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1. 发明申请

US20120276005A1 CONJUGATES FOR DUAL IMAGING AND RADIOCHEMOTHERAPY: COMPOSITION, MANUFACTURING, AND APPLICATIONS 审中-公开
标题翻译：双重成像和放射治疗相结合：组合物，制造和应用
公开(公告)号：US20120276005A1
公开(公告)日：2012-11-01
申请号：US13438641
申请日：2012-04-03
申请人： David Yang , Dongfang Yu , Mithu Chanda , Ali Azhdarinia , Changsok Oh , E. Edmund Kim
发明人： David Yang , Dongfang Yu , Mithu Chanda , Ali Azhdarinia , Changsok Oh , E. Edmund Kim
IPC分类号： A61K49/00 , A61K51/04 , A61K49/22 , A61K49/04 , A61K49/10
CPC分类号： A61K47/549 , A61K47/61 , A61K49/0002 , A61K49/0438 , A61K51/0491 , C08B37/00 , C08B37/003
摘要： Compositions and methods for dual imaging and for dual chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns compounds comprising the structure X1—Y—X2, wherein Y comprises two or more carbohydrate residues covalently attached to one another, X1 and X2 are diagnostic or therapeutic moieties covalently attached to Y, provided that when Y does not comprise a glucosamine residue, X1 and X2 are diagnostic moieties. The present invention also concerns methods of synthesis of these compounds, application of such compounds for dual imaging and treatment of hyperproliferative disease, and kits for preparing a radiolabeled therapeutic or diagnostic compound.
摘要翻译：公开了用于双重成像和双重化疗和放疗的组合物和方法。更具体地，本发明涉及包含结构X1-Y-X2的化合物，其中Y包含彼此共价连接的两个或更多个碳水化合物残基，X1和X2是共价连接到Y的诊断或治疗部分，条件是当Y不包含氨基葡萄糖残基X1和X2是诊断部分。本发明还涉及这些化合物的合成方法，这种化合物在双成像和治疗过度增殖性疾病中的应用，以及用于制备放射性标记的治疗或诊断化合物的试剂盒。

2. 发明申请

US20120265601A1 Advertising Campaigns in Retail Outlets and Restaurants 审中-公开
标题翻译：零售店和餐馆的广告活动
公开(公告)号：US20120265601A1
公开(公告)日：2012-10-18
申请号：US13397707
申请日：2012-02-16
申请人： David Yang , Maxim Nalsky
发明人： David Yang , Maxim Nalsky
IPC分类号： G06Q30/02
CPC分类号： G06Q30/0207 , G06Q30/0241
摘要： Disclosed is advertising campaigns to attract customers to a business or establishment. One or more advertising campaign parameters are provided to a location based service operating on one or more computer systems. An identification for each appropriate customer is provided by a location based service. A promotion code for a discount for a service or product offered by the business is provided to each appropriate customer. The promotion code is used at a point of sale device of the business when an appropriate customer presents the promotion code at the point of sale. Variations are described.
摘要翻译：披露了广告活动，吸引客户到企业或机构。将一个或多个广告活动参数提供给在一个或多个计算机系统上操作的基于位置的服务。每个适当客户的识别由基于位置的服务提供。为每个适当的客户提供由业务提供的服务或产品的优惠促销代码。促销代码用于商业销售点，当适当的客户在销售点提供促销代码时。描述变化。

3. 发明授权

US07575629B2 Pollutant emission control sorbents and methods of manufacture 有权
标题翻译：污染物排放控制吸附剂和制造方法
公开(公告)号：US07575629B2
公开(公告)日：2009-08-18
申请号：US11290630
申请日：2005-11-30
申请人： Xiaolin David Yang , Pascaline Harrison Tran , Lawrence Shore , Stanley Scott Mack , James Eugene Staudt
发明人： Xiaolin David Yang , Pascaline Harrison Tran , Lawrence Shore , Stanley Scott Mack , James Eugene Staudt
IPC分类号： C04B14/02 , B01J20/00 , B01J20/10 , B32B18/00 , C22B3/00 , C01G3/12 , C01G45/00 , C01G23/00 , C01G19/00 , C01G49/12 , B01D53/46 , C01B17/22
CPC分类号： B01J20/28004 , B01J20/0207 , B01J20/0211 , B01J20/0214 , B01J20/0218 , B01J20/0222 , B01J20/0229 , B01J20/0237 , B01J20/024 , B01J20/0244 , B01J20/0248 , B01J20/0251 , B01J20/0281 , B01J20/0285 , B01J20/0288 , B01J20/0296 , B01J20/045 , B01J20/12 , B01J20/28059 , B01J20/3021 , B01J20/3078 , B01J20/3204 , B01J20/3236 , B01J20/3293 , B01J2220/42 , B01J2220/4887 , Y10T428/2991
摘要： Sorbents for removal of mercury and other pollutants from gas streams, such as a flue gas stream from coal-fired utility plants, and methods for their manufacture and use are disclosed. The methods include mixing fly ash particles with a sulfide salt and a metal salt to form a metal sulfide on the outer surface of the fly ash particles.
摘要翻译：公开了用于从燃气流中除去汞和其他污染物的吸附剂，例如来自燃煤电厂的烟道气，以及用于其制造和使用的方法。所述方法包括将飞灰颗粒与硫化物盐和金属盐混合以在飞灰颗粒的外表面上形成金属硫化物。

4. 发明申请

US20070075210A1 Expandable and adjustable display stand 审中-公开
标题翻译：可展开和可调节的展示架
公开(公告)号：US20070075210A1
公开(公告)日：2007-04-05
申请号：US11243248
申请日：2005-10-05
申请人： David Yang
发明人： David Yang
IPC分类号： A47B23/00 , A47B97/04 , A47G1/24 , A47B41/06
CPC分类号： A47F5/01 , A47G1/142 , G09F1/10
摘要： A display stand is made from continuous bending of a piece of metal round wire or flat stripe. It is configured in a compact storage size prior to usage. By a simple unfolding method, it is expandable to a self-standing full size display stand in an adjustable inclined position during usage. It is adaptable to a base for attaching the display stand to a horizontal or vertical flat surface.
摘要翻译：显示支架由一块金属圆形线或扁平条带连续弯曲制成。它在使用前被配置为紧凑的存储大小。通过简单的展开方法，它可以在使用期间以可调节的倾斜位置扩展到独立的全尺寸显示支架。它适用于将显示支架连接到水平或垂直平面的基座。

5. 发明申请

US20070043510A1 Assay system 审中-公开
标题翻译：测定系统
公开(公告)号：US20070043510A1
公开(公告)日：2007-02-22
申请号：US11208145
申请日：2005-08-19
申请人： David Yang , Paul Kraght
发明人： David Yang , Paul Kraght
IPC分类号： G06F19/00
CPC分类号： G01N33/582 , G01N15/1459 , G01N21/47 , G01N21/6428 , G01N21/645 , G01N33/54393 , G01N2021/4707 , G01N2021/4769 , G01N2021/6439
摘要： Different targets in a sample are assayed utilizing a control substrate and different sets of detector substrates, each set being adapted to capture a particular target. The substrates contain identifiers such as fluorescent dyes, which generate signals in a detection step. To minimize false negatives and false positives and misidentification of detector substrates, expected signals from the substrates are calculated based on the signals from the control substrate, and this data is utilized to determine what targets are present in a sample.
摘要翻译：使用控制衬底和不同组的检测器底物来测定样品中的不同靶，每组检测器底物适于捕获特定靶标。衬底包含诸如荧光染料的标识符，其在检测步骤中产生信号。为了最小化检测器基板的假阴性和假阳性以及错误识别，基于来自对照基板的信号计算来自基板的预期信号，并且使用该数据来确定样品中存在哪些目标。

6. 发明申请

US20070012850A1 Picture frame hanger 失效
公开(公告)号：US20070012850A1
公开(公告)日：2007-01-18
申请号：US11181963
申请日：2005-07-15
申请人： David Yang
发明人： David Yang
IPC分类号： A47G1/16
CPC分类号： A47G1/20
摘要： The hanger of present invention comprises of an integral hook and anchor sections in the upper and lower parts of hanger respectively. The hook section forms an U-hook for suspending and retaining the hanging wire of a picture frame. The anchor section guides a fastener such as a nail to drive through the anchor section and into the wall in inclined position. The hanger of present invention allows the hanging wire of the picture frame to directly engage into the U-hook without interference when a person holds the picture frame against the wall, and slides the picture frame downward to approach the hanger from the top of hanger.

7. 发明申请

US20060198786A1 Glycopeptide compositions 有权
标题翻译：糖肽组合物
公开(公告)号：US20060198786A1
公开(公告)日：2006-09-07
申请号：US11071975
申请日：2005-03-04
申请人： I-Chien Wei , David Yang , Dong-Fang Yu
发明人： I-Chien Wei , David Yang , Dong-Fang Yu
IPC分类号： A61K51/00 , C07K9/00
CPC分类号： A61K31/505 , A61K31/66 , A61K51/025
摘要： The invention include glycopeptides having a glycoside and a peptide covalently bound through an amide bond. The glycopeptides may also include a diagnostic or therapeutic agent bound to the glycopeptide. A metal, such as a radionuclide, may also be chelated to the glycopeptide. Specific embodiments of the invention relate to glycopeptides made of chitosan covalently bound to a poly(amino acid) such as poly(glutamic acid) or poly(aspartic acid). Diagnostic agents conjugated to the glycopeptide may facilitate imaging. Specific therapeutic agents that may be conjugated to the glycopeptide include anticancer drugs, rheumatoid arthritis drugs, anticoagulants, anti-angiogenesis drugs, apoptosis drugs, osteoporosis drugs, steroids, and anti-inflammatory drugs. Some agents, such as radionuclides, may have both diagnostic and therapeutic effects. The glycopeptides may be made by combining a glycoside and a peptide in the presence of a carbodiimide and an acid group activator to form an amide bond between the glycoside and the peptide.
摘要翻译：本发明包括具有糖苷和通过酰胺键共价结合的肽的糖肽。糖肽还可以包括与糖肽结合的诊断或治疗剂。诸如放射性核素的金属也可以与糖肽螯合。本发明的具体实施方案涉及由聚（氨基酸）如聚（谷氨酸）或聚（天冬氨酸）共价结合的壳聚糖制成的糖肽。与糖肽缀合的诊断剂可以促进成像。可以与糖肽结合的特异性治疗剂包括抗癌药物，类风湿关节炎药物，抗凝血剂，抗血管生成药物，凋亡药物，骨质疏松症药物，类固醇和抗炎药物。一些药剂如放射性核素可能具有诊断和治疗作用。糖肽可以通过在碳二亚胺和酸基活化剂的存在下组合糖苷和肽来在糖苷和肽之间形成酰胺键来制备。

8. 发明授权

US07034770B2 Printed dipole antenna 失效
标题翻译：打印偶极天线
公开(公告)号：US07034770B2
公开(公告)日：2006-04-25
申请号：US10842604
申请日：2004-05-10
申请人： Hung Yu David Yang , Jesus A Castaneda
发明人： Hung Yu David Yang , Jesus A Castaneda
IPC分类号： H01Q9/16 , H01Q1/38
CPC分类号： H01Q9/285 , H01Q1/38
摘要： A printed dipole antenna includes a metal trace having first type sections and second type sections, wherein currents within the first type sections substantially cancel and currents the second type sections are substantially cumulative.
摘要翻译：印刷偶极天线包括具有第一类型部分和第二类型部分的金属迹线，其中第一类型部分内的电流基本上消除并且第二类型部分的电流基本上是累积的。

9. 发明申请

US20050276751A1 System and method for an automated synthesis of gallium-68 generator-based radiopharmaceutical agents 审中-公开
标题翻译：用于自动合成镓-68发生器的放射性药剂的系统和方法
公开(公告)号：US20050276751A1
公开(公告)日：2005-12-15
申请号：US11038631
申请日：2005-01-19
申请人： K.S. Chao , David Yang , Firas Mourtada , Ali Azhdarinia
发明人： K.S. Chao , David Yang , Firas Mourtada , Ali Azhdarinia
IPC分类号： A61K51/00 , A61K51/02 , C07F5/00
CPC分类号： A61K51/02
摘要： Systems and methods are described for efficiently producing a radiopharmaceutical agent. The system includes a generator that provides an admixture comprising hydrochloric acid and gallium-68 (Ga-68). A heater initiates a removal process by evaporating the hydrochloric acid from the admixture resulting in a substantially purified Ga-68. A plurality of valves provides a buffer and a prodrug that gets mixed with the Ga-68 to produce Ga-68 radiopharmaceutical agent. Additionally, the valves may provide water or a transchelator to the Ga-68 radiopharmaceutical agent to optimize the yield. A method includes providing an admixture comprising hydrochloric acid and Ga-68. The method also includes removing the hydrochloric acid by heating the admixture and subsequently evaporating the hydrochloric acid, resulting in a substantially purified Ga-68. The method further includes adding a buffer and a prodrug to the substantially purified Ga-68 to produce the Ga-68 radiopharmaceutical agent.
摘要翻译：描述了用于有效地生产放射性药剂的系统和方法。该系统包括提供包含盐酸和镓-68（Ga-68）的混合物的发生器。加热器通过从混合物中蒸发盐酸来引发去除过程，导致基本上纯化的Ga-68。多个阀提供与Ga-68混合以制备Ga-68放射性药剂的缓冲液和前药。此外，阀门可以向Ga-68放射性药剂提供水或转运器以优化产量。一种方法包括提供包含盐酸和Ga-68的混合物。该方法还包括通过加热混合物并随后蒸发盐酸除去盐酸，得到基本纯化的Ga-68。该方法还包括向基本纯化的Ga-68中加入缓冲液和前药以制备Ga-68放射性药剂。

10. 发明申请

US20050188603A1 Snag-free and stress-free fish catcher 审中-公开
标题翻译：无捕捞和无压力的捕鱼者
公开(公告)号：US20050188603A1
公开(公告)日：2005-09-01
申请号：US11118239
申请日：2005-04-29
申请人： David Yang , Wayne Yang
发明人： David Yang , Wayne Yang
IPC分类号： A01K77/00
CPC分类号： A01K77/00
摘要： A snag-free and stress-free fish catcher includes a supporting frame, a fish pocket, having a fish cavity, supported by the supporting frame, and a tension resting bed, having a tension surface, supported within the fish cavity, wherein the tension surface of the tension resting bed has a predetermined tension larger than a weight of the fish. Therefore, when the fish is captured within the fish cavity of the fish pocket, the fish lies on the tension surface of the tension resting bed in a flatten manner.
摘要翻译：无阻力和无压力的捕鱼器包括支撑框架，具有鱼腔的鱼窝，由支撑框架支撑，以及张紧床，其具有支撑在鱼腔内的张力表面，其中张力张力搁置床的表面具有大于鱼的重量的预定张力。因此，当鱼被捕获在鱼袋的鱼腔中时，鱼以平坦的方式位于张力休息床的张力表面上。

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