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1. 发明授权

US07198939B2 Apparatus for interrogating an addressable array 失效
标题翻译：用于询问可寻址阵列的装置
公开(公告)号：US07198939B2
公开(公告)日：2007-04-03
申请号：US10080641
申请日：2002-02-21
申请人： Andreas N. Dorsel , David A. King , Nicholas M. Sampas
发明人： Andreas N. Dorsel , David A. King , Nicholas M. Sampas
IPC分类号： C12M1/36 , G01N15/06 , B32B5/02
CPC分类号： G01N21/6452 , B01J2219/00527 , B01J2219/00547 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00695 , B01J2219/00702 , B01J2219/00722 , C40B40/06 , C40B70/00 , G01N21/6428 , G01N2021/6421 , G01N2021/6441
摘要： A method and apparatus of interrogating an addressable array unit, which includes a substrate, a light reflecting layer on a front side of the substrate, and a plurality of features on a front side of the array. The method may include, for each of multiple features, illuminating the feature simultaneously with reflected and non-reflected interrogating light. A light emitted from respective features is detected. Either or both, constructive interference of interrogating light at the features, or constructive interference of light emitted from the features, can be obtained to allow lowering of light power from the source, enhanced signal, or reduced noise, or combinations of the foregoing. High depth discrimination may also be obtained without the need for a confocal detection system with conventional pinhole.
摘要翻译：一种询问可寻址阵列单元的方法和装置，其包括基板，在基板的前侧上的光反射层，以及阵列的前侧上的多个特征。对于多个特征中的每一个，该方法可以包括与反射和未反射的询问光同时照亮特征。检测从各个特征发射的光。可以获得在特征中询问光的建构性干扰或从特征发射的光的建构性干扰，以允许降低源的光功率，增强的信号或降低的噪声或前述的组合。也可以获得高深度鉴别，而不需要具有常规针孔的共焦检测系统。

2. 发明授权

US08885153B2 Differentiation of flow cytometry pulses and applications 有权
标题翻译：流式细胞术脉冲和应用的分化
公开(公告)号：US08885153B2
公开(公告)日：2014-11-11
申请号：US13461713
申请日：2012-05-01
申请人： Richard Pittaro , Bruce Goldman , Ray Lefebvre , David A. King
发明人： Richard Pittaro , Bruce Goldman , Ray Lefebvre , David A. King
IPC分类号： G01N15/14
CPC分类号： G01N15/14 , G01N15/1429 , G01N15/1459 , G01N2015/1006 , G01N2015/1477 , G01N2015/1486
摘要： A method of analyzing pulses from a flow cytometer in which particles in a fluid pass through an excitation volume of an electromagnetic radiation and interact with the electromagnetic radiation to generate signals in the form of pulses includes generating a time-dependent pulse indicative of the characteristics of one or more particles passing through the excitation volume of the electromagnetic radiation, determining a measurement window by selecting a portion of the pulse with a starting point and an ending point above a predetermined value, and calculating a first derivative of the pulse with respect to time over the measurement window.
摘要翻译：一种分析来自流式细胞仪的脉冲的方法，其中流体中的颗粒通过电磁辐射的激发体积并与电磁辐射相互作用以产生脉冲形式的信号，包括产生指示时间相关脉冲的时间相关脉冲一个或多个颗粒通过电磁辐射的激发体积，通过以高于预定值的起点和终点选择脉冲的一部分来确定测量窗口，并计算相对于时间的脉冲的一阶导数在测量窗口上。

3. 发明授权

US07086059B2 Throttling queue 有权
公开(公告)号：US07086059B2
公开(公告)日：2006-08-01
申请号：US09894162
申请日：2001-06-26
申请人： Eric B. Remer , David A. King
发明人： Eric B. Remer , David A. King
IPC分类号： G06F9/50
CPC分类号： H04L47/10 , H04L47/2433 , H04L47/245 , H04L49/90 , H04L49/901 , H04L49/9078
摘要： A method of processing work units in a system is achieved using a throttling queue. The throttling queue assigns work units to a predetermined number of processing slots. Each slot processes an assigned work unit, sends the work units to client systems for processing, and upon finishing, works on a subsequent work unit. The predetermined number of slots, in one embodiment, may be scaled as resources are added or removed from the system. In one embodiment, the work units are network data packets.

4. 发明授权

US06898221B2 Apparatus for frequency tuning and locking and method for operating same 失效
标题翻译：用于频率调谐和锁定的装置及其操作方法
公开(公告)号：US06898221B2
公开(公告)日：2005-05-24
申请号：US10099414
申请日：2002-03-15
申请人： Jill D. Berger , Subrata K. Dutta , Alan A. Fennema , Olga A. Gorbounova , Stephen J. Hrinya , Fedor A. Ilkov , David A. King , Heather L. Tavernier , Alexander A. Tselikov
发明人： Jill D. Berger , Subrata K. Dutta , Alan A. Fennema , Olga A. Gorbounova , Stephen J. Hrinya , Fedor A. Ilkov , David A. King , Heather L. Tavernier , Alexander A. Tselikov
IPC分类号： H01S5/06 , H01S5/0687 , H04B10/155 , H01S3/13 , H01S3/10
CPC分类号： H04B10/504 , H01S5/0617 , H01S5/0687 , H04B10/503 , H04B10/506 , H04B10/564 , H04B10/572
摘要： An apparatus comprising a first reference element having an output power that varies monotonically with input frequency over an operating frequency range and receiving at least a portion of an output beam of light from an optical source. A second reference element having an output power that is frequency dependent receives at least a portion of the output beam of light. A first optical detector measures the power of a first reference beam of light from the first reference element. A second optical detector measures the power of a second reference beam of light from the second reference element. Electronic circuitry is coupled to the first and second optical detectors for receiving first and second reference signals therefrom and producing a coarse error signal for permitting coarse adjustment and a fine error signal for permitting fine adjustment of the frequency of the output beam of light.
摘要翻译：一种装置，包括具有输出功率的第一参考元件，所述输出功率在工作频率范围内与输入频率单调变化，并且接收来自光源的输出光束的至少一部分。具有频率依赖性的输出功率的第二参考元件接收输出光束的至少一部分。第一光学检测器测量来自第一参考元件的第一参考光束的光焦度。第二光学检测器测量来自第二参考元件的第二参考光束的光焦度。电子电路耦合到第一和第二光学检测器，用于从其接收第一和第二参考信号，并产生用于允许粗略调整的粗略误差信号和用于允许微调输出光束的频率的精细误差信号。

5. 发明授权

US5871494A Reproducible lancing for sampling blood 失效
标题翻译：可重复采血采血
公开(公告)号：US5871494A
公开(公告)日：1999-02-16
申请号：US985303
申请日：1997-12-04
申请人： Tad Decatur Simons , Michael Greenstein , Dominique Freeman , Leslie Anne Leonard , David A. King , Paul Lum
发明人： Tad Decatur Simons , Michael Greenstein , Dominique Freeman , Leslie Anne Leonard , David A. King , Paul Lum
IPC分类号： A61B5/15 , A61B17/14
CPC分类号： A61B5/157 , A61B5/150022 , A61B5/15019 , A61B5/150358 , A61B5/150412 , A61B5/15109 , A61B5/15117 , A61B5/15194
摘要： A blood analysis apparatus for obtaining blood for analysis from the skin of a patient with a controlled degree of lancing. The apparatus including a cartridge and a driver. The cartridge includes a cartridge case and a lancet. The lancet has a tip and is housed in the cartridge case. The lancet can be driven to extend the tip outside the cartridge case through an opening for lancing the skin of the patient to yield blood. The driver drives the lancet to move the tip distally to lance the skin. The driver is triggerable by the skin which is to be lanced exerting a force exceeding a preset amount against the triggering mechanism of the apparatus, to drive the lancet toward the skin.
摘要翻译：一种血液分析装置，用于从具有受控的穿刺程度的患者的皮肤获得用于分析的血液。该装置包括一个盒和一个驱动器。药筒包括药筒盒和刺血针。刺血针具有尖端并且容纳在盒壳体中。可以驱动刺血针以通过用于使病人的皮肤穿刺以产生血液的开口将尖端延伸到药筒壳体外部。驾驶员驱动刺血针向远端移动尖端以刺激皮肤。驱动器可以由皮肤触发，该皮肤将针对装置的触发机构施加超过预设量的力，以将刺血针驱动到皮肤。

6. 发明授权

US5835522A Robust passively-locked optical cavity system 失效
标题翻译：坚固的被动锁定光腔系统
公开(公告)号：US5835522A
公开(公告)日：1998-11-10
申请号：US752704
申请日：1996-11-19
申请人： David A. King , Richard J. Pittaro , Alexander Huber
发明人： David A. King , Richard J. Pittaro , Alexander Huber
IPC分类号： H01S3/08 , H01S3/081 , H01S3/082 , H01S5/065 , H01S5/14
CPC分类号： H01S3/082 , H01S5/065 , H01S5/141 , H01S5/142
摘要： A laser system capable of providing light of high intensity is disclosed. This system includes a laser gain medium and three reflectors. A first reflector and a second reflector spaced from the first reflector define a laser cavity that contains the laser gain medium. Light reflected by the first reflector is amplified by the laser gain medium. A third reflector is spaced from the second reflector to define a resonant cavity external to the laser cavity. Light passes from the laser cavity to resonate in the external resonant cavity. Part of the light passes from the external resonant cavity to the laser cavity. A light-screening device, e.g., an aperture, is disposed between the second reflector and the gain medium to screen light reflected from the external cavity such that the light portion of constructive interference is preferentially passed over the light portion of destructive interference. This enables the gain medium to optically lock to the resonant frequency of the external cavity.
摘要翻译：公开了一种能够提供高强度光的激光系统。该系统包括激光增益介质和三个反射器。与第一反射器间隔开的第一反射器和第二反射器限定包含激光增益介质的激光腔。由第一反射器反射的光被激光增益介质放大。第三反射器与第二反射器间隔开以限定激光腔外部的谐振腔。光通过激光腔，在外部谐振腔谐振。部分光从外部谐振腔传递到激光腔。遮光装置，例如孔，设置在第二反射器和增益介质之间，以屏蔽从外部空腔反射的光，使得建构性干涉的光部分优先通过相对干涉的光部分。这使得增益介质能够光学锁定到外部腔的谐振频率。

7. 发明授权

US5812272A Apparatus and method with tiled light source array for integrated assay sensing 失效
标题翻译：具有平铺光源阵列的装置和方法，用于集成测定感测
公开(公告)号：US5812272A
公开(公告)日：1998-09-22
申请号：US790837
申请日：1997-01-30
申请人： David A. King , Nicholas Sampas , Carol T. Schembri
发明人： David A. King , Nicholas Sampas , Carol T. Schembri
IPC分类号： B01J19/00 , C40B40/06 , C40B40/10 , C40B40/12 , C40B70/00 , G01N21/01 , G01N21/77 , G01N21/78 , G01N33/543 , G01N21/55 , G01N21/47 , G01N21/63 , G01N21/64
CPC分类号： G01N21/6452 , B01J19/0046 , G01N33/54373 , B01J2219/00527 , B01J2219/00538 , B01J2219/00547 , B01J2219/00563 , B01J2219/00565 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , C40B40/06 , C40B40/10 , C40B40/12 , C40B70/00 , G01N2201/0612
摘要： A technique for analyzing target chemicals is provided. The apparatus of the technique contains an array of two or more light sources. Each of the array elements includes a light source. The light source has an emitting surface from which light can be emitted. Two or more binder chemical moieties are associated with the light sources at the emitting surfaces. These binder chemical moieties can bind target chemicals such that different target chemicals can be bound to the array. Light emitted by the light sources impinges on target chemicals bound to the light sources and will cause light interaction (e.g., fluorescence) with the target chemicals to result in a light pattern or patterns to indicate the presence or quantity of the target chemicals. The array is formed by a tiling technique involving the arrangement of tiles of array elements in a desired pattern.
摘要翻译：提供了一种用于分析目标化学物质的技术。该技术的装置包含两个或更多个光源的阵列。每个阵列元件包括光源。光源具有可以从其发射光的发射表面。两个或多个粘合剂化学部分与发射表面处的光源相关联。这些粘合剂化学部分可以结合目标化学品，使得不同的目标化学物质可以结合到阵列。由光源发射的光照射到与光源结合的目标化学物上，并且将引起与目标化学物质的光相互作用（例如荧光），导致光图案或图案以指示目标化学物质的存在或数量。该阵列通过平铺技术形成，该技术涉及以期望的图案排列阵列元件的瓦片。

8. 发明授权

US5514596A Method for intracavity sensing of macroscopic properties of chemicals 失效
标题翻译：化学品宏观特性的腔内感测方法
公开(公告)号：US5514596A
公开(公告)日：1996-05-07
申请号：US419653
申请日：1995-04-10
申请人： David A. King , Jens-Peter Seher
发明人： David A. King , Jens-Peter Seher
IPC分类号： G01N21/64 , G01N21/27 , G01N21/39 , G01N21/55 , G01N33/542 , G01N21/41
CPC分类号： G01N21/648 , G01N21/552 , G01N2021/391 , Y10S436/805
摘要： The presence of trace materials in a sample is detected using both macroscopic and microscopic properties. A detector includes a light source and an optical resonator. The light source may be located either inside the resonance cavity of the resonator or outside the cavity, in which case it may be a semi-conductor such as a semi-conductor laser or a superluminescent diode. The detector also includes at least one reflective member that has a total internal reflection (TIR) surface and may be a passive device or an active gain element. Light from the light source is preferably focussed onto a single point of reflection on the TIR surface. The test sample is positioned within the evanescent field region of the TIR surface. Optical changes arising within the evanescent field region, such as excitation of fluorescence in the sample, changes in its refractive index, and changes in the resonant frequency of the optical resonator, are then detected. These changes are then sensed to determine the amount or at least presence of analyte located at the TIR surface.
摘要翻译：使用宏观和微观性质检测样品中痕量物质的存在。检测器包括光源和光谐振器。光源可以位于谐振器的谐振腔内部或腔的外部，在这种情况下，它可以是诸如半导体激光器或超发光二极管的半导体。检测器还包括具有全内反射（TIR）表面的至少一个反射构件，并且可以是无源器件或有源增益元件。来自光源的光优选聚焦在TIR表面上的单个反射点上。测试样品位于TIR表面的消逝场区域内。然后检测在消逝场区域内产生的光学变化，例如样品中荧光的激发，其折射率的变化以及光谐振器的谐振频率的变化。然后感测这些变化以确定位于TIR表面处的分析物的量或至少存在。

9. 发明授权

US5435161A Extrusion method utilizing variable billet preheat temperature 失效
标题翻译：使用可变坯料预热温度的挤出方法
公开(公告)号：US5435161A
公开(公告)日：1995-07-25
申请号：US141823
申请日：1993-10-22
申请人： David A. King
发明人： David A. King
IPC分类号： B21C31/00
CPC分类号： B21C31/00
摘要： A method of extruding a plurality of billets. The method includes (a) preheating a billet to a preheat temperature; (b) extruding the billet so that the exit temperature of the extrusion is within a predetermined temperature range; (c) measuring the extrusion pressure during (b); (d) comparing the measured extrusion pressure to a reference pressure range; (e) if the extrusion pressure was below said reference pressure range, resetting the preheat temperature so that it is lowered by a predetermined increment; (f) if the extrusion pressure climbed above the reference pressure range, resetting the preheat temperature so that it is raised by a predetermined increment; (g) preheating another billet to the preheat temperature; and (h) repeating (b)-(g) until all the billets have been extruded. In a preferred embodiment, the billet is formed form an aluminum alloy.
摘要翻译：一种挤出多个坯料的方法。该方法包括（a）将坯料预热至预热温度; （b）挤出坯料使得挤出物的出口温度在预定的温度范围内; （c）测量（b）期间的挤出压力; （d）将所测量的挤出压力与参考压力范围进行比较; （e）如果挤出压力低于所述参考压力范围，则重置预热温度使其降低预定增量; （f）如果挤出压力超过参考压力范围，则重置预热温度使其升高预定的增量; （g）将另一坯料预热至预热温度; 和（h）重复（b） - （g）直到所有的坯料已经挤出。在优选实施例中，坯料由铝合金形成。

10. 发明申请

US20120236291A1 DIFFERENTIATION OF FLOW CYTOMETRY PULSES AND APPLICATIONS 有权
标题翻译：流动细胞计数脉冲和应用的差异
公开(公告)号：US20120236291A1
公开(公告)日：2012-09-20
申请号：US13461713
申请日：2012-05-01
申请人： Richard Pittaro , Bruce Goldman , Ray Lefebvre , David A. King
发明人： Richard Pittaro , Bruce Goldman , Ray Lefebvre , David A. King
IPC分类号： G01P3/36
CPC分类号： G01N15/14 , G01N15/1429 , G01N15/1459 , G01N2015/1006 , G01N2015/1477 , G01N2015/1486
摘要： A method of analyzing pulses from a flow cytometer in which particles in a fluid pass through an excitation volume of an electromagnetic radiation and interact with the electromagnetic radiation to generate signals in the form of pulses includes generating a time-dependent pulse indicative of the characteristics of one or more particles passing through the excitation volume of the electromagnetic radiation, determining a measurement window by selecting a portion of the pulse with a starting point and an ending point above a predetermined value, and calculating a first derivative of the pulse with respect to time over the measurement window.
摘要翻译：一种分析来自流式细胞仪的脉冲的方法，其中流体中的颗粒通过电磁辐射的激发体积并与电磁辐射相互作用以产生脉冲形式的信号，包括产生指示时间相关脉冲的时间相关脉冲一个或多个颗粒通过电磁辐射的激发体积，通过以高于预定值的起点和终点选择脉冲的一部分来确定测量窗口，并计算相对于时间的脉冲的一阶导数在测量窗口上。

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