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1. 发明授权

US08940148B2 Nano-fluidic field effective device to control DNA transport through the same 有权
标题翻译：纳米流体场有效装置通过其控制DNA转运
公开(公告)号：US08940148B2
公开(公告)日：2015-01-27
申请号：US12820516
申请日：2010-06-22
申请人： Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Glenn J. Martyna , Dennis M. Newns , Hongbo Peng , Stanislav Polonsky , Stephen Rossnagel , Gustavo Stolovitzky
发明人： Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Glenn J. Martyna , Dennis M. Newns , Hongbo Peng , Stanislav Polonsky , Stephen Rossnagel , Gustavo Stolovitzky
IPC分类号： B03C5/02 , G01N33/487 , B01L3/00 , B82Y15/00
CPC分类号： G01N27/44756 , B01L3/502761 , B01L2200/0663 , B01L2300/0645 , B01L2300/0816 , B01L2300/0896 , B01L2400/0421 , B01L2400/0424 , B82Y15/00 , G01N27/447 , G01N27/44791 , G01N33/48721
摘要： The present invention provides a nano-fluidic field effective device. The device includes a channel having a first side and a second side, a first set of electrodes adjacent to the first side, a second set of electrodes adjacent to the second side, a control unit for applying electric potentials to the electrodes and a fluid within the channel containing a charge molecule. The first set of electrodes is disposed such that application of electric potentials produces a spatially varying electric field that confines a charged molecule within a predetermined area of said channel. The second set of electrodes is disposed such that application of electric potentials relative to the electric potentials applied to the first set of electrodes creates an electric field that confines the charged molecule to an area away from the second side of the channel.
摘要翻译：本发明提供一种纳米流体场有效装置。该装置包括具有第一侧和第二侧的通道，与第一侧相邻的第一组电极，与第二侧相邻的第二组电极，用于向电极施加电势的控制单元和该通道含有电荷分子。第一组电极被布置成使得施加电势产生空间变化的电场，该电场将带电分子限制在所述通道的预定区域内。第二组电极被布置成使得施加相对于施加到第一组电极的电位的电势产生将带电分子限制在远离通道的第二侧的区域的电场。

2. 发明授权

US10040682B2 Functionally switchable self-assembled coating compound for controlling translocation of molecule through nanopores 有权
公开(公告)号：US10040682B2
公开(公告)日：2018-08-07
申请号：US13465280
申请日：2012-05-07
申请人： Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Hongbo Peng , Gustavo A. Stolovitzky , Deqiang Wang
发明人： Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Hongbo Peng , Gustavo A. Stolovitzky , Deqiang Wang
IPC分类号： G01N27/40 , B82Y30/00 , B82Y40/00 , F03B11/02 , B82Y15/00 , G01N27/00
CPC分类号： B82Y15/00 , B82Y30/00 , B82Y40/00 , G01N27/00 , Y10T137/8593
摘要： A technique for a nanodevice is provided. The nanodevice includes a fluidic cell, and a membrane dividing the fluidic cell. A nanopore is formed through the membrane, and the nanopore is coated with an organic compound. A first part of the organic compound binds to a surface of the nanopore and a second part of the organic compound is exposed freely inside of the nanopore. The second part of the organic compound is configured to be switched among a first neutral hydrophilic end group, a second negatively charged hydrophilic end group, and a third neutral hydrophobic end group based on a switching mechanism.

3. 发明授权

US08986524B2 DNA sequence using multiple metal layer structure with different organic coatings forming different transient bondings to DNA 有权
标题翻译： DNA序列使用多个金属层结构，不同的有机涂层与DNA形成不同的瞬时键合
公开(公告)号：US08986524B2
公开(公告)日：2015-03-24
申请号：US13359766
申请日：2012-01-27
申请人： Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Hongbo Peng , Stephen M. Rossnagel , Ajay K. Royyuru , Gustavo A. Stolovitzky , Philip S. Waggoner
发明人： Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Hongbo Peng , Stephen M. Rossnagel , Ajay K. Royyuru , Gustavo A. Stolovitzky , Philip S. Waggoner
IPC分类号： G01N27/447 , B82Y15/00 , G01N33/487 , C12Q1/68
CPC分类号： G01N33/48721 , B82Y15/00 , C12Q1/6869 , G01N27/44743 , G01N27/44791 , Y10S977/924 , C12Q2563/157
摘要： A nanodevice includes a reservoir filled with conductive fluid and a membrane separating the reservoir. A nanopore is formed through the membrane having electrode layers separated by insulating layers. A certain electrode layer has a first type of organic coating and a pair of electrode layers has a second type. The first type of organic coating forms a motion control transient bond to a molecule in the nanopore for motion control, and the second type forms first and second transient bonds to different bonding sites of a base of the molecule. When a voltage is applied to the pair of electrode layers a tunneling current is generated by the base in the nanopore, and the tunneling current travels via the first and second transient bonds formed to be measured as a current signature for distinguishing the base. The motion control transient bond is stronger than first and second transient bonds.
摘要翻译：纳米器件包括填充有导电流体的储存器和分离储存器的膜。通过具有由绝缘层分隔的电极层的膜形成纳米孔。某一电极层具有第一类型的有机涂层，并且一对电极层具有第二类型。第一类型的有机涂层形成运动控制瞬态键合到用于运动控制的纳米孔中的一个分子，而第二种类型形成与分子的基底的不同键合位点的第一和第二瞬态键。当对一对电极层施加电压时，由纳米孔中的基底产生隧穿电流，并且隧穿电流通过形成为要测量的第一和第二瞬态键作为用于区分基底的当前签名行进。运动控制瞬态键比第一和第二瞬态键强。

4. 发明授权

US08764968B2 DNA sequencing using multiple metal layer structure with organic coatings forming transient bonding to DNA bases 有权
标题翻译：使用多层金属层结构进行DNA测序，其中有机涂层形成与DNA碱基的瞬时键合
公开(公告)号：US08764968B2
公开(公告)日：2014-07-01
申请号：US13607070
申请日：2012-09-07
申请人： Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Glenn J. Martyna , Hongbo Peng , Stephen M. Rossnagel , Gustavo A. Stolovitzky , Philip S. Waggoner , George F. Walker
发明人： Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Glenn J. Martyna , Hongbo Peng , Stephen M. Rossnagel , Gustavo A. Stolovitzky , Philip S. Waggoner , George F. Walker
IPC分类号： G01N27/327
CPC分类号： G01N33/48721 , C12Q1/6869 , C12Q2563/116 , C12Q2563/157 , C12Q2565/607 , C12Q2565/631
摘要： A technique for nanodevice is provided. A reservoir is filled with an ionic fluid. A membrane separates the reservoir, and the membrane includes electrode layers separated by insulating layers in which the electrode layers have an organic coating. A nanopore is formed through the membrane, and the organic coating on the electrode layers forms transient bonds to a base of a molecule in the nanopore. When a first voltage is applied to the electrode layers a tunneling current is generated by the base in the nanopore, and the tunneling current travels through the transient bonds formed to the base to be measured as a current signature for distinguishing the base.
摘要翻译：提供了一种纳米设备技术。储存器充满离子流体。膜分离储存器，并且膜包括由绝缘层分离的电极层，其中电极层具有有机涂层。通过膜形成纳米孔，并且电极层上的有机涂层与纳米孔中分子的碱基形成瞬态键。当向电极层施加第一电压时，通过纳米孔中的基底产生隧道电流，并且隧道电流通过形成到待测量的基极的瞬态键作为用于区分基极的电流特征行进。

5. 发明申请

US20130263946A1 FUNCTIONALLY SWITCHABLE SELF-ASSEMBLED COATING COMPOUND FOR CONTROLLING TRANSLOCATION OF MOLECULE THROUGH NANOPORES 审中-公开
标题翻译：功能可切换的自组装涂料化合物，用于控制通过纳米光子转移分子
公开(公告)号：US20130263946A1
公开(公告)日：2013-10-10
申请号：US13439265
申请日：2012-04-04
申请人： Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Hongbo Peng , Gustavo A. Stolovitzky , Deqiang Wang
发明人： Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Hongbo Peng , Gustavo A. Stolovitzky , Deqiang Wang
IPC分类号： F03B11/02
CPC分类号： B82Y15/00 , B82Y30/00 , B82Y40/00 , G01N27/00 , Y10T137/8593
摘要： A technique for a nanodevice is provided. The nanodevice includes a fluidic cell, and a membrane dividing the fluidic cell. A nanopore is formed through the membrane, and the nanopore is coated with an organic compound. A first part of the organic compound binds to a surface of the nanopore and a second part of the organic compound is exposed freely inside of the nanopore. The second part of the organic compound is configured to be switched among a first neutral hydrophilic end group, a second negatively charged hydrophilic end group, and a third neutral hydrophobic end group based on a switching mechanism.
摘要翻译：提供了一种纳米设备的技术。纳米器件包括流体细胞和分离流体细胞的膜。通过膜形成纳米孔，并且纳米孔涂覆有机化合物。有机化合物的第一部分与纳米孔的表面结合，并且有机化合物的第二部分在纳米孔内自由地暴露。有机化合物的第二部分被配置为基于切换机制在第一中性亲水端基，第二带负电荷亲水端基和第三中性疏水端基之间切换。

6. 发明授权

US08491769B2 Embedding a nanotube inside a nanopore for DNA translocation 有权
标题翻译：在纳米孔内嵌入纳米管用于DNA易位
公开(公告)号：US08491769B2
公开(公告)日：2013-07-23
申请号：US13611701
申请日：2012-09-12
申请人： Ali Afzali-Ardakani , Binquan Luan , Hongbo Peng
发明人： Ali Afzali-Ardakani , Binquan Luan , Hongbo Peng
IPC分类号： G01N27/26 , B82Y40/00
CPC分类号： B82Y30/00 , B82Y40/00 , C12Q1/6869 , C25D3/665 , C25D5/028 , C25D13/04 , G01N33/48721
摘要： A technique for embedding a nanotube in a nanopore is provided. A membrane separates a reservoir into a first reservoir part and a second reservoir part, and the nanopore is formed through the membrane for connecting the first and second reservoir parts. An ionic fluid fills the nanopore, the first reservoir part, and the second reservoir part. A first electrode is dipped in the first reservoir part, and a second electrode is dipped in the second reservoir part. Driving the nanotube into the nanopore causes an inner surface of the nanopore to form a covalent bond to an outer surface of the nanotube via an organic coating so that the inner surface of the nanotube will be the new nanopore with a super smooth surface for studying bio-molecules while they translocate through the nanotube.
摘要翻译：提供了一种在纳米孔中嵌入纳米管的技术。膜将储存器分离成第一储存部分和第二储存部分，并且纳米孔通过膜形成，用于连接第一和第二储存部分。离子流体填充纳米孔，第一储存部分和第二储存部分。将第一电极浸入第一储存部分中，将第二电极浸入第二储存部分。将纳米管驱动到纳米孔中导致纳米孔的内表面通过有机涂层与纳米管的外表面形成共价键，使得纳米管的内表面将成为具有超光滑表面的新纳米孔，用于研究生物分子，同时它们转移通过纳米管。

7. 发明授权

US08354336B2 Forming an electrode having reduced corrosion and water decomposition on surface using an organic protective layer 失效
标题翻译：使用有机保护层形成表面上具有降低的腐蚀和水分解的电极
公开(公告)号：US08354336B2
公开(公告)日：2013-01-15
申请号：US12820543
申请日：2010-06-22
申请人： Ali Afzali-Ardakani , Shafaat Ahmed , Hariklia Deligianni , Dario L. Goldfarb , Stefan Harrer , Binquan Luan , Glenn J. Martyna , Hongbo Peng , Stanislav Polonsky , Stephen Rossnagel , Xiaoyan Shao , Gustavo A. Stolovitzky
发明人： Ali Afzali-Ardakani , Shafaat Ahmed , Hariklia Deligianni , Dario L. Goldfarb , Stefan Harrer , Binquan Luan , Glenn J. Martyna , Hongbo Peng , Stanislav Polonsky , Stephen Rossnagel , Xiaoyan Shao , Gustavo A. Stolovitzky
IPC分类号： H01L21/28 , H01L21/3205
CPC分类号： B82Y10/00 , H01L21/76834 , H01L29/0665 , H01L51/0093 , H01L51/0504 , H01L51/102
摘要： Accordingly, the present invention provides a method of forming an electrode having reduced corrosion and water decomposition on a surface thereof. A substrate which has a conductive layer disposed thereon is provided and the conductive layer has an oxide layer with an exposed surface. The exposed surface of the oxide layer contacts a solution of an organic surface active compound in an organic solvent to form a protective layer of the organic surface active compound over the oxide layer. The protective layer has a thickness of from about 0.5 nm to about 5 nm and ranges therebetween depending on a chemical structure of the surface active compound.
摘要翻译：因此，本发明提供一种在其表面上形成具有降低的腐蚀和水分解的电极的方法。提供了具有设置在其上的导电层的衬底，并且导电层具有具有暴露表面的氧化物层。氧化物层的暴露表面接触有机表面活性化合物在有机溶剂中的溶液，以在氧化物层上形成有机表面活性化合物的保护层。根据表面活性化合物的化学结构，保护层的厚度为约0.5nm至约5nm，并且其范围。

8. 发明申请

US20130062206A1 EMBEDDING A NANOTUBE INSIDE A NANOPORE FOR DNA TRANSLOCATION 有权
标题翻译：嵌入一个NANOTUBE内部的NANOPORE进行DNA转录
公开(公告)号：US20130062206A1
公开(公告)日：2013-03-14
申请号：US13611701
申请日：2012-09-12
申请人： Ali Afzali-Ardakani , Binquan Luan , Hongbo Peng
发明人： Ali Afzali-Ardakani , Binquan Luan , Hongbo Peng
IPC分类号： C25D15/00 , B82Y40/00
CPC分类号： B82Y30/00 , B82Y40/00 , C12Q1/6869 , C25D3/665 , C25D5/028 , C25D13/04 , G01N33/48721
摘要： A technique for embedding a nanotube in a nanopore is provided. A membrane separates a reservoir into a first reservoir part and a second reservoir part, and the nanopore is formed through the membrane for connecting the first and second reservoir parts. An ionic fluid fills the nanopore, the first reservoir part, and the second reservoir part. A first electrode is dipped in the first reservoir part, and a second electrode is dipped in the second reservoir part. Driving the nanotube into the nanopore causes an inner surface of the nanopore to form a covalent bond to an outer surface of the nanotube via an organic coating so that the inner surface of the nanotube will be the new nanopore with a super smooth surface for studying bio-molecules while they translocate through the nanotube.
摘要翻译：提供了一种在纳米孔中嵌入纳米管的技术。膜将储存器分离成第一储存部分和第二储存部分，并且纳米孔通过膜形成，用于连接第一和第二储存部分。离子流体填充纳米孔，第一储存部分和第二储存部分。将第一电极浸入第一储存部分中，将第二电极浸入第二储存部分。将纳米管驱动到纳米孔中导致纳米孔的内表面通过有机涂层与纳米管的外表面形成共价键，使得纳米管的内表面将成为具有超光滑表面的新纳米孔，用于研究生物分子，同时它们转移通过纳米管。

9. 发明申请

US20120193235A1 DNA MOTION CONTROL BASED ON NANOPORE WITH ORGANIC COATING FORMING TRANSIENT BONDING TO DNA 审中-公开
标题翻译：基于NANOPORE的DNA运动控制与有机涂层形成瞬态结合到DNA
公开(公告)号：US20120193235A1
公开(公告)日：2012-08-02
申请号：US13359743
申请日：2012-01-27
申请人： Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Glenn J. Martyna , Hongbo Peng , Stephen M. Rossnagel , Ajay K. Royyuru , Gustavo A. Stolovitzky , Philip S. Waggoner
发明人： Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Glenn J. Martyna , Hongbo Peng , Stephen M. Rossnagel , Ajay K. Royyuru , Gustavo A. Stolovitzky , Philip S. Waggoner
IPC分类号： G01N27/453
CPC分类号： G01N27/4473 , C12Q1/6869 , C12Q2523/303 , C12Q2565/631
摘要： A nanodevice includes a reservoir filled with a conductive fluid and a membrane separating the reservoir. The membrane includes an insulating layer. A nanopore is formed through the membrane, and an organic coating is provided on the insulating layer to form a transient bond to a DNA molecule in the nanopore. The transient bond is stronger than thermal motion, such that the transient bond can hold the DNA molecule against the thermal motion. When a voltage is applied across the membrane, the voltage will break the transient bond to move the DNA molecule through the nanopore in a controllable state.
摘要翻译：纳米器件包括填充有导电流体的储存器和分离储存器的膜。膜包括绝缘层。通过膜形成纳米孔，并且在绝缘层上提供有机涂层以与纳米孔中的DNA分子形成瞬时键合。瞬态键比热运动强，使得瞬态键可以保持DNA分子抵抗热运动。当跨膜施加电压时，电压将破坏瞬态键合，以在可控状态下将DNA分子移动通过纳米孔。

10. 发明申请

US20120193231A1 DNA SEQUENCING USING MULTIPLE METAL LAYER STRUCTURE WITH ORGANIC COATINGS FORMING TRANSIENT BONDING TO DNA BASES 审中-公开
标题翻译：使用多种金属层结构的DNA序列与有机涂层形成瞬态结合到DNA基础
公开(公告)号：US20120193231A1
公开(公告)日：2012-08-02
申请号：US13359750
申请日：2012-01-27
申请人： Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Glenn J. Martyna , Hongbo Peng , Stephen M. Rossnagel , Gustavo A. Stolovitzky , Philip S. Waggoner , George F. Walker
发明人： Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Glenn J. Martyna , Hongbo Peng , Stephen M. Rossnagel , Gustavo A. Stolovitzky , Philip S. Waggoner , George F. Walker
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： G01N33/48721 , C12Q1/6869 , C12Q2563/116 , C12Q2563/157 , C12Q2565/607 , C12Q2565/631
摘要： A nanodevice is provided. A reservoir is filled with an ionic fluid. A membrane separates the reservoir, and the membrane includes electrode layers separated by insulating layers in which the electrode layers have an organic coating. A nanopore is formed through the membrane, and the organic coating on the electrode layers forms transient bonds to a base of a molecule in the nanopore. When a first voltage is applied to the electrode layers a tunneling current is generated by the base in the nanopore, and the tunneling current travels through the transient bonds formed to the base to be measured as a current signature for distinguishing the base.
摘要翻译：提供了一个纳米设备。储存器充满离子流体。膜分离储存器，并且膜包括由绝缘层分离的电极层，其中电极层具有有机涂层。通过膜形成纳米孔，并且电极层上的有机涂层与纳米孔中分子的碱基形成瞬态键。当第一电压施加到电极层时，通过纳米孔中的基底产生隧道电流，并且隧道电流通过形成到待测量的基极的瞬态键作为用于区分基极的电流签名传播。

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