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1. 发明授权

US07789834B2 Plaque characterization using multiple intravascular ultrasound datasets having distinct filter bands 有权
标题翻译：使用具有不同滤光片带的多个血管内超声数据集的斑块表征
公开(公告)号：US07789834B2
公开(公告)日：2010-09-07
申请号：US11689327
申请日：2007-03-21
申请人： Anuja Nair , David Geoffrey Vince , Marja Paulina Margolis , Kendall Rand Waters
发明人： Anuja Nair , David Geoffrey Vince , Marja Paulina Margolis , Kendall Rand Waters
IPC分类号： A61B8/00 , G01N9/24
CPC分类号： A61B8/5207 , A61B5/02007 , A61B8/085 , A61B8/12 , A61B8/4488 , A61B8/461 , G01S7/52036 , G01S15/8956
摘要： A system and method are disclosed that facilitate generating visual representations of characterized tissue based upon ultrasound echo information obtained from a portion of an imaged body. The system includes a first filter having a first filter band that is applied to a near range portion of the ultrasound echo information to render near range filtered echo information. A second filter, having a second filter band that covers a frequency range of the first filter band, is applied to a far range portion of the ultrasound echo information to render far range filtered echo information. The system furthermore includes a set of characterization criteria that are applied to the near and far range filtered echo information. The characterized near and far range image data are thereafter combined into a single tissue-characterization image.
摘要翻译：公开了一种系统和方法，其基于从成像体的一部分获得的超声回波信息便于生成特征性组织的视觉表示。该系统包括具有第一滤波器带的第一滤波器，该滤波器频带被施加到超声回波信息的近距离部分以呈现近距离滤波的回波信息。具有覆盖第一滤波器频带的频率范围的第二滤波器带的第二滤波器被施加到超声波回波信息的远程部分，以产生远距离滤波的回波信息。该系统还包括应用于近距离和远距离过滤的回波信息的一组表征标准。然后将表征的近距离和远距离图像数据组合成单个组织表征图像。

2. 发明申请

US20100331695A1 Plaque Characterization Using Multiple Intravascular Ultrasound Datasets Having Distinct Filter Bands 有权
标题翻译：使用具有不同过滤带的多个血管内超声数据的斑块表征
公开(公告)号：US20100331695A1
公开(公告)日：2010-12-30
申请号：US12875390
申请日：2010-09-03
申请人： Anuja Nair , David Geoffrey Vince , Marja Pauliina Margolis , Kendall Rand Waters
发明人： Anuja Nair , David Geoffrey Vince , Marja Pauliina Margolis , Kendall Rand Waters
IPC分类号： A61B8/14 , G06K9/00
CPC分类号： A61B8/5207 , A61B5/02007 , A61B8/085 , A61B8/12 , A61B8/4488 , A61B8/461 , G01S7/52036 , G01S15/8956
摘要： A system and method are disclosed that facilitate generating visual representations of characterized tissue based upon ultrasound echo information obtained from a portion of an imaged body. The system includes a first filter having a first filter band that is applied to a near range portion of the ultrasound echo information to render near range filtered echo information. A second filter, having a second filter band that covers a frequency range of the first filter band, is applied to a far range portion of the ultrasound echo information to render far range filtered echo information. The system furthermore includes a set of characterization criteria that are applied to the near and far range filtered echo information. The characterized near and far range image data are thereafter combined into a single tissue-characterization image.
摘要翻译：公开了一种系统和方法，其基于从成像体的一部分获得的超声回波信息便于生成特征性组织的视觉表示。该系统包括具有第一滤波器带的第一滤波器，该滤波器频带被施加到超声回波信息的近距离部分以呈现近距离滤波的回波信息。具有覆盖第一滤波器频带的频率范围的第二滤波器带的第二滤波器被施加到超声波回波信息的远程部分，以产生远距离滤波的回波信息。该系统还包括应用于近距离和远距离过滤的回波信息的一组表征标准。然后将表征的近距离和远距离图像数据组合成单个组织表征图像。

3. 发明授权

US08425423B2 Plaque characterization using multiple intravascular ultrasound datasets having distinct filter bands 有权
公开(公告)号：US08425423B2
公开(公告)日：2013-04-23
申请号：US12875390
申请日：2010-09-03
申请人： Anuja Nair , David Geoffrey Vince , Marja Pauliina Margolis , Kendall Rand Waters
发明人： Anuja Nair , David Geoffrey Vince , Marja Pauliina Margolis , Kendall Rand Waters
IPC分类号： A61B8/00 , G01N9/24
CPC分类号： A61B8/5207 , A61B5/02007 , A61B8/085 , A61B8/12 , A61B8/4488 , A61B8/461 , G01S7/52036 , G01S15/8956
摘要： A system and method are disclosed that facilitate generating visual representations of characterized tissue based upon ultrasound echo information obtained from a portion of an imaged body. The system includes a first filter having a first filter band that is applied to a near range portion of the ultrasound echo information to render near range filtered echo information. A second filter, having a second filter band that covers a frequency range of the first filter band, is applied to a far range portion of the ultrasound echo information to render far range filtered echo information. The system furthermore includes a set of characterization criteria that are applied to the near and far range filtered echo information. The characterized near and far range image data are thereafter combined into a single tissue-characterization image.

4. 发明申请

US20080234582A1 PLAQUE CHARACTERIZATION USING MULTIPLE INTRAVASCULAR ULTRASOUND DATASETS HAVING DISTINCT FILTER BANDS 有权
标题翻译：使用具有异常过滤器的多个超声波超声波数据的PLAQUE特征
公开(公告)号：US20080234582A1
公开(公告)日：2008-09-25
申请号：US11689327
申请日：2007-03-21
申请人： Anuja Nair , David Geoffrey Vince , Marja Pauliina Margolis , Kendall Rand Waters
发明人： Anuja Nair , David Geoffrey Vince , Marja Pauliina Margolis , Kendall Rand Waters
IPC分类号： A61B8/13
CPC分类号： A61B8/5207 , A61B5/02007 , A61B8/085 , A61B8/12 , A61B8/4488 , A61B8/461 , G01S7/52036 , G01S15/8956
摘要： A system and method are disclosed that facilitate generating visual representations of characterized tissue based upon ultrasound echo information obtained from a portion of an imaged body. The system includes a first filter having a first filter band that is applied to a near range portion of the ultrasound echo information to render near range filtered echo information. A second filter, having a second filter band that covers a frequency range of the first filter band, is applied to a far range portion of the ultrasound echo information to render far range filtered echo information. The system furthermore includes a set of characterization criteria that are applied to the near and far range filtered echo information. The characterized near and far range image data are thereafter combined into a single tissue-characterization image.
摘要翻译：公开了一种系统和方法，其基于从成像体的一部分获得的超声回波信息便于生成特征性组织的视觉表示。该系统包括具有第一滤波器带的第一滤波器，该滤波器频带被施加到超声回波信息的近距离部分以呈现近距离滤波的回波信息。具有覆盖第一滤波器频带的频率范围的第二滤波器带的第二滤波器被施加到超声波回波信息的远程部分，以产生远距离滤波的回波信息。该系统还包括应用于近距离和远距离过滤的回波信息的一组表征标准。然后将表征的近距离和远距离图像数据组合成单个组织表征图像。

5. 发明授权

US08808183B2 System and method for determining a transfer function 有权
标题翻译：用于确定传递函数的系统和方法
公开(公告)号：US08808183B2
公开(公告)日：2014-08-19
申请号：US12878770
申请日：2010-09-09
申请人： Anuja Nair , David Geoffrey Vince , Jon D. Klingensmith , Barry D. Kuban
发明人： Anuja Nair , David Geoffrey Vince , Jon D. Klingensmith , Barry D. Kuban
IPC分类号： A61B8/00
CPC分类号： A61B5/02007 , A61B5/726 , A61B8/12
摘要： A system and method is provided for using ultrasound data backscattered from vascular tissue to estimate the transfer function of a catheter (including components attached thereto—e.g., IVUS console, transducer, etc.). Specifically, in accordance with a first embodiment of the present invention, a computing device is electrically connected to a catheter and used to acquire RF backscattered data from a vascular structure (e.g., a blood vessel, etc.). The backscattered ultrasound data is then used, together with an algorithm, to estimate the transfer function. The transfer function can then be used (at least in a preferred embodiment) to calculate response data for the vascular tissue (i.e., the tissue component of the backscattered ultrasound data). In a second embodiment of the present invention, an IVUS console is electrically connected to a catheter and a computing device and is used to acquire RF backscattered data from a vascular structure. The backscattered data is then transmitted to the computing device, where it is used to estimate the catheter's transfer function and to calculate response data for the vascular tissue. The response data and histology data are then used to characterize at least a portion of the vascular tissue (e.g., identify tissue type, etc.).
摘要翻译：提供了一种系统和方法，用于使用从血管组织反向散射的超声数据来估计导管（包括与其连接的部件，例如，IVUS控制台，换能器等）的传递功能。具体地，根据本发明的第一实施例，计算设备电连接到导管并用于从血管结构（例如，血管等）获取RF背散射数据。然后将后向散射的超声数据与算法一起用于估计传递函数。然后可以使用传递函数（至少在一个优选实施例中）来计算血管组织的反应数据（即背散射超声数据的组织分量）。在本发明的第二实施例中，IVUS控制台电连接到导管和计算设备，并用于从血管结构获取RF背散射数据。然后将背散射数据传输到计算设备，其中其用于估计导管的传递函数并计算血管组织的反应数据。然后使用响应数据和组织学数据来表征血管组织的至少一部分（例如，识别组织类型等）。

6. 发明申请

US20130066212A1 Device and Method for Determining the Likelihood of a Patient Having a Clinical Event or a Clinically Silent Event Based on Ascertained Physiological Parameters 审中-公开
标题翻译：用于确定具有基于确定的生理参数的临床事件或临床静默事件的患者的可能性的装置和方法
公开(公告)号：US20130066212A1
公开(公告)日：2013-03-14
申请号：US13497668
申请日：2010-09-25
申请人： Marja Margolis , David Geoffrey Vince , Anuja Nair
发明人： Marja Margolis , David Geoffrey Vince , Anuja Nair
IPC分类号： A61B8/12 , A61B8/06
CPC分类号： A61B5/7275 , A61B5/02007 , A61B8/12 , G16H50/20 , Y02A90/26
摘要： A patient's physiological parameters, ascertained using intravascular ultrasound (IVUS) in combination with virtual histology (VH), are evaluated to predict whether the patient's physiology has an increased risk of producing a Clinical Event or a Silent Clinical Event. In one embodiment, one or more physiological parameters, such as Plaque Burden, Minimum Lumen Area, and whether or multiple VH-TCFAs are present, are compared to target values and/or ranges. A concurrence of the values for the physiological parameters to the target ranges indicates that a patient's physiology has an increased risk of producing a Clinical Event or a Silent Clinical Event.
摘要翻译：评估使用血管内超声（IVUS）与虚拟组织学（VH）联合确定的患者的生理参数，以预测患者的生理学是否具有产生临床事件或静默临床事件的风险增加。在一个实施例中，将一个或多个生理参数，例如斑块负荷，最小流明面积以及是否存在多个VH-TCFA存在，与目标值和/或范围进行比较。生理参数值与目标范围的一致表明，患者的生理学具有产生临床事件或静默临床事件的风险增加。

7. 发明授权

US08630492B2 System and method for identifying a vascular border 有权
标题翻译：识别血管边界的系统和方法
公开(公告)号：US08630492B2
公开(公告)日：2014-01-14
申请号：US13563299
申请日：2012-07-31
申请人： Jon D. Klingensmith , D. Geoffrey Vince , Anuja Nair , Barry D. Kuban
发明人： Jon D. Klingensmith , D. Geoffrey Vince , Anuja Nair , Barry D. Kuban
IPC分类号： G06K9/48 , G06K9/00 , A61B6/00 , A61F11/00
CPC分类号： G06T7/0012 , A61B5/02007 , A61B8/12 , G06T7/12 , G06T2207/10132 , G06T2207/20101 , G06T2207/30101
摘要： A system and method are provided for using a first vascular image, or more particularly a plurality of control points located thereon, to identify a border on a second vascular image. Embodiments of the present invention operate in accordance with an intra-vascular ultrasound (IVUS) device and a computing device electrically connected thereto. In one embodiment, the computing device includes a plurality of applications operating thereon that are used to (I) identify a border and control points on a first IVUS image (i.e., any IVUS image), (ii) extrapolate the control points to a second IVUS image (i.e., another IVUS image), (iii) identify a border on the second IVUS image, and (iv) adjust the border on the second IVUS image in accordance with at least one factor.
摘要翻译：提供了一种系统和方法，用于使用位于其上的第一血管图像，或更具体地多个控制点来识别第二血管图像上的边界。本发明的实施例根据血管内超声（IVUS）装置和与其电连接的计算装置进行操作。在一个实施例中，计算设备包括多个在其上操作的应用，其用于（I）识别第一IVUS图像（即，任何IVUS图像）上的边界和控制点，（ii）将控制点外推到第二IVUS IVUS图像（即另一IVUS图像），（iii）识别第二IVUS图像上的边界，以及（iv）根据至少一个因素调整第二IVUS图像上的边界。

8. 发明授权

US08622910B2 System and method of aquiring blood-vessel data 有权
标题翻译：获取血管数据的系统和方法
公开(公告)号：US08622910B2
公开(公告)日：2014-01-07
申请号：US13066659
申请日：2011-04-19
申请人： Barry D. Kuban , Jon D. Klingensmith , D. Geoffrey Vince , Anuja Nair
发明人： Barry D. Kuban , Jon D. Klingensmith , D. Geoffrey Vince , Anuja Nair
IPC分类号： A61B8/00
CPC分类号： A61B8/543 , A61B8/12 , A61B8/445 , G06T7/0012 , G06T2207/30101
摘要： A system and method is provided for substantially synchronizing the acquisition of blood-vessel data to an identifiable portion of heartbeat data. Specifically, a data-gathering device is adapted to acquire heartbeat data and blood-vessel data from a heart-monitoring device and a data-gathering probe, respectively. In a preferred embodiment of the present invention, the blood-vessel data is acquired during a cyclical portion of the heartbeat data. By identifying a cyclical (or commonly reoccurring) portion of the heartbeat data and acquiring blood-vessel data during this cyclical portion (or during an interval that substantially corresponds thereto), the blood vessel can be analyzed as if it were standing still—i.e., not expanding and relaxing. In one embodiment of the present invention, the heart-monitoring device includes an EKG device, the data-gathering device includes an intra-vascular ultrasound (IVUS) device and a computing device, and the data-gathering probe includes at least one transducer. In another embodiment of the present invention, the data-gathering system further includes a retraction device adapted to move the data-gathering probe though a blood vessel at a substantially steady speed.
摘要翻译：提供了一种用于将血管数据的获取基本上同步到心跳数据的可识别部分的系统和方法。具体地，数据收集装置适于分别从心脏监测装置和数据收集探针获取心跳数据和血管数据。在本发明的优选实施例中，在心跳数据的周期部分期间获取血管数据。通过在该循环部分（或在与其基本对应的间隔期间）识别心跳数据的周期性（或通常重复发生的）部分并获取血管数据，可以像静置时一样分析血管，不扩大和放松。在本发明的一个实施例中，所述心脏监测装置包括EKG装置，所述数据收集装置包括血管内超声（IVUS）装置和计算装置，并且所述数据收集探针包括至少一个换能器。在本发明的另一个实施例中，数据收集系统还包括一个缩回装置，其适于以基本上稳定的速度移动通过血管的数据收集探针。

9. 发明授权

US07899224B2 System and method of characterizing vascular tissue 有权
公开(公告)号：US07899224B2
公开(公告)日：2011-03-01
申请号：US11445591
申请日：2006-06-01
申请人： Anuja Nair , D. Geoffrey Vince , Jon D. Klingensmith , Barry D. Kuban
发明人： Anuja Nair , D. Geoffrey Vince , Jon D. Klingensmith , Barry D. Kuban
IPC分类号： G06K9/00 , A61B8/14
CPC分类号： A61B8/12 , A61B5/02007 , A61B5/7257 , A61B5/726 , A61B8/0833 , G06T7/0012 , G06T2207/30101
摘要： A system and method is provided for using backscattered data and known parameters to characterize vascular tissue. Specifically, in one embodiment of the present invention, an ultrasonic device is used to acquire RF backscattered data (i.e., IVUS data) from a blood vessel. The IVUS data is then transmitted to a computing device and used to create an IVUS image. The blood vessel is then cross-sectioned and used to identify its tissue type and to create a corresponding image (i.e., histology image). A region of interest (ROI), preferably corresponding to the identified tissue type, is then identified on the histology image. The computing device, or more particularly, a characterization application operating thereon, is then adapted to identify a corresponding region on the IVUS image. To accurately match the ROI, however, it may be necessary to warp or morph the histology image to substantially fit the contour of the IVUS image. After the corresponding region is identified, the IVUS data that corresponds to this region is identified. Signal processing is then performed and at least one parameter is identified. The identified parameter and the tissue type (e.g., characterization data) is stored in a database. In another embodiment of the present invention, the characterization application is adapted to receive IVUS data, determine parameters related thereto (either directly or indirectly), and use the parameters stored in the database to identify a tissue type or a characterization thereof.

10. 发明授权

US07463759B2 System and method for vascular border detection 有权
标题翻译：血管边界检测系统和方法
公开(公告)号：US07463759B2
公开(公告)日：2008-12-09
申请号：US11449569
申请日：2006-06-08
申请人： Jon D. Klingensmith , Anuja Nair , Barry D. Kuban , D. Geoffrey Vince
发明人： Jon D. Klingensmith , Anuja Nair , Barry D. Kuban , D. Geoffrey Vince
IPC分类号： G06K9/00 , A61B5/02
CPC分类号： A61B8/12 , A61B5/02007 , A61B8/0858
摘要： A system and method use the frequency spectrum of a radio frequency (RF) signal backscattered from vascular tissue to identify at least one border on a vascular image. A data gathering device is connected to a computing device and a transducer via a catheter. RF data generated via the transducer is provided to the computing device via the data-gathering device. The computing device includes: at least one data storage device for storing a plurality of tissue types and parameters related thereto, and at least one application (e.g., a characterization application, a gradient-border application, a frequency-border application and/or an active-contour application). The characterization application converts the RF data into the frequency domain and identifies a plurality of associate parameters. The identified parameters are compared to the parameters stored in the data storage device to identify the corresponding tissue type and thereafter determine at least one border on a vascular image.
摘要翻译：系统和方法使用从血管组织反向散射的射频（RF）信号的频谱来识别血管图像上的至少一个边界。数据采集装置通过导管连接到计算装置和换能器。通过传感器生成的RF数据经由数据采集装置提供给计算装置。计算设备包括：用于存储与之相关的多个组织类型和参数的至少一个数据存储设备，以及至少一个应用（例如，特征应用，梯度边界应用，频率边界应用和/或主动轮廓应用）。表征应用将RF数据转换成频域并识别多个关联参数。将识别的参数与存储在数据存储设备中的参数进行比较，以识别相应的组织类型，然后确定血管图像上的至少一个边界。

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