G06K9/00 , G01J1/58
CPC分类号： A61B5/0073
摘要： A system for optical tomography includes an apparent light source adapted to project excitation light toward a specimen having fluorescent proteins therein, wherein the excitation light enters the specimen becoming intrinsic light within the specimen, wherein the intrinsic light is adapted to excite fluorescent light from the fluorescent proteins, and wherein the intrinsic light and the fluorescent light are diffuse. A method of optical tomography includes generating the excitation light with the apparent light source, wherein the intrinsic light and the fluorescent light are diffuse.
摘要翻译：一种用于光学断层摄影的系统包括适于将激发光投射到其中具有荧光蛋白的样本的表观光源，其中所述激发光进入所述样本中成为所述样本内的固有光，其中所述本征光适于激发来自所述荧光的荧光蛋白质，并且其中本征光和荧光是扩散的。光学断层摄影的方法包括产生具有视光源的激发光，其中固有光和荧光扩散。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式