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1. 发明授权

US6100046A Methods of identifying modulators of alpha9, a novel acetylcholine-gated ion channel receptor subunit 失效
标题翻译：鉴定α9调节剂的方法，一种新的乙酰胆碱门控离子通道受体亚基
公开(公告)号：US6100046A
公开(公告)日：2000-08-08
申请号：US471961
申请日：1995-06-05
申请人： Ana Belen Elgoyhen , David S. Johnson , James Richard Boulter , Stephen Fox Heinemann
发明人： Ana Belen Elgoyhen , David S. Johnson , James Richard Boulter , Stephen Fox Heinemann
IPC分类号： A01K67/027 , C07K14/705 , C07K16/28 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/08 , C12Q1/68 , G01N33/53
CPC分类号： C07K14/70571 , A01K2217/05
摘要： The present invention provides isolated nucleic acids encoding alpha9 nicotinic acetylcholine receptor subunit and receptor subunit protein encoded thereby. Also provided are vectors containing the invention nucleic acids, host cells transformed therewith, alpha9 nicotinic acetylcholine receptor subunit and functional nicotinic acetylcholine receptors comprising at least one alpha9 subunit expressed recombinantly in such host cells as well as transgenic non-human mammals that express the invention receptor subunit and mutants thereof. Receptors of the invention comprise at least one alpha9 nicotinic acetylcholine subunit and form cationic channels activated by acetylcholine, but blocked by nicotine and muscarine. The invention also provides methods for identifying compounds that modulate the ion channel activity of the functional invention receptors containing at least one invention subunit.
摘要翻译：本发明提供编码α9烟碱型乙酰胆碱受体亚基的分离核酸和由此编码的受体亚基蛋白。还提供了含有本发明的核酸，其转化的宿主细胞，α9烟碱乙酰胆碱受体亚基和功能性烟碱乙酰胆碱受体的载体，其包含在这种宿主细胞中重组表达的至少一个α9亚基以及表达本发明受体的转基因非人哺乳动物亚单位及其突变体。本发明的受体包含至少一个α9烟碱乙酰胆碱亚基，并形成由乙酰胆碱活化但由尼古丁和毒蕈碱胺阻断的阳离子通道。本发明还提供了用于鉴定调节含有至少一个本发明亚单位的功能性受体的离子通道活性的化合物的方法。

2. 发明授权

US6013766A Cloning and expression of a novel acetylcholine-gated ion channel receptor subunit 失效
公开(公告)号：US6013766A
公开(公告)日：2000-01-11
申请号：US464258
申请日：1995-06-05
申请人： Ana Belen Elgoyhen , David S. Johnson , James Richard Boulter , Stephen Fox Heinemann
发明人： Ana Belen Elgoyhen , David S. Johnson , James Richard Boulter , Stephen Fox Heinemann
IPC分类号： A01K67/027 , C07K14/705 , C07K16/28 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/08 , C12Q1/68 , G01N33/53
CPC分类号： C07K14/70571 , A01K2217/05
摘要： The present invention provides isolated nucleic acids encoding alpha9 nicotinic acetylcholine receptor subunit and receptor subunit protein encoded thereby. Also provided are vectors containing the invention nucleic acids, host cells transformed therewith, alpha9 nicotinic acetylcholine receptor subunit and functional nicotinic acetylcholine receptors comprising at least one alpha9 subunit expressed recombinantly in such host cells as well as transgenic non-human mammals that express the invention receptor subunit and mutants thereof. Receptors of the invention comprise at least one alpha9 nicotinic acetylcholine subunit and form cationic channels activated by acetylcholine, but blocked by nicotine and muscarine. The invention also provides methods for identifying compounds that modulate the ion channel activity of the functional invention receptors containing at least one invention subunit.

3. 发明授权

US06646109B1 Cloning and expression of a novel acetylcholine-gated ion channel receptor subunit 失效
标题翻译：新型乙酰胆碱门控离子通道受体亚基的克隆和表达
公开(公告)号：US06646109B1
公开(公告)日：2003-11-11
申请号：US09345109
申请日：1999-06-29
申请人： Ana Belen Elgoyhen , David S. Johnson , James Richard Boulter , Stephen Fox Heinemann
发明人： Ana Belen Elgoyhen , David S. Johnson , James Richard Boulter , Stephen Fox Heinemann
IPC分类号： C07K1628
CPC分类号： C07K14/70571 , A01K2217/05
摘要： The present invention provides isolated nucleic acids encoding alpha9 nicotinic acetylcholine receptor subunit and receptor subunit protein encoded thereby. Also provided are vectors containing the invention nucleic acids, host cells transformed therewith, alpha9 nicotinic acetylcholine receptor subunit and functional nicotinic acetylcholine receptors comprising at least one alpha9 subunit expressed recombinantly in such host cells as well as transgenic non-human mammals that express the invention receptor subunit and mutants thereof. Receptors of the invention comprise at least one alpha9 nicotinic acetylcholine subunit and form cationic channels activated by acetylcholine, but blocked by nicotine and muscarine. The invention also provides methods for identifying compounds that modulate the ion channel activity of the functional invention receptors containing at least one invention subunit.
摘要翻译：本发明提供编码α9烟碱型乙酰胆碱受体亚基的分离核酸和由此编码的受体亚基蛋白。还提供了含有本发明的核酸，其转化的宿主细胞，α9烟碱乙酰胆碱受体亚基和功能性烟碱乙酰胆碱受体的载体，其包含在这种宿主细胞中重组表达的至少一个α9亚基以及表达本发明受体的转基因非人哺乳动物亚单位及其突变体。本发明的受体包含至少一个α9烟碱乙酰胆碱亚基，并形成由乙酰胆碱活化但由尼古丁和毒蕈碱胺阻断的阳离子通道。本发明还提供了用于鉴定调节含有至少一个本发明亚单位的功能性受体的离子通道活性的化合物的方法。

4. 发明授权

US5683912A Cloning and expression of a novel acetylcholine-gated ion channel receptor subunit 失效
标题翻译：新型乙酰胆碱门控离子通道受体亚基的克隆和表达
公开(公告)号：US5683912A
公开(公告)日：1997-11-04
申请号：US278635
申请日：1994-07-21
申请人： Ana Belen Elgoyhen , David S. Johnson , James Richard Boulter , Stephen Fox Heinemann
发明人： Ana Belen Elgoyhen , David S. Johnson , James Richard Boulter , Stephen Fox Heinemann
IPC分类号： A01K67/027 , C07K14/705 , C07K16/28 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/08 , C12Q1/68 , G01N33/53
CPC分类号： C07K14/70571 , A01K2217/05
摘要： The present invention provides isolated nucleic acids encoding alpha9 nicotinic acetylcholine receptor subunit and receptor subunit protein encoded thereby. Also provided are vectors containing the invention nucleic acids, host cells transformed therewith, alpha9 nicotinic acetylcholine receptor subunit and functional nicotinic acetylcholine receptors comprising at least one alpha9 subunit expressed recombinantly in such host cells as well as transgenic non-human mammals that express the invention receptor subunit and mutants thereof. Receptors of the invention comprise at least one alpha9 nicotinic acetylcholine subunit and form cationic channels activated by acetylcholine, but blocked by nicotine and muscarine. The invention also provides methods for identifying compounds that modulate the ion channel activity of the functional invention receptors containing at least one invention subunit.
摘要翻译：本发明提供编码α9烟碱型乙酰胆碱受体亚基的分离核酸和由此编码的受体亚基蛋白。还提供了含有本发明的核酸，其转化的宿主细胞，α9烟碱乙酰胆碱受体亚基和功能性烟碱乙酰胆碱受体的载体，其包含在这种宿主细胞中重组表达的至少一个α9亚基以及表达本发明受体的转基因非人哺乳动物亚单位及其突变体。本发明的受体包含至少一个α9烟碱乙酰胆碱亚基，并形成由乙酰胆碱活化但由尼古丁和毒蕈碱胺阻断的阳离子通道。本发明还提供了用于鉴定调节含有至少一个本发明亚单位的功能性受体的离子通道活性的化合物的方法。

5. 发明授权

US5629869A Intelligent circuit breaker providing synchronous switching and condition monitoring 失效
公开(公告)号：US5629869A
公开(公告)日：1997-05-13
申请号：US226274
申请日：1994-04-11
申请人： David S. Johnson , Aftab H. Khan , Paul H. Stiller , Jeffry R. Meyer
发明人： David S. Johnson , Aftab H. Khan , Paul H. Stiller , Jeffry R. Meyer
IPC分类号： H01H11/00 , H01H33/59 , G07C3/00
CPC分类号： H01H33/593 , H01H11/0062 , H01H2011/0068
摘要： An intelligent circuit breaker or switching device system comprises three separate microprocessor-based units, including a condition monitoring unit (CMU) 40, a breaker control unit (BCU) 50, and a synchronous control unit (SCU) 60. The CMU 40 provides detailed diagnostic information by monitoring key quantities associated with circuit breaker or switching device reliability. On-line analysis performed by the CMU provides information facilitating the performance of maintenance as needed and the identification of impending failures. The BCU 50 is a programmable system having self-diagnostic and remote communications. The BCU replaces the conventional electromechanical control circuits typically employed to control a circuit breaker or switching device. The SCU 60 provides synchronous switching control for both closing and opening the circuit interrupters. The control processes carried out by the SCU reduce system switching transients and interrupter wear. The intelligent circuit breaker or switching device system improves system operation and equipment maintenance.

6. 发明申请

US20080032575A1 IMPACT RESISTANT SURFBOARD 审中-公开
标题翻译：抗冲击波纹管
公开(公告)号：US20080032575A1
公开(公告)日：2008-02-07
申请号：US11462753
申请日：2006-08-07
申请人： Michael D. Wyrsta , David S. Johnson
发明人： Michael D. Wyrsta , David S. Johnson
IPC分类号： A63C5/03
CPC分类号： B63B35/7909
摘要： Waterboards such as surfboards are described that are formed of a combination of a resilient foam core with an outer shell of polycarbonate or polyurethane. Such waterboards may further include fibrous material bonded to or embedded in the outer shell for additional strength.
摘要翻译：描述了诸如冲浪板的水板，其由弹性泡沫芯与聚碳酸酯或聚氨酯的外壳的组合形成。这种水板还可以包括结合到外壳或嵌入外壳中的纤维材料，以增加强度。

7. 发明授权

US07102101B1 High voltage circuit breaker with internal tank heater 有权
标题翻译：高压断路器带内部加热器
公开(公告)号：US07102101B1
公开(公告)日：2006-09-05
申请号：US11244926
申请日：2005-10-06
申请人： David S. Johnson , Jeffry R. Meyer , Daniel C. Schiffbauer
发明人： David S. Johnson , Jeffry R. Meyer , Daniel C. Schiffbauer
IPC分类号： H05B1/00
CPC分类号： H01H33/562
摘要： A high voltage circuit breaker with a gas-insulated tank is provided. Enclosed with the tank is an elongated heater having at least one heating element enclosed in an outer tube. The heater is located coaxially within the tank and is surrounded by the insulating gas.
摘要翻译：提供具有气体绝缘箱的高压断路器。用罐封闭的是细长加热器，其具有封闭在外管中的至少一个加热元件。加热器同轴地位于罐内并被绝缘气体包围。

8. 发明授权

US5466891A Conical composite SF.sub.6 high voltage bushing with floating shield 失效
标题翻译：锥形复合SF6高压套管带浮动屏蔽
公开(公告)号：US5466891A
公开(公告)日：1995-11-14
申请号：US225239
申请日：1994-04-08
申请人： Willie B. Freeman , David S. Johnson , Klaus B. Froehlich
发明人： Willie B. Freeman , David S. Johnson , Klaus B. Froehlich
IPC分类号： H01B17/28 , H01B17/26
CPC分类号： H01B17/28
摘要： The present invention provides a floating shield for a high voltage bushing. Preferably the bushing is conically shaped and has a composite housing for substantially optimizing the electrical performance of the bushing according to the invention. The floating shield is preferably suspended within the bushing housing by a supporting insulator placed in a low electrical stress region of the bushing. In a preferred embodiment, the supporting insulator is disposed between a ground grading shield and the bushing housing. The composite housing preferably provides a protective inner tube made of a fiber reinforced material and an outer silicone rubber housing having weather sheds formed in a helix on the surface of the housing.
摘要翻译：本发明提供一种用于高压套管的浮动屏蔽。优选地，衬套是圆锥形的并且具有用于基本上优化根据本发明的衬套的电性能的复合壳体。浮动屏蔽优选地通过布置在衬套的低电应力区域中的支撑绝缘体悬挂在衬套壳体内。在优选实施例中，支撑绝缘体设置在地平面屏蔽和衬套壳体之间。复合外壳优选地提供由纤维增强材料制成的保护性内管和外部硅橡胶外壳，其具有在壳体的表面上以螺旋形式形成的天气棚。

9. 发明授权

US4271648A Subterranean drain system for basements 失效
标题翻译：地下水排水系统
公开(公告)号：US4271648A
公开(公告)日：1981-06-09
申请号：US72440
申请日：1979-09-04
申请人： David S. Johnson
发明人： David S. Johnson
IPC分类号： E02D31/02 , E04B1/70 , E02D19/00
CPC分类号： E02D31/02 , E04B1/7023
摘要： An apparatus for relieving static subterranean water heads surrounding subterranean walls which includes a perforated hollow sleeve arranged to extend through the subterranean wall and into a surrounding static water head. The sleeve has distal and proximal ends, with a plurality of spaced perforations being formed in the wall of the sleeve substantially along the length thereof. The distal end is tapered substantially to a pointed tip, and the tapered tip portion is of generally solid construction. A flanged coupling means is formed adjacent the proximal end for coupling water conduits internally thereof. When desirable, an imperforate sleeve means may be provided adjacent the proximal end for rendering a portion of the perforated hollow sleeve adjacent the proximal end substantially watertight, thereby protecting paneling which may be pre-positioned in the subterranean wall.
摘要翻译：一种用于缓解围绕地下壁的静态地下水头的装置，其包括布置成延伸穿过地下壁并进入周围的静态水头的穿孔中空套筒。套筒具有远端和近端，基本沿着其长度在套筒的壁上形成有多个隔开的穿孔。该远端基本上成锥形尖端，并且该锥形尖端部分具有一般的坚固结构。法兰连接装置邻近近端形成，用于在其内部连接水管道。当需要时，可以邻近近端设置无孔套筒装置，以使穿孔中空套管的一部分邻近近端基本上防水，从而保护预定位于地下壁中的镶板。

10. 发明申请

US20110092763A1 Methods for Embryo Characterization and Comparison 审中-公开
标题翻译：胚胎表征与比较方法
公开(公告)号：US20110092763A1
公开(公告)日：2011-04-21
申请号：US12994260
申请日：2009-05-27
申请人： Matthew Rabinowitz , David S. Johnson , Nigam Shah , George Gemelos
发明人： Matthew Rabinowitz , David S. Johnson , Nigam Shah , George Gemelos
IPC分类号： A61B17/435 , G06F19/00
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： Disclosed herein are methods for determining which embryos from a group of embryos are most likely to implant and develop as desired. In an embodiment of the present disclosure, one or more cells are biopsied from each of the embryos, and the genetic condition of those cells are determined. Within a group of embryos that each test positive for aneuploidy, the likelihood that each embryo contains euploid cells may be determined from the type of aneuploidy observed in the biopsied cells. This knowledge may be used to make a decision as to which embryos to transfer to a uterus. In an embodiment of the present disclosure, these determinations are made for the purpose of embryo selection in the context of in vitro fertilization.
摘要翻译：本文公开了用于根据需要确定来自一组胚胎最可能植入和发育的胚胎的方法。在本公开的一个实施方案中，从每个胚胎活检一个或多个细胞，并确定那些细胞的遗传条件。在一组胚胎中，每个胚胎均检测到非整倍体阳性，每个胚胎含有整倍体细胞的可能性可以从活检细胞中观察到的非整倍体类型确定。这些知识可能用于决定哪些胚胎转移到子宫。在本公开的一个实施方案中，这些确定是为了在体外受精的背景下进行胚胎选择的目的。

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