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1. 发明公开

US20240327922A1 METHODS OF CANCER DETECTION USING EXTRAEMBRYONICALLY METHYLATED CPG ISLANDS 审中-公开
公开(公告)号：US20240327922A1
公开(公告)日：2024-10-03
申请号：US18268240
申请日：2021-12-17
申请人： Jiantao SHI , Zachary D. SMITH , Alexander MEISSNER , Franziska MICHOR , President and Fellows of Harvard College , DANA-FARBER CANCER INSTITUTE, INC.
发明人： Jiantao Shi , Zachary D. Smith , Alexander Meissner , Franziska Michor
IPC分类号： C12Q1/6886 , G16B20/10 , G16B40/20
CPC分类号： C12Q1/6886 , G16B20/10 , G16B40/20 , C12Q2600/154
摘要： The present invention relates to methods of characterizing cell-free DNA (cfDNA), detecting cancer, detecting the eradication of cancer, and determining a probability distribution of haplotypes. The methods use the data from genomic sequences from CpG Islands (CGI) methylated in the genome of extraembryonic ectoderm (ExE) to determine a proportion of fully methylated haplotypes in order to characterize the cfDNA sample and detect certain cancers.

2. 发明申请

US20110045194A1 ROBOT COMPRISING A CLEANING DEVICE AND ASSOCIATED OPERATING METHOD 有权
标题翻译：包含清洁装置的机器人和相关的操作方法
公开(公告)号：US20110045194A1
公开(公告)日：2011-02-24
申请号：US12682205
申请日：2008-10-06
申请人： Frank Herre , Rainer Melcher , Manfred Michelfelder , Thomas Hezel , Juergen Haas , Bernd Leiensetter , Alexander Meissner , Marcus Frey
发明人： Frank Herre , Rainer Melcher , Manfred Michelfelder , Thomas Hezel , Juergen Haas , Bernd Leiensetter , Alexander Meissner , Marcus Frey
IPC分类号： B05D1/02 , B05C13/00 , B05C21/00 , B25J19/00
CPC分类号： B05B13/0292 , B05B13/0285 , Y10S901/49
摘要： Exemplary robots and corresponding exemplary operating methods for a painting system are disclosed. In one example, the robot is a handling robot for opening and closing doors or bonnets of motor vehicle bodies. A robot element of a handling robot that is susceptible to dirt retention, e.g., a handling tool, may be arranged away from the spray jet of a paint during the painting operation and is applied to the component that is to be painted. The robot may include a cleaning device for cleaning or for keeping the robot element of the handling robot that is susceptible to dirt retention clean from paint that is applied with spray jet in the painting operation.
摘要翻译：公开了用于绘画系统的示例性机器人和相应的示例性操作方法。在一个示例中，机器人是用于打开和关闭机动车体的门或阀盖的处理机器人。在涂装操作期间，可以将远离涂料的喷射喷射布置的易于污染的处理机器人的机器人元件，例如处理工具，并且被施加到待涂漆的部件上。机器人可以包括用于清洁或保持处理机器人的机器人元件的清洁装置，其易于在涂漆操作中施加有喷射喷射的涂料清洁。

3. 发明申请

US20100211205A1 METHOD FOR PROCESS DIAGNOSIS AND ROTARY ATOMIZER ARRANGEMENT 有权
标题翻译：过程诊断和旋转原子装置的方法
公开(公告)号：US20100211205A1
公开(公告)日：2010-08-19
申请号：US12669926
申请日：2008-07-11
申请人： Michael Baumann , Torsten Block , Juergen Haas , Frank Herre , Marcus Frey , Alexander Meissner , Hans-Jurgen Nolte , Bernhard Seiz
发明人： Michael Baumann , Torsten Block , Juergen Haas , Frank Herre , Marcus Frey , Alexander Meissner , Hans-Jurgen Nolte , Bernhard Seiz
IPC分类号： G06F17/00 , B05B3/02 , G05D7/06
CPC分类号： B05B5/0415 , B05B5/0422 , B05B12/08 , B05B15/14 , H02P29/10
摘要： A rotary atomizer arrangement and methods for operating the same are disclosed. An exemplary atomizer may be used for the coating of work pieces, and may include a bell plate driven by an electric motor. The exemplary atomizer may further be configured for the detection of errors in the spraying process and/or the drive system of the bell plate, such as by analyzing corresponding parameters of typical values of the drive motor.
摘要翻译：公开了一种旋转雾化器装置及其操作方法。示例性的雾化器可以用于工件的涂覆，并且可以包括由电动机驱动的钟板。示例性雾化器还可以被配置为用于检测喷射过程和/或钟板的驱动系统中的错误，例如通过分析驱动马达的典型值的相应参数。

4. 发明授权

US08298342B2 Dusting method and corresponding dusting device 有权
标题翻译：除尘方法及相应的除尘装置
公开(公告)号：US08298342B2
公开(公告)日：2012-10-30
申请号：US12681264
申请日：2008-10-01
申请人： Juergen Haas , Alexander Meissner , Marcus Frey
发明人： Juergen Haas , Alexander Meissner , Marcus Frey
IPC分类号： E01H1/02 , B08B7/00
CPC分类号： A46B13/02 , A46B3/18 , A46B2200/3026 , A46B2200/3046 , B08B1/008
摘要： A dedusting device and method is disclosed for the dry or moist dedusting (i.e., cleaning, dusting, or removal of dirt, dust, or other debris) from components, e.g., of motor vehicles. An exemplary method may generally include positioning a dusting tool driven by a drive motor in a predetermined dusting position such that the tool contacts or touches the component, and determining a first operating variable of the drive motor of the dusting tool when positioning the dusting tool in the predetermined dusting position. The first operating variable may reflect a mechanical load of the drive motor due to the contact with the component to be dusted. The method may further include calculating a corrected dusting position as a function of the predetermined dusting position and the first operating variable of the drive motor, and positioning the dusting tool in the corrected dusting position.
摘要翻译：公开了用于干燥或潮湿除尘（即，清洁，除尘或除去污垢，灰尘或其它碎屑）的除尘装置和方法，例如机动车辆的部件。示例性方法通常可以包括将由驱动电动机驱动的除尘工具定位在预定的除尘位置，使得工具接触或接触该部件，并且当将除尘工具定位时，确定除尘工具的驱动电动机的第一操作变量预定的除尘位置。第一个操作变量可能会反映由于与待除尘部件的接触而导致的驱动电机的机械负载。该方法可以进一步包括根据预定的除尘位置和驱动电动机的第一操作变量来计算校正的除尘位置，并将该除尘工具定位在校正的除尘位置。

5. 发明申请

US20110076678A1 REPROGRAMMING OF SOMATIC CELLS 有权
标题翻译：自然细胞的重组
公开(公告)号：US20110076678A1
公开(公告)日：2011-03-31
申请号：US12595041
申请日：2008-04-07
申请人： Rudolf Jaenisch , Jaqub Hanna , Marius Wernig , Christopher J. Lengner , Alexander Meissner , Oliver Tobias Brambrink , G. Grant Welstead , Ruth Foreman
发明人： Rudolf Jaenisch , Jaqub Hanna , Marius Wernig , Christopher J. Lengner , Alexander Meissner , Oliver Tobias Brambrink , G. Grant Welstead , Ruth Foreman
IPC分类号： C12Q1/68 , C12N5/071 , C12N15/85 , C12N15/86 , C12N15/87
CPC分类号： C12N5/0696 , A01K67/0273 , A01K67/0275 , A01K2217/05 , A01K2227/105 , C07K14/4702 , C12N15/8509 , C12N15/8775 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2506/11 , C12N2506/13 , C12N2800/30 , C12N2830/003 , C12N2830/006 , G01N33/5023 , G01N2333/91011
摘要： The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.
摘要翻译：本公开涉及将一种或多种体细胞（例如部分分化或完全/终末分化的体细胞）重新编程为较少分化状态（例如多能或多能状态）的方法。在另外的实施方案中，本发明还涉及通过本发明的方法产生的重编程体细胞，所述细胞的用途以及用于鉴定用于重编程体细胞的药剂的方法。

6. 发明申请

US20100198405A1 MOVEMENT CONTROLLER FOR ELASTIC ROBOT STRUCTURES 有权
标题翻译：弹性机器人结构的运动控制器
公开(公告)号：US20100198405A1
公开(公告)日：2010-08-05
申请号：US12601745
申请日：2008-05-07
申请人： Jens Hacker , Bjoern Schoell , Alexander Meissner
发明人： Jens Hacker , Bjoern Schoell , Alexander Meissner
IPC分类号： B25J9/16
CPC分类号： B25J9/1641 , G05B2219/39181 , G05B2219/39186 , G05B2219/41127 , G05B2219/41443 , G05B2219/41448
摘要： The invention relates to a control method for a painting robot, comprising the following steps: (a) a robot path is set using several path points that are to be traversed by a reference point of the robot and are each defined by space coordinates; (b) the space coordinates of the individual path points are converted into corresponding axis coordinates according to inverse robot kinematics, said axis coordinates reproducing the position of the individual robot axes in the respective path points; (c) axis-related regulators for the individual robot axes are triggered according to the converted axis coordinates; (d) axis-related driving motors are triggered in the individual robot axes by means of the associated axis-related regulators; (e) corrective path values for the individual path points are calculated according to a dynamic robot model, said corrective path values taking into account the elasticity and/or friction and/or inertia of the robot; (f) corrected axis coordinates for the individual path points are calculated from the non-corrected axis coordinates of the individual path points and the corrective path values; (g) the axis-related regulators are triggered using the corrected axis coordinates.
摘要翻译：本发明涉及一种用于绘画机器人的控制方法，包括以下步骤：（a）使用由机器人的参考点穿过的几个路径点设置机器人路径，并且各自由空间坐标定义; （b）根据反向机器人运动学将各个路径点的空间坐标转换成相应的轴坐标，所述轴坐标再现各个路径点中各个机器人轴的位置; （c）根据转换的轴坐标触发各个机器人轴的与轴相关的调节器; （d）轴相关驱动电机通过相关的轴相关调节器在各个机器人轴上触发; （e）根据动态机器人模型计算各个路径点的校正路径值，所述校正路径值考虑到机器人的弹性和/或摩擦力和/或惯性; （f）根据各个路径点的非校正轴坐标和校正路径值计算各个路径点的校正轴坐标; （g）使用校正的轴坐标触发与轴相关的调节器。

7. 发明授权

US09382515B2 Reprogramming of somatic cells 有权
标题翻译：体细胞重编程
公开(公告)号：US09382515B2
公开(公告)日：2016-07-05
申请号：US12595041
申请日：2008-04-07
申请人： Rudolf Jaenisch , Yaqub Hanna , Marius Wernig , Christopher J. Lengner , Alexander Meissner , Oliver Tobias Brambrink , G. Grant Welstead , Ruth Foreman
发明人： Rudolf Jaenisch , Yaqub Hanna , Marius Wernig , Christopher J. Lengner , Alexander Meissner , Oliver Tobias Brambrink , G. Grant Welstead , Ruth Foreman
IPC分类号： C12N5/00 , C12N5/074 , C07K14/47 , A01K67/027 , C12N15/85 , C12N15/877 , G01N33/50
CPC分类号： C12N5/0696 , A01K67/0273 , A01K67/0275 , A01K2217/05 , A01K2227/105 , C07K14/4702 , C12N15/8509 , C12N15/8775 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2506/11 , C12N2506/13 , C12N2800/30 , C12N2830/003 , C12N2830/006 , G01N33/5023 , G01N2333/91011
摘要： The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.
摘要翻译：本公开涉及将一种或多种体细胞（例如部分分化或完全/终末分化的体细胞）重新编程为较少分化状态（例如多能或多能状态）的方法。在另外的实施方案中，本发明还涉及通过本发明的方法产生的重编程体细胞，所述细胞的用途以及用于鉴定用于重编程体细胞的药剂的方法。

8. 发明授权

US09016596B2 Method for process diagnosis and rotary atomizer arrangement 有权
标题翻译：过程诊断和旋转雾化器布置方法
公开(公告)号：US09016596B2
公开(公告)日：2015-04-28
申请号：US12669926
申请日：2008-07-11
申请人： Michael Baumann , Torsten Block , Juergen Haas , Frank Herre , Marcus Frey , Alexander Meissner , Hans-Jurgen Nolte , Bernhard Seiz
发明人： Michael Baumann , Torsten Block , Juergen Haas , Frank Herre , Marcus Frey , Alexander Meissner , Hans-Jurgen Nolte , Bernhard Seiz
IPC分类号： B05B3/02 , B05B5/04
CPC分类号： B05B5/0415 , B05B5/0422 , B05B12/08 , B05B15/14 , H02P29/10
摘要： A rotary atomizer arrangement and methods for operating the same are disclosed. An exemplary atomizer may be used for the coating of work pieces, and may include a bell plate driven by an electric motor. The exemplary atomizer may further be configured for the detection of errors in the spraying process and/or the drive system of the bell plate, such as by analyzing corresponding parameters of typical values of the drive motor.
摘要翻译：公开了一种旋转雾化器装置及其操作方法。示例性的雾化器可以用于工件的涂覆，并且可以包括由电动机驱动的钟板。示例性雾化器还可以被配置为用于检测喷射过程和/或钟板的驱动系统中的错误，例如通过分析驱动马达的典型值的相应参数。

9. 发明授权

US08807077B2 Coating device and coating method having a constant directing air temperature 有权
标题翻译：涂布装置和涂布方法具有恒定的引导空气温度
公开(公告)号：US08807077B2
公开(公告)日：2014-08-19
申请号：US12667249
申请日：2008-06-20
申请人： Alexander Meissner , Frank Herre , Marcus Frey , Torsten Block , Michael Baumann
发明人： Alexander Meissner , Frank Herre , Marcus Frey , Torsten Block , Michael Baumann
IPC分类号： B05C11/10 , B05B3/00 , B05B3/10 , B05B1/28
CPC分类号： B05B3/1092 , B05B3/001
摘要： Exemplary coating devices and methods are disclosed. An exemplary coating device may include an atomizer for applying a spray jet of a coating means or material to a component, at least one directing air nozzle for outputting shaping or directing air in order to shape the spray jet, and a temperature-control device for controlling the temperature of the directing air. The coating device may further include a control unit which activates the temperature-control device as a function of at least one operating variable of the atomizer in order to set a predetermined directing air temperature.
摘要翻译：公开了示例性的涂覆装置和方法。示例性的涂覆装置可以包括用于将涂覆装置或材料的喷射射流施加到部件的雾化器，至少一个引导空气喷嘴，用于输出成形或引导空气以便形成喷射射流;以及温度控制装置，控制导向空气的温度。涂覆装置还可以包括控制单元，其根据雾化器的至少一个操作变量激活温度控制装置，以便设定预定的引导空气温度。

10. 发明申请

US20130296183A1 FUNCTIONAL GENOMICS ASSAY FOR CHARACTERIZING PLURIPOTENT STEM CELL UTILITY AND SAFETY 审中-公开
标题翻译：功能性基因测定用于表征多发性骨髓瘤细胞应用和安全性
公开(公告)号：US20130296183A1
公开(公告)日：2013-11-07
申请号：US13822336
申请日：2011-09-16
申请人： Kevin C. Eggan , Alexander Meissner , Christoph Bock , Evangelos Kiskinis , Griet Annie Frans Verstappen
发明人： Kevin C. Eggan , Alexander Meissner , Christoph Bock , Evangelos Kiskinis , Griet Annie Frans Verstappen
IPC分类号： C12N15/10
CPC分类号： C12N15/1072 , C12Q1/6881 , C12Q2600/154 , C12Q2600/158
摘要： The present invention generally relates set of reference data or “scorecard” for a pluripotent stem cell, and methods, systems and kits to generate a scorecard for predicting the functionality and suitability of a pluripotent stem cell line for a desired use. In some aspects, a method for generating a scorecard comprises using at least 2 stem cell assays selected from: epigenetic profiling, differentiation assay and gene expression assay to predict the functionality and suitability of a pluripotent stem cell line for a desired use. In some embodiments, the scorecard reference data can be compared with the pluripotent stem cells data to effectively and accurately predict the utility of the pluripotent stem cell for a given application, as well as any to identify specific characteristics of the pluripotent stem cell line to determine their suitability for downstream applications, such as for example, their suitability for therapeutic use, drug screening and toxicity assays, differentiation into a desired cell lineage, and the like.
摘要翻译：本发明通常涉及多能干细胞的参考数据或“记分卡”，以及生成用于预测多能干细胞系用于期望用途的功能和适用性的记分卡的方法，系统和试剂盒。在一些方面，用于产生记分卡的方法包括使用选自以下的至少2种干细胞测定：表观遗传学分析，分化测定和基因表达测定来预测多能干细胞系用于期望用途的功能性和适用性。在一些实施方案中，记分卡参考数据可以与多能干细胞数据进行比较，以有效和准确地预测给定应用的多能干细胞的效用，以及任何鉴定多能干细胞系的特定特征以确定它们对下游应用的适用性，例如其对治疗用途的适用性，药物筛选和毒性测定，分化成所需细胞谱系等。

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