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1. 发明申请

US20060025423A1 N-pyrazinyl-phenylsulphonamides and their use in the treatment of chemokine mediated diseases 失效
标题翻译： N-吡嗪基 - 苯基磺酰胺及其在治疗趋化因子介导的疾病中的应用
公开(公告)号：US20060025423A1
公开(公告)日：2006-02-02
申请号：US10501510
申请日：2003-01-14
申请人： Andrew Baxter , Timothy Johnson , Nicholas Kindon , Bryan Roberts , Michael Stocks
发明人： Andrew Baxter , Timothy Johnson , Nicholas Kindon , Bryan Roberts , Michael Stocks
IPC分类号： A61K31/4965 , C07D241/02
CPC分类号： C07D231/12 , C07D233/56 , C07D241/22 , C07D249/08 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07F7/0812
摘要： The invention provides N-pyrazinyl-phenyl-sulphonamides of formula (I) for use in the treatment of chemokine mediated diseases. Particularly inflammatory diseases, such as asthma.
摘要翻译：本发明提供了用于治疗趋化因子介导的疾病的式（I）的N-吡嗪基 - 苯基 - 磺酰胺。特别是炎性疾病，如哮喘。

2. 发明申请

US20100081670A1 N-PYRAZINYL-PHENYLSULPHONAMIDES AND THEIR USE IN THE TREATMENT OF CHEMOKINE MEDIATED DISEASES 审中-公开
标题翻译： N-吡嗪基苯并咪唑及其在治疗介导性疾病中的应用
公开(公告)号：US20100081670A1
公开(公告)日：2010-04-01
申请号：US12435864
申请日：2009-05-05
申请人： Andrew Baxter , Timothy Johnson , Nicholas Kindon , Bryan Roberts , Michael Stocks
发明人： Andrew Baxter , Timothy Johnson , Nicholas Kindon , Bryan Roberts , Michael Stocks
IPC分类号： A61K31/497 , C07D401/12 , C07D241/20 , A61K31/4965 , A61P11/06 , A61P37/06
CPC分类号： C07D231/12 , C07D233/56 , C07D241/22 , C07D249/08 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07F7/0812
摘要： The invention provides N-pyrazinyl-phenyl-sulphonamides of formula (I) for use in the treatment of chemokine mediated diseases. Particularly inflammatory diseases, such as asthma.
摘要翻译：本发明提供了用于治疗趋化因子介导的疾病的式（I）的N-吡嗪基 - 苯基 - 磺酰胺。特别是炎性疾病，如哮喘。

3. 发明授权

US07410972B2 Compounds 失效
标题翻译：化合物
公开(公告)号：US07410972B2
公开(公告)日：2008-08-12
申请号：US10499102
申请日：2002-12-17
申请人： Andrew Baxter , Timothy Johnson , Nicholas Kindon , Bryan Roberts , John Steele , Michael Stocks , Nicholas Tomkinson
发明人： Andrew Baxter , Timothy Johnson , Nicholas Kindon , Bryan Roberts , John Steele , Michael Stocks , Nicholas Tomkinson
IPC分类号： A61K31/4965 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D409/12 , C07D409/14 , C07D413/14
摘要： The invention provides N-pyrazinyl-thienylsulphonamides of formula (I) for use in the treatment of chemokine mediated diseases. Particularly inflammatory diseases, such as asthma
摘要翻译：本发明提供了用于治疗趋化因子介导的疾病的式（I）的N-吡嗪基 - 噻吩基磺酰胺。特别是炎性疾病，如哮喘

4. 发明授权

US07662825B2 N-pyrazinyl-phenylsulphonamides and their use in the treatment of chemokine mediated diseases 失效
标题翻译： N-吡嗪基 - 苯基磺酰胺及其在治疗趋化因子介导的疾病中的应用
公开(公告)号：US07662825B2
公开(公告)日：2010-02-16
申请号：US10501510
申请日：2003-01-14
申请人： Andrew Baxter , Timothy Johnson , Nicholas Kindon , Bryan Roberts , Michael Stocks
发明人： Andrew Baxter , Timothy Johnson , Nicholas Kindon , Bryan Roberts , Michael Stocks
IPC分类号： A61K31/4965 , C07D241/02
CPC分类号： C07D231/12 , C07D233/56 , C07D241/22 , C07D249/08 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07F7/0812
摘要： The invention provides N-pyrazinyl-phenyl-sulphonamides of formula (I) for use in the treatment of chemokine mediated diseases. Particularly inflammatory diseases, such as asthma.
摘要翻译：本发明提供了用于治疗趋化因子介导的疾病的式（I）的N-吡嗪基 - 苯基 - 磺酰胺。特别是炎性疾病，如哮喘。

5. 发明申请

US20070093491A1 Novel condensed n-pyrazinyl-sulphonamides and their use in the treament of chemokine mediated diseases 审中-公开
标题翻译：新型缩合的正吡嗪基磺酰胺及其在趋化因子介导的疾病中的应用
公开(公告)号：US20070093491A1
公开(公告)日：2007-04-26
申请号：US10570178
申请日：2004-08-25
申请人： Andrew Baxter , Nicholas Kindon , Michael Stocks
发明人： Andrew Baxter , Nicholas Kindon , Michael Stocks
IPC分类号： A61K31/498 , C07D487/02 , C07D409/02
CPC分类号： C07D409/12 , C07D241/44 , C07D471/04
摘要： The invention provides novel condensed N-pyrazinyl-sulphonamides of formula (I) and their use in the treatment of chemokine mediated diseases.
摘要翻译：本发明提供式（I）的新的缩合N-吡嗪基 - 磺酰胺及其在治疗趋化因子介导的疾病中的用途。

6. 发明申请

US20050075346A1 Novel compounds 失效
标题翻译：新型化合物
公开(公告)号：US20050075346A1
公开(公告)日：2005-04-07
申请号：US10499102
申请日：2002-12-17
申请人： Andrew Baxter , Timothy Johnson , Nicholas Kindon , Bryan Roberts , John Steele , Michael Stocks , Nicholas Tomkinson
发明人： Andrew Baxter , Timothy Johnson , Nicholas Kindon , Bryan Roberts , John Steele , Michael Stocks , Nicholas Tomkinson
IPC分类号： A61K31/497 , A61P11/06 , A61P29/00 , A61P43/00 , C07D409/12 , C07D409/14 , C07D413/14 , C07D521/00 , C07D49/02
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D409/12 , C07D409/14 , C07D413/14
摘要： The invention provides N-pyrazinyl-thienylsulphonamides of formula (I) for use in the treatment of chemokine mediated diseases. Particularly inflammatory diseases, such as asthma.
摘要翻译：本发明提供了用于治疗趋化因子介导的疾病的式（I）的N-吡嗪基 - 噻吩基磺酰胺。特别是炎性疾病，如哮喘。

7. 发明授权

US06946478B2 Compounds 失效
标题翻译：化合物
公开(公告)号：US06946478B2
公开(公告)日：2005-09-20
申请号：US10339261
申请日：2003-01-09
申请人： Andrew Baxter , Stephen Brough , Nicholas Kindon , Thomas McInally , Bryan Roberts , Stephen Thom
发明人： Andrew Baxter , Stephen Brough , Nicholas Kindon , Thomas McInally , Bryan Roberts , Stephen Thom
IPC分类号： C07D295/18 , A61K31/427 , A61K31/4375 , A61K31/445 , A61K31/4468 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/495 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/541 , A61P1/00 , A61P3/10 , A61P9/10 , A61P11/00 , A61P17/00 , A61P17/06 , A61P17/14 , A61P19/00 , A61P19/02 , A61P29/00 , A61P31/00 , A61P31/18 , A61P37/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07D20060101 , C07D211/14 , C07D211/22 , C07D211/32 , C07D211/36 , C07D211/40 , C07D211/46 , C07D211/58 , C07D217/14 , C07D241/04 , C07D295/192 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/02 , C07D413/12 , C07D417/02 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/02 , C07D471/04 , C07D473/34 , C07D487/04 , C07D495/04 , C07D513/04
CPC分类号： C07D401/12 , C07D211/32 , C07D211/46 , C07D211/58 , C07D217/14 , C07D295/192 , C07D401/14 , C07D405/04 , C07D409/04 , C07D413/12 , C07D417/12 , C07D471/04 , C07D473/34 , C07D487/04 , C07D495/04 , C07D513/04
摘要： The invention provides compounds of general formula wherein R1, m, Q, T, n, R2, R3, V, W, X and R4 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译：本发明提供通式的化合物其中R 1，m，Q，T，n，R 2，R 3，V，W， X和R 4如说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途。

8. 发明授权

US06812226B2 P2X7 receptor antagonists for use in the treatment of inflammatory, immune or cardiovascular disease 失效
标题翻译： P2X7受体拮抗剂，用于治疗炎症，免疫或心血管疾病
公开(公告)号：US06812226B2
公开(公告)日：2004-11-02
申请号：US10149760
申请日：2002-06-13
申请人： Andrew Baxter , Nicholas Kindon , Garry Pairaudeau , Bryan Roberts , Stephen Thom
发明人： Andrew Baxter , Nicholas Kindon , Garry Pairaudeau , Bryan Roberts , Stephen Thom
IPC分类号： A61K3133
CPC分类号： C07D401/04 , C07D401/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D453/02
摘要： The invention provides piperidine compounds of general formula (I) in which A, B, X, Y, Z, R, R1 and R2 are as defined in the specification, their use as medicaments, compositions containing them and processes for their for their preparation.

9. 发明授权

US06518286B1 Compounds 失效
标题翻译：化合物
公开(公告)号：US06518286B1
公开(公告)日：2003-02-11
申请号：US09555565
申请日：2000-06-01
申请人： Andrew Baxter , Stephen Brough , Nicholas Kindon , Thomas McInally , Bryan Roberts , Stephen Thom
发明人： Andrew Baxter , Stephen Brough , Nicholas Kindon , Thomas McInally , Bryan Roberts , Stephen Thom
IPC分类号： C07D40112
CPC分类号： C07D401/12 , C07D211/32 , C07D211/46 , C07D211/58 , C07D217/14 , C07D295/192 , C07D401/14 , C07D405/04 , C07D409/04 , C07D413/12 , C07D417/12 , C07D471/04 , C07D473/34 , C07D487/04 , C07D495/04 , C07D513/04
摘要： The invention provides compounds of general formula (I) wherein: R1 represents optionally substituted, C1-C12 alkyl or optionally substituted 3- to 10-membered saturated or unsaturated ring system comprising up to two ring carbon atoms that form carbonyl groups and comprising up to 4 ring heteroatoms independently selected from nitrogen, oxygen and sulfur; m is 0-1; Q represents OCH2, C1-C4 alkylene or C2-C4 alkenylene; T represents C(O)NH, or when m is 0, T may additionally represent a bond or NH, or when m is 1 and Q represents C1-C4 alkylene, T may additionally represent NH; n is 1-4; each R2 and R3 independently represents H or C1-C4 alkyl; V represents N, and W represents N or CH; X represents O, C(O), CH(OH), SO2, NH or N(C1-C6 alkyl), provided that when W represents N, then X represents either C(O) or SO2 and when W represents CH, then X is other than SO2; R4 represents optionally substituted phenyl; R5 and R6 each independently represent H, C1-C6 alkyl or hydroxyC1-C6 alkyl, or R5 and R6 together with the nitrogen atom to which they are attached form a 4- to 7-membered saturated heterocyclic ring; R7 and R8 each independently represent H or C1-C6 alkyl; and R9 represents OH or —NR7R8; processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译：本发明提供了通式（I）的化合物，其中：R 1表示任选取代的C 1 -C 12烷基或任选取代的3至10元饱和或不饱和环体系，其包含至多两个形成羰基的环碳原子，独立地选自氮，氧和硫的4个环杂原子; m为0-1; Q表示OCH 2，C 1 -C 4亚烷基或C 2 -C 4亚烯基; T表示C（O）NH，或当m为0时，T可另外表示键或NH，或当m为1且Q表示C1-C4亚烷基时，T可另外表示NH; n为1-4; 每个R 2和R 3独立地表示H或C 1 -C 4烷基; V表示N，W表示N或CH; X表示O，C（O），CH（OH），SO 2，NH或N（C 1 -C 6烷基），条件是当W表示N时，X表示C（O）或SO 2，当W表示CH时， X不是SO2; R 4表示任选取代的苯基; R 5和R 6各自独立地表示H，C 1 -C 6烷基或羟基C 1 -C 6烷基，或者R 5和R 6与它们所连接的氮原子一起形成4-至7-元饱和杂环; R 7和R 8各自独立地表示H或C 1 -C 6烷基; 并且R 9表示OH或-NR 7 R 8; 其制备方法，含有它们的药物组合物及其在治疗中的用途。

10. 发明申请

US20100144759A1 NOVEL N-(FLUORO-PYRAZINYL)-PHENYLSULFONAMIDES AS MODULATORS OF CHEMOKINE RECEPTOR CCR4 审中-公开
标题翻译：新型N-（氟代 - 吡啶基） - 苯基磺酰胺作为化合物受体CCR4的调节剂
公开(公告)号：US20100144759A1
公开(公告)日：2010-06-10
申请号：US12633548
申请日：2009-12-08
申请人： David CHESHIRE , Nicholas Kindon , Antonio Mete , Bryan Roberts
发明人： David CHESHIRE , Nicholas Kindon , Antonio Mete , Bryan Roberts
IPC分类号： A61K31/4965 , C07D241/22 , A61P11/06 , A61P11/00
CPC分类号： C07D241/22
摘要： The invention provides N-(fluoro-pyrazinyl)-phenylsulfonamides of formula (I) wherein R1-R5 are as defined in the specification; processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy
摘要翻译：本发明提供式（I）的N-（氟 - 吡嗪基） - 苯基磺酰胺，其中R 1 -R 5如说明书中所定义; 制备中使用的方法和中间体，含有它们的药物组合物及其在治疗中的用途

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