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1. 发明授权

US06446011B1 Tandem repeat detection using pattern discovery 失效
标题翻译：使用模式发现进行串联重复检测
公开(公告)号：US06446011B1
公开(公告)日：2002-09-03
申请号：US09528601
申请日：2000-03-20
申请人： Aris Floratos , Isidore Rigoutsos , Gustavo A. Stolovitzky
发明人： Aris Floratos , Isidore Rigoutsos , Gustavo A. Stolovitzky
IPC分类号： G01N3348
CPC分类号： G06F19/22 , G06F19/24 , Y10S707/99936
摘要： An algorithm which detects tandem repeats (TR) is provided. In an illustrative embodiment, a set of repeating units contained in an input sequence is identified, wherein each given repeating unit satisfies at least the following conditions: (a) a first measure of similarity between adjacent repeating units in the set is greater than a first user defined threshold, and (b) the given repeating unit includes at least one unit having a second measure of similarity with any other unit in the set that is a greater than a second user defined threshold. The method then provides for reporting positions in the input sequence that are covered by the set of repeating units.
摘要翻译：提供了一种检测串联重复（TR）的算法。在说明性实施例中，识别包含在输入序列中的一组重复单元，其中每个给定的重复单元至少满足以下条件：（a）该组中相邻重复单元之间的相似度的第一测量值大于第一用户定义的阈值，以及（b）所述给定的重复单元包括至少一个单元，所述至少一个单元具有与所述集合中的大于第二用户定义的阈值的任何其他单元的相似度的第二度量。该方法然后提供在输入序列中报告由该组重复单元覆盖的位置。

2. 发明授权

US10040682B2 Functionally switchable self-assembled coating compound for controlling translocation of molecule through nanopores 有权
公开(公告)号：US10040682B2
公开(公告)日：2018-08-07
申请号：US13465280
申请日：2012-05-07
申请人： Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Hongbo Peng , Gustavo A. Stolovitzky , Deqiang Wang
发明人： Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Hongbo Peng , Gustavo A. Stolovitzky , Deqiang Wang
IPC分类号： G01N27/40 , B82Y30/00 , B82Y40/00 , F03B11/02 , B82Y15/00 , G01N27/00
CPC分类号： B82Y15/00 , B82Y30/00 , B82Y40/00 , G01N27/00 , Y10T137/8593
摘要： A technique for a nanodevice is provided. The nanodevice includes a fluidic cell, and a membrane dividing the fluidic cell. A nanopore is formed through the membrane, and the nanopore is coated with an organic compound. A first part of the organic compound binds to a surface of the nanopore and a second part of the organic compound is exposed freely inside of the nanopore. The second part of the organic compound is configured to be switched among a first neutral hydrophilic end group, a second negatively charged hydrophilic end group, and a third neutral hydrophobic end group based on a switching mechanism.

3. 发明授权

US09453831B2 Nanopore capture system 有权
公开(公告)号：US09453831B2
公开(公告)日：2016-09-27
申请号：US13452857
申请日：2012-04-21
申请人： Stanislav Polonsky , Ali Afzali-Ardakani , Hongbo Peng , Gustavo A. Stolovitzky , Ajay A. Royyuru , Mark N. Wegman
发明人： Stanislav Polonsky , Ali Afzali-Ardakani , Hongbo Peng , Gustavo A. Stolovitzky , Ajay A. Royyuru , Mark N. Wegman
IPC分类号： G01N33/487 , G01N33/543
CPC分类号： G01N33/48721 , G01N33/54373
摘要： A nanopore capture system may include a material configured to pass through a nanopore device in a controlled manner based upon its interaction with the nanopore device. The system may also include a capture mechanism connected to one end of the material. The capture mechanism may be configured to catch a particular type of molecule while ignoring other types of molecules. The system may also include a controller to manipulate and/or detect the particular type of molecule.

4. 发明授权

US08641879B2 Charged entities as locomotive to control motion of polymers through a nanochannel 有权
公开(公告)号：US08641879B2
公开(公告)日：2014-02-04
申请号：US13611662
申请日：2012-09-12
申请人： Stefan Harrer , Binquan Luan , Glenn J. Martyna , Hongbo Peng , Stanislav Polonsky , Stephen M. Rossnagel , Ajay K. Royyuru , Gustavo A. Stolovitzky , George F. Walker
发明人： Stefan Harrer , Binquan Luan , Glenn J. Martyna , Hongbo Peng , Stanislav Polonsky , Stephen M. Rossnagel , Ajay K. Royyuru , Gustavo A. Stolovitzky , George F. Walker
IPC分类号： G01N27/26
CPC分类号： B82Y15/00 , C12Q1/6869 , C12Q2565/631
摘要： A technique for controlling the motion of one or more charged entities linked to a polymer through a nanochannel is provided. A first reservoir and a second reservoir are connected by the nanochannel. An array of electrodes is positioned along the nanochannel, where fluid fills the first reservoir, the second reservoir, and the nanochannel. A first electrode is in the first reservoir and a second electrode is in the second reservoir. The first and second electrodes are configured to direct the one or more charged entities linked to the polymer into the nanochannel. An array of electrodes is configured to trap the one or more charged entities in the nanochannel responsive to being controlled for trapping. The array of electrodes is configured to move the one or more charged entities along the nanochannel responsive to being controlled for moving.

5. 发明授权

US08598018B2 Forming an electrode having reduced corrosion and water decomposition on surface using a custom oxide layer 失效
标题翻译：使用定制的氧化物层形成表面上具有降低的腐蚀和水分解的电极
公开(公告)号：US08598018B2
公开(公告)日：2013-12-03
申请号：US12820487
申请日：2010-06-22
申请人： Ali Afzali-Azdakani , Shafaat Ahmed , Hariklia Deligianni , Dario L. Goldfarb , Stefan Harrer , Hongbo Peng , Stanislav Polonsky , Stephen Rossnagel , Xiaoyan Shao , Gustavo A. Stolovitzky
发明人： Ali Afzali-Azdakani , Shafaat Ahmed , Hariklia Deligianni , Dario L. Goldfarb , Stefan Harrer , Hongbo Peng , Stanislav Polonsky , Stephen Rossnagel , Xiaoyan Shao , Gustavo A. Stolovitzky
IPC分类号： H01L21/20 , H01L21/36 , H01L21/283
CPC分类号： C23C8/02 , C23C8/36 , C23C14/5853 , G01N33/48721
摘要： The present invention provides a method of forming an electrode having reduced corrosion and water decomposition on a surface thereof. A conductive layer is deposited on a substrate. The conductive layer is partially oxidized by an oxygen plasma process to convert a portion thereof to an oxide layer thereby forming the electrode. The oxide layer is free of surface defects and the thickness of the oxide layer is from about 0.09 nm to about 10 nm and ranges therebetween, controllable with 0.2 nm precision.
摘要翻译：本发明提供一种在其表面上形成具有降低的腐蚀和水分解的电极的方法。导电层沉积在基底上。导电层被氧等离子体工艺部分地氧化，将其一部分转化成氧化层，从而形成电极。氧化物层没有表面缺陷，氧化物层的厚度为约0.09nm至约10nm，并且其间的范围可以0.2nm精度控制。

6. 发明申请

US20130299945A1 FABRICATE SELF-FORMED NANOMETER PORE ARRAY AT WAFER SCALE FOR DNA SEQUENCING 有权
公开(公告)号：US20130299945A1
公开(公告)日：2013-11-14
申请号：US13469220
申请日：2012-05-11
申请人： Gustavo A. Stolovitzky , Deqiang Wang
发明人： Gustavo A. Stolovitzky , Deqiang Wang
IPC分类号： H01L29/02
CPC分类号： C12Q1/6874 , B81C1/00087 , B82Y5/00 , B82Y15/00 , B82Y40/00 , C12Q1/6869 , G01N33/48721 , Y10S977/723 , Y10S977/74 , Y10S977/742 , Y10S977/781 , Y10S977/904 , Y10S977/92 , Y10S977/953 , Y10S977/958 , C12Q2565/631
摘要： A technique is provided for a structure. A substrate has a nanopillar vertically positioned on the substrate. A bottom layer is formed beneath the substrate. A top layer is formed on top of the substrate and on top of the nanopillar, and a cover layer covers the top layer and the nanopillar. A window is formed through the bottom layer and formed through the substrate, and the window ends at the top layer. A nanopore is formed through the top layer by removing the cover layer and the nanopillar.

7. 发明申请

US20110312164A1 FORMING AN ELECTRODE HAVING REDUCED CORROSION AND WATER DECOMPOSITION ON SURFACE USING A CUSTOM OXIDE LAYER 失效
标题翻译：使用自定义氧化层形成具有降低腐蚀性和表面水分解的电极
公开(公告)号：US20110312164A1
公开(公告)日：2011-12-22
申请号：US12820487
申请日：2010-06-22
申请人： Ali Afzali-Azdakani , Shafaat Ahmed , Hariklia Deligianni , Dario L. Goldfarb , Stefan Harrer , Hongbo Peng , Stanislav Polonsky , Stephen Rossnagel , Xiaoyan Shao , Gustavo A. Stolovitzky
发明人： Ali Afzali-Azdakani , Shafaat Ahmed , Hariklia Deligianni , Dario L. Goldfarb , Stefan Harrer , Hongbo Peng , Stanislav Polonsky , Stephen Rossnagel , Xiaoyan Shao , Gustavo A. Stolovitzky
IPC分类号： H01L21/20 , H01L21/36 , C23C14/34 , G03F7/20 , C30B23/02 , C30B25/02 , C23C28/00 , B05D3/06 , C23C14/08
CPC分类号： C23C8/02 , C23C8/36 , C23C14/5853 , G01N33/48721
摘要： The present invention provides a method of forming an electrode having reduced corrosion and water decomposition on a surface thereof. A conductive layer is deposited on a substrate. The conductive layer is partially oxidized by an oxygen plasma process to convert a portion thereof to an oxide layer thereby forming the electrode. The oxide layer is free of surface defects and the thickness of the oxide layer is from about 0.09 nm to about 10 nm and ranges therebetween, controllable with 0.2 nm precision.
摘要翻译：本发明提供一种在其表面上形成具有降低的腐蚀和水分解的电极的方法。导电层沉积在基底上。导电层被氧等离子体工艺部分地氧化，将其一部分转化成氧化层，从而形成电极。氧化物层没有表面缺陷，氧化物层的厚度为约0.09nm至约10nm，并且其间的范围可以0.2nm精度控制。

8. 发明授权

US08039250B2 Piezoelectric-based nanopore device for the active control of the motion of polymers through the same 有权
标题翻译：用于主动控制聚合物运动的压电基纳米孔装置
公开(公告)号：US08039250B2
公开(公告)日：2011-10-18
申请号：US12723724
申请日：2010-03-15
申请人： Hongbo Peng , Gustavo A. Stolovitzky , Stephen M. Rossnagel , Stanislav Polonsky , Binquan Luan , Glenn J. Martyna
发明人： Hongbo Peng , Gustavo A. Stolovitzky , Stephen M. Rossnagel , Stanislav Polonsky , Binquan Luan , Glenn J. Martyna
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： C12Q1/6869 , Y10T29/42 , C12Q2565/631
摘要： Apparatus, system, and methods are provided for utilizing piezoelectric material for controlling a polymer through a nanopore. A reservoir is formed filled with conductive fluid. A membrane is formed that separates the reservoir. A nanopore is formed through the membrane. The membrane comprises electrical conductive layers, piezoelectric layers, and insulating layers. The piezoelectric layers are operative to control a size of the nanopore for clamping/releasing a polymer as well as to control the thickness of part of the membrane when a voltage is applied to the piezoelectric layers. Combinations of clamping/releasing the polymer and changing the thickness of part of the membrane can move a polymer through the nanopore at any electrically controlled speed and also stretch or break a polymer in the nanopore.
摘要翻译：提供了利用压电材料通过纳米孔控制聚合物的装置，系统和方法。形成填充有导电流体的储存器。形成隔离储存器的膜。通过膜形成纳米孔。膜包括导电层，压电层和绝缘层。压电层可操作以控制用于夹紧/释放聚合物的纳米孔的尺寸，以及当向压电层施加电压时控制膜的一部分的厚度。夹持/释放聚合物和改变膜的一部分厚度的组合可以以任何电控速度移动聚合物通过纳米孔，并且还拉伸或破坏纳米孔中的聚合物。

9. 发明授权

US08003319B2 Systems and methods for controlling position of charged polymer inside nanopore 有权
标题翻译：用于控制纳米孔内带电聚合物位置的系统和方法
公开(公告)号：US08003319B2
公开(公告)日：2011-08-23
申请号：US11670621
申请日：2007-02-02
申请人： Stanislav Polonsky , Stephen M. Rossnagel , Gustavo A. Stolovitzky
发明人： Stanislav Polonsky , Stephen M. Rossnagel , Gustavo A. Stolovitzky
IPC分类号： C12Q1/68 , G01N33/53 , C12M1/00 , C12M1/34 , C12M3/00
CPC分类号： G01N33/48721 , B82Y15/00 , B82Y30/00 , C12Q1/6825 , C12Q1/6869 , G01N2015/0038 , Y10S977/924 , C12Q2565/631 , C12Q2565/607 , C12Q2563/155
摘要： Techniques for controlling the position of a charged polymer inside a nanopore are provided. For example, one technique includes using electrostatic control to position a linear charged polymer inside a nanopore, and creating an electrostatic potential well inside the nanopore, wherein the electrostatic potential well controls a position of the linear charged polymer inside the nanopore.
摘要翻译：提供了用于控制纳米孔内带电聚合物位置的技术。例如，一种技术包括使用静电控制将线性带电聚合物定位在纳米孔内，并在纳米孔内产生静电势阱，其中静电势阱控制纳米孔内线性带电聚合物的位置。

10. 发明授权

US09758821B2 Graphene transistor gated by charges through a nanopore for bio-molecular sensing and DNA sequencing 有权
公开(公告)号：US09758821B2
公开(公告)日：2017-09-12
申请号：US13448509
申请日：2012-04-17
申请人： Hongbo Peng , Gustavo A. Stolovitzky , Wenjuan Zhu
发明人： Hongbo Peng , Gustavo A. Stolovitzky , Wenjuan Zhu
IPC分类号： G01N27/62 , C12Q1/68 , G01N33/487 , B82Y5/00
CPC分类号： C12Q1/6869 , B82Y5/00 , G01N33/48721 , Y10T436/143333
摘要： A technique for a nanodevice is provided. A reservoir is separated into two parts by a membrane. A nanopore is formed through the membrane, and the nanopore connects the two parts of the reservoir. The nanopore and the two parts of the reservoir are filled with ionic buffer. The membrane includes a graphene layer and insulating layers. The graphene layer is wired to first and second metal pads to form a graphene transistor in which transistor current flowing through the graphene transistor is modulated by charges passing through the nanopore.

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