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    • 3. 发明授权
    • Device and method for integrated diagnostics with multiple independent flow paths
    • 具有多个独立流路的集成诊断的装置和方法
    • US06436722B1
    • 2002-08-20
    • US09551496
    • 2000-04-18
    • Scott M. ClarkRobert H. SuvaMichael R. KepronStanislaw Barski, Jr.Erwin F. Workman, Jr.
    • Scott M. ClarkRobert H. SuvaMichael R. KepronStanislaw Barski, Jr.Erwin F. Workman, Jr.
    • G01N33543
    • G01N33/558G01N33/54366Y10T436/11Y10T436/12Y10T436/255
    • Invention performs an assay to determine presence or quantity of specific analyte in fluid sample. Representative device has two separate flow paths established sequentially in device with a single user activation step. First flow path delivers sample, and conjugate soluble binding reagents to solid phase. If analyte is present, an analyte:conjugate complex is formed and immobilized. Sample volume delivered by first path determined by absorbent capacity of solid phase, and not by amount of sample added to device. User need not measure sample volume. Sample/conjugate mixture is prevented from entering second flow path because capillary and surface energy of second flow path prevent it from being wetted by this mixture. Second flow path allows wash reagent to remove unbound conjugate and sample from solid phase to the absorbant, and optionally deliver detection reagents. Adaptable for many formats including, sandwich immunoassays, colloidal gold, sol particle, heterogeneous generic capture, and competitive assays.
    • 本发明进行测定以确定流体样品中特定分析物的存在或数量。 代表性设备具有在具有单个用户激活步骤的设备中顺序建立的两个单独的流路径。 第一流路将样品和可溶性结合试剂结合到固相中。 如果存在分析物,则形成并固定分析物:缀合物。 由第一路径输送的样品体积由固相的吸收能力确定,而不是通过添加到设备的样品量。 用户不需要测量样品量。 防止样品/共轭物混合物进入第二流路,因为第二流路的毛细管和表面能阻止其被该混合物润湿。 第二流路允许洗涤剂将未结合的结合物和样品从固相除去到吸收剂,并且任选地递送检测试剂。 适用于多种形式,包括夹心免疫测定,胶体金,溶胶颗粒,异种通用捕获和竞争性测定。