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1. 发明申请

US20110092763A1 Methods for Embryo Characterization and Comparison 审中-公开
标题翻译：胚胎表征与比较方法
公开(公告)号：US20110092763A1
公开(公告)日：2011-04-21
申请号：US12994260
申请日：2009-05-27
申请人： Matthew Rabinowitz , David S. Johnson , Nigam Shah , George Gemelos
发明人： Matthew Rabinowitz , David S. Johnson , Nigam Shah , George Gemelos
IPC分类号： A61B17/435 , G06F19/00
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： Disclosed herein are methods for determining which embryos from a group of embryos are most likely to implant and develop as desired. In an embodiment of the present disclosure, one or more cells are biopsied from each of the embryos, and the genetic condition of those cells are determined. Within a group of embryos that each test positive for aneuploidy, the likelihood that each embryo contains euploid cells may be determined from the type of aneuploidy observed in the biopsied cells. This knowledge may be used to make a decision as to which embryos to transfer to a uterus. In an embodiment of the present disclosure, these determinations are made for the purpose of embryo selection in the context of in vitro fertilization.
摘要翻译：本文公开了用于根据需要确定来自一组胚胎最可能植入和发育的胚胎的方法。在本公开的一个实施方案中，从每个胚胎活检一个或多个细胞，并确定那些细胞的遗传条件。在一组胚胎中，每个胚胎均检测到非整倍体阳性，每个胚胎含有整倍体细胞的可能性可以从活检细胞中观察到的非整倍体类型确定。这些知识可能用于决定哪些胚胎转移到子宫。在本公开的一个实施方案中，这些确定是为了在体外受精的背景下进行胚胎选择的目的。

2. 发明申请

US20070178501A1 System and method for integrating and validating genotypic, phenotypic and medical information into a database according to a standardized ontology 审中-公开
标题翻译：根据标准化本体将基因型，表型和医学信息整合并验证成数据库的系统和方法
公开(公告)号：US20070178501A1
公开(公告)日：2007-08-02
申请号：US11634550
申请日：2006-12-06
申请人： Matthew Rabinowitz , Jonathan Sheena , Zachary Demko , Christopher Clark , Nigam Shah
发明人： Matthew Rabinowitz , Jonathan Sheena , Zachary Demko , Christopher Clark , Nigam Shah
IPC分类号： C12Q1/68 , G06F19/00 , G06Q50/00
CPC分类号： G06Q50/22 , G06Q50/24
摘要： The system described herein enables clinicians and researchers to use aggregated genetic and phenotypic data from clinical trials and medical records to make the safest, most effective treatment decisions for each patient. This involves (i) the creation of a standardized ontology for genetic, phenotypic, clinical, pharmacokinetic, pharmacodynamic and other data sets, (ii) the creation of a translation engine to integrate heterogeneous data sets into a database using the standardized ontology, and (iii) the development of statistical methods to perform data validation and outcome prediction with the integrated data. The system is designed to interface with patient electronic medical records (EMRs) in hospitals and laboratories to extract a particular patient's relevant data. The system may also be used in the context of generating phenotypic predictions and enhanced medical laboratory reports for treating clinicians. The system may also be used in the context of leveraging the huge amount of data created in medical and pharmaceutical clinical trials. The ontology and validation rules are designed to be flexible so as to accommodate a disparate set of clients. The system is also designed to be flexible so that it can change to accommodate scientific progress and remain optimally configured.
摘要翻译：本文描述的系统使临床医师和研究人员能够使用来自临床试验和医疗记录的综合遗传和表型数据，为每位患者做出最安全，最有效的治疗决定。这涉及（i）为遗传，表型，临床，药代动力学，药效学和其他数据集创建标准化本体，（ii）创建翻译引擎以将异构数据集合集成到使用标准化本体的数据库中，以及（ iii）开发统计方法，使用综合数据进行数据验证和结果预测。该系统旨在与医院和实验室中的患者电子病历（EMR）进行接口，以提取特定患者的相关数据。该系统也可用于产生表型预测和增强的用于治疗临床医师的医学实验室报告。该系统也可以在利用在医疗和药物临床试验中创造的大量数据的背景下使用。本体和验证规则被设计为灵活的，以容纳不同的客户端集合。该系统还被设计为灵活的，以便它可以改变以适应科学进步并保持最佳配置。

3. 发明申请

US20130096944A1 Method and System for Ontology Based Analytics 审中-公开
标题翻译：基于本体的分析方法与系统
公开(公告)号：US20130096944A1
公开(公告)日：2013-04-18
申请号：US13273038
申请日：2011-10-13
申请人： Nigam Shah , Mark A. Musen
发明人： Nigam Shah , Mark A. Musen
IPC分类号： G06Q50/24
CPC分类号： G06Q50/24 , G06F19/326 , G16H50/70
摘要： The present invention provides a mechanism to use terminologies and ontologies for the purpose of indexing, annotating and semantically marking up existing collections of datasets. The invention further provides a system for incorporating terminologies, ontologies, and contextual annotation in specific domains, such as utilizing biomedical concept hierarchies in data analytics. The resulting rich structure supports specific mechanisms for data mining and machine learning.
摘要翻译：本发明提供了一种用于为索引，注释和语义地标记现有数据集合的目的而使用术语和本体的机制。本发明还提供了一种用于在特定领域中并入术语，本体和上下文注释的系统，例如在数据分析中利用生物医学概念层次。结果丰富的结构支持数据挖掘和机器学习的特定机制。

4. 发明申请

US20130096947A1 Method and System for Ontology Based Analytics 审中-公开
公开(公告)号：US20130096947A1
公开(公告)日：2013-04-18
申请号：US13424376
申请日：2012-03-20
申请人： Nigam Shah , Paea LePendu , Srinivasan Iyer
发明人： Nigam Shah , Paea LePendu , Srinivasan Iyer
IPC分类号： G06Q50/24
CPC分类号： G06Q50/24
摘要： The present invention provides a mechanism to use terminologies and ontologies for the purpose of indexing, annotating and semantically marking up existing collections of datasets. The invention further provides a system for incorporating terminologies, ontologies, and contextual annotation in specific domains, such as utilizing biomedical concept hierarchies in data analytics. The resulting rich structure supports specific mechanisms for data mining and machine learning.

5. 发明申请

US20130096946A1 Method and System for Ontology Based Analytics 审中-公开
公开(公告)号：US20130096946A1
公开(公告)日：2013-04-18
申请号：US13424375
申请日：2012-03-19
申请人： Nigam Shah , Paea LePendu , Srinivasan Iyer , Yi Liu
发明人： Nigam Shah , Paea LePendu , Srinivasan Iyer , Yi Liu
IPC分类号： G06Q50/24
CPC分类号： G06Q50/24
摘要： The present invention provides a mechanism to use terminologies and ontologies for the purpose of indexing, annotating and semantically marking up existing collections of datasets. The invention further provides a system for incorporating terminologies, ontologies, and contextual annotation in specific domains, such as utilizing biomedical concept hierarchies in data analytics. The resulting rich structure supports specific mechanisms for data mining and machine learning.

6. 发明申请

US20130096945A1 Method and System for Ontology Based Analytics 审中-公开
公开(公告)号：US20130096945A1
公开(公告)日：2013-04-18
申请号：US13420402
申请日：2012-03-14
申请人： Nigam Shah , Mark A. Musen , Paea LePendu
发明人： Nigam Shah , Mark A. Musen , Paea LePendu
IPC分类号： G06Q50/24
CPC分类号： G06Q50/24 , G06F19/326 , G16H50/70
摘要： The present invention provides a mechanism to use terminologies and ontologies for the purpose of indexing, annotating and semantically marking up existing collections of datasets. The invention further provides a system for incorporating terminologies, ontologies, and contextual annotation in specific domains, such as utilizing biomedical concept hierarchies in data analytics. The resulting rich structure supports specific mechanisms for data mining and machine learning.

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