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1. 发明申请

US20130230930A2 TREATMENT OF A SAMPLE WITH FOCUSED ACOUSTIC ENERGY 有权
标题翻译：用聚焦能量处理样品
公开(公告)号：US20130230930A2
公开(公告)日：2013-09-05
申请号：US13273677
申请日：2010-04-09
申请人： Arie R. VanDoorn , Ronald De Gier , Louis Stroucken , Marloes M.E.B. Van De Wal , Sergei Shulepov , Nicolaas B. Roozen , Contantijn W. M. Brantjes , Hendrick S. Van Damme , Michiel De Jong
发明人： Arie R. VanDoorn , Ronald De Gier , Louis Stroucken , Marloes M.E.B. Van De Wal , Sergei Shulepov , Nicolaas B. Roozen , Contantijn W. M. Brantjes , Hendrick S. Van Damme , Michiel De Jong
IPC分类号： G01N1/00 , B01L3/00
CPC分类号： G01N1/44
摘要： A device for treating a sample with focused acoustic energy is provided. The device transmits the generated acoustic energy from the source to the sample via a complete dry propagation path. A cartridge containing the sample is inserted into an instrument, wherein the insertion forms a dry propagation path.
摘要翻译：提供了一种用聚焦声能处理样品的装置。该装置通过完整的干燥传播路径将生成的声能从源传送到样品。将包含样品的盒插入仪器中，其中插入形成干传播路径。

2. 发明申请

US20120088310A1 DEVICE FOR CUTTING A SAMPLE CARRIER 有权
标题翻译：切割样品载体的装置
公开(公告)号：US20120088310A1
公开(公告)日：2012-04-12
申请号：US13273677
申请日：2011-10-14
申请人： Arie R. Van Doorn , Ronald De Gier , Louis Stroucken , Marloes M. E. B. Van De Wal , Sergei Shulepov , Nicolaas B. Roozen , Contantijn W. M. Brantjes , Hendrik S. Van Damme , Michiel De Jong
发明人： Arie R. Van Doorn , Ronald De Gier , Louis Stroucken , Marloes M. E. B. Van De Wal , Sergei Shulepov , Nicolaas B. Roozen , Contantijn W. M. Brantjes , Hendrik S. Van Damme , Michiel De Jong
IPC分类号： G01N1/00 , B01L3/00
CPC分类号： G01N1/44
摘要： A device for receiving a sample carrier is provided. The device includes an opening for receiving part of the sample carrier and a cutter for removing a part of the sample carrier. The cutter is coupled to a lid, which is movable to allow the cutter to make an incision in the sample carrier and, at the same time, to close at least part of the opening left open after receipt of the sample carrier. The disclosure further relates to a system comprising such a device and a method for operating such a device.
摘要翻译：提供了一种用于接收样品载体的装置。该装置包括用于容纳样品载体的一部分的开口和用于去除样品载体的一部分的切割器。切割器联接到盖子，该盖子可移动以允许切割器在样品载体中进行切口，并且同时在接收到样品载体之后关闭开放的开口的至少一部分。本公开还涉及包括这种装置的系统和用于操作这种装置的方法。

3. 发明授权

US08563324B2 Device and method for irradiating a sample with focused acoustic energy including a fully solid coupler 有权
标题翻译：用于用包含全固体成色剂的聚焦声能照射样品的装置和方法
公开(公告)号：US08563324B2
公开(公告)日：2013-10-22
申请号：US13273677
申请日：2011-10-14
申请人： Arie R. Van Doorn , Ronald De Gier , Louis Stroucken , Marloes M. E. B. Van De Wal , Sergei Shulepov , Nicolaas B. Roozen , Contantijn W. M. Brantjes , Hendrik S. Van Damme , Michiel de Jong
发明人： Arie R. Van Doorn , Ronald De Gier , Louis Stroucken , Marloes M. E. B. Van De Wal , Sergei Shulepov , Nicolaas B. Roozen , Contantijn W. M. Brantjes , Hendrik S. Van Damme , Michiel de Jong
IPC分类号： G01N1/00
CPC分类号： G01N1/44
摘要： A device for receiving a sample carrier is provided. The device includes an opening for receiving part of the sample carrier and a cutter for removing a part of the sample carrier. The cutter is coupled to a lid, which is movable to allow the cutter to make an incision in the sample carrier and, at the same time, to close at least part of the opening left open after receipt of the sample carrier. The disclosure further relates to a system comprising such a device and a method for operating such a device.
摘要翻译：提供了一种用于接收样品载体的装置。该装置包括用于容纳样品载体的一部分的开口和用于去除样品载体的一部分的切割器。切割器联接到盖子，该盖子可移动以允许切割器在样品载体中进行切口，并且同时在接收到样品载体之后关闭开放的开口的至少一部分。本公开还涉及包括这种装置的系统和用于操作这种装置的方法。

4. 发明申请

US20100047774A1 CARTRIDGE, SYSTEM AND METHOD FOR AUTOMATED MEDICAL DIAGNOSTICS 有权
标题翻译： CARTRIDGE，SYSTEM AND METHOD FOR AUTOMATED MEDICAL DIAGNOSTICS
公开(公告)号：US20100047774A1
公开(公告)日：2010-02-25
申请号：US11917955
申请日：2006-06-16
申请人： Chris Van Haag , Michiel Johannes Jongerius , Danny Genius Aldegonda Schaefer , Adrianus Wilhelmus Dionisius Maria Van Den Bijgaart , Ronald De Gier , Michiel De Jong , Gerhard Pross , Johannes Bacher , Andreas Boos , Gerd Luedke , Jens-Peter Seher
发明人： Chris Van Haag , Michiel Johannes Jongerius , Danny Genius Aldegonda Schaefer , Adrianus Wilhelmus Dionisius Maria Van Den Bijgaart , Ronald De Gier , Michiel De Jong , Gerhard Pross , Johannes Bacher , Andreas Boos , Gerd Luedke , Jens-Peter Seher
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： B01L7/52 , B01L3/502715 , B01L3/502738 , B01L3/545 , B01L2200/027 , B01L2200/028 , B01L2200/10 , B01L2300/02 , B01L2300/087 , B01L2300/1805 , G01N21/6428 , G01N35/00069 , G01N2035/00158
摘要： Disclosed is a cartridge for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. The cartridge comprises a generic part and one or more separate application-specific parts, which are connectable to the generic part. Also disclosed is a system for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. This system comprising a reusable apparatus, wherein said apparatus is configured to receive a cartridge and to control a process for the detection of the presence, absence and/or amount of a target nucleotide sequence in the sample, being present in said cartridge.
摘要翻译：公开了用于检测包含一个或多个核酸序列的样品中靶核苷酸序列的存在，不存在和/或量的盒。盒包括通用部分和一个或多个单独的应用特定部分，其可连接到通用部分。还公开了用于检测包含一个或多个核酸序列的样品中靶核苷酸序列的存在，不存在和/或量的系统。该系统包括可重复使用的装置，其中所述装置被配置为接收盒并且控制用于检测存在于所述盒中的样品中目标核苷酸序列的存在，不存在和/或量的过程。

5. 发明授权

US09568424B2 Cartridge, system and method for automated medical diagnostics 有权
标题翻译：墨盒，系统和自动化诊断方法
公开(公告)号：US09568424B2
公开(公告)日：2017-02-14
申请号：US11917955
申请日：2006-06-16
申请人： Chris Van Haag , Michiel Johannes Jongerius , Danny Genius Aldegonda Schaefer , Adrianus Wilhelmus Dionisius Maria Van Den Bijgaart , Ronald De Gier , Michiel De Jong , Gerhard Pross , Johannes Bacher , Andreas Boos , Gerd Luedke , Jens-Peter Seher
发明人： Chris Van Haag , Michiel Johannes Jongerius , Danny Genius Aldegonda Schaefer , Adrianus Wilhelmus Dionisius Maria Van Den Bijgaart , Ronald De Gier , Michiel De Jong , Gerhard Pross , Johannes Bacher , Andreas Boos , Gerd Luedke , Jens-Peter Seher
IPC分类号： C12M1/36 , G01N21/64 , B01L3/00 , G01N35/00
CPC分类号： B01L7/52 , B01L3/502715 , B01L3/502738 , B01L3/545 , B01L2200/027 , B01L2200/028 , B01L2200/10 , B01L2300/02 , B01L2300/087 , B01L2300/1805 , G01N21/6428 , G01N35/00069 , G01N2035/00158
摘要： Cartridge and method for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. The cartridge comprises a one or more nucleic acid sequences, and the cartridge includes a generic part and one or more separate application-specific parts, which are connectable to the generic part.
摘要翻译：用于检测包含一个或多个核酸序列的样品中靶核苷酸序列的存在，不存在和/或数量的盒和方法。盒包括一个或多个核酸序列，并且盒包括通用部分和一个或多个单独的应用特定部分，其可连接到通用部分。

6. 发明授权

US09492823B2 Manifold for a fluidic cartridge 有权
标题翻译：流体盒的歧管
公开(公告)号：US09492823B2
公开(公告)日：2016-11-15
申请号：US13503407
申请日：2010-10-20
申请人： Ronald De Gier , Arthur R Van Es , Peter Wilnauer
发明人： Ronald De Gier , Arthur R Van Es , Peter Wilnauer
IPC分类号： B01L3/00
CPC分类号： B01L3/502738 , B01L2300/0861 , B01L2400/0644 , Y10T137/598 , Y10T137/6851 , Y10T137/85938
摘要： A manifold system is provided that includes a manifold housing and a manifold core. The manifold housing is configured to receive the manifold core. The manifold housing includes an oblique inner surface and at least one fluidic channel. The fluidic channel ends with one of its ends at the oblique inner surface. The manifold housing together with the at least one fluidic channel has no undercut.
摘要翻译：提供了一种歧管系统，其包括歧管壳体和歧管芯。歧管壳体构造成接收歧管芯。歧管壳体包括倾斜的内表面和至少一个流体通道。流体通道以其端部之一在倾斜内表面处终止。歧管壳体与至少一个流体通道一起没有底切。

7. 发明申请

US20120034687A1 PROTECTION OF BIOANALYTICAL SAMPLE CHAMBERS 有权
标题翻译：保护生物样品瓶
公开(公告)号：US20120034687A1
公开(公告)日：2012-02-09
申请号：US13273533
申请日：2011-10-14
申请人： Ronald De Gier , Jozef C.M. Versleegers
发明人： Ronald De Gier , Jozef C.M. Versleegers
IPC分类号： C12M1/34 , G01N21/00
CPC分类号： B01L9/52 , B01L7/52 , B01L2200/141 , B01L2200/18 , B01L2300/041
摘要： An apparatus for performing bioanalytic processing and analysis, a bioanalytical reaction device, and a cartridge thereof are provided. The cartridge contains a housing and at least one sample chamber in a platform for storing biological samples, which the bioanalytical reaction device can process and analyze. The platform is movably connected to the housing such that the platform is movable between a stowed position, in which the sample chamber is protected by the housing, and an extended position, in which the sample chamber is outside of the housing. The bioanalytical reaction device includes an actuation device for moving the platform between the stowed and extended positions.
摘要翻译：提供了一种用于进行生物分析处理和分析的装置，生物分析反应装置及其盒。所述筒包含壳体和用于存储生物样品的平台中的至少一个样品室，所述生物分析反应装置可以处理和分析。平台可移动地连接到壳体，使得平台可以在收起位置之间移动，在收起位置，样本室被壳体保护，并且延伸位置，样本室在壳体的外部。生物分析反应装置包括用于在收起位置和伸展位置之间移动平台的致动装置。

8. 发明申请

US20120325334A1 MANIFOLD FOR A FLUIDIC CARTRIDGE 有权
标题翻译：用于流体盒的歧管
公开(公告)号：US20120325334A1
公开(公告)日：2012-12-27
申请号：US13503407
申请日：2010-10-20
申请人： Ronald De Gier , Arthur R. Van Es , Peter Wilnauer
发明人： Ronald De Gier , Arthur R. Van Es , Peter Wilnauer
IPC分类号： F16L3/00 , F16L41/00
CPC分类号： B01L3/502738 , B01L2300/0861 , B01L2400/0644 , Y10T137/598 , Y10T137/6851 , Y10T137/85938
摘要： A manifold system is provided that includes a manifold housing and a manifold core. The manifold housing is configured to receive the manifold core. The manifold housing includes an oblique inner surface and at least one fluidic channel. The fluidic channel ends with one of its ends at the oblique inner surface. The manifold housing together with the at least one fluidic channel has no undercut.
摘要翻译：提供了一种歧管系统，其包括歧管壳体和歧管芯。歧管壳体构造成接收歧管芯。歧管壳体包括倾斜的内表面和至少一个流体通道。流体通道以其端部之一在倾斜内表面处终止。歧管壳体与至少一个流体通道一起没有底切。

9. 发明授权

US09079182B2 Protection of bioanalytical sample chambers 有权
标题翻译：保护生物分析样品室
公开(公告)号：US09079182B2
公开(公告)日：2015-07-14
申请号：US13273533
申请日：2011-10-14
申请人： Ronald De Gier , Jozef C. M. Versleegers
发明人： Ronald De Gier , Jozef C. M. Versleegers
IPC分类号： C12M1/34 , C12M3/00 , B01L9/00 , B01L7/00
CPC分类号： B01L9/52 , B01L7/52 , B01L2200/141 , B01L2200/18 , B01L2300/041
摘要： An apparatus for performing bioanalytic processing and analysis, a bioanalytical reaction device, and a cartridge thereof are provided. The cartridge contains a housing and at least one sample chamber in a platform for storing biological samples, which the bioanalytical reaction device can process and analyze. The platform is movably connected to the housing such that the platform is movable between a stowed position, in which the sample chamber is protected by the housing, and an extended position, in which the sample chamber is outside of the housing. The bioanalytical reaction device includes an actuation device for moving the platform between the stowed and extended positions.
摘要翻译：提供了一种用于进行生物分析加工和分析的装置，生物分析反应装置及其盒。所述筒包含壳体和用于存储生物样品的平台中的至少一个样品室，所述生物分析反应装置可以处理和分析。平台可移动地连接到壳体，使得平台可以在收起位置之间移动，在收起位置，样本室被壳体保护，并且延伸位置，样本室在壳体的外部。生物分析反应装置包括用于在收起位置和伸展位置之间移动平台的致动装置。

10. 发明申请

US20140271410A1 SEALING DEVICE FOR USE IN A CARTRIDGE FOR MEDICAL DIAGNOSTICS 有权
标题翻译：密封设备用于医疗诊断的盒子
公开(公告)号：US20140271410A1
公开(公告)日：2014-09-18
申请号：US14344646
申请日：2012-09-27
申请人： Rob Bosma , Ronald De Gier
发明人： Rob Bosma , Ronald De Gier
IPC分类号： B01L3/00
CPC分类号： B01L3/508 , A61B10/0096 , B01L3/502 , B01L3/5023 , B01L2200/025 , B01L2200/0689 , B01L2200/141 , B01L2300/045 , B01L2300/069 , Y10S435/81 , Y10S435/975
摘要： The present invention relates to a sealing device for closing an introduction aperture, the sealing device comprising a fixed support and a shutter mounted movably in translation relative to the support between an extended position and a final retracted position, wherein the sealing device is in a final retracted configuration and wherein the shutter closes introduction aperture. The device includes locking means for preventing any movement of the shutter when it is in the final retracted position. The sealing device further comprises an intermediate retracted configuration, wherein the shutter is at least partly retracted. The sealing device also comprises motion guiding means for guiding the movement of the shutter and designed so that the extension of the shutter is required to move the shutter from the intermediate retracted position to the final retracted position.
摘要翻译：本发明涉及一种用于封闭导入孔的密封装置，该密封装置包括一个固定的支撑件和一个在延伸位置和最后的缩回位置之间相对于支撑件可移动平移的快门，其中密封装置处于最后缩回配置，并且其中快门关闭引入孔。该装置包括锁定装置，用于当快门处于最终缩回位置时防止快门的任何运动。密封装置还包括中间缩回构型，其中挡板至少部分缩回。密封装置还包括用于引导活门的运动的运动引导装置，并被设计成使得快门的延伸需要使活门从中间缩回位置移动到最终缩回位置。

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