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1. 发明申请

US20100160754A1 Method and Apparatus for Quantification of Optical Properties of Superficial Volumes Using Small Source-to-Detector Separations 有权
标题翻译：用于使用小的源到检测器分离来定量表面体积的光学性质的方法和装置
公开(公告)号：US20100160754A1
公开(公告)日：2010-06-24
申请号：US12643789
申请日：2009-12-21
申请人： Anthony J. Durkin , Sheng-hao Tseng
发明人： Anthony J. Durkin , Sheng-hao Tseng
IPC分类号： A61B5/1459
CPC分类号： A61B5/1459 , A61B5/0075 , A61B5/0086 , A61B5/14532 , A61B5/4312 , A61B5/443 , A61B2562/0242
摘要： A probe for obtaining quantitative optical properties and chromophore concentrations of tissue components in tissue in-vivo at superficial depths and at source-detector separations of 5 mm or less includes a source fiber providing light to expose the tissue, a diffuser layer into which light from the source fiber is directed and then from the diffuser layer to and/or into the tissue, and a detector fiber arranged relative to the diffuser layer for detecting backscattered and/or reflected light returned from the tissue without transmission through the diffuser layer.
摘要翻译：用于在表面深度和源检测器间隔5mm以下的组织中获得组织组分的定量光学性质和发色团浓度的探针包括提供光以暴露组织的源光纤，漫射层，源光纤被引导，然后从扩散层引导到组织和/或进入组织，以及检测器光纤相对于漫射层布置，用于检测从组织返回的反向散射和/或反射光，而不通过扩散层传播。

2. 发明授权

US06200308B1 Dynamic cooling of tissue for radiation treatment 有权
标题翻译：动态冷却组织进行放射治疗
公开(公告)号：US06200308B1
公开(公告)日：2001-03-13
申请号：US09240464
申请日：1999-01-29
申请人： Karl Pope , Anthony J. Durkin , James C. Hsia
发明人： Karl Pope , Anthony J. Durkin , James C. Hsia
IPC分类号： A61B1818
CPC分类号： A61B18/203 , A61B18/0218 , A61B2018/00017 , A61B2018/00023 , A61B2018/00029 , A61B2018/00452
摘要： A method for performing radiation treatment of skin in connection with dynamic cooling of tissue, while minimizing or preventing occurrence of light flash during the treatment.
摘要翻译：一种用于在组织的动态冷却下进行皮肤的放射治疗的方法，同时在处理期间最小化或防止发生闪光。

3. 发明申请

US20100210931A1 METHOD FOR PERFORMING QUALITATIVE AND QUANTITATIVE ANALYSIS OF WOUNDS USING SPATIALLY STRUCTURED ILLUMINATION 审中-公开
标题翻译：使用空间结构照明实现绕线的定性和定量分析的方法
公开(公告)号：US20100210931A1
公开(公告)日：2010-08-19
申请号：US12418515
申请日：2009-04-03
申请人： David Cuccia , Anthony J. Durkin , Joon S. You
发明人： David Cuccia , Anthony J. Durkin , Joon S. You
IPC分类号： A61B5/1455 , A61B6/00
CPC分类号： A61B5/0059 , A61B5/02028 , A61B5/14551 , A61B5/445
摘要： A method of noncontact imaging for performing qualitative and quantitative analysis of wounds includes the step of performing structured illumination of surface and subsurface tissue by both diffuse optical tomography and rapid, wide-field quantitative mapping of tissue optical properties within a single measurement platform. Structured illumination of a skin flap is performed to monitor a burn wound, a diabetic ulcer, a decubitis ulcer, a peripheral vascular disease, a skin graft, and/or tissue response to photomodulation. Quantitative imaging of optical properties is performed of superficial (0-5 mm depth) tissues in vivo. The step of quantitative imaging of optical properties of superficial (0-5 mm depth) tissues in vivo comprises pixel-by-pixel demodulating and diffusion-model fitting or model-based analysis of spatial frequency data to extract the local absorption and reduced scattering optical coefficients.
摘要翻译：用于对伤口进行定性和定量分析的非接触成像方法包括通过漫射光学层析成像和在单个测量平台内的组织光学性质的快速，宽场定量映射来执行表面和表面下组织的结构照明的步骤。执行皮瓣的结构照明以监测烧伤伤口，糖尿病性溃疡，褥疮性溃疡，外周血管疾病，皮肤移植物和/或组织对光调制的反应。光学性质的定量成像在体内进行表面（0-5mm深度）组织。表面（0-5mm深度）组织的光学性质的定量成像步骤包括逐像素解调和扩散模拟拟合或空间频率数据的基于模型的分析，以提取局部吸收和减少散射光学系数。

4. 发明申请

US20090187169A1 Method of Treating Disorders Associated with Sebaceous Follicles 审中-公开
标题翻译：治疗与皮脂腺相关的疾病的方法
公开(公告)号：US20090187169A1
公开(公告)日：2009-07-23
申请号：US12414316
申请日：2009-03-30
申请人： Anthony J. Durkin , Dilip Y. Paithankar , Yacov Domankevitz
发明人： Anthony J. Durkin , Dilip Y. Paithankar , Yacov Domankevitz
IPC分类号： A61B18/20
CPC分类号： A61B18/203 , A61B2018/00005 , A61B2018/00011 , A61B2018/00452 , A61B2018/00476 , A61B2018/1807
摘要： Disclosed herein is a method of treating mammalian, for example, human, skin afflicted with a sebaceous follicle disorder, for example, acne. The method involves cooling an exposed surface of a region afflicted with the disorder and applying light, for example, light from a coherent or incoherent light source, to the region. The applied light reduces the size and/or density of lesions associated with the disorder in the treated region, and can reduce or otherwise alleviate lesion-associated skin inflammation in the treated region. Cooling preserves the surface, for example, epidermis, of the skin. The method, therefore, is effective at treating the disorder while at the same time avoiding or minimizing thermal damage to the exposed surface of the skin.
摘要翻译：本文公开了一种治疗哺乳动物例如患有皮脂腺滤泡障碍（例如痤疮）的人类皮肤的方法。该方法包括冷却受到障碍的区域的暴露表面，并将光（例如，来自相干或非相干光源的光）施加到该区域。所应用的光减少与处理区域中的病症相关的损伤的大小和/或密度，并且可以减少或以其它方式减轻治疗区域中与病变相关的皮肤炎症。冷却保留皮肤表面，例如皮肤表皮。因此，该方法在治疗疾病方面是有效的，同时避免或最小化对皮肤暴露表面的热损伤。

5. 发明授权

US06571118B1 Combined fluorescence and reflectance spectroscopy 有权
标题翻译：组合荧光和反射光谱
公开(公告)号：US06571118B1
公开(公告)日：2003-05-27
申请号：US09304922
申请日：1999-05-04
申请人： Urs Utzinger , Anthony J. Durkin , Holger Fuchs , Ann M. Gillenwater , Douglas L. Heintzelman , Rebecca R. Richards-Kortum
发明人： Urs Utzinger , Anthony J. Durkin , Holger Fuchs , Ann M. Gillenwater , Douglas L. Heintzelman , Rebecca R. Richards-Kortum
IPC分类号： A61B500
CPC分类号： G01N21/645 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/0088 , G01J3/02 , G01J3/0218 , G01J3/28 , G01J3/2823 , G01J3/42 , G01J3/4406 , G01N21/4738 , G01N21/6456 , G01N21/6486 , G01N2021/6484
摘要： Methods and apparatus for performing fluorescence and spatially resolved reflectance spectroscopy on a sample. A sample is irradiated with a fluorescence excitation fiber and radiation is collected from the sample with a fluorescence collection fiber and detected to form fluorescence spectra. The sample is also illuminated with a reflectance illumination fiber and reflected light from the sample is collected at a plurality of collection positions and detected to form spatially resolved reflectance spectra. The fibers may form a probe arranged in concentric sections. The spectra are analyzed by pre-processing and reducing the dimensionality of the spectral data.
摘要翻译：在样品上进行荧光和空间分辨反射光谱的方法和装置。用荧光激发纤维照射样品，并用荧光收集纤维从样品中收集辐射，并检测形成荧光光谱。样品也用反射照明光纤照射，并且在多个采集位置收集来自样品的反射光，并检测以形成空间分辨反射光谱。纤维可以形成以同心部分布置的探针。通过预处理和降低光谱数据的维数来分析光谱。

6. 发明授权

US08301216B2 Method and apparatus for quantification of optical properties of superficial volumes using small source-to-detector separations 有权
标题翻译：用于使用小的源到检测器分离来定量表面体积的光学性质的方法和装置
公开(公告)号：US08301216B2
公开(公告)日：2012-10-30
申请号：US12643789
申请日：2009-12-21
申请人： Anthony J. Durkin , Sheng-hao Tseng
发明人： Anthony J. Durkin , Sheng-hao Tseng
IPC分类号： A61B5/00
CPC分类号： A61B5/1459 , A61B5/0075 , A61B5/0086 , A61B5/14532 , A61B5/4312 , A61B5/443 , A61B2562/0242
摘要： A probe for obtaining quantitative optical properties and chromophore concentrations of tissue components in tissue in-vivo at superficial depths and at source-detector separations of 5 mm or less includes a source fiber providing light to expose the tissue, a diffuser layer into which light from the source fiber is directed and then from the diffuser layer to and/or into the tissue, and a detector fiber arranged relative to the diffuser layer for detecting backscattered and/or reflected light returned from the tissue without transmission through the diffuser layer.
摘要翻译：用于在表面深度和源检测器间隔5mm以下的组织中获得组织组分的定量光学性质和发色团浓度的探针包括提供光以暴露组织的源光纤，漫射层，源光纤被引导，然后从扩散层引导到组织和/或进入组织，以及检测器光纤相对于漫射层布置，用于检测从组织返回的反向散射和/或反射光，而不通过扩散层传播。

7. 发明授权

US08014569B2 Method and apparatus for performing qualitative and quantitative analysis of produce (fruit, vegetables) using spatially structured illumination 有权
标题翻译：使用空间结构照明进行产品（水果，蔬菜）定性和定量分析的方法和设备
公开(公告)号：US08014569B2
公开(公告)日：2011-09-06
申请号：US11927396
申请日：2007-10-29
申请人： Anthony J. Durkin , David Cuccia , Frederic Bevilacqua , Bruce J. Tromberg
发明人： Anthony J. Durkin , David Cuccia , Frederic Bevilacqua , Bruce J. Tromberg
IPC分类号： G06K9/00 , G01N21/00
CPC分类号： G01J3/4412 , G01J3/02 , G01J3/021 , G01J3/10 , G01J3/32 , G01N21/4795 , G01N21/6456 , G01N21/6486 , G01N21/94 , G01N33/025 , G01N2021/1787 , G01N2021/6421
摘要： A method and an apparatus for noninvasively and quantitatively determining spatially resolved absorption and reduced scattering coefficients over a wide field-of-view of a food object, including fruit or produce, uses spatial-frequency-domain imaging (SFDI). A single modulated imaging platform is employed. It includes a broadband light source, a digital micromirror optically coupled to the light source to control a modulated light pattern directed onto the food object at a plurality of selected spatial frequencies, a multispectral camera for taking a spectral image of a reflected modulated light pattern from the food object, a spectrally variable filter optically coupled between the food object and the multispectral camera to select a discrete number of wavelengths for image capture, and a computer coupled to the digital micromirror, camera and variable filter to enable acquisition of the reflected modulated light pattern at the selected spatial frequencies.
摘要翻译：使用空间 - 频域成像（SFDI），在食品物体（包括果实或产品）的宽视野范围内非侵入和定量地测定空间分辨吸收和降低的散射系数的方法和装置。采用单一调制成像平台。其包括宽带光源，光学耦合到光源的数字微镜，以以多个选定的空间频率来控制指向食物的调制光图案;多光谱相机，用于从反射调制光图案中获取反射调制光图案的光谱图像，食品对象，光学耦合在食物和多光谱相机之间的光谱可变滤光器，用于选择用于图像捕获的离散数量的波长，以及耦合到数字微镜，照相机和可变滤波器的计算机，以使得能够获取反射的调制光图案在所选择的空间频率。

8. 发明授权

US07729750B2 Method and apparatus for high resolution spatially modulated fluorescence imaging and tomography 有权
标题翻译：用于高分辨率空间调制荧光成像和断层扫描的方法和装置
公开(公告)号：US07729750B2
公开(公告)日：2010-06-01
申请号：US11336065
申请日：2006-01-19
申请人： Bruce J. Tromberg , Anthony J. Durkin , David Cuccia , Frederic Bevilacqua
发明人： Bruce J. Tromberg , Anthony J. Durkin , David Cuccia , Frederic Bevilacqua
IPC分类号： A61B6/00 , G01J3/42 , G01J3/30
CPC分类号： G01N21/4795 , A61B5/0071 , A61B5/0073 , A61B5/0091 , A61B5/7257 , A61B5/726 , G01N21/6456 , G01N2021/6417 , G01N2021/6423 , G01N2021/6491
摘要： An improvement in a method for quantitative modulated imaging to perform depth sectioned reflectance or transmission imaging in a turbid medium, such as human or animal tissue is directed to the steps of encoding periodic pattern of illumination preferably with a fluorescent excitation wavelength when exposing a turbid medium to the periodic pattern to provide depth-resolved discrimination of structures within the turbid medium; and reconstructing a non-contact three dimensional image of the structure within a turbid medium. As a result, wide field imaging, separation of the average background optical properties from the heterogeneity components from a single image, separation of superficial features from deep features based on selection of spatial frequency of illumination, or qualitative and quantitative structure, function and composition information is extracted from spatially encoded data.
摘要翻译：用于在诸如人或动物组织的混浊介质中进行深度切片反射或透射成像的定量调制成像方法的改进涉及以下步骤：当暴露混浊介质时，优选用荧光激发波长编码周期性图案以提供在混浊介质内的结构的深度分辨鉴别的周期性模式; 以及在混浊介质内重构所述结构的非接触三维图像。因此，宽场成像，将平均背景光学性质与异质性成分从单一图像分离，基于选择照明空间频率或定性和定量结构，功能和成分信息，将表面特征与深层特征分离从空间编码数据中提取出来。

9. 发明授权

US07400754B2 Method and apparatus for characterization of chromophore content and distribution in skin using cross-polarized diffuse reflectance imaging 有权
标题翻译：使用交叉极化漫反射成像表征发色团含量和皮肤分布的方法和装置
公开(公告)号：US07400754B2
公开(公告)日：2008-07-15
申请号：US10818918
申请日：2004-04-07
申请人： Byungjo Jung , Bernard Choi , Anthony J. Durkin , J. Stuart Nelson
发明人： Byungjo Jung , Bernard Choi , Anthony J. Durkin , J. Stuart Nelson
IPC分类号： H04N7/18
CPC分类号： A61B5/444 , A61B5/0059 , A61B5/445 , A61B2560/0233
摘要： A digital imaging system provides color information of an entire port wine stain or other skin condition with a single image in CIE L*a*b* color space (L*, a*) derived from RGB pixel data (R, G, B). Cross-polarization optics produce marked reduction in specularly reflected light in the images. A patient positioning device allows for repeatable positioning of the patient's head or body portion. The digital nature of the system provides a near real-time mapping of melanin and erythema or other skin chromophore metrics. The cross-polarized diffuse reflectance color digital imaging system obtains subsurface skin color information and acquisition of facial images in a reproducible fashion at a fixed distance from an illumination source at optimized angles of view depending on the region of interest being imaged.
摘要翻译：数字成像系统在从RGB像素数据（R，G，B）得到的CIE L * a * b *颜色空间（L *，a *）中提供具有单个图像的整个端口葡萄酒渍或其它皮肤状况的颜色信息，。交叉偏振光学在图像中产生镜面反射光的显着减少。患者定位装置允许患者的头部或身体部分的可重复定位。该系统的数字性质提供了近乎实时的黑色素和红斑或其他皮肤发色团指标的绘图。交叉偏振漫反射彩色数字成像系统根据所成像的感兴趣区域以优化的视角从照明源以固定的距离以可再现的方式获得地下皮肤颜色信息和面部图像。

10. 发明申请

US20080101657A1 METHOD AND APPARATUS FOR PERFORMING QUALITATIVE AND QUANTITATIVE ANALYSIS OF PRODUCE (FRUIT, VEGETABLES) USING SPATIALLY STRUCTURED ILLUMINATION 有权
标题翻译：使用空间结构照明进行生产（水果，蔬菜）的定性和定量分析的方法和装置
公开(公告)号：US20080101657A1
公开(公告)日：2008-05-01
申请号：US11927396
申请日：2007-10-29
申请人： Anthony J. Durkin , David Cuccia , Frederic Bevilacqua , Bruce J. Tromberg
发明人： Anthony J. Durkin , David Cuccia , Frederic Bevilacqua , Bruce J. Tromberg
IPC分类号： G06K9/00
CPC分类号： G01J3/4412 , G01J3/02 , G01J3/021 , G01J3/10 , G01J3/32 , G01N21/4795 , G01N21/6456 , G01N21/6486 , G01N21/94 , G01N33/025 , G01N2021/1787 , G01N2021/6421
摘要： A method and an apparatus for noninvasively and quantitatively determining spatially resolved absorption and reduced scattering coefficients over a wide field-of-view of a food object, including fruit or produce, uses spatial-frequency-domain imaging (SFDI). A single modulated imaging platform is employed. It includes a broadband light source, a digital micromirror optically coupled to the light source to control a modulated light pattern directed onto the food object at a plurality of selected spatial frequencies, a multispectral camera for taking a spectral image of a reflected modulated light pattern from the food object, a spectrally variable filter optically coupled between the food object and the multispectral camera to select a discrete number of wavelengths for image capture, and a computer coupled to the digital micromirror, camera and variable filter to enable acquisition of the reflected modulated light pattern at the selected spatial frequencies.
摘要翻译：使用空间 - 频域成像（SFDI），在食品物体（包括果实或产品）的宽视野范围内非侵入和定量地测定空间分辨吸收和降低的散射系数的方法和装置。采用单一调制成像平台。其包括宽带光源，光学耦合到光源的数字微镜，以以多个选定的空间频率来控制指向食物的调制光图案;多光谱相机，用于从反射调制光图案中获取反射调制光图案的光谱图像，食品对象，光学耦合在食物和多光谱相机之间的光谱可变滤光器，用于选择用于图像捕获的离散数量的波长，以及耦合到数字微镜，照相机和可变滤波器的计算机，以使得能够获取反射的调制光图案在所选择的空间频率。

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