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1. 发明申请

US20130109762A1 SILK PARTICLES FOR CONTROLLED AND SUSTAINED DELIVERY OF COMPOUNDS 有权
标题翻译：用于控制和持续输送化合物的丝状颗粒
公开(公告)号：US20130109762A1
公开(公告)日：2013-05-02
申请号：US13512789
申请日：2010-11-30
申请人： Andreas Lammel , Thomas Scheibel , Martin Schwab , Gerhard Winter , Markus Hofer , Julia Myschik
发明人： Andreas Lammel , Thomas Scheibel , Martin Schwab , Gerhard Winter , Markus Hofer , Julia Myschik
IPC分类号： A61K9/00
CPC分类号： A61K9/0002 , A61K31/137 , A61K31/138 , A61K31/245 , A61K31/285 , A61K31/40 , A61K31/485 , A61K38/00 , C07K14/43518
摘要： The present invention relates to a method of producing and loading silk particles, preferably spider silk particles, with a compound. In particular, the present invention provides a novel two step method for loading silk particles, preferably spider silk particles, with small and water-soluble compounds. Also disclosed are silk particles, preferably spider silk particles, loaded with at least one compound which are eminently suited as carriers for controlled and sustained delivery applications. Furthermore, the invention relates to pharmaceutical or cosmetic compositions comprising said silk particles, preferably spider silk particles, and a pharmaceutically active compound or cosmetic compound for controlled and sustained release. The present invention is also directed to silk particles, preferably spider silk particles, loaded with a compound obtainable by the method according to the invention.
摘要翻译：本发明涉及一种用化合物生产和加载丝粒子，优选蜘蛛丝粒子的方法。特别地，本发明提供了一种用于将丝状颗粒，优选蜘蛛丝颗粒加载到小的和水溶性化合物的新颖的两步法。还公开了装载有至少一种非常适合用作控制和持续递送应用的载体的化合物的丝粒子，优选蜘蛛丝粒子。此外，本发明涉及包含所述丝粒，优选蜘蛛丝颗粒的药物或化妆品组合物，以及用于受控和持续释放的药学活性化合物或化妆品化合物。本发明还涉及装有可通过本发明方法获得的化合物的丝粒子，优选蜘蛛丝粒子。

2. 发明授权

US09233067B2 Silk particles for controlled and sustained delivery of compounds 有权
标题翻译：用于控制和持续输送化合物的丝粒
公开(公告)号：US09233067B2
公开(公告)日：2016-01-12
申请号：US13512789
申请日：2010-11-30
申请人： Andreas Lammel , Thomas Scheibel , Martin Schwab , Gerhard Winter , Markus Hofer , Julia Myschik
发明人： Andreas Lammel , Thomas Scheibel , Martin Schwab , Gerhard Winter , Markus Hofer , Julia Myschik
IPC分类号： A61K9/00 , A61K31/137 , A61K31/138 , A61K31/245 , A61K31/285 , A61K31/40 , A61K31/485 , C07K14/435 , A61K38/00
CPC分类号： A61K9/0002 , A61K31/137 , A61K31/138 , A61K31/245 , A61K31/285 , A61K31/40 , A61K31/485 , A61K38/00 , C07K14/43518
摘要： The present invention relates to a method of producing and loading silk particles, preferably spider silk particles, with a compound. In particular, the present invention provides a novel two step method for loading silk particles, preferably spider silk particles, with small and water-soluble compounds. Also disclosed are silk particles, preferably spider silk particles, loaded with at least one compound which are eminently suited as carriers for controlled and sustained delivery applications. Furthermore, the invention relates to pharmaceutical or cosmetic compositions comprising said silk particles, preferably spider silk particles, and a pharmaceutically active compound or cosmetic compound for controlled and sustained release. The present invention is also directed to silk particles, preferably spider silk particles, loaded with a compound obtainable by the method according to the invention.
摘要翻译：本发明涉及一种用化合物生产和加载丝粒子，优选蜘蛛丝粒子的方法。特别地，本发明提供了一种用于将丝状颗粒，优选蜘蛛丝颗粒加载到小的和水溶性化合物的新颖的两步法。还公开了装载有至少一种非常适合用作控制和持续递送应用的载体的化合物的丝粒子，优选蜘蛛丝粒子。此外，本发明涉及包含所述丝粒，优选蜘蛛丝颗粒的药物或化妆品组合物，以及用于受控和持续释放的药学活性化合物或化妆品化合物。本发明还涉及装有可通过本发明方法获得的化合物的丝粒子，优选蜘蛛丝粒子。

3. 发明授权

US08758747B2 Stable lyophilized pharmaceutical preparations of monoclonal or polyclonal antibodies 有权
标题翻译：稳定的冻干药物制剂的单克隆或多克隆抗体
公开(公告)号：US08758747B2
公开(公告)日：2014-06-24
申请号：US12180794
申请日：2008-07-28
申请人： Georg Kallmeyer , Gerhard Winter , Christian Klessen , Heinrich Woog
发明人： Georg Kallmeyer , Gerhard Winter , Christian Klessen , Heinrich Woog
IPC分类号： A61K39/395 , C07K16/00 , C12P21/08 , A61K9/19
CPC分类号： A61K47/10 , A61K9/0019 , A61K9/19 , A61K38/00 , A61K39/395 , A61K39/39591 , A61K47/183 , A61K47/22 , A61K47/26 , C07K16/00 , C07K16/082 , C07K16/2863
摘要： The invention concerns lyophilized pharmaceutical preparations of monoclonal or polyclonal antibodies which contain a sugar or an amino sugar, an amino acid and a surfactant as stabilizers. In addition the invention concerns a process for the production of this stable lyophilizate as well as the use of a sugar or amino sugar, an amino acid and a surfactant as stabilizers for therapeutic or diagnostic agents containing antibodies.
摘要翻译：本发明涉及含有糖或氨基糖，氨基酸和表面活性剂作为稳定剂的单克隆或多克隆抗体的冻干药物制剂。此外，本发明涉及生产这种稳定的冻干物的方法，以及使用糖或氨基糖，氨基酸和表面活性剂作为含有抗体的治疗剂或诊断剂的稳定剂。

4. 发明授权

US08753839B2 Compositions and methods for crystallizing antibodies 失效
标题翻译：用于结晶抗体的组合物和方法
公开(公告)号：US08753839B2
公开(公告)日：2014-06-17
申请号：US12228038
申请日：2008-08-08
申请人： Wolfgang Fraunhofer , David W. Borhani , Gerhard Winter , Stefan Gottschalk
发明人： Wolfgang Fraunhofer , David W. Borhani , Gerhard Winter , Stefan Gottschalk
IPC分类号： C12P21/06 , A61K39/395 , A01N61/00 , C07K16/24 , A61K39/00
CPC分类号： C07K16/241 , A61K2039/505 , C07K1/306 , C07K2299/00 , C07K2317/14 , C07K2317/54 , C07K2317/76 , C30B29/58 , Y02A50/388
摘要： The present invention relates to a batch crystallization method for crystallizing anti-human TNFalpha (hTNFalpha) antibody and antibody fragments which allows the production of said antibody on an industrial scale; a method of controlling the size of antibody crystals, for example, crystals of anti-hTNFalpha antibody fragments, compositions containing said crystals as well as methods of use of said crystals and compositions.
摘要翻译：本发明涉及用于结晶抗人TNFα（hTNFα）抗体的分批结晶方法和允许以工业规模生产所述抗体的抗体片段; 控制抗体晶体大小的方法，例如抗hTNFα抗体片段的晶体，含有所述晶体的组合物以及使用所述晶体和组合物的方法。

5. 发明申请

US20100239654A1 VESICULAR PHOSPHOLIPID GELS COMPRISING PROTEINACEOUS SUBSTANCES 审中-公开
标题翻译：包含蛋白质物质的囊状磷脂凝胶
公开(公告)号：US20100239654A1
公开(公告)日：2010-09-23
申请号：US12692416
申请日：2010-01-22
申请人： Gerhard Winter
发明人： Gerhard Winter
IPC分类号： A61K9/127 , A61K38/18 , A61K38/20 , A61K38/21 , A61K39/395 , A61K38/16 , A61K38/28 , A61K38/30 , A61K38/22 , A61K38/24 , A61K38/09 , A61K38/26 , A61P19/04 , A61P29/00 , A61P35/00 , A61P37/00 , A61P19/02 , A61P21/00
CPC分类号： A61K9/127 , A61K9/1277 , A61K38/1816 , A61K38/193 , A61K2039/545 , C07K16/1027 , C07K16/18 , C07K16/22 , C07K16/241 , C07K16/28 , C07K16/2803 , C07K16/2809 , C07K16/2839 , C07K16/2845 , C07K16/2863 , C07K16/2866 , C07K16/2887 , C07K16/2893 , C07K16/32 , C07K16/42
摘要： The present invention relates to a pharmaceutical composition for sustained release of a pharmaceutically active compound, the composition comprising a vesicular phospholipid gel. More particularly, the invention relates to a pharmaceutical composition comprising at least one proteinaceous substance as the pharmaceutically active compound in encapsulated form, the at least one proteinaceous substance being a biologically active protein, peptide or polypeptide. Furthermore, the present invention relates to a method for the production of said pharmaceutical composition comprising dual asymmetric centrifugation and to the use of said pharmaceutical composition for immunotherapy and/or for stimulating selective tissue regeneration in the treatment of surgical defects in the course of surgical interventions.
摘要翻译：本发明涉及用于药物活性化合物持续释放的药物组合物，该组合物包含泡状磷脂凝胶。更具体地说，本发明涉及包含至少一种蛋白质物质作为包封形式的药物活性化合物的药物组合物，所述至少一种蛋白质物质是生物活性蛋白质，肽或多肽。此外，本发明涉及生产包含双重不对称离心的所述药物组合物的方法，以及所述药物组合物在外科手术过程中用于免疫治疗和/或刺激选择性组织再生治疗手术缺陷的用途的方法。

6. 发明授权

US07172999B2 Method and preparations for stabilizing biological materials by drying methods without freezing 失效
标题翻译：通过干燥方法稳定生物材料而不冻结的方法和制剂
公开(公告)号：US07172999B2
公开(公告)日：2007-02-06
申请号：US09051918
申请日：1996-10-24
申请人： Markus Mattern , Gerhard Winter
发明人： Markus Mattern , Gerhard Winter
IPC分类号： A61K38/18 , C07K14/505
CPC分类号： A61K47/26 , A61K38/1816 , A61K38/193 , A61K38/443 , A61K47/183 , F26B5/04
摘要： The present invention concerns processes for the production of dry, partially amorphous products containing biologically active and in particular therapeutically active material which are macroscopically homogeneous substance mixtures, the substance mixtures being selected from at least one substance of each of the groups (i) carbohydrate or zwitterion with a polar residue and derivatives thereof, and (ii) zwitterion with an apolar residue and derivatives thereof, wherein a solution is prepared of the biologically or therapeutically active material and of substances (i) and (ii) and the solution is dried at a product temperature above the freezing point of the solution. In addition the invention concerns new substance mixtures which are obtained by the said process as well as the use thereof in diagnostic or therapeutic methods.
摘要翻译：本发明涉及生产含有生物活性的，特别是宏观上均匀的物质混合物的治疗活性物质的干燥，部分无定形产物的方法，所述物质混合物选自每个组的至少一种物质（i）碳水化合物或具有极性残基及其衍生物的两性离子，和（ii）与非极性残基及其衍生物的两性离子，其中制备生物或治疗活性物质和物质（i）和（ii）的溶液，并将溶液在产品温度高于溶液的冰点。此外，本发明涉及通过所述方法获得的新物质混合物以及其在诊断或治疗方法中的用途。

7. 发明授权

US5919757A Aqueous pharmaceutical preparations of G-CSF with a long shelf life 失效
标题翻译： G-CSF的水性药物制剂，保质期长
公开(公告)号：US5919757A
公开(公告)日：1999-07-06
申请号：US857172
申请日：1997-05-15
申请人： Uwe Michaelis , Rainer Rudolph , Gerhard Winter , Heinrich Woog
发明人： Uwe Michaelis , Rainer Rudolph , Gerhard Winter , Heinrich Woog
IPC分类号： A61K9/08 , A61K9/00 , A61K9/14 , A61K38/00 , A61K38/19 , A61K47/02 , A61K47/12 , A61K47/18 , A61K38/17
CPC分类号： A61K47/02 , A61K38/193 , A61K47/12 , A61K9/0019
摘要： Aqueous pharmaceutical preparations of G-CSF are disclosed that are stable on storage and a buffer selected from the group consisting of a salt of citrate, maleate, a combination of phosphate and citrate, and arginine; and at least one surfactant.
摘要翻译：公开了G-CSF的水性药物制剂，其在储存时稳定，并且选自柠檬酸盐，马来酸盐，磷酸盐和柠檬酸盐的组合以及精氨酸的缓冲液; 和至少一种表面活性剂。

8. 发明授权

US5612662A Thermal fuse and method for its activation 失效
标题翻译：热熔丝及其激活方法
公开(公告)号：US5612662A
公开(公告)日：1997-03-18
申请号：US384821
申请日：1995-02-07
申请人： Karl G. Drekmeier , Gerhard Winter
发明人： Karl G. Drekmeier , Gerhard Winter
IPC分类号： H01H37/76 , H01H37/46 , H01H37/60 , H01H69/02
CPC分类号： H01H37/761 , H01H2037/046 , H01H2037/763 , Y10T29/49107
摘要： A thermal fuse includes a leaf spring formed of a narrow sheet metal strip. The leaf spring has ends and at least two contact points at the ends. At least one of the contact points is a soldering point for connection with corresponding circuit contacts of a circuit substrate. The leaf spring has at least one spring arm interconnecting the contact points. The spring arm has a roof-shaped deformation in the vicinity of one contact point. The spring arm has a flat and elongated spring segment with a transition adjoining the deformation and a transition extending to the other contact point. The spring segment is bending resistant in the vicinities of the transitions, for transforming a compressive deformation applied to the roof-shaped deformation into a lateral movement and into an arching of the spring segment, with both ends of the leaf spring attached to the circuit substrate without pretensioning. A method for activation of the thermal fuse includes placing the contact points of the leaf springs free of tension on the circuit contacts, soldering the contact points to the circuit contacts, and compressively deforming the roof-shaped deformation after the soldering for creating an arching of the spring segment and a desired pretensioning.
摘要翻译：热熔丝包括由窄金属片条形成的板簧。板簧在端部具有端部和至少两个接触点。接触点中的至少一个是用于与电路基板的相应电路触点连接的焊接点。板簧具有互连接触点的至少一个弹簧臂。弹簧臂在一个接触点附近具有屋顶形变形。弹簧臂具有平坦且细长的弹簧段，其具有与变形相邻的过渡以及延伸到另一个接触点的过渡。弹簧段在过渡附近是抗弯曲的，用于将应用于屋顶形变形的压缩变形转变为横向运动并进入弹簧段的拱形，其中板簧的两端附接到电路基板没有预张力。用于激活热熔丝的方法包括将板簧的接触点放置在电路触点上，将接触点焊接到电路触点上，并且在焊接之后对屋顶形变形进行压缩变形，以产生拱形弹簧段和所需的预张紧。

9. 发明授权

US5296117A Method for the production of a radiographic screen 失效
标题翻译：用于生产放射线照相屏幕的方法
公开(公告)号：US5296117A
公开(公告)日：1994-03-22
申请号：US983708
申请日：1992-12-01
申请人： Nikolaas De Jaeger , Guy Damen , Gerhard Winter , Jan Van Havenbergh
发明人： Nikolaas De Jaeger , Guy Damen , Gerhard Winter , Jan Van Havenbergh
IPC分类号： C09K11/02 , C25D13/00 , G21K4/00 , H01J9/22 , C25D13/02
CPC分类号： G21K4/00 , C09K11/025 , C25D13/00 , H01J9/225 , G21K2004/06
摘要： A method for the production of a radiographic screen comprising the following steps:1) dispersing phosphor particles in an organic liquid in the presence of a charge controlling agent that charges said phosphor particles with a positive or negative net charge,2) arranging said dispersion between a pair of electrodes, wherein one of said electrodes is or carries a conductive support of said radiographic screen,3) applying and maintaining between said electrodes a sufficiently high direct current voltage to deposit charged phosphor particles onto said conductive support, and4) separating said support carrying electrophoretically deposited phosphor particles from said organic liquid,wherein the dispersing of said phosphor particles proceeds by means of an organic surface active compound acting as dispersing agent for said phosphor particles, and said phosphor particles are electrostatically charged through adsorption thereon of ionic components of said organic surface active compound and/or through adsorption of cations or anions stemming from an ionic inorganic compound incorporated in said liquid.
摘要翻译：一种用于生产射线照相屏幕的方法，包括以下步骤：1）在电荷控制剂的存在下，将荧光体颗粒分散在有机液体中，所述电荷控制剂用正或负净电荷对所述荧光体颗粒进行充电，2）将所述分散体布置在一对电极，其中所述电极之一是或承载所述放射线照相屏幕的导电支撑件，3）在所述电极之间施加和保持足够高的直流电压以将带电荧光粉颗粒沉积到所述导电支撑件上，以及4）将所述从所述有机液体中携带电泳沉积的荧光体颗粒的载体，其中所述荧光体颗粒的分散通过作为所述荧光体颗粒的分散剂的有机表面活性化合物进行，并且所述荧光体颗粒通过其上的离子组分的吸附静电所述有机表面活性化合物和/或通过吸附由所述液体中引入的离子型无机化合物产生的阳离子或阴离子。

10. 发明授权

US5194073A Sintered composite abrasive materials, a process for its production and its use 失效
标题翻译：烧结复合材料，其生产工艺及其使用
公开(公告)号：US5194073A
公开(公告)日：1993-03-16
申请号：US789759
申请日：1991-11-08
申请人： Gerhard Winter , Paul Moltgen , Dietmar Fister
发明人： Gerhard Winter , Paul Moltgen , Dietmar Fister
IPC分类号： B24D3/14 , C04B35/117 , C04B35/624 , C09K3/14
CPC分类号： C04B35/117 , B24D3/14 , C04B35/624 , C09K3/1418
摘要： Sintered composite abrasive material useful in abrasives (grinding wheels, abrasive discs and paper, etc.) and cutting tools, comprising an .alpha.-Al.sub.2 O.sub.3 matrix of sub-micron crystallite size made by sol-gel processing with a dispersed phase therein of mechanically resistant material, preferably essentially isotropic grains, added directly to the sol or gel stage of matrix formation.
摘要翻译：用于研磨剂（研磨轮，研磨盘和纸等）和切削工具的烧结复合研磨材料，包括通过溶胶 - 凝胶加工制成的亚微米微晶尺寸的α-Al2O3基体，其中分散相具有机械抗性材料，优选基本上各向同性的颗粒，直接添加到基质形成的溶胶或凝胶阶段。

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