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1. 发明授权

US5155022A Assay for lyme disease 失效
标题翻译：测定LYME疾病
公开(公告)号：US5155022A
公开(公告)日：1992-10-13
申请号：US652681
申请日：1991-02-08
申请人： Ali Naqui , Liane F. Gossett , James P. Mapes
发明人： Ali Naqui , Liane F. Gossett , James P. Mapes
IPC分类号： G01N33/569 , G01N33/58
CPC分类号： G01N33/586 , G01N33/56911 , Y10S435/962 , Y10S435/975 , Y10S436/80 , Y10S436/808 , Y10S436/81 , Y10S436/811 , Y10S436/825 , Y10S436/829 , Y10T436/25 , Y10T436/25125
摘要： Diagnosis of Lyme disease by immunoassay for anti-Borrelia burgdorferi antibodies in the serum of a patient includes adsorption of crossreactive antibodies in the serum with antigen of Acinetobacter calcoaceticus or Treponema phagedensis prior to binding of anti-Borrelia antibodies to Borrelia burgdorferi antigen absorbed onto a solid support. The preferred assay is a flow-through assay using a porous membrane as the support and a dye-loaded liposome conjugated to a goat antihuman antibody for detection. The invention includes a kit of materials for performing the assay.

2. 发明授权

US5753456A Method for quantification of biological material in a liquid sample 失效
标题翻译：液体样品中生物材料定量方法
公开(公告)号：US5753456A
公开(公告)日：1998-05-19
申请号：US394315
申请日：1995-02-22
申请人： Ali Naqui , Mark W. Pierson , Thomas R. Weschler , Stephen C. Wardlaw , Michael P. Finnerty , Charles R. Carpenter
发明人： Ali Naqui , Mark W. Pierson , Thomas R. Weschler , Stephen C. Wardlaw , Michael P. Finnerty , Charles R. Carpenter
IPC分类号： G01N33/487 , B01L3/00 , B65D75/32 , B65D75/34 , B65D75/36 , B65D75/40 , C12M1/34 , C12Q1/04 , C12Q1/02
CPC分类号： B01L3/5085 , B01L3/505 , B65D75/324 , C12Q1/04 , G01N2333/245 , Y10S435/81 , Y10S435/975
摘要： An article adapted for holding a liquid sample for quantification of biological material in the liquid sample. The article includes a bag having an upper surface sheet and a lower surface sheet enclosing a volume therebetween. The bag has an upper opening through which the liquid sample can be poured into the volume in the bag. The bag also has a plurality of partitions configured to separate one or more portions of adequate sample in the bag. Also provided is a passage through which a liquid sample can be distributed throughout the volume in the bag. The bag is made of material which can be caused to form discreet non-permeable compartments for holding separate aliquots of the liquid sample.
摘要翻译：一种用于容纳用于定量液体样品中的生物材料的液体样品的制品。该物品包括具有上表面片和在其间包围体积的下表面片的袋。该袋具有上部开口，液体样品可以通过该上部开口倒入袋中的体积中。该袋还具有多个分隔件，其被配置为分离袋中足够样品的一个或多个部分。还提供了一种通道，液体样品可通过该通道分布在袋中的整个体积中。该袋由材料制成，其可以形成离散的非渗透性隔室，用于保持液体样品的单独等分试样。

3. 发明授权

US07384778B2 Methods and devices for the detection of pathogenic microorganisms and their antimicrobial susceptibility 有权
标题翻译：用于检测病原微生物及其抗菌药物敏感性的方法和装置
公开(公告)号：US07384778B2
公开(公告)日：2008-06-10
申请号：US10340569
申请日：2003-01-09
申请人： Chun-Ming Chen , Charles Carpenter , Haoyi Gu , Ali Naqui , Gary Madsen , Thomas O'Connor, Jr. , Katherine Jean Esty
发明人： Chun-Ming Chen , Charles Carpenter , Haoyi Gu , Ali Naqui , Gary Madsen , Thomas O'Connor, Jr. , Katherine Jean Esty
IPC分类号： C12M1/34 , C12Q1/04
CPC分类号： B01L3/50853 , B01L2300/045 , B01L2300/0809 , C12Q1/04 , C12Q1/18
摘要： The present invention provides devices and methods for determining the presence or absence of pathogens in a biological sample and for the concurrent determination of the antimicrobial susceptibility of pathogens present. The devices and methods of the present invention are able to make the determinations without pre-selection of target bacteria. Instead, all organisms from the sample are applied to the device. In wells where one or more antimicrobial agents are present only pathogens resistant to the antimicrobial agent grow. This allows the user to determine the presence of target pathogens and concurrently determine the resistance patterns of the organisms without the need to subculture the organisms. The present invention also provides methods of performing a business service of performing the determinations described above, and kits containing the devices and descriptions of the methods.
摘要翻译：本发明提供用于确定生物样品中病原体的存在或不存在以及同时测定存在的病原体的抗微生物易感性的装置和方法。本发明的装置和方法能够在不预先选择目标细菌的情况下进行测定。相反，将来自样品的所有生物体施加到装置上。在存在一种或多种抗微生物剂的孔中，只有抗微生物剂抗性的病原体生长。这允许用户确定目标病原体的存在并且同时确定生物体的抗性模式，而不需要传代培养生物体。本发明还提供了执行上述确定的业务服务的方法，以及包含所述设备的方法和所述方法的描述的套件的方法。

4. 发明申请

US20070065894A1 Method for quantification of biological material in a sample 审中-公开
标题翻译：用于定量样品中生物材料的方法
公开(公告)号：US20070065894A1
公开(公告)日：2007-03-22
申请号：US11526147
申请日：2006-09-21
申请人： Andrew Croteau , Mark Pierson , David Townsend , Ali Naqui
发明人： Andrew Croteau , Mark Pierson , David Townsend , Ali Naqui
IPC分类号： C12Q1/34 , C12M3/00
CPC分类号： B01L3/5088 , B01L3/5085 , B01L3/50853 , B01L2300/0803 , C12M23/12 , C12M23/20 , C12M23/22 , C12M23/38 , C12M25/14 , C12M35/08 , C12M37/00 , C12M41/36 , C12Q1/24
摘要： Methods for the detection and/or quantification of a biological material in a sample. The method includes the steps of liquefying the sample (if necessary) and pouring the liquefied sample into the incubation vessel. The incubation vessel has a generally flat horizontal surface and the surface is divided into at least one incubation site. Each incubation site is adapted to hold an aliquot of liquid and is sized and shaped, and formed of a suitable material, to hold the aliquot within the well by surface tension. Any excess liquid from the liquefied sample is poured from the surface of the incubation vessel. The method then involves incubating that incubation vessel until the presence or absence of the biological material is determined. The presence of air bubbles can be dramatically reduced by the presence of a surface acting agent in the liquid sample deposited on the device surface. Such an agent can be added to the sterile diluent used to prepare the test reagent, can be separately added to the test reagent after it is prepared, or can be added to the test sample directly while it is being prepared for testing.
摘要翻译：用于检测和/或定量样品中生物材料的方法。该方法包括如下步骤：将样品液化（如有必要）并将液化的样品倒入培养容器中。培养容器具有大致平坦的水平表面，并且将表面分成至少一个孵育位点。每个孵化位点适于保持液体的等分试样，并且其尺寸和形状由合适的材料形成，以通过表面张力将等分试样保持在孔内。从培养容器的表面倒出来自液化样品的任何多余的液体。然后，该方法包括孵育该培养容器，直到确定生物材料的存在或不存在。通过在沉积在器件表面上的液体样品中存在表面作用剂，可以显着降低气泡的存在。可以将这样的试剂加入用于制备测试试剂的无菌稀释剂中，可以在制备试剂后分别添加到试验试剂中，或者可以在制备试剂时直接加入试验样品中。

5. 发明授权

US06509168B2 Method for quantification of biological material in a sample 有权
公开(公告)号：US06509168B2
公开(公告)日：2003-01-21
申请号：US09838590
申请日：2001-04-18
申请人： Andrew J. Croteau , Mark W. Pierson , David E. Townsend , Ali Naqui
发明人： Andrew J. Croteau , Mark W. Pierson , David E. Townsend , Ali Naqui
IPC分类号： C12Q124
CPC分类号： B01L3/5088 , B01L3/5085 , C12M23/10 , C12M23/12 , C12M23/20 , C12M23/38 , C12M41/36
摘要： Method for detection of a biological material in a sample. The method includes the steps of liquifying the sample (if necessary) and pouring the liquified sample into the incubation plate. The incubation plate has a generally flat horizontal surface and the surface is divided into a plurality of at least 20 recessed wells. Each well is adapted to hold an aliquot of liquid and is sized and shaped, and formed of a suitable material, to hold the aliquot within the well by surface tension. Any excess liquid from the liquified sample is poured from the surface of the plate. The method then involves incubating that incubation plate until the presence or absence of the biological material is determined.

6. 发明授权

US06287797B1 Method for quantification of biological material in a sample 有权
标题翻译：用于定量样品中生物材料的方法
公开(公告)号：US06287797B1
公开(公告)日：2001-09-11
申请号：US09277522
申请日：1999-03-26
申请人： Andrew J. Croteau , Mark W. Pierson , David E. Townsend , Ali Naqui
发明人： Andrew J. Croteau , Mark W. Pierson , David E. Townsend , Ali Naqui
IPC分类号： C12Q124
CPC分类号： B01L3/5088 , B01L3/5085 , C12M23/10 , C12M23/12 , C12M23/20 , C12M23/38 , C12M41/36
摘要： Method for detection of a biological material in a sample. The method includes the steps of liquifying the sample (if necessary) and pouring the liquified sample into the incubation plate. The incubation plate has a generally flat horizontal surface and the surface is divided into a plurality of at least 20 recessed wells. Each well is adapted to hold an aliquot of liquid and is sized and shaped, and formed of a suitable material, to hold the aliquot within the well by surface tension. Any excess liquid from the liquified sample is poured from the surface of the plate. The method then involves incubating that incubation plate until the presence or absence of the biological material is determined.
摘要翻译：检测样品中生物材料的方法。该方法包括将样品液化（如果需要）并将液化样品倒入培养板中的步骤。培养板具有大致平坦的水平表面，并且表面被分成多个至少20个凹入的孔。每个孔适于保持液体的等分试样，并且其尺寸和形状由合适的材料形成，以通过表面张力将等分试样保持在孔内。从液体样品的任何多余液体从板的表面倒出。然后该方法包括孵育该培养板直到确定生物材料的存在或不存在。

7. 发明授权

US07122338B2 Method for quantification of biological material in a sample 有权
标题翻译：用于定量样品中生物材料的方法
公开(公告)号：US07122338B2
公开(公告)日：2006-10-17
申请号：US10349196
申请日：2003-01-21
申请人： Andrew J. Crouteau , Mark W. Pierson , David E. Townsend , Ali Naqui
发明人： Andrew J. Crouteau , Mark W. Pierson , David E. Townsend , Ali Naqui
IPC分类号： C12Q1/24
CPC分类号： B01L3/5088 , B01L3/5085 , B01L3/50853 , B01L2300/0803 , C12M23/12 , C12M23/20 , C12M23/22 , C12M23/38 , C12M25/14 , C12M35/08 , C12M37/00 , C12M41/36 , C12Q1/24
摘要： Methods for the detection and/or quantification of a biological material in a sample. The method includes the steps of liquefying the sample (if necessary) and pouring the liquefied sample into the incubation vessel. The incubation vessel has a generally flat horizontal surface and the surface is divided into at least one incubation site. Each incubation site is adapted to hold an aliquot of liquid and is sized and shaped, and formed of a suitable material, to hold the aliquot within the well by surface tension. Any excess liquid from the liquefied sample is poured from the surface of the incubation vessel. The method then involves incubating that incubation vessel until the presence or absence of the biological material is determined. The presence of air bubbles can be dramatically reduced by the presence of a surface acting agent in the liquid sample deposited on the device surface. Such an agent can be added to the sterile diluent used to prepare the test reagent, can be separately added to the test reagent after it is prepared, or can be added to the test sample directly while it is being prepared for testing.
摘要翻译：用于检测和/或定量样品中生物材料的方法。该方法包括如下步骤：将样品液化（如有必要）并将液化的样品倒入培养容器中。培养容器具有大致平坦的水平表面，并且将表面分成至少一个孵育位点。每个孵化位点适于保持液体的等分试样，并且其尺寸和形状由合适的材料形成，以通过表面张力将等分试样保持在孔内。从培养容器的表面倒出来自液化样品的任何多余的液体。然后，该方法包括孵育该培养容器，直到确定生物材料的存在或不存在。通过在沉积在器件表面上的液体样品中存在表面作用剂，可以显着降低气泡的存在。可以将这样的试剂加入用于制备测试试剂的无菌稀释剂中，可以在制备试剂后分别添加到试验试剂中，或者可以在制备试剂时直接加入试验样品中。

8. 发明授权

US06060266A Self-contained incubator for growth of microorganism 失效
标题翻译：用于微生物生长的独立孵化器
公开(公告)号：US06060266A
公开(公告)日：2000-05-09
申请号：US43960
申请日：1998-09-28
申请人： Ali Naqui , Erwin F. Workman, Jr. , Haoyi Gu , Mark W. Pierson
发明人： Ali Naqui , Erwin F. Workman, Jr. , Haoyi Gu , Mark W. Pierson
IPC分类号： C12M1/02 , C12M1/12 , C12M1/24 , C12Q1/04 , C12Q1/02 , C12N1/12 , G01N33/53
CPC分类号： C12M23/08 , C12M23/38 , C12M23/54 , C12M41/14 , F24J1/00 , Y10S435/848 , Y10S435/849 , Y10S435/975
摘要： A self-contained incubator for growth of microorganism kit and methods for use of such a kit are provided. The kit and methods may detect the presence of microorganisms and may utilie a microorganism growth and indicator medium provided in a sample container along with a heat source, preferably generating heat through chemical means, and optionally heat shields, allowing for on-site testing of a microorganism present in a sample. The sample container may also include a removable vessel cap that includes a barrier separating the sample from a material capable of disinfecting the sample, thereby preventing contact of the sample and the material for a desired time period. The vessel cap may also be used independently in other applications.
摘要翻译： PCT No.PCT / US96 / 15525 Sec。 371日期：1998年9月28日 102（e）1998年9月28日PCT PCT 1996年9月27日PCT公布。第WO97 / 12029号公报日期1997年4月3日提供了用于生长微生物试剂盒的独立培养箱和使用这种试剂盒的方法。试剂盒和方法可以检测微生物的存在，并且可以利用提供在样品容器中的微生物生长和指示剂介质以及热源，优选通过化学方法产生热量，并且可选地加热屏蔽，允许现场测试存在于样品中的微生物。样品容器还可以包括可移除的容器盖，其包括将样品与能够对样品进行消毒的材料隔离的屏障，从而防止样品和材料在期望的时间段内接触。容器盖也可以在其它应用中独立使用。

9. 发明授权

US5166054A Method for immunoassay using lactoperoxidase, starch and iodine 失效
标题翻译：使用乳过氧化物酶，淀粉和碘的免疫测定方法
公开(公告)号：US5166054A
公开(公告)日：1992-11-24
申请号：US636800
申请日：1991-01-02
申请人： Ali Naqui
发明人： Ali Naqui
IPC分类号： C12Q1/28 , G01N33/58
CPC分类号： G01N33/581 , C12Q1/28
摘要： A method for immoassay includes a membrane coated with a capture antibody and starch. A solution suspected of containing an antigen is passed through the membrane. Antigen binds to the capture antibody. A conjugate of a detection antibody and lactoperoxidase is passed through the membrane to form a sandwich on the membrane. A substrate composition including peroxide and iodide is passed through. The lactoperoxidase catalyzes oxidation of iodide by the peroxide to give iodine which reacts with the starch to give a blue color. The invention includes a kit of materials for performing the assay of the invention.
摘要翻译：非免疫测定方法包括涂覆有捕获抗体和淀粉的膜。怀疑含有抗原的溶液通过膜。抗原结合捕获抗体。检测抗体和乳过氧化物酶的缀合物通过膜以在膜上形成三明治。包含过氧化物和碘化物的底物组合物通过。乳过氧化物酶催化由过氧化物氧化碘化物，得到与淀粉反应的碘，得到蓝色。本发明包括用于进行本发明测定的一组材料。

10. 发明授权

US06984499B2 Method and apparatus for concurrently detecting pathogenic organisms and antimicrobial susceptibility 失效
标题翻译：同时检测病原菌和抗菌药物敏感性的方法和装置
公开(公告)号：US06984499B2
公开(公告)日：2006-01-10
申请号：US08942369
申请日：1997-10-02
申请人： Chun-Ming Chen , Charles R. Carpenter , Haoyi Gu , Ali Naqui
发明人： Chun-Ming Chen , Charles R. Carpenter , Haoyi Gu , Ali Naqui
IPC分类号： C12Q1/04 , C12Q1/18
CPC分类号： C12Q1/20 , C12Q1/08
摘要： The present invention relates to a method of detecting the presence of target microorganisms in a biological sample and of simultaneously determining the susceptibility of the microorganisms to antimicrobial agents. The target microbial organisms may be urinary pathogens. The methods include the steps of providing a multicompartment assay device with at least one compartment containing a medium capable of sustaining the growth of total viable microorganisms, at least one compartment containing a medium capable of sustaining the growth of target microorganisms, and at least one compartment containing an antimicrobial susceptibility interpretation medium. A biological sample is placed in each compartment and the presence and antimicrobial susceptibility of the target microorganisms which may be present is determined by analyzing which compartments exhibit microbial growth.
摘要翻译：本发明涉及一种检测生物样品中目标微生物的存在并同时测定微生物对抗微生物剂的敏感性的方法。目标微生物可能是尿病原体。所述方法包括以下步骤：提供具有至少一个隔室的步骤，所述隔室包含能够维持总存活微生物生长的培养基，至少一个含有能够维持靶微生物生长的培养基的隔室，以及至少一个室含有抗微生物敏感性解释培养基。将生物样品置于每个隔室中，通过分析哪些隔室呈现微生物生长来确定可能存在的目标微生物的存在和抗微生物敏感性。

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