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1. 发明授权

US5812272A Apparatus and method with tiled light source array for integrated assay sensing 失效
标题翻译：具有平铺光源阵列的装置和方法，用于集成测定感测
公开(公告)号：US5812272A
公开(公告)日：1998-09-22
申请号：US790837
申请日：1997-01-30
申请人： David A. King , Nicholas Sampas , Carol T. Schembri
发明人： David A. King , Nicholas Sampas , Carol T. Schembri
IPC分类号： B01J19/00 , C40B40/06 , C40B40/10 , C40B40/12 , C40B70/00 , G01N21/01 , G01N21/77 , G01N21/78 , G01N33/543 , G01N21/55 , G01N21/47 , G01N21/63 , G01N21/64
CPC分类号： G01N21/6452 , B01J19/0046 , G01N33/54373 , B01J2219/00527 , B01J2219/00538 , B01J2219/00547 , B01J2219/00563 , B01J2219/00565 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , C40B40/06 , C40B40/10 , C40B40/12 , C40B70/00 , G01N2201/0612
摘要： A technique for analyzing target chemicals is provided. The apparatus of the technique contains an array of two or more light sources. Each of the array elements includes a light source. The light source has an emitting surface from which light can be emitted. Two or more binder chemical moieties are associated with the light sources at the emitting surfaces. These binder chemical moieties can bind target chemicals such that different target chemicals can be bound to the array. Light emitted by the light sources impinges on target chemicals bound to the light sources and will cause light interaction (e.g., fluorescence) with the target chemicals to result in a light pattern or patterns to indicate the presence or quantity of the target chemicals. The array is formed by a tiling technique involving the arrangement of tiles of array elements in a desired pattern.
摘要翻译：提供了一种用于分析目标化学物质的技术。该技术的装置包含两个或更多个光源的阵列。每个阵列元件包括光源。光源具有可以从其发射光的发射表面。两个或多个粘合剂化学部分与发射表面处的光源相关联。这些粘合剂化学部分可以结合目标化学品，使得不同的目标化学物质可以结合到阵列。由光源发射的光照射到与光源结合的目标化学物上，并且将引起与目标化学物质的光相互作用（例如荧光），导致光图案或图案以指示目标化学物质的存在或数量。该阵列通过平铺技术形成，该技术涉及以期望的图案排列阵列元件的瓦片。

2. 发明申请

US20080171397A1 Multiple analyte detection systems and methods of detecting multiple analytes 有权
标题翻译：多种分析物检测系统和检测多种分析物的方法
公开(公告)号：US20080171397A1
公开(公告)日：2008-07-17
申请号：US11653568
申请日：2007-01-16
申请人： Ian Hardcastle , Carol T. Schembri , John Francis Petrilla , Rene B. Helbing , Daniel B. Roitman
发明人： Ian Hardcastle , Carol T. Schembri , John Francis Petrilla , Rene B. Helbing , Daniel B. Roitman
IPC分类号： G01N21/76
CPC分类号： G01N21/78 , G01N21/253 , G01N21/8483
摘要： A multiple analyte detection system includes a carrier having reagents disposed thereat, with each of the reagents capable of optically changing in response to exposure to a respective analyte. The system further includes a photodetector positioned to collectively detect light interacted with each of the reagents, a processor to determine a presence or an absence of each of the analytes in response to the light collectively-detected, and an indicator to provide an indication of the presence or the absence of each of the analytes. A method of detecting multiple analytes includes exposing reagents capable of optically changing in response to exposure to a respective analyte to a sample. The method further includes collectively detecting light interacted with each of the reagents, determining a presence or an absence of each of the analytes in response to the light collectively detected, and indicating the presence or the absence of each of the analytes determined.
摘要翻译：多分析物检测系统包括具有在其上设置的试剂的载体，其中每种试剂能够响应于暴露于相应分析物而光学变化。该系统还包括光电检测器，其被定位成共同检测与每个试剂相互作用的光;处理器，用于响应于总体检测的光来确定每个分析物的存在或不存在;以及指示器，存在或不存在每种分析物。检测多种分析物的方法包括将暴露于相应分析物的样品响应于能够进行光学变化的试剂露出。该方法还包括共同检测与每种试剂相互作用的光，响应于共同检测的光，确定每种分析物的存在或不存在，并指示所确定的每种分析物的存在或不存在。

3. 发明授权

US07300798B2 Chemical arrays 失效
标题翻译：化学阵列
公开(公告)号：US07300798B2
公开(公告)日：2007-11-27
申请号：US10167662
申请日：2001-10-18
申请人： Michel G. M. Perbost , Steven M. Lefkowitz , Roy H. Kanemoto , Carol T. Schembri
发明人： Michel G. M. Perbost , Steven M. Lefkowitz , Roy H. Kanemoto , Carol T. Schembri
IPC分类号： G01N30/00
CPC分类号： B01J19/0046 , Y10T436/110833 , Y10T436/143333 , Y10T436/25
摘要： A method and apparatus for using arrays of polymers each having a pattern of features over a corresponding array region on a surface of a flexible elongated web. In this method each array region may be exposed to a corresponding continuous volume of a sample fluid. A method and apparatus are also provided for reading arrays disposed along a surface of a flexible elongated web. In one such method the web with the arrays thereon may be transported in a lengthwise direction past a reading location at which a characteristic of the features is read, while restraining the web on both surfaces on either side of the reading location to assist in maintaining the reading location flat.
摘要翻译：一种使用聚合物阵列的方法和装置，每个聚合物阵列具有在柔性细长网的表面上的相应阵列区域上的特征图案。在该方法中，每个阵列区域可以暴露于相应的连续体积的样品流体。还提供了一种用于读取沿着柔性细长网的表面设置的阵列的方法和装置。在一种这样的方法中，其上具有阵列的幅材可以沿长度方向传送通过读取特征的特征的读取位置，同时在读取位置的任一侧的两个表面上限制纸幅以帮助维持阅读位置平坦。

4. 发明授权

US06884580B2 Fabricating biopolymer arrays 失效
公开(公告)号：US06884580B2
公开(公告)日：2005-04-26
申请号：US10059957
申请日：2001-11-26
申请人： Michael P. Caren , Carol T. Schembri , Peter G. Webb
发明人： Michael P. Caren , Carol T. Schembri , Peter G. Webb
IPC分类号： B01J19/00 , C40B40/06 , C40B40/10 , C40B60/14 , C12G1/68 , C07H21/02 , C07H21/04 , C12M1/34 , C12P19/34
CPC分类号： B01J19/0046 , B01J2219/00378 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B60/14 , Y10T436/2575
摘要： A method and apparatus for fabricating an array of biopolymers on a substrate using a biopolymer or biomonomer fluid, and using a dispensing head. The head has a reservoir chamber and at least one jet which can dispense droplets onto a substrate. The jet includes a capillary delivery chamber communicating with the reservoir chamber, which delivery chamber has an orifice. The jet further includes an ejector which, when activated, causes a droplet to be ejected from the orifice. The method includes loading the head by positioning the head with the orifice adjacent and facing a biomonomer or biopolymer fluid, and providing a load pressure to the reservoir chamber. The load pressure is sufficiently negative such that the fluid is drawn into the reservoir chamber through the orifice and delivery chamber, while simultaneously being insufficient to result in ambient atmosphere entering the delivery chamber through the orifice once the head has been loaded and no further fluid is facing and adjacent the orifice. The head is positioned with the orifice facing the substrate and multiple droplets are dispensed from the head orifice so as to form an array of droplets on the substrate.

5. 发明授权

US06773676B2 Devices for performing array hybridization assays and methods of using the same 失效
标题翻译：用于进行阵列杂交测定的装置及其使用方法
公开(公告)号：US06773676B2
公开(公告)日：2004-08-10
申请号：US09884792
申请日：2001-06-19
申请人： Carol T. Schembri
发明人： Carol T. Schembri
IPC分类号： B01L300
CPC分类号： G02B21/34 , B01L3/508 , B01L2200/0689 , B01L2300/041 , B01L2300/0809 , G01N21/0332 , Y10T436/2575
摘要： Array hybridization devices and methods for their use are provided. The subject devices are characterized by having a substantially planar bottom surface, a cover, at least one fluid port and at least one adjustable spacing element for adjusting the spacing between an array and the bottom surface. In using the subject devices, an array is placed on the at least one adjustable spacing element in the chamber and the space between the array and the bottom surface is adjusted by moving the at least one adjustable spacing element. The adjusted array is contacted with at least one biological sample introduced into the chamber. The subject inventions find use in a variety of array-based applications, including nucleic acid array hybridizations.
摘要翻译：提供阵列杂交装置及其使用方法。主题装置的特征在于具有基本上平坦的底表面，盖，至少一个流体端口和用于调节阵列和底表面之间的间隔的至少一个可调间隔元件。在使用主体装置时，将阵列放置在腔室中的至少一个可调间隔元件上，并且通过移动至少一个可调间隔元件来调节阵列与底表面之间的空间。经调节的阵列与引入腔室的至少一个生物样品接触。本发明可用于各种基于阵列的应用，包括核酸阵列杂交。

6. 发明授权

US06518056B2 Apparatus, systems and method for assaying biological materials using an annular format 失效
标题翻译：使用环形格式测定生物材料的装置，系统和方法
公开(公告)号：US06518056B2
公开(公告)日：2003-02-11
申请号：US09302011
申请日：1999-04-27
申请人： Carol T. Schembri , Arthur Schleifer
发明人： Carol T. Schembri , Arthur Schleifer
IPC分类号： C12M134
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00378 , B01J2219/00421 , B01J2219/00536 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00702 , B01J2219/00722 , B01L3/5085 , C12Q1/6832 , C12Q1/6837 , C40B40/06 , C40B50/14 , C40B60/14 , G01N1/2813 , G01N33/54366 , G01N35/00069 , G01N35/025 , G01N35/1083 , G01N2035/00158 , G01N2035/00504 , C12Q2523/32
摘要： An apparatus, systems and methods use an r, &thgr; format for the manufacture and analysis of biological materials. The apparatus is an array of biological material in an annular region on a substrate. The apparatus is formed with a system for synthesizing arrays that includes a spinner assembly for rotating the substrate during the synthesis of the biological material thereon. The apparatus is hybridized with complementary biological material using a system for hybridizing that includes a spinner assembly to spin the apparatus after the complementary biological material is added. The hybridized apparatus is optically interrogated with a system for interrogation that includes a light source, optics, and a scanning assembly that holds and rotates the apparatus so that the light source can remain stationary. The method of assaying biological materials uses the systems for synthesizing, hybridizing and optically interrogating the apparatus in accordance with the invention.
摘要翻译：设备，系统和方法使用r，θ格式来生产和分析生物材料。该装置是在衬底上的环形区域中的生物材料阵列。该装置形成有用于合成阵列的系统，该系统包括用于在其上生物材料的合成期间旋转衬底的旋转器组件。该装置与互补生物材料杂交，使用包含旋转器组件的用于杂交的系统以在补充生物材料被添加之后旋转该装置。杂交装置用询问系统进行光学询问，该系统包括光源，光学器件和保持和旋转设备的扫描组件，使得光源可以保持静止。测定生物材料的方法使用根据本发明的用于合成，杂交和光学询问装置的系统。

7. 发明授权

US06513968B2 Apparatus and method for mixing a film of fluid 有权
标题翻译：用于混合流体膜的装置和方法
公开(公告)号：US06513968B2
公开(公告)日：2003-02-04
申请号：US09782542
申请日：2001-02-12
申请人： Carol T. Schembri
发明人： Carol T. Schembri
IPC分类号： B01F1302
CPC分类号： B01L3/502707 , B01F13/0059 , B01F13/02 , B01F2215/0431 , B01F2215/0472 , B01J19/0046 , B01J2219/00479 , B01J2219/00495 , B01J2219/00536 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00653 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , B01J2219/1941 , B01L3/50273 , B01L2300/0636 , B01L2300/0803 , B01L2300/0887 , B01L2300/1827 , B01L2400/0406 , B01L2400/0409 , B01L2400/0442 , B01L2400/0448 , B01L2400/0487 , C40B40/06 , C40B40/10 , C40B40/14 , C40B60/14 , Y10S366/03 , Y10T436/25
摘要： A method and apparatus is provided for mixing a film of fluid, particularly a film of chemical, biochemical, or biological fluids undergoing a reaction. The apparatus comprises a means for nucleating a bubble using a discrete heat source, such as a resistor, and moving the bubble in the fluid by creating a temperature gradient, thereby mixing the fluid.
摘要翻译：提供了一种用于混合流体薄膜，特别是经历反应的化学，生物化学或生物流体的薄膜的方法和装置。该装置包括用于使用诸如电阻器的离散热源使气泡成核的装置，并且通过产生温度梯度来移动流体中的气泡，由此混合流体。

8. 发明授权

US06461812B2 Method and multiple reservoir apparatus for fabrication of biomolecular arrays 失效
标题翻译：用于制造生物分子阵列的方法和多储层装置
公开(公告)号：US06461812B2
公开(公告)日：2002-10-08
申请号：US09150507
申请日：1998-09-09
申请人： Phillip W. Barth , Michael P. Caren , William H. McAllister , Carol T. Schembri , Arthur Schleifer
发明人： Phillip W. Barth , Michael P. Caren , William H. McAllister , Carol T. Schembri , Arthur Schleifer
IPC分类号： C12Q168
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00378 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00659 , B01J2219/00722 , B41J2/14145 , B41J2002/14387 , C12Q1/6837 , C40B40/06 , C40B60/14
摘要： Apparatus for delivering a plurality of different biological materials onto discrete locations on a receiving surface, as for example to fabricate an array of different biological material, includes a plurality of orifices in an orifice member, at least six delivery chambers each in fluid conducting relationship with at least one of the orifices, a plurality of reservoirs each in fluid communication with at least one of the delivery chambers, means associated with each orifice for propelling fluid through the associated orifice from the delivery chamber that is in fluid conducting relationship with the orifice, and a vent for commonly venting at least two of the reservoirs. In some embodiments the chambers and reservoirs are loaded with fluids containing selected biomolecules by drawing the selected fluids into the chambers through the orifices; in other embodiments the fluids are introduced into the reservoirs. Also, methods for depositing biological materials onto a surface, as for example to fabricate a biomolecular array, employ the apparatus.
摘要翻译：用于将多个不同生物材料输送到接收表面上的离散位置上的装置，例如制造不同生物材料的阵列，包括孔口构件中的多个孔，至少六个输送腔，其各自与所述孔中的至少一个，多个储存器，每个储存器各自与至少一个输送室流体连通，与每个孔相关联的装置，用于将流体从与所述孔流体导通关系的输送室相推进，以及用于通常排放至少两个储存器的通风口。在一些实施例中，腔室和储存器通过将所选择的流体通过孔抽入室中来装载含有选定的生物分子的流体; 在其它实施例中，将流体引入储存器。此外，用于将生物材料沉积到表面上的方法，例如制备生物分子阵列，采用该装置。

9. 发明授权

US06395553B1 Method for controlling reactions 失效
标题翻译：控制反应的方法
公开(公告)号：US06395553B1
公开(公告)日：2002-05-28
申请号：US09695008
申请日：2000-10-23
申请人： Carol T. Schembri
发明人： Carol T. Schembri
IPC分类号： G01N110
CPC分类号： G01N35/1097 , B01L3/502 , B01L2300/0636 , B01L2300/0877 , B01L2400/0409 , B01L2400/0633 , G01N33/491 , Y10T137/108 , Y10T436/111666 , Y10T436/2575
摘要： The invention relates to a method and an apparatus for performing an assay on chemical, biochemical, or biological fluids. The apparatus includes an assay chamber for fluid reactions and a centrifugal force activated-valve for controlling fluid movement through the assay chamber. An active surface can be positioned in the assay chamber to react with fluids passed through the assay chamber. The active surface may contain biomolecular probes. The biomolecular probes can be DNA, DNA fragments, RNA, RNA fragments, reagents, protein, protein fragments, lipids, and lipid fragments. The apparatus is particularly useful when multiple reactions, dilutions, or washing steps are required to determine a final answer. The centrifugal force activated-valve provides positive control over fluid in the assay chamber and allows for repeated use of the same chamber for multiple reaction steps. The apparatus can be disposed of after an assay to eliminate potential contamination from reuse of the same apparatus. Fluids passed through the assay chamber may be recovered for subsequent analysis, processing, or reactions.
摘要翻译：本发明涉及用于对化学，生物化学或生物流体进行测定的方法和装置。该装置包括用于流体反应的测定室和用于控制通过测定室的流体运动的离心力活化阀。可以将活性表面置于测定室中以与通过测定室的流体反应。活性表面可以含有生物分子探针。生物分子探针可以是DNA，DNA片段，RNA，RNA片段，试剂，蛋白质，蛋白质片段，脂质和脂质片段。当需要多次反应，稀释或洗涤步骤来确定最终答案时，该装置特别有用。离心力活化阀对分析室中的流体提供积极控制，并允许反复使用相同的室进行多个反应步骤。该装置可以在分析之后进行处置，以消除重复使用相同装置的潜在污染。通过测定室的流体可以被回收用于随后的分析，处理或反应。

10. 发明授权

US06235531B1 Modified siphons for improved metering precision 失效
标题翻译：改进的虹吸管，以提高计量精度
公开(公告)号：US06235531B1
公开(公告)日：2001-05-22
申请号：US08562327
申请日：1995-11-22
申请人： Anne R. Kopf-Sill , Carol T. Schembri
发明人： Anne R. Kopf-Sill , Carol T. Schembri
IPC分类号： G01N3500
CPC分类号： B01L3/502738 , B01L2300/0806 , B01L2300/0867 , B01L2300/087 , B01L2400/0409 , G01N21/07 , Y10T436/111666 , Y10T436/25375 , Y10T436/2575
摘要： The present invention provides centrifugal rotors for delivering a premeasured volume of liquid to a chamber in the rotor. In particular the rotors include siphons for delivering a premeasured volume of liquid between a first and a second chamber in the rotor. The siphons of the invention are designed such that the inlet of the siphon on the first chamber is radially outward of the siphon outlet on the second chamber. The first chamber is emptied to a level equivalent to the radial position of the siphon outlet.
摘要翻译：本发明提供了用于将预先测量的体积的液体输送到转子中的室的离心转子。特别地，转子包括用于在转子中的第一和第二室之间输送预先测量的液体体积的虹吸管。本发明的虹吸设计成使得第一室上的虹吸入口在第二室上的虹吸出口的径向外侧。第一个室被排空到与虹吸出口的径向位置相当的水平。

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