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1. 发明授权

US3969410A 1-(2'-Alkyl-3',4'-dihydroxy-phenyl)-2-(phenylalkyl-amino)-alkanols-(1) and salts thereof 失效
标题翻译： 1-（2 {40-烷基-3 {40,4（40-二羟基 - 苯基）-2-（苯基烷基 - 氨基） - 链烷醇 - （1）
公开(公告)号：US3969410A
公开(公告)日：1976-07-13
申请号：US485348
申请日：1974-07-03
申请人： Anton Mentrup , Kurt Schromm , Otto Thoma , Karl Zeile
发明人： Anton Mentrup , Kurt Schromm , Otto Thoma , Karl Zeile
IPC分类号： A61K31/135 , C07C91/22 , C07D473/00
CPC分类号： A61K31/135
摘要： Compounds of the formula ##SPC1##WhereinR.sub.1 is alkyl of 1 to 5 carbon atoms,R.sub.2 is hydrogen or lower alkyl,R.sub.3 is hydrogen or hydroxyl, andZ is alkylene of 2 to 6 carbon atoms,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful as sympathomimetics.
摘要翻译：式WHEREIN R1的化合物是1至5个碳原子的烷基，R2是氢或低级烷基，R3是氢或羟基，Z是2到6个碳原子的亚烷基，和非毒性，药理学上可接受的酸加法盐 ; 化合物作为口服作为症状有用的化合物。

2. 发明授权

US4042713A Pharmaceutical compositions containing a 1-(2-alkyl-3,4-dihydroxy-phenyl)-2-(phenylalkyl-amino)-alkanol-(1) and method of use 失效
标题翻译：含有1-（2-烷基-3,4-二羟基 - 苯基）-2-（苯基烷基 - 氨基） - 烷醇 - （1）和使用方法的药物组合物
公开(公告)号：US4042713A
公开(公告)日：1977-08-16
申请号：US678612
申请日：1976-04-20
申请人： Anton Mentrup , Kurt Schromm , Otto Thoma , Karl Zeile
发明人： Anton Mentrup , Kurt Schromm , Otto Thoma , Karl Zeile
IPC分类号： A61K31/135
CPC分类号： A61K31/135
摘要： Pharmaceutical compositions containing as an active ingredient a compound of the formula ##STR1## wherein R.sub.1 is alkyl of 1 to 5 carbon atoms,R.sub.2 is hydrogen or lower alkyl,R.sub.3 is hydrogen or hydroxyl, andZ is alkylene of 2 to 6 carbon atoms,Or a non-toxic, pharmacologically acceptable acid addition salt thereof; and a method of using the same as sympathomimetics.
摘要翻译：作为活性成分含有下式化合物的药物组合物，其中R1是1〜5个碳原子的烷基，R2是氢或低级烷基，R3是氢或羟基，Z是2到6个碳原子的亚烷基，或非毒性，药理学上可接受的酸添加盐; 和使用它们作为症状的方法。

3. 发明授权

US4581367A 1-phenyl-2-(heterocyclyl-alkyl-amino)-ethanols 失效
标题翻译： 1-苯基-2-（杂环基 - 烷基 - 氨基） - 乙醇
公开(公告)号：US4581367A
公开(公告)日：1986-04-08
申请号：US443912
申请日：1982-11-23
申请人： Kurt Schromm , Anton Mentrup , Ernst-Otto Renth , Armin Fugner , Ilse Streller
发明人： Kurt Schromm , Anton Mentrup , Ernst-Otto Renth , Armin Fugner , Ilse Streller
IPC分类号： A61K31/41 , A61K31/415 , A61K31/4166 , A61K31/4184 , A61K31/42 , A61K31/496 , A61K31/505 , A61K31/517 , A61K31/535 , A61K31/5355 , A61P1/04 , A61P1/06 , A61P9/00 , A61P9/06 , A61P9/12 , A61P11/00 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/24 , A61P25/26 , A61P27/02 , A61P27/14 , A61P37/08 , C07D233/36 , C07D233/54 , C07D233/58 , C07D233/61 , C07D235/06 , C07D235/08 , C07D235/18 , C07D239/88 , C07D239/90 , C07D239/96 , C07D249/18 , C07D413/12 , C07D521/00 , C07D235/00
CPC分类号： C07D233/64 , C07D231/12 , C07D233/36 , C07D233/56 , C07D235/06 , C07D235/08 , C07D235/18 , C07D239/88 , C07D239/96 , C07D249/08 , C07D249/18 , Y10S514/821 , Y10S514/826 , Y10S514/849 , Y10S514/906 , Y10S514/914
摘要： Compounds of the formula whereinHet is a heterocycle;n is an integer from 1 to 4, inclusive, preferably 2 or 3;R.sub.1 is H or acyl;R.sub.2 is H, R.sub.1 O, --NHSO.sub.2 R.sub.7, --NHCOR.sub.8, --NHCONHR.sub.8, --NH--CH.sub.2 --C.sub.6 H.sub.4 --R.sub.9, --CH.sub.2 OH, --CH.sub.2 SO.sub.2 R.sub.7, --CONHR.sub.8, halogen or --CN;R.sub.3 is H, halogen, R.sub.7 or --OR.sub.7 ; orR.sub.2 and R.sub.3, together with each other, are ##STR1## N.sub.4 is H, --CH.sub.3 or --C.sub.2 H.sub.5 ; R.sub.5 and R.sub.6 are each H or --CH.sub.3 ;R.sub.7 is C.sub.1 -C.sub.4 alkyl;R.sub.8 is H or C.sub.1 -C.sub.4 alkyl; andR.sub.9 is H, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy optionally interrupted by oxygen;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as the salts are useful as bronchospasmolytics, spasmolytics, muscle-relaxants, antiallergics and hypotensives.
摘要翻译：其中Het是杂环的式“IMAGE”的化合物; n为1〜4的整数，优选为2或3; R1是H或酰基; R2是H，R1O，-NHSO2R7，-NHCOR8，-NHCONHR8，-NH-CH2-C6H4-R9，-CH2OH，-CH2SO2R7，-CONHR8，卤素或-CN; R3是H，卤素，R7或-OR7; 或R 2和R 3彼此一起是H，-CH 3或-C 2 H 5; R5和R6各自为H或-CH3; R7是C1-C4烷基; R8是H或C1-C4烷基; 并且R 9为H，任选被氧中断的C 1 -C 4烷基或C 1 -C 4烷氧基; 和无毒的，药学上可接受的酸加成盐。化合物和盐可用作支气管解痉药，解痉药，肌肉松弛剂，抗过敏药和低血压药。

4. 发明授权

US4100282A N-Aryl-N'-(phenyl- or phenoxy-alkyl)-piperazines and salts thereof 失效
标题翻译： N-芳基-N {40-（苯基 - 或苯氧基 - 烷基） - 哌嗪及其盐
公开(公告)号：US4100282A
公开(公告)日：1978-07-11
申请号：US793736
申请日：1977-05-04
申请人： Ernst-Otto Renth , Anton Mentrup , Kurt Schromm , Peter Danneberg
发明人： Ernst-Otto Renth , Anton Mentrup , Kurt Schromm , Peter Danneberg
IPC分类号： A61K31/495 , C07D207/26 , C07D207/27 , C07D279/02
CPC分类号： C07D207/27 , A61K31/495
摘要： Compounds of the formula ##STR1## wherein R is phenyl; phenyl having one or two substituents attached thereto, said substituents being selected from the group consisting of alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, alkylthio of 1 to 4 carbon atoms, chlorine and trifluoromethyl; naphthyl; tetrahydronaphthyl; indanyl; pyridyl; isoquinolyl; or thiazolyl;R.sub.1 is ##STR2## where R.sub.3 is hydrogen, alkyl of 1 to 4 carbon atoms,R.sub.4 and R.sub.5 are each hydrogen or alkyl of 1 to 4 carbon atoms, andQ is oxygen or two hydrogens,R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or halogen,A is a single carbon-to-carbon bond or --OCH.sub.2 --,R.sub.6 is hydrogen, hydroxyl, alkoxy of 1 to 4 carbon atoms or alkanoyloxy of 1 to 4 carbon atoms, andm is 0, 1, 2, 3, 4 or 5, but other than 0 when R.sub.6 is hydroxyl,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as CNS-depressants, adrenolytics, antiphlogistics, analgesics, antihistaminics and anticholesteremics.
摘要翻译：其中R是苯基的式“IMAGE”的化合物; 所述取代基选自1至4个碳原子的烷基，1至4个碳原子的烷氧基，1至4个碳原子的烷硫基，氯和三氟甲基; 萘基; 四氢萘基; 茚满基吡啶基异喹啉基或噻唑基; R1是，其中R3是氢，1-4个碳原子的烷基，R4和R5分别是氢或1-4个碳原子的烷基，Q是氧或两个氢，R2是氢，1-4个碳原子数为1〜4的烷氧基或卤素，A为单碳 - 碳键或-OCH2-，R6为氢，羟基，1〜4个碳原子的烷氧基或1〜4个碳原子的烷酰氧基，并且M IS为0,1,2,3,4或5，但当R6为羟基时为0以及非毒性，药理学上可接受的酸添加量; 化合物作为它们的有效作为CNS抑制剂，肾上腺素，消炎药，镇痛药，抗组胺药和抗胆碱血症有用。

5. 发明授权

US3992537A Pharmaceutical compositions containing an N-phenyl-imidazolidine-2-one and method of use 失效
标题翻译：含有N-苯基 - 咪唑烷-2-酮的药物组合物及其使用方法
公开(公告)号：US3992537A
公开(公告)日：1976-11-16
申请号：US636738
申请日：1975-12-01
申请人： Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Peter Danneberg
发明人： Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Peter Danneberg
IPC分类号： A61K31/495 , C07D401/14 , C07D403/10
CPC分类号： C07D401/14 , A61K31/495 , C07D403/10
摘要： Pharmaceutical compositions containing as an active ingredient a compound of the formula ##SPC1##Wherein R' is in the m- or p-position and is selected from the group consisting of--CH.sub.2 --A, --CHR.sub.1 --CH.sub.2 --Aand ##EQU1## where R.sub.1 is hydrogen or hydroxyl, andA is ##SPC2##WhereR.sub.3 is hydrogen, chlorine, methyl, ethyl, trifluoromethyl or lower alkoxy, andR.sub.4 is hydrogen or methyl, orR.sub.3 and R.sub.4, together with each other and neighboring carbon atoms of the phenyl ring to which they are attached, are naphthyl,Or a non-toxic, pharmacologically acceptable acid addition salt thereof; and a method of using the same as CNS-depressants, neuroleptics and anticholesteremics.
摘要翻译：含有式+ q，10的化合物作为活性成分的药物组合物在m-或p-位，并且选自-CH2-A，-CHR1-CH2-A和-CHR1 -CH-A，| CH3，其中R1是氢或羟基，A是+ q，12，其中R3是氢，氯，甲基，乙基，三氟甲基或低级烷氧基，R4是氢或甲基，或R3和R4一起与它们所连接的苯环的彼此和相邻的碳原子是萘基，或非毒性，药理学上可接受的酸加成盐; 和使用它们作为CNS抑制剂，精神安定药和抗胆固醇药的方法。

6. 发明授权

US4647563A Heterocyclic compounds 失效
标题翻译：杂环化合物
公开(公告)号：US4647563A
公开(公告)日：1987-03-03
申请号：US806692
申请日：1985-12-09
申请人： Kurt Schromm , Anton Mentrup , Ernst-Otto Renth , Armin Fugner , Ilse Streller
发明人： Kurt Schromm , Anton Mentrup , Ernst-Otto Renth , Armin Fugner , Ilse Streller
IPC分类号： A61K31/41 , A61K31/415 , A61K31/4166 , A61K31/4184 , A61K31/42 , A61K31/496 , A61K31/505 , A61K31/517 , A61K31/535 , A61K31/5355 , A61P1/04 , A61P1/06 , A61P9/00 , A61P9/06 , A61P9/12 , A61P11/00 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/24 , A61P25/26 , A61P27/02 , A61P27/14 , A61P37/08 , C07D233/36 , C07D233/54 , C07D233/58 , C07D233/61 , C07D235/06 , C07D235/08 , C07D235/18 , C07D239/88 , C07D239/90 , C07D239/96 , C07D249/18 , C07D413/12 , C07D521/00
CPC分类号： C07D233/64 , C07D231/12 , C07D233/36 , C07D233/56 , C07D235/06 , C07D235/08 , C07D235/18 , C07D239/88 , C07D239/96 , C07D249/08 , C07D249/18 , Y10S514/821 , Y10S514/826 , Y10S514/849 , Y10S514/906 , Y10S514/914
摘要： Compounds of the formula ##STR1## wherein Het is ##STR2## n is an integer from 1 to 4, inclusive, preferably 2 or 3, R.sub.1 is H or acyl,R.sub.2 is H, R.sub.1 O, --NHSO.sub.2 R.sub.7, --NHCOR.sub.8, --NHCONHR.sub.8, --NH--CH.sub.2 --C.sub.6 H.sub.4 --R.sub.9, --CH.sub.2 OH, --CH.sub.2 SO.sub.2 R.sub.7, --CONHR.sub.8, halogen or --CN,R.sub.3 is H, halogen, R.sub.7 or --OR.sub.7,R.sub.2 and R.sub.3 together with each other are ##STR3## R.sub.4 is H, --CH.sub.3 or --C.sub.2 H.sub.5, R.sub.5 and R.sub.6 are each H or --CH.sub.3,R.sub.7 is C.sub.1 -C.sub.4 alkyl,R.sub.8 is H or C.sub.1 -C.sub.4 alkyl,R.sub.9 is H, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy optionally interrupted by oxygen,R.sub.10 and R.sub.12 are each H, CH.sub.3, Cl or OCH.sub.3, or together methylenedioxy,X is ##STR4## or N, and Z is --CH.sub.2 or --CO;in the form of racemates, enantiomers, diastereoisomeric antipode pairs, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as the salts are useful as bronchospasmolytics, spasmolytics, muscle-relaxants, antiallergics and hypotensives.
摘要翻译：其中Het为+4 的化合物，n为1〜4的整数，优选2或3，R 1为H或酰基，R 2为H，R 10，-NHSO 2 R 7， NHCOR 8，-NHCONHR 8，-NH-CH 2 -C 6 H 4 -R 9，-CH 2 OH，-CH 2 SO 2 R 7，-CONHR 8，卤素或-CN，R 3是H，卤素，R 7或-OR 7，R 2和R 3彼此是 R4是H，-CH3或-C2H5，R5和R6分别是H或-CH3，R7是C1-C4烷基，R8是H或C1-C4烷基，R9是H，C1-C4烷基或C1-C4烷氧基被氧中断，R 10和R 12各自为H，CH 3，Cl或OCH 3，或一起亚甲二氧基，X为或N，Z为-CH 2或-CO; 以外消旋物，对映异构体，非对映异构体对映体对及其无毒的药学上可接受的酸加成盐的形式存在。化合物和盐可用作支气管解痉药，解痉药，肌肉松弛剂，抗过敏药和低血压药。

7. 发明授权

US4604468A Intermediate 1-alkylenyl-1H-benzimidazol-2-one derivatives 失效
标题翻译：中间体1-亚烷基-1H-苯并咪唑-2-酮衍生物
公开(公告)号：US4604468A
公开(公告)日：1986-08-05
申请号：US634446
申请日：1984-07-25
申请人： Herbert Koppe , Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Wolfgang Hoefke , Gojko Muaceic
发明人： Herbert Koppe , Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Wolfgang Hoefke , Gojko Muaceic
IPC分类号： C07D233/36 , A61K31/415 , A61K31/4166 , A61K31/4184 , A61K31/435 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/5355 , A61K31/5375 , A61K31/538 , A61P9/00 , A61P25/24 , A61P25/26 , C07D205/04 , C07D209/34 , C07D215/22 , C07D215/227 , C07D233/32 , C07D235/26 , C07D265/18 , C07D265/28 , C07D265/30
CPC分类号： C07D215/227 , C07D209/34 , C07D233/32 , C07D235/26 , C07D265/18 , C07D265/28
摘要： Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen or substituents of various types;R.sub.4 is hydrogen; alkyl of 1 to 5 carbon atoms; or optionally substituted aralkyl or 7 to 14 carbon atoms;R.sub.5 is a heterocycle;D is alkylene of 1 to 12 carbon atoms; andA is hydrogen or acyl; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as .alpha.- and .beta.-adrenergic receptor blocking agents and antidepressants.
摘要翻译：其中R 1，R 2和R 3为氢或各种取代基的式IMAMA的化合物; R4是氢; 1至5个碳原子的烷基; 或任选取代的芳烷基或7至14个碳原子; R5是杂环; D是1至12个碳原子的亚烷基; A是氢或酰基; 和无毒的，药学上可接受的酸加成盐。化合物及其盐可用作α-和β-肾上腺素能受体阻断剂和抗抑郁药。

8. 发明授权

US4539323A N-[1-(4-Amino-6,7-dialkoxy-2-quinazolinyl)-4-piperidy l]-oxazolidine-2,4-diones 失效
标题翻译： N- [1-（4-氨基-6,7-二烷氧基-2-喹唑啉基）-4-哌啶基] - 恶唑烷-2,4-二酮
公开(公告)号：US4539323A
公开(公告)日：1985-09-03
申请号：US531842
申请日：1983-09-14
申请人： Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Wolfgang Hoefke , Wolfram Gaida
发明人： Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Wolfgang Hoefke , Wolfram Gaida
IPC分类号： C07D239/95 , A61K31/505 , A61K31/517 , A61P9/08 , A61P9/12 , A61P25/02 , C07D263/44 , C07D401/14 , C07D413/04 , C07D413/14 , C07D491/056
CPC分类号： C07D413/04 , C07D413/14
摘要： Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2, which may be identical to or different from each other, are each independently hydrogen, straight or branched alkyl of 1 to 8 carbon atoms or arylmethyl; orR.sub.1 and R.sub.2, together with each other, are --(CH.sub.2).sub.4 or --(CH.sub.2).sub.5 --; andR.sub.3 and R.sub.4, which may be identical to or different from each other, are each independently hydrogen, straight or branched alkyl of 1 to 4 carbon atoms or arylmethyl; orR.sub.3 and R.sub.4, together with each other, are --CH.sub.3 -- or --CH.sub.2 --CH.sub.2 --;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful for the treatment of cardiovascular diseases, especially hypertension.
摘要翻译：其中R 1和R 2可以相同或不同，各自独立地为氢，1至8个碳原子的直链或支链烷基或芳基甲基; 或R 1和R 2彼此一起为 - （CH 2）4或 - （CH 2）5 - ; 并且可以相同或不同的R 3和R 4各自独立地为氢，1至4个碳原子的直链或支链烷基或芳基甲基; 或R 3和R 4彼此一起为-CH 3 - 或-CH 2 -CH 2 - ; 和无毒的，药学上可接受的酸加成盐。化合物及其盐可用于治疗心血管疾病，特别是高血压。

9. 发明授权

US4460581A (1-Hydroxy-2-amino-alkyl)-substituted benzoxazinones and benzoxazolinones 失效
标题翻译：（1-羟基-2-氨基 - 烷基）取代的苯并恶嗪酮和苯并恶唑啉酮
公开(公告)号：US4460581A
公开(公告)日：1984-07-17
申请号：US433681
申请日：1982-10-12
申请人： Kurt Schromm , Anton Mentrup , Ernst-Otto Renth , Armin Fugner
发明人： Kurt Schromm , Anton Mentrup , Ernst-Otto Renth , Armin Fugner
IPC分类号： C07D263/58 , C07D265/36 , C07D413/12 , A61K31/47
CPC分类号： C07D263/58 , C07D265/36 , C07D413/12
摘要： Compounds of the formula ##STR1## wherein A is a single bond, ##STR2## R.sub.1 is --OH, --0--acyl, chlorine or hydrogen; R.sub.2 is hydrogen, methyl or ethyl;R.sub.3 is ##STR3## m is 2, 3 or 4; n is 1, 2 or 3;R.sub.4 is hydrogen or lower alkyl;R.sub.5 is hydrogen, lower alkyl or, when R.sub.4 is hydrogen, also phenyl;R.sub.6, R.sub.7 and R.sub.8 are each hydrogen or methyl;R.sub.9 is hydrogen, --Ar, --OAr or --NH--CO--Ar;Ar is ##STR4## R.sub.10, R.sub.11 and R.sub.12 which may be identical to or different from each other, are each hydrogen, hydroxyl, methyl, methoxy, halogen, methylenedioxy, --NH--R.sub.13 or --CONH.sub.2 ; andR.sub.13 is hydrogen, acyl or lower alkylsulfonyl;and non-toxic, pharmaceutically acceptable acid addition salts thereof; the compounds as well as their salts are useful for the treatment of asthma, bronchitis, urticaria, conjunctivities, hay fever, colds and cardiovascular disorders, and for relaxation of the uterine musculature.
摘要翻译：其中A是单键的式“IMAGE”的化合物，R 1是-OH，-O-酰基，氯或氢; R2是氢，甲基或乙基; R3为 m为2,3或4; n为1,2或3; R4是氢或低级烷基; R5是氢，低级烷基，或当R4是氢时也是苯基; R6，R7和R8各自为氢或甲基; R9是氢，-Ar，-OAr或-NH-CO-Ar; Ar可以相同或不同，分别是氢，羟基，甲基，甲氧基，卤素，亚甲二氧基，-NH-R13或-CONH 2; R 1，R 2，和R 13是氢，酰基或低级烷基磺酰基; 和无毒的药学上可接受的酸加成盐; 化合物及其盐可用于治疗哮喘，支气管炎，荨麻疹，结膜炎，花粉症，感冒和心血管疾病，以及用于放松子宫肌肉组织。

10. 发明授权

US4381309A 1-Aryloxy-2-hydroxy-3-((heterocyclic-substituted alkyl)-amino)-propanes and salts thereof 失效
标题翻译： 1-芳氧基-2-羟基-3 - （（杂环取代的烷基） - 氨基） - 丙烷及其盐
公开(公告)号：US4381309A
公开(公告)日：1983-04-26
申请号：US195650
申请日：1980-10-09
申请人： Herbert Koppe , Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Wolfgang Hoefke , Gojko Muacevic
发明人： Herbert Koppe , Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Wolfgang Hoefke , Gojko Muacevic
IPC分类号： C07D233/36 , A61K31/415 , A61K31/4166 , A61K31/4184 , A61K31/435 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/5355 , A61K31/5375 , A61K31/538 , A61P9/00 , A61P25/24 , A61P25/26 , C07D205/04 , C07D209/34 , C07D215/22 , C07D215/227 , C07D233/32 , C07D235/26 , C07D265/18 , C07D265/28 , C07D265/30
CPC分类号： C07D215/227 , C07D209/34 , C07D233/32 , C07D235/26 , C07D265/18 , C07D265/28
摘要： Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen or substituents of various types;R.sub.4 is hydrogen, alkyl of 1 to 5 carbon atoms, or optionally substituted aralkyl of 7 to 14 carbon atoms;R.sub.5 is a heterocycle;D is alkylene of 1 to 12 carbon atoms; andA is hydrogen or acyl;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as .alpha.- and .beta.-adrenergic receptor blocking agents and antidepressants.
摘要翻译：其中R 1，R 2和R 3为氢或各种取代基的式IMAMA的化合物; R4是氢，1至5个碳原子的烷基或任选取代的具有7-14个碳原子的芳烷基; R5是杂环; D是1至12个碳原子的亚烷基; A是氢或酰基; 和无毒的，药学上可接受的酸加成盐。化合物及其盐可用作α-和β-肾上腺素能受体阻断剂和抗抑郁药。

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