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1. 发明授权

US10040682B2 Functionally switchable self-assembled coating compound for controlling translocation of molecule through nanopores 有权
公开(公告)号：US10040682B2
公开(公告)日：2018-08-07
申请号：US13465280
申请日：2012-05-07
申请人： Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Hongbo Peng , Gustavo A. Stolovitzky , Deqiang Wang
发明人： Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Hongbo Peng , Gustavo A. Stolovitzky , Deqiang Wang
IPC分类号： G01N27/40 , B82Y30/00 , B82Y40/00 , F03B11/02 , B82Y15/00 , G01N27/00
CPC分类号： B82Y15/00 , B82Y30/00 , B82Y40/00 , G01N27/00 , Y10T137/8593
摘要： A technique for a nanodevice is provided. The nanodevice includes a fluidic cell, and a membrane dividing the fluidic cell. A nanopore is formed through the membrane, and the nanopore is coated with an organic compound. A first part of the organic compound binds to a surface of the nanopore and a second part of the organic compound is exposed freely inside of the nanopore. The second part of the organic compound is configured to be switched among a first neutral hydrophilic end group, a second negatively charged hydrophilic end group, and a third neutral hydrophobic end group based on a switching mechanism.

2. 发明申请

US20130299945A1 FABRICATE SELF-FORMED NANOMETER PORE ARRAY AT WAFER SCALE FOR DNA SEQUENCING 有权
公开(公告)号：US20130299945A1
公开(公告)日：2013-11-14
申请号：US13469220
申请日：2012-05-11
申请人： Gustavo A. Stolovitzky , Deqiang Wang
发明人： Gustavo A. Stolovitzky , Deqiang Wang
IPC分类号： H01L29/02
CPC分类号： C12Q1/6874 , B81C1/00087 , B82Y5/00 , B82Y15/00 , B82Y40/00 , C12Q1/6869 , G01N33/48721 , Y10S977/723 , Y10S977/74 , Y10S977/742 , Y10S977/781 , Y10S977/904 , Y10S977/92 , Y10S977/953 , Y10S977/958 , C12Q2565/631
摘要： A technique is provided for a structure. A substrate has a nanopillar vertically positioned on the substrate. A bottom layer is formed beneath the substrate. A top layer is formed on top of the substrate and on top of the nanopillar, and a cover layer covers the top layer and the nanopillar. A window is formed through the bottom layer and formed through the substrate, and the window ends at the top layer. A nanopore is formed through the top layer by removing the cover layer and the nanopillar.

3. 发明授权

US10029915B2 Functionally switchable self-assembled coating compound for controlling translocation of molecule through nanopores 有权
公开(公告)号：US10029915B2
公开(公告)日：2018-07-24
申请号：US13439265
申请日：2012-04-04
申请人： Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Hongbo Peng , Gustavo A. Stolovitzky , Deqiang Wang
发明人： Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Hongbo Peng , Gustavo A. Stolovitzky , Deqiang Wang
IPC分类号： G01N27/40 , B82Y30/00 , B82Y40/00 , F03B11/02 , B82Y15/00 , G01N27/00
摘要： A technique for a nanodevice is provided. The nanodevice includes a fluidic cell, and a membrane dividing the fluidic cell. A nanopore is formed through the membrane, and the nanopore is coated with an organic compound. A first part of the organic compound binds to a surface of the nanopore and a second part of the organic compound is exposed freely inside of the nanopore. The second part of the organic compound is configured to be switched among a first neutral hydrophilic end group, a second negatively charged hydrophilic end group, and a third neutral hydrophobic end group based on a switching mechanism.

4. 发明申请

US20140027287A1 INCREASED MOLECULE CAPTURE RATE INTO A NANOPORE 失效
标题翻译：增加的分子获取率纳入纳米比亚
公开(公告)号：US20140027287A1
公开(公告)日：2014-01-30
申请号：US13570600
申请日：2012-08-09
申请人： Hongbo Peng , Gustavo A. Stolovitzky , Deqiang Wang
发明人： Hongbo Peng , Gustavo A. Stolovitzky , Deqiang Wang
IPC分类号： B03C11/00 , B82Y30/00
CPC分类号： B03C5/005 , B03C5/026 , B03C2201/26 , B82Y15/00
摘要： A mechanism for capturing molecules is provided. A nanopore through a membrane separates a first chamber from a second chamber, and the nanopore, the first chamber, and the second chamber are filled with ionic buffer. A narrowed neck is at a middle area of the first chamber, and the narrowed neck is aligned to an entrance of the nanopore. The narrowed neck has a high intensity electric field compared to other areas of the first chamber having low intensity electric fields. The narrowed neck having the high intensity electric field concentrates the molecules at the middle area aligned to the entrance of the nanopore. Voltage applied between the first chamber and the second chamber drives the molecules, concentrated at the entrance of the nanopore, through the nanopore.
摘要翻译：提供了捕获分子的机制。通过膜的纳米孔将第一室与第二室分开，并且纳米孔，第一室和第二室用离子缓冲液填充。狭窄的颈部位于第一腔室的中间区域，并且狭窄的颈部与纳米孔的入口对准。与具有低强度电场的第一室的其他区域相比，变窄的颈部具有高强度电场。具有高强度电场的狭窄颈部将分子集中在与纳米孔入口对准的中间区域。施加在第一室和第二室之间的电压驱动分子，浓缩在纳米孔的入口处，通过纳米孔。

5. 发明申请

US20130264219A1 FUNCTIONALLY SWITCHABLE SELF-ASSEMBLED COATING COMPOUND FOR CONTROLLING TRANSLOCATION OF MOLECULE THROUGH NANOPORES 审中-公开
公开(公告)号：US20130264219A1
公开(公告)日：2013-10-10
申请号：US13465280
申请日：2012-05-07
申请人： Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Hongbo Peng , Gustavo A. Stolovitzky , Deqiang Wang
发明人： Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Hongbo Peng , Gustavo A. Stolovitzky , Deqiang Wang
IPC分类号： G01N27/40 , B82Y99/00 , B82Y40/00 , B82Y30/00
CPC分类号： B82Y15/00 , B82Y30/00 , B82Y40/00 , G01N27/00 , Y10T137/8593
摘要： A technique for a nanodevice is provided. The nanodevice includes a fluidic cell, and a membrane dividing the fluidic cell. A nanopore is formed through the membrane, and the nanopore is coated with an organic compound. A first part of the organic compound binds to a surface of the nanopore and a second part of the organic compound is exposed freely inside of the nanopore. The second part of the organic compound is configured to be switched among a first neutral hydrophilic end group, a second negatively charged hydrophilic end group, and a third neutral hydrophobic end group based on a switching mechanism.

6. 发明申请

US20120325656A1 ELECTRON BEAM SCULPTING OF TUNNELING JUNCTION FOR NANOPORE DNA SEQUENCING 有权
标题翻译：用于纳米DNA序列的隧道结的电子束扫描
公开(公告)号：US20120325656A1
公开(公告)日：2012-12-27
申请号：US13606815
申请日：2012-09-07
申请人： Hongbo Peng , Stephen M. Rossnagel , Ajay K. Royyuru , Gustavo A. Stolovitzky , Deqiang Wang
发明人： Hongbo Peng , Stephen M. Rossnagel , Ajay K. Royyuru , Gustavo A. Stolovitzky , Deqiang Wang
IPC分类号： C23F1/02 , C25D13/14 , C25D13/04 , B82Y40/00 , B82Y30/00
CPC分类号： G01N33/48721 , Y10S977/712
摘要： A technique for a nanodevice is provided that includes a reservoir filled with a conductive fluid and a membrane separating the reservoir. The membrane includes an electrode layer having a tunneling junction formed therein. A nanopore is formed through the membrane, and the nanopore is formed through other layers of the membrane such that the nanopore is aligned with the tunneling junction of the electrode layer. When a voltage is applied to the electrode layer, a tunneling current is generated by a base in the tunneling junction to be measured as a signature for distinguishing the base. When an organic coating is formed on an inside surface of the tunneling junction, transient bonds are formed between the electrode layer and the base.
摘要翻译：提供了一种纳米器件的技术，其包括填充有导电流体的储存器和分离储存器的膜。膜包括其中形成有隧道结的电极层。通过膜形成纳米孔，并且纳米孔通过膜的其它层形成，使得纳米孔与电极层的隧道结对准。当向电极层施加电压时，通过作为区分基底的标记的待测量的隧道结中的基底产生隧穿电流。当在隧道结的内表面上形成有机涂层时，在电极层和基底之间形成瞬态结合。

7. 发明授权

US08858764B2 Electron beam sculpting of tunneling junction for nanopore DNA sequencing 有权
标题翻译：用于纳米孔DNA测序的隧道结的电子束雕刻
公开(公告)号：US08858764B2
公开(公告)日：2014-10-14
申请号：US13606815
申请日：2012-09-07
申请人： Hongbo Peng , Stephen M. Rossnagel , Ajay K. Royyuru , Gustavo A. Stolovitzky , Deqiang Wang
发明人： Hongbo Peng , Stephen M. Rossnagel , Ajay K. Royyuru , Gustavo A. Stolovitzky , Deqiang Wang
IPC分类号： H01L21/00 , G01N33/487
CPC分类号： G01N33/48721 , Y10S977/712
摘要： A technique for a nanodevice is provided that includes a reservoir filled with a conductive fluid and a membrane separating the reservoir. The membrane includes an electrode layer having a tunneling junction formed therein. A nanopore is formed through the membrane, and the nanopore is formed through other layers of the membrane such that the nanopore is aligned with the tunneling junction of the electrode layer. When a voltage is applied to the electrode layer, a tunneling current is generated by a base in the tunneling junction to be measured as a signature for distinguishing the base. When an organic coating is formed on an inside surface of the tunneling junction, transient bonds are formed between the electrode layer and the base.
摘要翻译：提供了一种纳米器件的技术，其包括填充有导电流体的储存器和分离储存器的膜。膜包括其中形成有隧道结的电极层。通过膜形成纳米孔，并且纳米孔通过膜的其它层形成，使得纳米孔与电极层的隧道结对准。当向电极层施加电压时，通过作为区分基底的标记的待测量的隧道结中的基底产生隧穿电流。当在隧道结的内表面上形成有机涂层时，在电极层和基底之间形成瞬态结合。

8. 发明授权

US08702940B2 Increased molecule capture rate into a nanopore 失效
标题翻译：增加分子捕获速率进入纳米孔
公开(公告)号：US08702940B2
公开(公告)日：2014-04-22
申请号：US13570600
申请日：2012-08-09
申请人： Hongbo Peng , Gustavo A. Stolovitzky , Deqiang Wang
发明人： Hongbo Peng , Gustavo A. Stolovitzky , Deqiang Wang
IPC分类号： G01N27/447 , G01N27/453 , B82Y35/00
CPC分类号： B03C5/005 , B03C5/026 , B03C2201/26 , B82Y15/00
摘要： A mechanism for capturing molecules is provided. A nanopore through a membrane separates a first chamber from a second chamber, and the nanopore, the first chamber, and the second chamber are filled with ionic buffer. A narrowed neck is at a middle area of the first chamber, and the narrowed neck is aligned to an entrance of the nanopore. The narrowed neck has a high intensity electric field compared to other areas of the first chamber having low intensity electric fields. The narrowed neck having the high intensity electric field concentrates the molecules at the middle area aligned to the entrance of the nanopore. Voltage applied between the first chamber and the second chamber drives the molecules, concentrated at the entrance of the nanopore, through the nanopore.
摘要翻译：提供了捕获分子的机制。通过膜的纳米孔将第一室与第二室分开，并且纳米孔，第一室和第二室用离子缓冲液填充。狭窄的颈部位于第一腔室的中间区域，并且狭窄的颈部与纳米孔的入口对准。与具有低强度电场的第一室的其他区域相比，变窄的颈部具有高强度电场。具有高强度电场的狭窄颈部将分子集中在与纳米孔入口对准的中间区域。施加在第一室和第二室之间的电压驱动分子，浓缩在纳米孔的入口处，通过纳米孔。

9. 发明授权

US08986980B2 Fabricate self-formed nanometer pore array at wafer scale for DNA sequencing 有权
标题翻译：制造晶圆规模的自制纳米孔阵列进行DNA测序
公开(公告)号：US08986980B2
公开(公告)日：2015-03-24
申请号：US13469220
申请日：2012-05-11
申请人： Gustavo A. Stolovitzky , Deqiang Wang
发明人： Gustavo A. Stolovitzky , Deqiang Wang
IPC分类号： H01L29/02 , B82Y15/00 , B82Y40/00 , B82Y5/00
CPC分类号： C12Q1/6874 , B81C1/00087 , B82Y5/00 , B82Y15/00 , B82Y40/00 , C12Q1/6869 , G01N33/48721 , Y10S977/723 , Y10S977/74 , Y10S977/742 , Y10S977/781 , Y10S977/904 , Y10S977/92 , Y10S977/953 , Y10S977/958 , C12Q2565/631
摘要： A technique is provided for a structure. A substrate has a nanopillar vertically positioned on the substrate. A bottom layer is formed beneath the substrate. A top layer is formed on top of the substrate and on top of the nanopillar, and a cover layer covers the top layer and the nanopillar. A window is formed through the bottom layer and formed through the substrate, and the window ends at the top layer. A nanopore is formed through the top layer by removing the cover layer and the nanopillar.
摘要翻译：为结构提供了一种技术。衬底具有垂直定位在衬底上的纳米柱。在基底下方形成底层。在衬底的顶部和纳米柱的顶部上形成顶层，并且覆盖层覆盖顶层和纳米柱。通过底层形成窗口并形成穿过基底，并且窗口在顶层结束。通过去除覆盖层和纳米柱，通过顶层形成纳米孔。

10. 发明授权

US08652340B2 Fabricate self-formed nanometer pore array at wafer scale for DNA sequencing 有权
标题翻译：制造晶圆规模的自制纳米孔阵列进行DNA测序
公开(公告)号：US08652340B2
公开(公告)日：2014-02-18
申请号：US13490618
申请日：2012-06-07
申请人： Gustavo A. Stolovitzky , Deqiang Wang
发明人： Gustavo A. Stolovitzky , Deqiang Wang
IPC分类号： B31D3/00
CPC分类号： C12Q1/6874 , B81C1/00087 , B82Y5/00 , B82Y15/00 , B82Y40/00 , C12Q1/6869 , G01N33/48721 , Y10S977/723 , Y10S977/74 , Y10S977/742 , Y10S977/781 , Y10S977/904 , Y10S977/92 , Y10S977/953 , Y10S977/958 , C12Q2565/631
摘要： A technique is provided for a structure. A substrate has a nanopillar vertically positioned on the substrate. A bottom layer is formed beneath the substrate. A top layer is formed on top of the substrate and on top of the nanopillar, and a cover layer covers the top layer and the nanopillar. A window is formed through the bottom layer and formed through the substrate, and the window ends at the top layer. A nanopore is formed through the top layer by removing the cover layer and the nanopillar.
摘要翻译：为结构提供了一种技术。衬底具有垂直定位在衬底上的纳米柱。在基底下方形成底层。在衬底的顶部和纳米柱的顶部上形成顶层，并且覆盖层覆盖顶层和纳米柱。通过底层形成窗口并形成穿过基底，并且窗口在顶层结束。通过去除覆盖层和纳米柱，通过顶层形成纳米孔。

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