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1. 发明申请

US20100160754A1 Method and Apparatus for Quantification of Optical Properties of Superficial Volumes Using Small Source-to-Detector Separations 有权
标题翻译：用于使用小的源到检测器分离来定量表面体积的光学性质的方法和装置
公开(公告)号：US20100160754A1
公开(公告)日：2010-06-24
申请号：US12643789
申请日：2009-12-21
申请人： Anthony J. Durkin , Sheng-hao Tseng
发明人： Anthony J. Durkin , Sheng-hao Tseng
IPC分类号： A61B5/1459
CPC分类号： A61B5/1459 , A61B5/0075 , A61B5/0086 , A61B5/14532 , A61B5/4312 , A61B5/443 , A61B2562/0242
摘要： A probe for obtaining quantitative optical properties and chromophore concentrations of tissue components in tissue in-vivo at superficial depths and at source-detector separations of 5 mm or less includes a source fiber providing light to expose the tissue, a diffuser layer into which light from the source fiber is directed and then from the diffuser layer to and/or into the tissue, and a detector fiber arranged relative to the diffuser layer for detecting backscattered and/or reflected light returned from the tissue without transmission through the diffuser layer.
摘要翻译：用于在表面深度和源检测器间隔5mm以下的组织中获得组织组分的定量光学性质和发色团浓度的探针包括提供光以暴露组织的源光纤，漫射层，源光纤被引导，然后从扩散层引导到组织和/或进入组织，以及检测器光纤相对于漫射层布置，用于检测从组织返回的反向散射和/或反射光，而不通过扩散层传播。

2. 发明授权

US07304724B2 Method and apparatus for quantification of optical properties of superficial volumes 有权
标题翻译：用于量化表面体积的光学性质的方法和装置
公开(公告)号：US07304724B2
公开(公告)日：2007-12-04
申请号：US11104033
申请日：2005-04-12
申请人： Anthony J. Durkin , Sheng-Hao Tseng
发明人： Anthony J. Durkin , Sheng-Hao Tseng
IPC分类号： G01N21/00
CPC分类号： G01N21/49 , G01N21/31 , G01N21/3563 , G01N2201/08
摘要： A device and method for accurately performing quantitative diffuse optical spectroscopy on a sample includes a light source and a source optical fiber that is optically coupled to the light source. A diffuser material is interposed between the source optical fiber and the sample, the diffuser material comprising a high scattering, low absorption material. The diffuser material effectively increases the photon path length from the light source to the sample, which limits the depth of interrogation to superficial volumes despite the penetrating nature of the radiation typically used. A detector optical fiber is provided adjacent to or laterally disposed from the source optical fiber. The detector optical fiber is coupled to a detector which detects photons collected in the detector optical fiber. The detector optical fiber and the source optical fiber may be separated by a distance of less than 5 mm while still permitting the diffusion approximation to remain valid.
摘要翻译：用于在样品上精确地进行定量扩散光谱的装置和方法包括光源和光学耦合到光源的源光纤。漫射材料插入在源光纤和样品之间，漫射材料包含高散射低吸收材料。扩散器材料有效地增加了从光源到样品的光子路径长度，这限制了询问到表面体积的深度，尽管通常使用的辐射的穿透性质。检测器光纤被设置成与源光纤相邻或横向设置。检测器光纤耦合到检测器，该检测器检测在检测器光纤中收集的光子。检测器光纤和源光纤可以分开小于5mm的距离，同时仍允许扩散近似保持有效。

3. 发明授权

US08301216B2 Method and apparatus for quantification of optical properties of superficial volumes using small source-to-detector separations 有权
标题翻译：用于使用小的源到检测器分离来定量表面体积的光学性质的方法和装置
公开(公告)号：US08301216B2
公开(公告)日：2012-10-30
申请号：US12643789
申请日：2009-12-21
申请人： Anthony J. Durkin , Sheng-hao Tseng
发明人： Anthony J. Durkin , Sheng-hao Tseng
IPC分类号： A61B5/00
CPC分类号： A61B5/1459 , A61B5/0075 , A61B5/0086 , A61B5/14532 , A61B5/4312 , A61B5/443 , A61B2562/0242
摘要： A probe for obtaining quantitative optical properties and chromophore concentrations of tissue components in tissue in-vivo at superficial depths and at source-detector separations of 5 mm or less includes a source fiber providing light to expose the tissue, a diffuser layer into which light from the source fiber is directed and then from the diffuser layer to and/or into the tissue, and a detector fiber arranged relative to the diffuser layer for detecting backscattered and/or reflected light returned from the tissue without transmission through the diffuser layer.
摘要翻译：用于在表面深度和源检测器间隔5mm以下的组织中获得组织组分的定量光学性质和发色团浓度的探针包括提供光以暴露组织的源光纤，漫射层，源光纤被引导，然后从扩散层引导到组织和/或进入组织，以及检测器光纤相对于漫射层布置，用于检测从组织返回的反向散射和/或反射光，而不通过扩散层传播。

4. 发明授权

US06200308B1 Dynamic cooling of tissue for radiation treatment 有权
标题翻译：动态冷却组织进行放射治疗
公开(公告)号：US06200308B1
公开(公告)日：2001-03-13
申请号：US09240464
申请日：1999-01-29
申请人： Karl Pope , Anthony J. Durkin , James C. Hsia
发明人： Karl Pope , Anthony J. Durkin , James C. Hsia
IPC分类号： A61B1818
CPC分类号： A61B18/203 , A61B18/0218 , A61B2018/00017 , A61B2018/00023 , A61B2018/00029 , A61B2018/00452
摘要： A method for performing radiation treatment of skin in connection with dynamic cooling of tissue, while minimizing or preventing occurrence of light flash during the treatment.
摘要翻译：一种用于在组织的动态冷却下进行皮肤的放射治疗的方法，同时在处理期间最小化或防止发生闪光。

5. 发明申请

US20100210931A1 METHOD FOR PERFORMING QUALITATIVE AND QUANTITATIVE ANALYSIS OF WOUNDS USING SPATIALLY STRUCTURED ILLUMINATION 审中-公开
标题翻译：使用空间结构照明实现绕线的定性和定量分析的方法
公开(公告)号：US20100210931A1
公开(公告)日：2010-08-19
申请号：US12418515
申请日：2009-04-03
申请人： David Cuccia , Anthony J. Durkin , Joon S. You
发明人： David Cuccia , Anthony J. Durkin , Joon S. You
IPC分类号： A61B5/1455 , A61B6/00
CPC分类号： A61B5/0059 , A61B5/02028 , A61B5/14551 , A61B5/445
摘要： A method of noncontact imaging for performing qualitative and quantitative analysis of wounds includes the step of performing structured illumination of surface and subsurface tissue by both diffuse optical tomography and rapid, wide-field quantitative mapping of tissue optical properties within a single measurement platform. Structured illumination of a skin flap is performed to monitor a burn wound, a diabetic ulcer, a decubitis ulcer, a peripheral vascular disease, a skin graft, and/or tissue response to photomodulation. Quantitative imaging of optical properties is performed of superficial (0-5 mm depth) tissues in vivo. The step of quantitative imaging of optical properties of superficial (0-5 mm depth) tissues in vivo comprises pixel-by-pixel demodulating and diffusion-model fitting or model-based analysis of spatial frequency data to extract the local absorption and reduced scattering optical coefficients.
摘要翻译：用于对伤口进行定性和定量分析的非接触成像方法包括通过漫射光学层析成像和在单个测量平台内的组织光学性质的快速，宽场定量映射来执行表面和表面下组织的结构照明的步骤。执行皮瓣的结构照明以监测烧伤伤口，糖尿病性溃疡，褥疮性溃疡，外周血管疾病，皮肤移植物和/或组织对光调制的反应。光学性质的定量成像在体内进行表面（0-5mm深度）组织。表面（0-5mm深度）组织的光学性质的定量成像步骤包括逐像素解调和扩散模拟拟合或空间频率数据的基于模型的分析，以提取局部吸收和减少散射光学系数。

6. 发明申请

US20090187169A1 Method of Treating Disorders Associated with Sebaceous Follicles 审中-公开
标题翻译：治疗与皮脂腺相关的疾病的方法
公开(公告)号：US20090187169A1
公开(公告)日：2009-07-23
申请号：US12414316
申请日：2009-03-30
申请人： Anthony J. Durkin , Dilip Y. Paithankar , Yacov Domankevitz
发明人： Anthony J. Durkin , Dilip Y. Paithankar , Yacov Domankevitz
IPC分类号： A61B18/20
CPC分类号： A61B18/203 , A61B2018/00005 , A61B2018/00011 , A61B2018/00452 , A61B2018/00476 , A61B2018/1807
摘要： Disclosed herein is a method of treating mammalian, for example, human, skin afflicted with a sebaceous follicle disorder, for example, acne. The method involves cooling an exposed surface of a region afflicted with the disorder and applying light, for example, light from a coherent or incoherent light source, to the region. The applied light reduces the size and/or density of lesions associated with the disorder in the treated region, and can reduce or otherwise alleviate lesion-associated skin inflammation in the treated region. Cooling preserves the surface, for example, epidermis, of the skin. The method, therefore, is effective at treating the disorder while at the same time avoiding or minimizing thermal damage to the exposed surface of the skin.
摘要翻译：本文公开了一种治疗哺乳动物例如患有皮脂腺滤泡障碍（例如痤疮）的人类皮肤的方法。该方法包括冷却受到障碍的区域的暴露表面，并将光（例如，来自相干或非相干光源的光）施加到该区域。所应用的光减少与处理区域中的病症相关的损伤的大小和/或密度，并且可以减少或以其它方式减轻治疗区域中与病变相关的皮肤炎症。冷却保留皮肤表面，例如皮肤表皮。因此，该方法在治疗疾病方面是有效的，同时避免或最小化对皮肤暴露表面的热损伤。

7. 发明授权

US06571118B1 Combined fluorescence and reflectance spectroscopy 有权
标题翻译：组合荧光和反射光谱
公开(公告)号：US06571118B1
公开(公告)日：2003-05-27
申请号：US09304922
申请日：1999-05-04
申请人： Urs Utzinger , Anthony J. Durkin , Holger Fuchs , Ann M. Gillenwater , Douglas L. Heintzelman , Rebecca R. Richards-Kortum
发明人： Urs Utzinger , Anthony J. Durkin , Holger Fuchs , Ann M. Gillenwater , Douglas L. Heintzelman , Rebecca R. Richards-Kortum
IPC分类号： A61B500
CPC分类号： G01N21/645 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/0088 , G01J3/02 , G01J3/0218 , G01J3/28 , G01J3/2823 , G01J3/42 , G01J3/4406 , G01N21/4738 , G01N21/6456 , G01N21/6486 , G01N2021/6484
摘要： Methods and apparatus for performing fluorescence and spatially resolved reflectance spectroscopy on a sample. A sample is irradiated with a fluorescence excitation fiber and radiation is collected from the sample with a fluorescence collection fiber and detected to form fluorescence spectra. The sample is also illuminated with a reflectance illumination fiber and reflected light from the sample is collected at a plurality of collection positions and detected to form spatially resolved reflectance spectra. The fibers may form a probe arranged in concentric sections. The spectra are analyzed by pre-processing and reducing the dimensionality of the spectral data.
摘要翻译：在样品上进行荧光和空间分辨反射光谱的方法和装置。用荧光激发纤维照射样品，并用荧光收集纤维从样品中收集辐射，并检测形成荧光光谱。样品也用反射照明光纤照射，并且在多个采集位置收集来自样品的反射光，并检测以形成空间分辨反射光谱。纤维可以形成以同心部分布置的探针。通过预处理和降低光谱数据的维数来分析光谱。

8. 发明申请

US20070282179A1 METHOD AND APPARATUS FOR ASSESSING THE MOLECULAR WATER BINDING OF DEEP TISSUE IN VIVO USING NONIONIZING RADIATION 审中-公开
标题翻译：使用非放射性辐射评估体内深层组织分子水结合的方法和装置
公开(公告)号：US20070282179A1
公开(公告)日：2007-12-06
申请号：US11757673
申请日：2007-06-04
申请人： Sean Merritt , Bruce J. Tromberg , Albert E. Cerussi , Anthony J. Durkin , So Hyun Chung
发明人： Sean Merritt , Bruce J. Tromberg , Albert E. Cerussi , Anthony J. Durkin , So Hyun Chung
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/0064 , A61B5/0075 , A61B5/0091 , A61B5/441 , A61B5/4875
摘要： A method of optically analyzing tissue in vivo in an individual to obtain a unique spectrum for the tissue of the individual includes the steps of optically measuring the tissue of the individual using broadband diffuse optical spectroscopy (DOS) to measure a normalized tissue water spectrum of the individual or noninvasively optically line scanning a tissue site on the individual at a plurality of points, then determining spectral differences between the normalized tissue water spectrum and a pure water spectrum at each point of a line scan, generating a bound water index (BWI) corresponding to the spectral differences, and identifying a tissue state corresponding to the scanned tissue based on the BWI.
摘要翻译：在个体中光学分析体内组织以获得个体组织的唯一光谱的方法包括以下步骤：使用宽带漫射光谱（DOS）光学测量个体的组织，以测量标准化组织水谱个体或非侵入式光线在多个点上扫描个体上的组织部位，然后确定标准化组织水谱与在线扫描的每个点处的纯水谱之间的光谱差异，生成对应的结合水指数（BWI）并且基于BWI识别与扫描的组织相对应的组织状态。

9. 发明授权

US06721583B1 Method for non-invasive identification of individuals at risk for diabetes 有权
标题翻译：用于非侵入性鉴定患有糖尿病风险的个体的方法
公开(公告)号：US06721583B1
公开(公告)日：2004-04-13
申请号：US09856186
申请日：2002-03-20
申请人： Anthony J. Durkin , Marwood N. Ediger , Vivian M. Chenault
发明人： Anthony J. Durkin , Marwood N. Ediger , Vivian M. Chenault
IPC分类号： A61B500
CPC分类号： A61B5/1455 , A61B3/10 , A61B5/14532
摘要： The invention provides methods for the use of Raman spectroscopy to non-invasively detect molecular characteristics of the constituents of the aqueous humor, vitreous humor, lens or retina. The method can be employed for the detection of molecular changes underlying ocular pathologies. In one embodiment of the invention, the method involves the steps of introducing light into the eye of the subject using a laser; collecting Raman spectra emitted from the eye; dispersing the collected Raman spectra onto a detector; and analyzing detected Raman spectral data to identify a molecular change related to an ocular pathology. The non-invasive method provided by the invention makes use of techniques and equipment that enable detection of Raman spectra with light intensities that fall within acceptable safety standards.
摘要翻译：本发明提供了使用拉曼光谱法非侵入性地检测房水，玻璃体液，晶状体或视网膜的成分的分子特征的方法。该方法可用于检测眼病理学上的分子变化。在本发明的一个实施例中，该方法包括以下步骤：使用激光将光引入对象的眼睛; 收集从眼睛发出的拉曼光谱; 将收集的拉曼光谱分散到检测器上; 并分析检测到的拉曼光谱数据以识别与眼病理相关的分子变化。本发明提供的非侵入性方法利用能够检测拉曼光谱的技术和设备，其光强度落在可接受的安全标准之内。

10. 发明授权

US6026816A Method of treating sleep-disordered breathing syndromes 失效
标题翻译：治疗睡眠呼吸障碍综合征的方法
公开(公告)号：US6026816A
公开(公告)日：2000-02-22
申请号：US10704
申请日：1998-01-22
申请人： Kathleen McMillan , James C. Hsia , Stanley M. Shapshay , Anthony J. Durkin
发明人： Kathleen McMillan , James C. Hsia , Stanley M. Shapshay , Anthony J. Durkin
IPC分类号： A61B17/24 , A61B18/20 , A61B19/00
CPC分类号： A61B18/20 , A61B2017/248
摘要： A method for treating sleep-disordered breathing syndromes, for example, snoring in a mammal. The method involves applying energy, for example, energy from laser light, to a preselected region of soft palate tissue in the mammal in an amount and duration sufficient to induce thermal injury to subepithelial tissue in the preselected region of soft palate tissue while minimizing thermal injury to epithelial tissue in the preselected region of soft palate tissue. Thermal injury of the subepithelial tissue results in stiffening of the preselected region of soft palate tissue thereby ameliorating the symptoms of the sleep-disordered breathing syndrome.
摘要翻译：一种治疗睡眠障碍呼吸综合征的方法，例如在哺乳动物中打鼾。该方法包括将能量（例如，来自激光的能量）以足以在软腭组织的预选区域中的上皮组织引起热损伤的量和持续时间施加到哺乳动物中软腭组织的预选区域，同时最小化热损伤到软腭组织的预选区域中的上皮组织。上皮组织的热损伤导致软腭组织的预选区域的硬化，从而改善睡眠呼吸综合征的症状。

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