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1. 发明申请

US20120319705A1 HYBRID THREE-DIMENSIONAL SENSOR ARRAY, IN PARTICULAR FOR MEASURING ELECTROGENIC CELL ASSEMBLIES, AND THE MEASURING ASSEMBLY 审中-公开
标题翻译：混合三维传感器阵列，特别是用于测量电化学电池组件和测量装置
公开(公告)号：US20120319705A1
公开(公告)日：2012-12-20
申请号：US13581060
申请日：2011-02-23
申请人： Andreas Schober , Jörg Hampl , Uta Fernekorn , Peter Husar , Michael Fischer , Daniel Laqua , Katharina Lilienthal
发明人： Andreas Schober , Jörg Hampl , Uta Fernekorn , Peter Husar , Michael Fischer , Daniel Laqua , Katharina Lilienthal
IPC分类号： G01R19/00 , G01R27/26
CPC分类号： A61N1/05 , A61B5/04001 , A61B5/685 , A61B2562/028 , A61B2562/046 , A61N1/0529
摘要： The invention relates to a hybrid three-dimensional sensor array, in particular for measuring biological cell assemblies. The sensor array has a plurality of microstructured sensor plates, each having one carrier section on which a plurality of sensor needles are arranged in a comb-like manner, which carry a plurality of electrode surfaces. Furthermore, a plurality of spacer elements are provided, which are fastened between the sensor plates so that both the carrier sections and the sensor needles of adjacent sensor plates are at a distance from each other. The invention further relates to a measuring assembly for measuring electrical activities of biological cell assemblies using such a sensor array.
摘要翻译：本发明涉及一种混合三维传感器阵列，特别是用于测量生物细胞组件。传感器阵列具有多个微结构传感器板，每个具有一个载体部分，多个传感器针以梳状布置在该载体部分上，该传感器带有多个电极表面。此外，设置有多个间隔元件，其被固定在传感器板之间，使得相邻传感器板的载体部分和传感器针头彼此相隔一定距离。本发明还涉及一种用于使用这种传感器阵列测量生物细胞组件的电活动的测量组件。

2. 发明申请

US20130197668A1 STRUCTURE MODELED ON A BIOLOGICAL TISSUE AND METHOD FOR PRODUCING SAID STRUCTURE 有权
标题翻译：生物组织建模结构和生产结构的方法
公开(公告)号：US20130197668A1
公开(公告)日：2013-08-01
申请号：US13877721
申请日：2011-09-30
申请人： Andreas Schober , Michael Gebinoga , Uta Fernekorn , Frank Weise , Jörg Hampl , Julia Katzmann , Thomas Klar
发明人： Andreas Schober , Michael Gebinoga , Uta Fernekorn , Frank Weise , Jörg Hampl , Julia Katzmann , Thomas Klar
IPC分类号： A61F2/02
CPC分类号： A61F2/02 , G05B19/4099 , G05B2219/49019 , G05B2219/49031 , G06F19/12 , G06F19/24
摘要： The present invention relates to a method for producing a structure modeled on a biological tissue. The invention also relates to a structure which can be produced using the method according to the invention. According to an embodiment of the invention, a precursor of a biopolymer is locally irradiated with electromagnetic radiation in a targeted manner, wherein the irradiation, in particular the selection of the areas to be irradiated, is effected according to data which describe a structural construction at least components of the extracellular matrix of the biological tissue. In this case, the electromagnetic radiation is such that two-photon or multi-photon absorption takes place in the irradiated areas of the precursor and results in the precursor being polymerized to form the biopolymer in the irradiated areas, with the result being that the precursor is at least partially solidified there.
摘要翻译：本发明涉及一种用于生产以生物组织为模型的结构的方法。本发明还涉及可以使用根据本发明的方法制造的结构。根据本发明的一个实施方案，生物聚合物的前体以目标方式用电磁辐射局部照射，其中照射，特别是对待照射区域的选择，是根据描述在生物组织的细胞外基质的最少组分。在这种情况下，电磁辐射使得在前体的照射区域中发生双光子或多光子吸收，并导致前体聚合以在照射区域中形成生物聚合物，结果是前体在那里至少部分固化。

3. 发明授权

US09375305B2 Structure modeled on a biological tissue and method for producing said structure 有权
标题翻译：以生物组织为模型的结构及其制造方法
公开(公告)号：US09375305B2
公开(公告)日：2016-06-28
申请号：US13877721
申请日：2011-09-30
申请人： Andreas Schober , Michael Gebinoga , Uta Fernekorn , Frank Weise , Jörg Hampl , Julia Katzmann , Thomas Klar
发明人： Andreas Schober , Michael Gebinoga , Uta Fernekorn , Frank Weise , Jörg Hampl , Julia Katzmann , Thomas Klar
IPC分类号： G01N33/48 , G01N33/50 , A61F2/02 , G05B19/4099 , G06F19/24 , G06F19/12
CPC分类号： A61F2/02 , G05B19/4099 , G05B2219/49019 , G05B2219/49031 , G06F19/12 , G06F19/24
摘要： The present invention relates to a method for producing a structure modeled on a biological tissue. The invention also relates to a structure which can be produced using the method according to the invention. According to an embodiment of the invention, a precursor of a biopolymer is locally irradiated with electromagnetic radiation in a targeted manner, wherein the irradiation, in particular the selection of the areas to be irradiated, is effected according to data which describe a structural construction at least components of the extracellular matrix of the biological tissue. In this case, the electromagnetic radiation is such that two-photon or multi-photon absorption takes place in the irradiated areas of the precursor and results in the precursor being polymerized to form the biopolymer in the irradiated areas, with the result being that the precursor is at least partially solidified there.
摘要翻译：本发明涉及一种用于生产以生物组织为模型的结构的方法。本发明还涉及可以使用根据本发明的方法制造的结构。根据本发明的一个实施方案，生物聚合物的前体以目标方式用电磁辐射局部照射，其中照射，特别是对待照射区域的选择，是根据描述在生物组织的细胞外基质的最少组分。在这种情况下，电磁辐射使得在前体的照射区域中发生双光子或多光子吸收，并导致前体聚合以在照射区域中形成生物聚合物，结果是前体在那里至少部分固化。

4. 发明申请

US20110130310A1 MICROBIOREACTOR AND MICROTITER PLATE COMPRISING A PLURALITY OF MICROBIOREACTORS 审中-公开
标题翻译：包含微生物多样性的微晶器和微孔板
公开(公告)号：US20110130310A1
公开(公告)日：2011-06-02
申请号：US12675225
申请日：2009-03-31
申请人： Andreas Schober , Caroline Augspurger , Frank Weise , Uta Fernekorn , Christian Hildmann , Jorg Hampl
发明人： Andreas Schober , Caroline Augspurger , Frank Weise , Uta Fernekorn , Christian Hildmann , Jorg Hampl
IPC分类号： C40B60/12 , C12M3/00 , C12M1/34
CPC分类号： F04B43/046 , B01L3/502715 , B01L3/50857 , B01L2200/0684 , B01L2300/0636 , B01L2300/0654 , B01L2400/0487 , B01L2400/0638 , C12M23/16
摘要： The present invention relates to a microbioreactor comprising a sample support (7) for holding cells; a bypass (3) with a capillary opening for feeding test reagent and/or for aeration and ventilation of the microbioreactor; a pump module (5) for perfusion of the microbioreactor with test reagent and/or gas feeding and purging of the microbioreactor; a transparent viewing window (2); and fluid channels (4) that form a circuit. The invention further relates to a bioreactor-microtiter plate comprising a plurality of such microbioreactors.
摘要翻译：本发明涉及包含用于保持细胞的样品支持体（7）的微生物反应器; 旁路（3），其具有用于供给测试试剂的毛细管孔和/或用于微生物反应器的通气和通风的旁路（3）; 泵组件（5），用于用微生物反应器的测试试剂和/或气体供给和清洗灌注微生物反应器; 透明的观察窗（2）; 和形成电路的流体通道（4）。本发明还涉及包含多个这样的微生物反应器的生物反应器 - 微量滴定板。

5. 发明申请

US20110020929A1 PARTIALLY ACTIVE MICROFLUIDIC SYSTEM FOR 3D CELL CULTIVATION AND METHOD FOR PERFUSION THEREOF 审中-公开
标题翻译：用于3D细胞培养的部分活性微流体系统及其灌注方法
公开(公告)号：US20110020929A1
公开(公告)日：2011-01-27
申请号：US12675195
申请日：2009-04-15
申请人： Andreas Schober , Caroline Augspurger , Frank Weise , Uta Fernekorn , Christian Hildmann , Jorg Hampl
发明人： Andreas Schober , Caroline Augspurger , Frank Weise , Uta Fernekorn , Christian Hildmann , Jorg Hampl
IPC分类号： C12N5/071 , C12M3/00
CPC分类号： C12M29/10 , B01L3/50853 , B01L2200/026 , B01L2300/046 , B01L2300/0681 , B01L2300/0829 , C12M21/08 , C12M23/12 , C12M23/16 , C12M25/04 , C12M25/14
摘要： The invention relates to a partially active microfluidic system for cell cultivation comprising a multiwell system (4) with multiple wells (17) and cavities formed therein that hold cells. Each cavity (11) is formed by at least one inlay (3) comprising an opening (1) that does not open up directly into the cavity (11), but rather into a space (17) surrounding the cavity, wherein the medium present in the surrounding space communicates with the medium contained in the cavity (11) by way of a sieve structure in the inlay. The invention is suitable in particular for 3D cell cultivation.
摘要翻译：本发明涉及一种用于细胞培养的部分活性的微流体系统，其包括具有多个孔（17）的多孔系统（4）和其中形成的保持细胞的空腔。每个空腔（11）由至少一个包括不直接打开到空腔（11）中的开口（1）的嵌体（3）形成，而是形成围绕空腔的空间（17），其中介质存在在周围空间中，通过在嵌体中的筛结构与容纳在空腔（11）中的介质连通。本发明特别适用于3D细胞培养。

6. 发明授权

US4172117A Method for the simultaneous measurement of antigens and their antibodies by solid-phase radioimmunoassay 失效
标题翻译：通过固相放射免疫测定同时测量抗原及其抗体的方法
公开(公告)号：US4172117A
公开(公告)日：1979-10-23
申请号：US838332
申请日：1977-09-30
申请人： Andreas Schober
发明人： Andreas Schober
IPC分类号： G01N33/543 , G01N23/00 , G01N33/16 , G01T1/16
CPC分类号： G01N33/54306 , Y10S436/804 , Y10S436/819 , Y10S436/82
摘要： Antigens and their antibodies are measured in a combined radioimmunoassay by incubating a sample of an unknown fluid with a known quantity of an antibody, contacting the mixture obtained with the walls of a vessel having a coating of known antigen content, again incubating, then aspirating the mixture and washing the walls of the vessel, adding a pure radioactive tracer antigen, aspirating and washing again, and finally measuring the radioactivty of the coated parts conventionally, e.g., in a gamma counter known in the art.
摘要翻译：通过将未知流体的样品与已知量的抗体一起孵育来测量抗原及其抗体，将获得的混合物与具有已知抗原含量的涂层的血管壁接触，再次孵育，混合物并洗涤容器的壁，加入纯的放射性示踪剂抗原，再次抽吸和洗涤，最后通常例如在本领域已知的γ计数器中测量涂覆部件的放射性。

7. 发明授权

US07132081B2 Device used in parallel microsynthesis 有权
标题翻译：平行微合成中使用的装置
公开(公告)号：US07132081B2
公开(公告)日：2006-11-07
申请号：US10296056
申请日：2001-04-27
申请人： Beate Diefenbach , Holger Deppe , Hanns Wurziger , Alexander Gross , Gregor Schlingloff , Andreas Schober , Dirk Tomandl
发明人： Beate Diefenbach , Holger Deppe , Hanns Wurziger , Alexander Gross , Gregor Schlingloff , Andreas Schober , Dirk Tomandl
IPC分类号： B01L3/00
CPC分类号： B01L3/50853 , B01J19/0046 , B01J2219/00286 , B01J2219/00317 , B01J2219/00333 , B01J2219/00585 , B01L3/50857 , B01L2300/0819 , C40B60/14
摘要： Microwells, which are open on both sides and are arranged two-dimensionally in a microwell matrix (4), are hermetically closed by pressure on both sides using plugs (6) covered with a sealing sheet (11). A layer of elastic material (9), which is arranged between the plug (6) and the sealing sheet (11), guarantees uniform pressure on all the microwells of a microwell matrix (4) which is loosely held by a frame structure (1). Continuous peripheral elevations (2), which protrude in both directions at right angles to the plane of the microwell matrix (4), ensure that the deformable thin layer of elastic material (9) does not escape sideways between the plug (6) and the microwell matrix (4) during the pressing process. A plurality of microwell matrices (4) are held simultaneously by the frame structure (1) and are hermetically closed by a corresponding number of allocated plugs (6), which are fastened to a base plate (7) and a cover plate (8), respectively.
摘要翻译：在两侧开口并且在微孔矩阵（4）中二维布置的微孔通过用密封片（11）覆盖的塞子（6）在两侧通过压力气密封闭。布置在塞子（6）和密封片（11）之间的一层弹性材料（9）保证了均匀的压力，所述的微孔基体（4）的所有微孔被框架结构（1）松动地保持）。在与微孔矩阵（4）的平面成直角的两个方向上突出的连续周边高度（2）确保弹性材料（9）的可变形薄层不会在插头（6）和微孔基质（4）。多个微孔矩阵（4）由框架结构（1）同时保持，并被相应数量的分配的塞子（6）气密地封闭，该插头固定到基板（7）和盖板（8）上，，分别。

8. 发明授权

US5065154A Digitally addressble electronic device with interchanged and inverted address lines 失效
标题翻译：具有交错和反相地址线的数字地址电子设备
公开(公告)号：US5065154A
公开(公告)日：1991-11-12
申请号：US340981
申请日：1989-04-20
申请人： Winfried Kaiser , Andreas Schober , E.-Peter Salfeld
发明人： Winfried Kaiser , Andreas Schober , E.-Peter Salfeld
IPC分类号： G06F13/14 , G06F12/06 , H04Q9/14
CPC分类号： G06F12/0676
摘要： In a system comprising a plurality of digitally addressable electronic devices, all devices have the same construction and are designed for being connected in series to a common central monitoring station. The addressing of these devices is accomplished by a plurality of address lines which are connected to input contacts of the respective device. Within each device, a selection gate is connected to the input contacts which provides an enabling signal if the signal on said address lines has a predetermined bit pattern. Each device has output contacts connected to its input contacts to which the input contacts of a next device are connected. The address lines are connected from the input contacts to the output contacts of the device in such a way that the contacts are interchanged, and an inverter is inserted in one of said lines so that the bit pattern forming the address provided at the output contacts is different from the bit pattern received at the input contacts. Thus, along the system of series connected devices a plurality of different bit patterns is produced so that the position of the correct bit pattern to which the device selection means responds, is shifted along the series connected devices in order to address the device which is in a predetermined position. A preferred application of such devices is in medical surveillance systems in which a plurality of racks are connected serially together and to a center monitoring station, each rack being allocated to a different task and including the units which are needed to monitor the vital functions of a patient required for that task.

9. 发明授权

US08703039B2 Microstructured composite component and method and device for producing the same 有权
标题翻译：微结构复合材料及其制造方法和装置
公开(公告)号：US08703039B2
公开(公告)日：2014-04-22
申请号：US13497814
申请日：2010-02-24
申请人： Andreas Schober , Alexander Gross , Joerg Hampl
发明人： Andreas Schober , Alexander Gross , Joerg Hampl
IPC分类号： B29C51/14
CPC分类号： B29C49/0047 , B29C2791/006 , B29C2791/007 , B29K2027/12 , B29L2031/756
摘要： A microstructured composite component is provided including structures for carrying out fluid processes. A device is provided for producing microstructured composite components. A method provided includes a first step during which a first film is arranged above a second film between first and second mold parts. The first and/or second mold parts have microstructured cavities to be filled. In a second step, the first and second mold parts are heated in at least one region in which they contact one of the films. An excess pressure is then produced between the first film and the second film to force the first and/or second films into the cavities. In a further step, the first and second mold parts are pressed together by a pressing force. Once the first mold part, the second mold part, the first film and the second film are cooled, they form a microstrutured composite component.
摘要翻译：提供了一种微结构化复合材料组件，包括用于进行流体过程的结构。提供了用于生产微结构化复合材料组件的装置。提供的方法包括第一步骤，在第一步骤中，第一薄膜布置在第一和第二模具部件之间的第二薄膜之上。第一和/或第二模具部件具有要填充的微结构化空腔。在第二步骤中，第一和第二模具部件在至少一个它们接触薄膜之一的区域中被加热。然后在第一膜和第二膜之间产生过量的压力，以迫使第一和/或第二膜进入空腔。在另一步骤中，第一和第二模具部件通过按压力被压在一起。一旦第一模具部件，第二模具部件，第一薄膜和第二薄膜被冷却，它们形成微导体复合部件。

10. 发明申请

US20120231226A1 MICROSTRUCTURED COMPOSITE COMPONENT AND METHOD AND DEVICE FOR PRODUCING THE SAME 有权
标题翻译：微结构复合组分及其制备方法和装置
公开(公告)号：US20120231226A1
公开(公告)日：2012-09-13
申请号：US13497814
申请日：2010-02-24
申请人： Andreas Schober , Alexander Gross , Joerg Hampl
发明人： Andreas Schober , Alexander Gross , Joerg Hampl
IPC分类号： B32B3/10 , B32B37/10 , B32B37/06 , B32B37/02
CPC分类号： B29C49/0047 , B29C2791/006 , B29C2791/007 , B29K2027/12 , B29L2031/756
摘要： A microstructured composite component is provided including structures for carrying out fluid processes. A device is provided for producing microstructured composite components. A method provided includes a first step during which a first film is arranged above a second film between first and second mold parts. The first and/or second mold parts have microstructured cavities to be filled. In a second step, the first and second mold parts are heated in at least one region in which they contact one of the films. An excess pressure is then produced between the first film and the second film to force the first and/or second films into the cavities. In a further step, the first and second mold parts are pressed together by a pressing force. Once the first mold part, the second mold part, the first film and the second film are cooled, they form a microstrutured composite component.
摘要翻译：提供了一种微结构化复合材料组件，包括用于进行流体过程的结构。提供了用于生产微结构化复合材料组件的装置。提供的方法包括第一步骤，在第一步骤中，第一薄膜布置在第一和第二模具部件之间的第二薄膜之上。第一和/或第二模具部件具有要填充的微结构化空腔。在第二步骤中，第一和第二模具部件在至少一个它们接触薄膜之一的区域中被加热。然后在第一膜和第二膜之间产生过量的压力，以迫使第一和/或第二膜进入空腔。在另一步骤中，第一和第二模具部件通过按压力被压在一起。一旦第一模具部件，第二模具部件，第一薄膜和第二薄膜被冷却，它们形成微导体复合部件。

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