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1. 发明申请

US20090087377A1 COMPOSITIONS FOR TARGETED IMAGING AND THERAPY 有权
标题翻译：用于定向成像和治疗的组合物
公开(公告)号：US20090087377A1
公开(公告)日：2009-04-02
申请号：US12057066
申请日：2008-03-27
申请人： Ali Azhdarinia , Ebrahim S. Delpassand , Izabela Tworowska , Jennifer Sims-Mourtada
发明人： Ali Azhdarinia , Ebrahim S. Delpassand , Izabela Tworowska , Jennifer Sims-Mourtada
IPC分类号： A61K51/04 , A61K103/00 , A61K103/10 , A61K103/40 , A61K103/20 , A61K103/34 , A61K103/32 , A61K49/10 , A61K47/48
CPC分类号： A61K51/0497 , A61K45/06 , A61K51/0482 , A61K51/0491 , A61K51/0493 , A61K51/08 , A61K51/088 , A61K51/1244 , A61K51/1248 , A61N5/10
摘要： The present invention relates to the field of radiochemistry, nuclear imaging, radionuclide therapy and chemical synthesis. More particularly, it concerns a strategy for radiolabeling target ligands. It further concerns methods of using those radiolabeled ligands for imaging, radionuclide therapy and tissue-specific disease imaging.
摘要翻译：本发明涉及放射化学，核成像，放射性核素治疗和化学合成领域。更具体地说，它涉及放射性标记靶配体的策略。它还涉及使用放射性标记的配体进行成像，放射性核素治疗和组织特异性疾病成像的方法。

2. 发明授权

US09408928B2 Compositions for targeted imaging and therapy 有权
标题翻译：用于靶向成像和治疗的组合
公开(公告)号：US09408928B2
公开(公告)日：2016-08-09
申请号：US12057066
申请日：2008-03-27
申请人： Ali Azhdarinia , Ebrahim S. Delpassand , Izabela Tworowska , Jennifer Sims-Mourtada
发明人： Ali Azhdarinia , Ebrahim S. Delpassand , Izabela Tworowska , Jennifer Sims-Mourtada
IPC分类号： C07F13/00 , A61K51/08 , A61K51/04 , A61K51/12
CPC分类号： A61K51/0497 , A61K45/06 , A61K51/0482 , A61K51/0491 , A61K51/0493 , A61K51/08 , A61K51/088 , A61K51/1244 , A61K51/1248 , A61N5/10
摘要： The present invention relates to the field of radiochemistry, nuclear imaging, radionuclide therapy and chemical synthesis. More particularly, it concerns a strategy for radiolabeling target ligands. It further concerns methods of using those radiolabeled ligands for imaging, radionuclide therapy and tissue-specific disease imaging.
摘要翻译：本发明涉及放射化学，核成像，放射性核素治疗和化学合成领域。更具体地说，它涉及放射性标记靶配体的策略。它还涉及使用放射性标记的配体进行成像，放射性核素治疗和组织特异性疾病成像的方法。

3. 发明申请

US20100316566A1 RADIOLABELED HEDGEHOG DERIVATIVES FOR IMAGING AND THERAPY 审中-公开
标题翻译：用于成像和治疗的放射性对称衍生物
公开(公告)号：US20100316566A1
公开(公告)日：2010-12-16
申请号：US12918443
申请日：2009-02-27
申请人： Jennifer Sims-Mourtada , Ali Azhdarinia , Izabela Tworowska , Hitomi Saso
发明人： Jennifer Sims-Mourtada , Ali Azhdarinia , Izabela Tworowska , Hitomi Saso
IPC分类号： A61K51/00 , A61K49/00 , A61K33/24 , A61K33/36 , A61K33/26 , A61P35/04
CPC分类号： A61K38/10 , A61K9/0019 , A61K9/08 , A61K33/24 , A61K33/26 , A61K33/34 , A61K38/08 , A61K38/16 , A61K45/06 , A61K51/088 , A61K2300/00
摘要： The present invention concerns methods and compositions related to a chelator and a HHRT ligand. In specific embodiments of the invention the chelator is conjugated to the HHRT ligand. In another specific embodiment of the invention, the chelator is chelated to a metal. In a particular embodiment of the invention, there is a metal species that is chelated to a chelator, which is then directly or indirectly conjugated to a HHRT ligand. In some embodiments, the composition further comprises a therapeutic agent. In particular cases, the compositions are employed for cancer diagnosis and/or therapy.
摘要翻译：本发明涉及与螯合剂和HHRT配体有关的方法和组合物。在本发明的具体实施方案中，螯合剂与HHRT配体缀合。在本发明的另一个具体实施方案中，螯合剂与金属螯合。在本发明的一个具体实施方案中，存在螯合螯合剂的金属物质，然后直接或间接地结合到HHRT配体上。在一些实施方案中，组合物还包含治疗剂。在特定情况下，组合物用于癌症诊断和/或治疗。

4. 发明申请

US20120276005A1 CONJUGATES FOR DUAL IMAGING AND RADIOCHEMOTHERAPY: COMPOSITION, MANUFACTURING, AND APPLICATIONS 审中-公开
标题翻译：双重成像和放射治疗相结合：组合物，制造和应用
公开(公告)号：US20120276005A1
公开(公告)日：2012-11-01
申请号：US13438641
申请日：2012-04-03
申请人： David Yang , Dongfang Yu , Mithu Chanda , Ali Azhdarinia , Changsok Oh , E. Edmund Kim
发明人： David Yang , Dongfang Yu , Mithu Chanda , Ali Azhdarinia , Changsok Oh , E. Edmund Kim
IPC分类号： A61K49/00 , A61K51/04 , A61K49/22 , A61K49/04 , A61K49/10
CPC分类号： A61K47/549 , A61K47/61 , A61K49/0002 , A61K49/0438 , A61K51/0491 , C08B37/00 , C08B37/003
摘要： Compositions and methods for dual imaging and for dual chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns compounds comprising the structure X1—Y—X2, wherein Y comprises two or more carbohydrate residues covalently attached to one another, X1 and X2 are diagnostic or therapeutic moieties covalently attached to Y, provided that when Y does not comprise a glucosamine residue, X1 and X2 are diagnostic moieties. The present invention also concerns methods of synthesis of these compounds, application of such compounds for dual imaging and treatment of hyperproliferative disease, and kits for preparing a radiolabeled therapeutic or diagnostic compound.
摘要翻译：公开了用于双重成像和双重化疗和放疗的组合物和方法。更具体地，本发明涉及包含结构X1-Y-X2的化合物，其中Y包含彼此共价连接的两个或更多个碳水化合物残基，X1和X2是共价连接到Y的诊断或治疗部分，条件是当Y不包含氨基葡萄糖残基X1和X2是诊断部分。本发明还涉及这些化合物的合成方法，这种化合物在双成像和治疗过度增殖性疾病中的应用，以及用于制备放射性标记的治疗或诊断化合物的试剂盒。

5. 发明授权

US07611693B2 Mechanism-based targeted pancreatic beta cell imaging and therapy 有权
标题翻译：基于机制的靶向胰腺β细胞成像和治疗
公开(公告)号：US07611693B2
公开(公告)日：2009-11-03
申请号：US10942615
申请日：2004-09-16
申请人： David J. Yang , Chang-Sok Oh , Saady Kohanim , Dong-Fang Yu , Ali Azhdarinia , Jerry Bryant
发明人： David J. Yang , Chang-Sok Oh , Saady Kohanim , Dong-Fang Yu , Ali Azhdarinia , Jerry Bryant
IPC分类号： A61K49/00
CPC分类号： A61K51/0497
摘要： Compositions for imaging pancreatic beta cells comprise chelator-antidiabetic agent conjugates and optionally chelated metals.
摘要翻译：用于成像胰腺β细胞的组合物包含螯合剂 - 抗糖尿病药物缀合物和任选的螯合金属。

6. 发明申请

US20050276751A1 System and method for an automated synthesis of gallium-68 generator-based radiopharmaceutical agents 审中-公开
标题翻译：用于自动合成镓-68发生器的放射性药剂的系统和方法
公开(公告)号：US20050276751A1
公开(公告)日：2005-12-15
申请号：US11038631
申请日：2005-01-19
申请人： K.S. Chao , David Yang , Firas Mourtada , Ali Azhdarinia
发明人： K.S. Chao , David Yang , Firas Mourtada , Ali Azhdarinia
IPC分类号： A61K51/00 , A61K51/02 , C07F5/00
CPC分类号： A61K51/02
摘要： Systems and methods are described for efficiently producing a radiopharmaceutical agent. The system includes a generator that provides an admixture comprising hydrochloric acid and gallium-68 (Ga-68). A heater initiates a removal process by evaporating the hydrochloric acid from the admixture resulting in a substantially purified Ga-68. A plurality of valves provides a buffer and a prodrug that gets mixed with the Ga-68 to produce Ga-68 radiopharmaceutical agent. Additionally, the valves may provide water or a transchelator to the Ga-68 radiopharmaceutical agent to optimize the yield. A method includes providing an admixture comprising hydrochloric acid and Ga-68. The method also includes removing the hydrochloric acid by heating the admixture and subsequently evaporating the hydrochloric acid, resulting in a substantially purified Ga-68. The method further includes adding a buffer and a prodrug to the substantially purified Ga-68 to produce the Ga-68 radiopharmaceutical agent.
摘要翻译：描述了用于有效地生产放射性药剂的系统和方法。该系统包括提供包含盐酸和镓-68（Ga-68）的混合物的发生器。加热器通过从混合物中蒸发盐酸来引发去除过程，导致基本上纯化的Ga-68。多个阀提供与Ga-68混合以制备Ga-68放射性药剂的缓冲液和前药。此外，阀门可以向Ga-68放射性药剂提供水或转运器以优化产量。一种方法包括提供包含盐酸和Ga-68的混合物。该方法还包括通过加热混合物并随后蒸发盐酸除去盐酸，得到基本纯化的Ga-68。该方法还包括向基本纯化的Ga-68中加入缓冲液和前药以制备Ga-68放射性药剂。

7. 发明申请

US20100278731A1 Mechanism-Based Targeted Pancreatic Beta Cell Imaging and Therapy 审中-公开
标题翻译：基于机制的靶向胰腺β细胞成像和治疗
公开(公告)号：US20100278731A1
公开(公告)日：2010-11-04
申请号：US12610857
申请日：2009-11-02
申请人： David J. Yang , Chang-Sok Oh , Saady Kohanim , Dong-Fang Yu , Ali Azhdarinia , Jerry Bryant
发明人： David J. Yang , Chang-Sok Oh , Saady Kohanim , Dong-Fang Yu , Ali Azhdarinia , Jerry Bryant
IPC分类号： A61K51/04 , A61K49/10
CPC分类号： A61K51/0497
摘要： Compositions for imaging pancreatic beta cells comprise chelator-antidiabetic agent conjugates and optionally chelated metals.
摘要翻译：用于成像胰腺β细胞的组合物包含螯合剂 - 抗糖尿病药物缀合物和任选的螯合金属。

8. 发明申请

US20060182687A1 Conjugates for dual imaging and radiochemotherapy: composition, manufacturing, and applications 有权
标题翻译：双重成像和放射化学治疗的结合体：组成，制造和应用
公开(公告)号：US20060182687A1
公开(公告)日：2006-08-17
申请号：US11326117
申请日：2006-01-05
申请人： David Yang , Dongfang Yu , Mithu Chanda , Ali Azhdarinia , Changsok Oh , E. Kim
发明人： David Yang , Dongfang Yu , Mithu Chanda , Ali Azhdarinia , Changsok Oh , E. Kim
IPC分类号： A61K49/10 , C08B37/00 , A61B10/00
CPC分类号： A61K47/48092 , A61K47/549 , A61K47/61 , A61K49/0002 , A61K49/0438 , A61K51/0491 , C08B37/00 , C08B37/003
摘要： Compositions and methods for dual imaging and for dual chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns compounds comprising the structure X1-Y-X2, wherein Y comprises two or more carbohydrate residues covalently attached to one another, X1 and X2 are diagnostic or therapeutic moieties covalently attached to Y, provided that when Y does not comprise a glucosamine residue, X1 and X2 are diagnostic moieties. The present invention also concerns methods of synthesis of these compounds, application of such compounds for dual imaging and treatment of hyperproliferative disease, and kits for preparing a radiolabeled therapeutic or diagnostic compound.
摘要翻译：公开了用于双重成像和双重化疗和放疗的组合物和方法。更具体地，本发明涉及包含结构X 1 -YX 2 2的化合物，其中Y包含彼此共价连接的两个或更多个碳水化合物残基，X 1， / SUB和X 2是与Y共价连接的诊断或治疗部分，条件是当Y不包含葡糖胺残基时，X 1和X 2 < / SUB>是诊断部分。本发明还涉及这些化合物的合成方法，这种化合物在双成像和治疗过度增殖性疾病中的应用，以及用于制备放射性标记的治疗或诊断化合物的试剂盒。

9. 发明授权

US07586102B2 Automated system for formulating radiopharmaceuticals 失效
标题翻译：配制放射性药物的自动化系统
公开(公告)号：US07586102B2
公开(公告)日：2009-09-08
申请号：US11726853
申请日：2007-03-23
申请人： Firas Mourtada , Ali Azhdarinia , David Yang , Changsok Oh
发明人： Firas Mourtada , Ali Azhdarinia , David Yang , Changsok Oh
IPC分类号： G01N33/53
CPC分类号： G21G4/08 , B01D15/10 , B01D15/325 , B01D15/362 , B01D15/363 , G21G1/0005 , G21H5/02
摘要： The present invention provides automated systems for the purification of radioisotopes, the formulation of radiopharmaceuticals or both. In preferred embodiments the radioisotopes are produced by a generator. In further preferred embodiments the automated systems comprise replaceable cassettes for easy replacement of the system's networks of tubing. Also provided are replaceable cassettes and kits for use with the automated systems of the invention.The invention further provides methods of using an automated system to purify radioisotopes, formulate radiopharmaceuticals or to do both in series.
摘要翻译：本发明提供用于纯化放射性同位素的自动化系统，放射性药物的配方或两者。在优选实施方案中，放射性同位素由发生器产生。在进一步的优选实施例中，自动化系统包括可更换的盒，用于容易地更换系统的管道网络。还提供了与本发明的自动化系统一起使用的可更换盒和套件。本发明还提供了使用自动化系统来净化放射性同位素，配制放射性药物或两者串联的方法。

10. 发明申请

US20080199370A1 Efficient infrared-based reaction vessel 审中-公开
标题翻译：高效的红外线反应容器
公开(公告)号：US20080199370A1
公开(公告)日：2008-08-21
申请号：US12004340
申请日：2007-12-20
申请人： Firas Mourtada , Ali Azhdarinia , David Yang , Christian Landry
发明人： Firas Mourtada , Ali Azhdarinia , David Yang , Christian Landry
IPC分类号： A61K51/00 , B01J19/12
CPC分类号： A61K51/0491
摘要： The present invention provides an efficient infrared (IR) reaction vessel system that includes an infrared reaction vessel having an optical window into a reaction reservoir that absorbs minimal infrared energy, a male cap attached to the reaction vessel that allows precise positioning with respect to an infrared heat source, and at least one access tube passing through the cap. The infrared reaction vessel of the present invention further provides vacuum lines that also repulse ions and minimize evaporation loss and novel temperature control feedbacks such as the use of a proximally positioned resistive thermal device (RTD).
摘要翻译：本发明提供了一种有效的红外（IR）反应容器系统，其包括红外反应容器，该红外反应容器具有进入反应容器中的光学窗口，其吸收最小的红外能量;连接到反应容器的阳盖，其允许相对于红外线的精确定位热源，以及至少一个通过盖的进入管。本发明的红外线反应容器进一步提供了真空管线，其也使脉冲离子和最小化蒸发损失以及新的温度控制反馈，例如使用近端定位的电阻热装置（RTD）。

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