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1. 发明申请

US20050276751A1 System and method for an automated synthesis of gallium-68 generator-based radiopharmaceutical agents 审中-公开
标题翻译：用于自动合成镓-68发生器的放射性药剂的系统和方法
公开(公告)号：US20050276751A1
公开(公告)日：2005-12-15
申请号：US11038631
申请日：2005-01-19
申请人： K.S. Chao , David Yang , Firas Mourtada , Ali Azhdarinia
发明人： K.S. Chao , David Yang , Firas Mourtada , Ali Azhdarinia
IPC分类号： A61K51/00 , A61K51/02 , C07F5/00
CPC分类号： A61K51/02
摘要： Systems and methods are described for efficiently producing a radiopharmaceutical agent. The system includes a generator that provides an admixture comprising hydrochloric acid and gallium-68 (Ga-68). A heater initiates a removal process by evaporating the hydrochloric acid from the admixture resulting in a substantially purified Ga-68. A plurality of valves provides a buffer and a prodrug that gets mixed with the Ga-68 to produce Ga-68 radiopharmaceutical agent. Additionally, the valves may provide water or a transchelator to the Ga-68 radiopharmaceutical agent to optimize the yield. A method includes providing an admixture comprising hydrochloric acid and Ga-68. The method also includes removing the hydrochloric acid by heating the admixture and subsequently evaporating the hydrochloric acid, resulting in a substantially purified Ga-68. The method further includes adding a buffer and a prodrug to the substantially purified Ga-68 to produce the Ga-68 radiopharmaceutical agent.
摘要翻译：描述了用于有效地生产放射性药剂的系统和方法。该系统包括提供包含盐酸和镓-68（Ga-68）的混合物的发生器。加热器通过从混合物中蒸发盐酸来引发去除过程，导致基本上纯化的Ga-68。多个阀提供与Ga-68混合以制备Ga-68放射性药剂的缓冲液和前药。此外，阀门可以向Ga-68放射性药剂提供水或转运器以优化产量。一种方法包括提供包含盐酸和Ga-68的混合物。该方法还包括通过加热混合物并随后蒸发盐酸除去盐酸，得到基本纯化的Ga-68。该方法还包括向基本纯化的Ga-68中加入缓冲液和前药以制备Ga-68放射性药剂。

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