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1. 发明授权

US4256756A 1-Aryloxy-2-hydroxy-3-[(substituted phenyl-donidazalidinon-2-yl)-alkyl-amino]-propanes and salts thereof 失效
标题翻译： 1-芳氧基-2-羟基-3 - [（取代的苯基 - 咪唑烷酮-2-基） - 烷基 - 氨基] - 丙烷及其盐
公开(公告)号：US4256756A
公开(公告)日：1981-03-17
申请号：US004279
申请日：1979-01-17
申请人： Herbert Koppe , Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Wolfgang Hoefke , Gojko Muacevic
发明人： Herbert Koppe , Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Wolfgang Hoefke , Gojko Muacevic
IPC分类号： C07D233/36 , A61K31/415 , A61K31/4166 , A61K31/4184 , A61K31/435 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/5355 , A61K31/5375 , A61K31/538 , A61P9/00 , A61P25/24 , A61P25/26 , C07D205/04 , C07D209/34 , C07D215/22 , C07D215/227 , C07D233/32 , C07D235/26 , C07D265/18 , C07D265/28 , C07D265/30
CPC分类号： C07D215/227 , C07D209/34 , C07D233/32 , C07D235/26 , C07D265/18 , C07D265/28
摘要： Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen or substituents of various types;R.sub.4 is hydrogen; alkyl of 1 to 5 carbon atoms; or optionally substituted aralkyl of 7 to 14 carbon atoms;R.sub.5 is a heterocycle;D is alkylene of 1 to 12 carbon atoms; andA is hydrogen or acyl;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as .alpha.- and .beta.-adrenergic receptor blocking agents and antidepressants.
摘要翻译：其中R 1，R 2和R 3为氢或各种取代基的式IMAMA的化合物; R4是氢; 1至5个碳原子的烷基; 或任选取代的具有7-14个碳原子的芳烷基; R5是杂环; D是1至12个碳原子的亚烷基; A是氢或酰基; 和无毒的，药学上可接受的酸加成盐。化合物及其盐可用作α-和β-肾上腺素能受体阻断剂和抗抑郁药。

2. 发明授权

US4381309A 1-Aryloxy-2-hydroxy-3-((heterocyclic-substituted alkyl)-amino)-propanes and salts thereof 失效
标题翻译： 1-芳氧基-2-羟基-3 - （（杂环取代的烷基） - 氨基） - 丙烷及其盐
公开(公告)号：US4381309A
公开(公告)日：1983-04-26
申请号：US195650
申请日：1980-10-09
申请人： Herbert Koppe , Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Wolfgang Hoefke , Gojko Muacevic
发明人： Herbert Koppe , Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Wolfgang Hoefke , Gojko Muacevic
IPC分类号： C07D233/36 , A61K31/415 , A61K31/4166 , A61K31/4184 , A61K31/435 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/5355 , A61K31/5375 , A61K31/538 , A61P9/00 , A61P25/24 , A61P25/26 , C07D205/04 , C07D209/34 , C07D215/22 , C07D215/227 , C07D233/32 , C07D235/26 , C07D265/18 , C07D265/28 , C07D265/30
CPC分类号： C07D215/227 , C07D209/34 , C07D233/32 , C07D235/26 , C07D265/18 , C07D265/28
摘要： Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen or substituents of various types;R.sub.4 is hydrogen, alkyl of 1 to 5 carbon atoms, or optionally substituted aralkyl of 7 to 14 carbon atoms;R.sub.5 is a heterocycle;D is alkylene of 1 to 12 carbon atoms; andA is hydrogen or acyl;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as .alpha.- and .beta.-adrenergic receptor blocking agents and antidepressants.
摘要翻译：其中R 1，R 2和R 3为氢或各种取代基的式IMAMA的化合物; R4是氢，1至5个碳原子的烷基或任选取代的具有7-14个碳原子的芳烷基; R5是杂环; D是1至12个碳原子的亚烷基; A是氢或酰基; 和无毒的，药学上可接受的酸加成盐。化合物及其盐可用作α-和β-肾上腺素能受体阻断剂和抗抑郁药。

3. 发明授权

US4296117A 1-Aryloxy-2-hydroxy-3-[(Benzimidazolinone-substituted alkyl)-amino]propanes and salts thereof 失效
标题翻译： 1-芳氧基-2-羟基-3 - [（苯并咪唑啉酮取代的烷基） - 氨基]丙烷及其盐
公开(公告)号：US4296117A
公开(公告)日：1981-10-20
申请号：US112640
申请日：1980-01-16
申请人： Herbert Koppe , Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Wolfgang Hoefke , Gojko Muacevic
发明人： Herbert Koppe , Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Wolfgang Hoefke , Gojko Muacevic
IPC分类号： C07D233/36 , A61K31/415 , A61K31/4166 , A61K31/4184 , A61K31/435 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/5355 , A61K31/5375 , A61K31/538 , A61P9/00 , A61P25/24 , A61P25/26 , C07D205/04 , C07D209/34 , C07D215/22 , C07D215/227 , C07D233/32 , C07D235/26 , C07D265/18 , C07D265/28 , C07D265/30
CPC分类号： C07D215/227 , C07D209/34 , C07D233/32 , C07D235/26 , C07D265/18 , C07D265/28
摘要： Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen or substituents of various types;R.sub.4 is hydrogen; alkyl of 1 to 5 carbon atoms; or optionally substituted aralkyl of 7 to 14 carbon atoms;R.sub.5 is a heterocycle;D is alkylene of 1 to 12 carbon atoms; andA is hydrogen or acyl;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as .alpha.- and .beta.-adrenergic receptor blocking agents and antidepressants.
摘要翻译：其中R 1，R 2和R 3为氢或各种取代基的式IMAMA的化合物; R4是氢; 1至5个碳原子的烷基; 或任选取代的具有7-14个碳原子的芳烷基; R5是杂环; D是1至12个碳原子的亚烷基; A是氢或酰基; 和无毒的，药学上可接受的酸加成盐。化合物及其盐可用作α-和β-肾上腺素能受体阻断剂和抗抑郁药。

4. 发明授权

US4212877A 1-Aryloxy-2-hydroxy-3-[(benzimidazolin-one-substituted alkyl)-amino]-propanes and salts thereof 失效
标题翻译： 1-芳氧基-2-羟基-3 - [（苯并咪唑啉-1-取代的烷基） - 氨基] - 丙烷及其盐
公开(公告)号：US4212877A
公开(公告)日：1980-07-15
申请号：US4280
申请日：1979-01-17
申请人： Herbert Koppe , Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Wolfgang Hoefke , Gojko Muacevic
发明人： Herbert Koppe , Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Wolfgang Hoefke , Gojko Muacevic
IPC分类号： C07D233/36 , A61K31/415 , A61K31/4166 , A61K31/4184 , A61K31/435 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/5355 , A61K31/5375 , A61K31/538 , A61P9/00 , A61P25/24 , A61P25/26 , C07D205/04 , C07D209/34 , C07D215/22 , C07D215/227 , C07D233/32 , C07D235/26 , C07D265/18 , C07D265/28 , C07D265/30
CPC分类号： C07D215/227 , C07D209/34 , C07D233/32 , C07D235/26 , C07D265/18 , C07D265/28
摘要： Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen or substituents of various types;R.sub.4 is hydrogen, alkyl of 1 to 5 carbon atoms, or optionally substituted aralkyl of 7 to 14 carbon atoms;R.sub.5 is a heterocycle;D is alkylene of 1 to 12 carbon atoms; andA is hydrogen or acyl;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as .alpha.- and .beta.-adrenergic receptor blocking agents and antidepressants.
摘要翻译：其中R 1，R 2和R 3为氢或各种取代基的式IMAMA的化合物; R4是氢，1至5个碳原子的烷基或任选取代的具有7-14个碳原子的芳烷基; R5是杂环; D是1至12个碳原子的亚烷基; A是氢或酰基; 和无毒的，药学上可接受的酸加成盐。化合物及其盐可用作α-和β-肾上腺素能受体阻断剂和抗抑郁药。

5. 发明授权

US4343800A 1-Aryloxy-2-hydroxy-3[(heterocyclic-substituted alkyl)-amino]propanes and salts thereof 失效
标题翻译： 1-芳氧基-2-羟基-3 [（杂环取代的烷基） - 氨基]丙烷及其盐
公开(公告)号：US4343800A
公开(公告)日：1982-08-10
申请号：US255751
申请日：1981-04-20
申请人： Herbert Koppe , Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Wolfgang Hoefke , Gojko Muacevic
发明人： Herbert Koppe , Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Wolfgang Hoefke , Gojko Muacevic
IPC分类号： C07D233/36 , A61K31/415 , A61K31/4166 , A61K31/4184 , A61K31/435 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/5355 , A61K31/5375 , A61K31/538 , A61P9/00 , A61P25/24 , A61P25/26 , C07D205/04 , C07D209/34 , C07D215/22 , C07D215/227 , C07D233/32 , C07D235/26 , C07D265/18 , C07D265/28 , C07D265/30 , C07D265/36
CPC分类号： C07D215/227 , C07D209/34 , C07D233/32 , C07D235/26 , C07D265/18 , C07D265/28
摘要： Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen or substituents of various types;R.sub.4 is hydrogen; alkyl of 1 to 5 carbon atoms; or optionally substituted aralkyl of 7 to 14 carbon atoms;R.sub.5 is heterocycle;D is alkylene of 1 to 12 carbon atoms; andA is hydrogen or acyl;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as .alpha.- and .beta.-adrenergic receptor blocking agents and antidepressants.
摘要翻译：其中R 1，R 2和R 3为氢或各种取代基的式IMAMA的化合物; R4是氢; 1至5个碳原子的烷基; 或任选取代的具有7-14个碳原子的芳烷基; R5是杂环; D是1至12个碳原子的亚烷基; A是氢或酰基; 和无毒的，药学上可接受的酸加成盐。化合物及其盐可用作α-和β-肾上腺素能受体阻断剂和抗抑郁药。

6. 发明授权

US4255430A 1-Aryloxy-2-hydroxy-3-[(tetrahydroquinolonylalkyl)-amino]-propanes and salts thereof 失效
标题翻译： - 丙烯酰氧基-2-羟基-3 - [（四氢喹啉基烷基） - 氨基] - 丙烷及其盐
公开(公告)号：US4255430A
公开(公告)日：1981-03-10
申请号：US103724
申请日：1979-12-14
申请人： Herbert Koppe , Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Wolfgang Hoefke , Gojko Muacevic
发明人： Herbert Koppe , Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Wolfgang Hoefke , Gojko Muacevic
IPC分类号： C07D233/36 , A61K31/415 , A61K31/4166 , A61K31/4184 , A61K31/435 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/5355 , A61K31/5375 , A61K31/538 , A61P9/00 , A61P25/24 , A61P25/26 , C07D205/04 , C07D209/34 , C07D215/22 , C07D215/227 , C07D233/32 , C07D235/26 , C07D265/18 , C07D265/28 , C07D265/30
CPC分类号： C07D215/227 , C07D209/34 , C07D233/32 , C07D235/26 , C07D265/18 , C07D265/28
摘要： Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are each hydrogen or a substituent of various types;R.sub.4 is hydrogen, alkyl of 1 to 5 carbon atoms, or optionally substituted aralkyl of 7 to 14 carbon atoms;R.sub.5 is a heterocycle;D is a alkylene of 1 to 12 carbon atoms; andA is hydrogen or acyl,and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as .alpha.- and .beta.-adrenergic receptor blocking agents and antidepressants.
摘要翻译：其中R1，R2和R3各自为氢或各种取代基的式“IMAGE”的化合物; R4是氢，1至5个碳原子的烷基或任选取代的具有7-14个碳原子的芳烷基; R5是杂环; D是1至12个碳原子的亚烷基; 和A是氢或酰基，以及无毒的药学上可接受的酸加成盐。化合物及其盐可用作α-和β-肾上腺素能受体阻断剂和抗抑郁药。

7. 发明授权

US4604468A Intermediate 1-alkylenyl-1H-benzimidazol-2-one derivatives 失效
标题翻译：中间体1-亚烷基-1H-苯并咪唑-2-酮衍生物
公开(公告)号：US4604468A
公开(公告)日：1986-08-05
申请号：US634446
申请日：1984-07-25
申请人： Herbert Koppe , Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Wolfgang Hoefke , Gojko Muaceic
发明人： Herbert Koppe , Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Wolfgang Hoefke , Gojko Muaceic
IPC分类号： C07D233/36 , A61K31/415 , A61K31/4166 , A61K31/4184 , A61K31/435 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/5355 , A61K31/5375 , A61K31/538 , A61P9/00 , A61P25/24 , A61P25/26 , C07D205/04 , C07D209/34 , C07D215/22 , C07D215/227 , C07D233/32 , C07D235/26 , C07D265/18 , C07D265/28 , C07D265/30
CPC分类号： C07D215/227 , C07D209/34 , C07D233/32 , C07D235/26 , C07D265/18 , C07D265/28
摘要： Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen or substituents of various types;R.sub.4 is hydrogen; alkyl of 1 to 5 carbon atoms; or optionally substituted aralkyl or 7 to 14 carbon atoms;R.sub.5 is a heterocycle;D is alkylene of 1 to 12 carbon atoms; andA is hydrogen or acyl; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as .alpha.- and .beta.-adrenergic receptor blocking agents and antidepressants.
摘要翻译：其中R 1，R 2和R 3为氢或各种取代基的式IMAMA的化合物; R4是氢; 1至5个碳原子的烷基; 或任选取代的芳烷基或7至14个碳原子; R5是杂环; D是1至12个碳原子的亚烷基; A是氢或酰基; 和无毒的，药学上可接受的酸加成盐。化合物及其盐可用作α-和β-肾上腺素能受体阻断剂和抗抑郁药。

8. 发明授权

US4558061A Bronchospasmolytic 1-(3-methanesulfonamido-4-hydroxyphenyl)-2-[(3-(4-acyl-aminophenyl)-imid azolidin-2-one-1-yl)-alkylamino]-ethanols 失效
标题翻译：支气管痉挛性1-（3-甲磺酰氨基-4-羟基苯基）-2 - [（3-（4-酰基 - 氨基苯基） - 咪唑烷-2-酮-1-基） - 烷基氨基] - 乙醇
公开(公告)号：US4558061A
公开(公告)日：1985-12-10
申请号：US628383
申请日：1984-07-06
申请人： Anton Mentrup , Kurt Schromm , Ernst-Otto Renth , Gojko Muacevic , Armin Fugner
发明人： Anton Mentrup , Kurt Schromm , Ernst-Otto Renth , Gojko Muacevic , Armin Fugner
IPC分类号： C07D233/34 , A61K31/415 , A61K31/4166 , A61P9/08 , A61P11/00 , A61P11/08 , A61P25/24 , A61P25/26 , C07D233/30 , C07D233/36
CPC分类号： C07D233/36
摘要： Compounds of the formula ##STR1## wherein n is 1 or 2, R.sub.1 is hydrogen, --CO--R.sub.2 or --SO.sub.2 R.sub.3,R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or (alkyl of 1 to 4 carbon atoms)amino, andR.sub.3 is alkyl of 1 to 4 carbon atoms,and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as bronchospasmolytics.
摘要翻译：其中n为1或2，R1为氢，-CO-R2或-SO2R3，R2为氢，1至4个碳原子的烷基，1至4个碳原子的烷氧基的化合物或（1〜4个碳原子的烷基）氨基，R3为1〜4个碳原子的烷基，以及无毒的药学上可接受的酸加成盐。化合物及其盐可用作支气管痉挛溶解剂。

9. 发明授权

US4539323A N-[1-(4-Amino-6,7-dialkoxy-2-quinazolinyl)-4-piperidy l]-oxazolidine-2,4-diones 失效
标题翻译： N- [1-（4-氨基-6,7-二烷氧基-2-喹唑啉基）-4-哌啶基] - 恶唑烷-2,4-二酮
公开(公告)号：US4539323A
公开(公告)日：1985-09-03
申请号：US531842
申请日：1983-09-14
申请人： Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Wolfgang Hoefke , Wolfram Gaida
发明人： Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Wolfgang Hoefke , Wolfram Gaida
IPC分类号： C07D239/95 , A61K31/505 , A61K31/517 , A61P9/08 , A61P9/12 , A61P25/02 , C07D263/44 , C07D401/14 , C07D413/04 , C07D413/14 , C07D491/056
CPC分类号： C07D413/04 , C07D413/14
摘要： Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2, which may be identical to or different from each other, are each independently hydrogen, straight or branched alkyl of 1 to 8 carbon atoms or arylmethyl; orR.sub.1 and R.sub.2, together with each other, are --(CH.sub.2).sub.4 or --(CH.sub.2).sub.5 --; andR.sub.3 and R.sub.4, which may be identical to or different from each other, are each independently hydrogen, straight or branched alkyl of 1 to 4 carbon atoms or arylmethyl; orR.sub.3 and R.sub.4, together with each other, are --CH.sub.3 -- or --CH.sub.2 --CH.sub.2 --;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful for the treatment of cardiovascular diseases, especially hypertension.
摘要翻译：其中R 1和R 2可以相同或不同，各自独立地为氢，1至8个碳原子的直链或支链烷基或芳基甲基; 或R 1和R 2彼此一起为 - （CH 2）4或 - （CH 2）5 - ; 并且可以相同或不同的R 3和R 4各自独立地为氢，1至4个碳原子的直链或支链烷基或芳基甲基; 或R 3和R 4彼此一起为-CH 3 - 或-CH 2 -CH 2 - ; 和无毒的，药学上可接受的酸加成盐。化合物及其盐可用于治疗心血管疾病，特别是高血压。

10. 发明授权

US4341778A 3,1 Benzoxazin-2-ones and use thereof 失效
标题翻译： 3，苯并恶嗪-2-酮及其用途
公开(公告)号：US4341778A
公开(公告)日：1982-07-27
申请号：US280349
申请日：1981-07-06
申请人： Anton Mentrup , Kurt Schromm , Ernst-Otto Renth , Wolfgang Hoefke , Wolfram Gaida , Ilse Streller , Armin Fugner
发明人： Anton Mentrup , Kurt Schromm , Ernst-Otto Renth , Wolfgang Hoefke , Wolfram Gaida , Ilse Streller , Armin Fugner
IPC分类号： C07D265/16 , A61K31/535 , A61K31/536 , A61P9/00 , A61P9/08 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , C07D265/18 , C07D265/22
CPC分类号： C07D265/18
摘要： The invention relates to compounds of general formula I ##STR1## (wherein R.sub.1 and R.sub.2, which may be the same or different, each represents a hydrogen atom or a (C.sub.1 -C.sub.4) alkyl group;R.sub.3 and R.sub.4, which may be the same or different, each represents a hydrogen, fluorine or chlorine atom or a hydroxy, methyl, ethyl or (C.sub.1 -C.sub.4) alkoxy group, or R.sub.3 together with R.sub.4 represents a methylenedioxy group;R.sub.5 and R.sub.6, which may be the same or different, each represents a hydrogen atom or a methyl group;R.sub.7 represents a group of formula ##STR2## R represents a hydrogen atom or a (C.sub.1 -C.sub.4) alkyl group; R.sub.8 represents a fluorine or chlorine atom or a (C.sub.1 -C.sub.4) alkyl, (C.sub.1 -C.sub.4) alkylthio, hydroxymethyl, CONHR.sub.11, SO.sub.2 NHR.sub.11, OR.sub.12, methoxycarbonyl, ethoxycarbonyl or NHSO.sub.2 CH.sub.3 group;R.sub.9 represents a hydrogen, fluorine or chlorine atom or a OR.sub.12 group;R.sub.10 represents a hydrogen or chlorine atom or an amino, methyl or methoxy group;R.sub.11 represents a hydrogen atom or a methyl, ethyl or hydroxyethyl group;R.sub.12 represents a hydrogen atom or a (C.sub.1 -C.sub.4) alkyl, (C.sub.1 -C.sub.4) alkyl-CO, aryl-CH.sub.2 or aryl-CO group; andn represents 1, 2 or 3) and acid addition salts thereof as well as to processes for their preparation and pharmaceutical compositions containing them. The compounds of the invention possess interesting pharmacological properties in particular displaying hypotensive and selective tocolytic effects.
摘要翻译：本发明涉及通式I（I）的化合物（其中R 1和R 2可以相同或不同，各自表示氢原子或（C 1 -C 4）烷基; R 3和R 4可以相同或不同，各自表示氢，氟或氯原子或羟基，甲基，乙基或（C1-C4）烷氧基，或R3与R4一起代表亚甲二氧基; R5和R6可以相同或不同的，各自表示氢原子或甲基; R 7表示下式的基团：R表示氢原子或（C 1 -C 4）烷基; R 8表示氟或氯原子或（C 1 -C 4））烷基，（C1-C4）烷硫基，羟甲基，CONHR11，SO2NHR11，OR12，甲氧基羰基，乙氧基羰基或NHSO2CH3基; R9表示氢，氟或氯原子或OR12基团; R10表示氢或氯原子或氨基，甲基或甲氧基; R11表示氢原子或甲基，乙基或羟乙基; R12表示a 氢原子或（C 1 -C 4）烷基，（C 1 -C 4）烷基-CO，芳基-CH 2或芳基-CO基团; 和n表示1,2或3）及其酸加成盐以及其制备方法和含有它们的药物组合物。本发明的化合物具有特别显示降血压和选择性溶瘤作用的有趣的药理学性质。

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