专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20080096935A1 Heterocyclic Indanone Potentiators of Metabotropic Glutamate Receptors 审中-公开
标题翻译：代谢型谷氨酸受体的杂环茚酮电解质
公开(公告)号：US20080096935A1
公开(公告)日：2008-04-24
申请号：US11666072
申请日：2005-10-21
申请人： Anthony Pinkerton , Jean-Michel Vernier , Rowena Cube , John Hutchinson
发明人： Anthony Pinkerton , Jean-Michel Vernier , Rowena Cube , John Hutchinson
IPC分类号： A61K31/4412 , A61K31/4196 , A61K31/4152
CPC分类号： C07D213/30 , C07D207/32 , C07D213/65 , C07D213/70 , C07D231/12 , C07D235/18 , C07D249/08
摘要： The present invention is directed to compounds which are potentiators of metabotropic glutamate receptors, including the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.
摘要翻译：本发明涉及作为代谢型谷氨酸受体的增强剂（包括mGluR2受体）的化合物，其可用于治疗或预防与谷氨酸能力障碍相关的神经和精神病学障碍以及其中涉及代谢型谷氨酸受体的疾病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及代谢型谷氨酸受体的疾病中的用途。

2. 发明申请

US20080312286A1 Indanone Potentiators of Metabotropic Glutamate Receptors 审中-公开
标题翻译：代谢型谷氨酸受体的茚酮电位器
公开(公告)号：US20080312286A1
公开(公告)日：2008-12-18
申请号：US11658490
申请日：2005-07-26
申请人： Anthony B. Pinkerton , Jean-Michel Vernier , Rowena Cube , John Hutchinson , Celine Bonnefous , Theodore Kamenecka
发明人： Anthony B. Pinkerton , Jean-Michel Vernier , Rowena Cube , John Hutchinson , Celine Bonnefous , Theodore Kamenecka
IPC分类号： C07D257/04 , A61K31/41 , C07C307/02 , A61K31/18 , C07C233/02 , A61K31/454 , C07D401/02 , A61K31/192 , C07C65/00 , C07D213/80 , A61K31/44 , A61K31/343 , C07D307/78 , A61P25/00 , A61P25/18 , A61P25/24 , A61P25/08
CPC分类号： C07C233/91 , C07C59/90 , C07C65/40 , C07C311/51 , C07C2601/08 , C07C2602/08 , C07D257/04 , C07D307/79 , C07D401/04
摘要： The present invention is directed to compounds which are potentiators of metabotropic glutamate receptors, including the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.
摘要翻译：本发明涉及作为代谢型谷氨酸受体的增强剂（包括mGluR2受体）的化合物，其可用于治疗或预防与谷氨酸能力障碍相关的神经和精神病学障碍以及其中涉及代谢型谷氨酸受体的疾病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及代谢型谷氨酸受体的疾病中的用途。

3. 发明申请

US20080167322A1 Substituted Pyrazoles as Modulators of Chemokine Receptors 审中-公开
标题翻译：取代的吡唑作为趋化因子受体的调节剂
公开(公告)号：US20080167322A1
公开(公告)日：2008-07-10
申请号：US11884325
申请日：2006-02-14
申请人： Anthony B. Pinkerton , Rowena Cube , John Hutchinson , Dehua Huang , Jean-Michel Vernier , Dong-Ming Shen
发明人： Anthony B. Pinkerton , Rowena Cube , John Hutchinson , Dehua Huang , Jean-Michel Vernier , Dong-Ming Shen
IPC分类号： A61K31/497 , C07D231/10 , A61K31/4155 , A61P19/02 , C07D401/02 , A61K31/4439
CPC分类号： C07D231/38 , C07D231/12 , C07D231/22 , C07D401/12 , C07D403/12
摘要： Substituted pyrazole compounds such compounds represented by formula I: which are used to modulate the CCR-2 chemokine receptor to prevent or treat inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis; and pharmaceutical compositions comprising these compounds and the use of these compounds and compositions.
摘要翻译：取代的吡唑化合物，由式I表示：用于调节CCR-2趋化因子受体以预防或治疗炎性和免疫调节性疾病和疾病，过敏性疾病，特应性疾病，包括过敏性鼻炎，皮炎，结膜炎和哮喘的化合物，以及作为自身免疫性病变如类风湿性关节炎和动脉粥样硬化; 和包含这些化合物的药物组合物以及这些化合物和组合物的用途。

4. 发明申请

US20070027321A1 Bipyridyl amines and ethers as modulators of metabotropic glutamate receptor-5 审中-公开
标题翻译：联吡啶胺和醚作为代谢型谷氨酸受体-5的调节剂
公开(公告)号：US20070027321A1
公开(公告)日：2007-02-01
申请号：US10570068
申请日：2004-08-27
申请人： Theodore Kamenecka , Jean-Michel Vernier , Celine Bonnefous , Steven Govek , John Hutchinson
发明人： Theodore Kamenecka , Jean-Michel Vernier , Celine Bonnefous , Steven Govek , John Hutchinson
IPC分类号： A61K31/4743 , C07D471/02 , C07D401/02 , C07D417/14
CPC分类号： C07D213/74 , C04B35/632 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D491/04
摘要： The present invention is directed to novel bipyridyl amine and ether compounds such as those of Formula (I): (I) (where R?1#191, R?2#191, R?3#191, X and Y are as defined herein) which are mGluR5 modulators useful in the treatment or prevention of diseases and conditions in which mGluR5 is involved, including but not limited to psychiatric and mood disorders such as schizophrenia, anxiety, depression, bipolar disorders, and panic, as well as in the treatment of pain, Parkinson's disease, cognitive dysfunction, epilepsy, circadian rhythm and sleep disorders, such as shift-work induced sleep disorder and jet-lag, drug addiction, drug abuse, drug withdrawal, obesity and other diseases. The invention is also directed to pharmaceutical compositions comprising these compounds. This invention further provides a method of treatment of these disorders and conditions by the administration of an effective amount of these novel bipyridyl amine and/or ether compounds and/or compositions containing these compounds.
摘要翻译：本发明涉及新型联吡啶胺和醚化合物，例如式（I）的那些：（I）（其中R 1＃191，R 2＃191，R 3＃191，X和Y如上所定义）这是mGluR5调节剂，其可用于治疗或预防涉及mGluR5的疾病和病症，包括但不限于精神和心境障碍如精神分裂症，焦虑，抑郁，双相情感障碍和恐慌，以及在治疗疼痛，帕金森病，认知功能障碍，癫痫，昼夜节律和睡眠障碍，如转移工作诱导的睡眠障碍和时差，药物成瘾，药物滥用，药物戒断，肥胖症等疾病。本发明还涉及包含这些化合物的药物组合物。本发明还提供了通过施用有效量的这些新型联吡啶胺和/或醚化合物和/或含有这些化合物的组合物来治疗这些病症和病症的方法。

5. 发明申请

US20060069088A1 Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors 有权
标题翻译：趋化因子受体的苯并恶嗪基酰胺基环戊基 - 杂环调节剂
公开(公告)号：US20060069088A1
公开(公告)日：2006-03-30
申请号：US11129512
申请日：2005-05-13
申请人： Stephen Goble , Sander Mills , Lihu Yang , Alexander Pasternak , Celine Bonnefous , Theodore Kamenecka , Jean-Michel Vernier , John Hutchinson , Essa Hu , Steven Govek
发明人： Stephen Goble , Sander Mills , Lihu Yang , Alexander Pasternak , Celine Bonnefous , Theodore Kamenecka , Jean-Michel Vernier , John Hutchinson , Essa Hu , Steven Govek
IPC分类号： A61K31/542 , A61K31/538 , A61K31/519 , C07D498/02 , C07D487/02 , C07D491/02
CPC分类号： C07D413/08 , C07D413/14 , C07D417/14
摘要： Cyclopentyl compounds linked to a benzoxazinyl group through an amido moiety utilizing the ring nitrogen of the benzoxazine, and further substituted with a heterocyclic moiety, such compounds represented by formula I: which are used to modulate the CCR-2 chemokine receptor to prevent or treat inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis; and pharmaceutical compositions comprising these compounds and the use of these compounds and compositions.
摘要翻译：通过使用苯并恶嗪的环氮通过酰胺部分连接到苯并恶嗪基的环戊基化合物，并进一步被杂环部分取代，由式I表示的化合物：

6. 发明申请

US20070287716A1 Pyrimidine and Quinoline Potentiators of Metabotropic Glutamate Receptors 审中-公开
标题翻译：代谢型谷氨酸受体的嘧啶和喹啉电位
公开(公告)号：US20070287716A1
公开(公告)日：2007-12-13
申请号：US11665422
申请日：2005-10-24
申请人： Essa Hu , Jean-Michel Vernier , Peter Chua , John Hutchinson , Nicholas Cosford
发明人： Essa Hu , Jean-Michel Vernier , Peter Chua , John Hutchinson , Nicholas Cosford
IPC分类号： A61K31/47 , A61P25/00 , C07D215/12 , C07D239/28
CPC分类号： C07D239/26 , C07D215/06
摘要： The present invention is directed to compounds which are potentiators of metabotropic glutamate receptors, including the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.
摘要翻译：本发明涉及作为代谢型谷氨酸受体的增强剂（包括mGluR2受体）的化合物，其可用于治疗或预防与谷氨酸能力障碍相关的神经和精神病学障碍以及其中涉及代谢型谷氨酸受体的疾病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及代谢型谷氨酸受体的疾病中的用途。

7. 发明授权

US08556941B2 Methods for correction of spinal deformities 有权
标题翻译：矫正脊柱畸形的方法
公开(公告)号：US08556941B2
公开(公告)日：2013-10-15
申请号：US13205248
申请日：2011-08-08
申请人： John Hutchinson
发明人： John Hutchinson
IPC分类号： A61B17/70
CPC分类号： A61B17/88 , A61B17/7002 , A61B17/7032 , A61B17/7038
摘要： A method of treating a spinal column shape deformation includes fixing at least two fixation screw assemblies to respective vertebrae, sliding a rod between the arm extensions on each of the fixation screw assemblies, swinging the channels of the screw assemblies relative to the fixation screws so that the channels become less inclined to the axes of the fixation screws, and so that the rod is located generally posteriorly of the spinal column, locking the channel against swinging relative to the screw, rotating the rod about its axis relative to at least one of the channels, and locking the rod against movement relative to the channel.
摘要翻译：治疗脊柱形变形的方法包括将至少两个固定螺钉组件固定到相应的椎骨上，在每个固定螺钉组件上的臂延伸部之间滑动杆，相对于固定螺钉摆动螺钉组件的通道，使得通道变得不那么倾向于固定螺钉的轴线，并且使得杆大体位于脊柱的后方，锁定通道相对于螺钉摆动，相对于其中的至少一个将杆绕其轴线旋转通道，并且锁定杆相对于通道的运动。

8. 发明申请

US20110295321A1 Methods for Correction of Spinal Deformities 有权
标题翻译：矫正脊柱畸形的方法
公开(公告)号：US20110295321A1
公开(公告)日：2011-12-01
申请号：US13205248
申请日：2011-08-08
申请人： John Hutchinson
发明人： John Hutchinson
IPC分类号： A61B17/88
CPC分类号： A61B17/88 , A61B17/7002 , A61B17/7032 , A61B17/7038
摘要： A method of treating a spinal column shape deformation includes fixing at least two fixation screw assemblies to respective vertebrae, sliding a rod between the arm extensions on each of the fixation screw assemblies, swinging the channels of the screw assemblies relative to the fixation screws so that the channels become less inclined to the axes of the fixation screws, and so that the rod is located generally posteriorly of the spinal column, locking the channel against swinging relative to the screw, rotating the rod about its axis relative to at least one of the channels, and locking the rod against movement relative to the channel.
摘要翻译：治疗脊柱形变形的方法包括将至少两个固定螺钉组件固定到相应的椎骨上，在每个固定螺钉组件上的臂延伸部之间滑动杆，相对于固定螺钉摆动螺钉组件的通道，使得通道变得不那么倾向于固定螺钉的轴线，并且使得杆大体位于脊柱的后方，锁定通道相对于螺钉摆动，相对于其中的至少一个将杆绕其轴线旋转通道，并且锁定杆相对于通道的运动。

9. 发明申请

US20060142602A1 Method of making methyl ester surfactants 审中-公开
标题翻译：制备甲酯表面活性剂的方法
公开(公告)号：US20060142602A1
公开(公告)日：2006-06-29
申请号：US10534244
申请日：2003-11-21
申请人： John Hutchinson , Jungsik Lee , Timothy Eigley , Robert Krueger
发明人： John Hutchinson , Jungsik Lee , Timothy Eigley , Robert Krueger
IPC分类号： C07C67/02
CPC分类号： C08G65/332 , C07C67/03 , C11D1/74 , C07C69/24
摘要： A method of making a methyl ester based surfactants is provided. The method includes the transesterfication or esterification of a methyl ester feedstock and a poly(alkyl ether) feedstock.
摘要翻译：提供了制备甲酯基表面活性剂的方法。该方法包括甲酯原料和聚（烷基醚）原料的酯交换或酯化。

10. 发明申请

US20050097901A1 Apparatus and method for producing water from air 失效
标题翻译：用于从空气中生产水的设备和方法
公开(公告)号：US20050097901A1
公开(公告)日：2005-05-12
申请号：US10977143
申请日：2004-10-29
申请人： John Hutchinson
发明人： John Hutchinson
IPC分类号： B01D5/00 , E03B3/28 , F25D17/06 , F25D21/14
CPC分类号： B01D5/0081 , B01D5/0039 , B01D5/0051 , E03B3/28 , Y02A20/109
摘要： An apparatus and method are extracting water from the ambient air comprising drawing air through an particle ionizer grid, evaporator plates of a refrigerant system the system and recirculating the ionized air and mixing said ionized air with ambient air and recycling said mixed air through said ionizer and evaporator plates to extract moisture from the air. The system utilizes sensors to constantly sense and predictively respond to multiple parameters, monitored at multiple points in the system to predictively and efficiently adjust the system operation to continually maximize the extraction of water regardless of ambient temperature and humidity.
摘要翻译：一种装置和方法是从环境空气中提取水，包括抽吸空气通过颗粒离子发生器网格，制冷剂系统的蒸发器板系统并使离子化空气再循环并将所述离子化空气与环境空气混合，并将所述混合空气再循环通过所述离子发生器和蒸发器板从空气中提取水分。该系统利用传感器不断地感测和预测性地响应多个参数，在系统的多个点进行监测，以预测和有效地调整系统运行，以连续地最大限度地提取水，而不管环境温度和湿度如何。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式