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1. 发明申请

US20120248308A1 ELECTROSTATIC TRAP 审中-公开
标题翻译：静电捕捉
公开(公告)号：US20120248308A1
公开(公告)日：2012-10-04
申请号：US13474020
申请日：2012-05-17
申请人： Alexander Makarov , Eduard V. Denisov , Gerhard Jung , Wilko Balschun , Steven Roy Horning
发明人： Alexander Makarov , Eduard V. Denisov , Gerhard Jung , Wilko Balschun , Steven Roy Horning
IPC分类号： H01J49/28
CPC分类号： H01J49/4245 , H01J49/0027 , H01J49/02 , H01J49/282 , H01J49/406 , H01J49/425
摘要： An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U′(r, φ, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U′(r, φ, z) is the result of a perturbation W to an ideal field U(r, φ, z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, φ, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2 π radians over an ion detection period Tm.
摘要翻译：公开了诸如轨道捕获器的静电捕获器，具有电极结构。产生形式为U'（r，＆phgr; z）的静电捕获场，以捕获陷阱内的离子，使得它们经历同步振荡。捕获场U'（r，＆phgr; z）是对于理想场U（r，＆phgr; z）的扰动W的结果，其在例如轨道捕获的情况下例如是超对数的。扰动W可以以各种方式引入，例如通过使陷波器的几何形状变形，使得其不再遵循理想场U（r，＆phgr; z）的等电位，或者通过添加失真场（电或磁性）。扰动的幅度使得至少一些捕获的离子具有大于零但小于2的绝对相位扩展; 弧度超过离子检测周期Tm。

2. 发明申请

US20080315080A1 Electrostatic Trap 有权
标题翻译：静电捕集阱
公开(公告)号：US20080315080A1
公开(公告)日：2008-12-25
申请号：US10587478
申请日：2006-06-05
申请人： Alexander Makarov , Eduard V. Denisov , Gerhard Jung , Wilko Balschun , Stevan Roy Horning
发明人： Alexander Makarov , Eduard V. Denisov , Gerhard Jung , Wilko Balschun , Stevan Roy Horning
IPC分类号： B01D59/46
CPC分类号： H01J49/4245 , H01J49/0027 , H01J49/02 , H01J49/282 , H01J49/406 , H01J49/425
摘要： An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U′(r,φ,z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U′(r, φ,z) is the result of a perturbation W to an ideal field U(r, φ,z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, φ,z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than about 2π radians over an ion detection period Tm.
摘要翻译：公开了诸如轨道捕获器的静电捕获器，具有电极结构。产生U'（r，phi，z）形式的静电捕获场，以捕获陷阱内的离子，使它们经历同步振荡。捕获场U'（r，phi，z）是对于理想场U（r，phi，z）的扰动W的结果，其在例如轨道捕获的情况下例如是超对数的。扰动W可以以各种方式引入，例如通过使陷波器的几何形状变形，使得其不再遵循理想场U（r，phi，z）的等电位，或者通过添加失真场（电或磁性）。扰动的幅度使得至少一些捕获的离子在离子检测周期Tm之后具有大于零但小于约2pi弧度的绝对相位扩展。

3. 发明授权

US07714283B2 Electrostatic trap 有权
标题翻译：静电诱捕器
公开(公告)号：US07714283B2
公开(公告)日：2010-05-11
申请号：US10587478
申请日：2006-06-05
申请人： Alexander Makarov , Eduard V. Denisov , Gerhard Jung , Wilko Balschun , Stevan Roy Horning
发明人： Alexander Makarov , Eduard V. Denisov , Gerhard Jung , Wilko Balschun , Stevan Roy Horning
IPC分类号： H01J49/28
CPC分类号： H01J49/4245 , H01J49/0027 , H01J49/02 , H01J49/282 , H01J49/406 , H01J49/425
摘要： An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U′(r,φ,z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U′(r, φ,z) is the result of a perturbation W to an ideal field U(r, φ,z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, φ,z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than about 2π radians over an ion detection period Tm.
摘要翻译：公开了诸如轨道捕获器的静电捕获器，具有电极结构。产生形式为U'（r，＆phgr，z）的静电捕获场，以捕获陷阱内的离子，使它们经历同步振荡。捕获场U'（r，＆phgr，，z）是对于理想场U（r，＆phgr;，z）的扰动W的结果，其在例如轨道捕获的情况下例如是超对数的。扰动W可以以各种方式引入，例如通过使陷波器的几何形状变形，使得其不再遵循理想场U（r，＆phgr，z）的等电位，或者通过添加失真场（电或磁性）。扰动的幅度使得至少一些捕获的离子具有大于零但小于约2的绝对相位扩展; 弧度超过离子检测周期Tm。

4. 发明申请

US20100181475A1 ELECTROSTATIC TRAP 有权
标题翻译：静电捕捉
公开(公告)号：US20100181475A1
公开(公告)日：2010-07-22
申请号：US12749334
申请日：2010-03-29
申请人： Alexander Makarov , Eduard V. Denisov , Gerhard Jung , Wilko Balschun , Stevan Roy Horning
发明人： Alexander Makarov , Eduard V. Denisov , Gerhard Jung , Wilko Balschun , Stevan Roy Horning
IPC分类号： H01J49/28
CPC分类号： H01J49/4245 , H01J49/0027 , H01J49/02 , H01J49/282 , H01J49/406 , H01J49/425
摘要： An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U′(r, φ, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U′(r, φ, z) is the result of a perturbation W to an ideal field U(r, φ, z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, φ, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2 π radians over an ion detection period Tm.
摘要翻译：公开了诸如轨道捕获器的静电捕获器，具有电极结构。产生形式为U'（r，＆phgr; z）的静电捕获场，以捕获陷阱内的离子，使得它们经历同步振荡。捕获场U'（r，＆phgr; z）是对于理想场U（r，＆phgr; z）的扰动W的结果，其在例如轨道捕获的情况下例如是超对数的。扰动W可以以各种方式引入，例如通过使陷波器的几何形状变形，使得其不再遵循理想场U（r，＆phgr; z）的等电位，或者通过添加失真场（电或磁性）。扰动的幅度使得至少一些捕获的离子具有大于零但小于2的绝对相位扩展; 弧度超过离子检测周期Tm。

5. 发明授权

US08198581B2 Electrostatic trap 有权
标题翻译：静电诱捕器
公开(公告)号：US08198581B2
公开(公告)日：2012-06-12
申请号：US12749334
申请日：2010-03-29
申请人： Alexander Makarov , Eduard V. Denisov , Gerhard Jung , Wilko Balschun , Stevan Roy Horning
发明人： Alexander Makarov , Eduard V. Denisov , Gerhard Jung , Wilko Balschun , Stevan Roy Horning
IPC分类号： H01J49/28
CPC分类号： H01J49/4245 , H01J49/0027 , H01J49/02 , H01J49/282 , H01J49/406 , H01J49/425
摘要： An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U′(r, φ, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U′(r, φ, z) is the result of a perturbation W to an ideal field U(r, φ, z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, φ, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2 Π radians over an ion detection period Tm.
摘要翻译：公开了诸如轨道捕获器的静电捕获器，具有电极结构。产生形式为U'（r，＆phgr; z）的静电捕获场，以捕获陷阱内的离子，使得它们经历同步振荡。捕获场U'（r，＆phgr; z）是对于理想场U（r，＆phgr; z）的扰动W的结果，其在例如轨道捕获的情况下例如是超对数的。扰动W可以以各种方式引入，例如通过使陷波器的几何形状变形，使得其不再遵循理想场U（r，＆phgr; z）的等电位，或者通过添加失真场（电或磁性）。扰动的幅度使得至少一些捕获的离子的绝对相位差大于零但小于2＆Pgr; 弧度超过离子检测周期Tm。

6. 发明授权

US08084749B2 Electrode for influencing ion motion in mass spectrometers 有权
标题翻译：用于影响质谱仪离子运动的电极
公开(公告)号：US08084749B2
公开(公告)日：2011-12-27
申请号：US12429460
申请日：2009-04-24
申请人： Jens Griep-Raming , Wilko Balschun , Alexander Makarov , Eduard V. Denisov , Joachim Müller
发明人： Jens Griep-Raming , Wilko Balschun , Alexander Makarov , Eduard V. Denisov , Joachim Müller
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/067 , H01J49/061
摘要： An electrode for influencing ion motion in mass spectrometers, having a dielectric substrate and a conducting layer on portions of the substrate, wherein peripheral borders, edges or convex shapes of the conducting layer adjoin free regions of the substrate. According to the invention, a dielectric layer is provided on transitions from the conducting layer to the adjoining free regions of the substrate such that at least some of the peripheral borders, edges or convex shapes of the conducting layer are covered.
摘要翻译：一种用于影响质谱仪中的离子运动的电极，其具有介电衬底和在衬底的部分上的导电层，其中导电层的周边边界，边缘或凸形形状与衬底的自由区域相邻。根据本发明，在从导电层到基板的相邻自由区的过渡处提供介电层，使得覆盖导电层的周边边界，边缘或凸形的至少一些。

7. 发明申请

US20100224774A1 Electrode for influencing ion motion in mass spectrometers 有权
标题翻译：用于影响质谱仪离子运动的电极
公开(公告)号：US20100224774A1
公开(公告)日：2010-09-09
申请号：US12429460
申请日：2009-04-24
申请人： Jens Griep-Raming , Wilko Balschun , Alexander Makarov , Eduard V. Denisov , Joachim Muller
发明人： Jens Griep-Raming , Wilko Balschun , Alexander Makarov , Eduard V. Denisov , Joachim Muller
IPC分类号： H01J49/26 , H01J49/40 , H01J49/06
CPC分类号： H01J49/067 , H01J49/061
摘要： An electrode for influencing ion motion in mass spectrometers, having a dielectric substrate and a conducting layer on portions of the substrate, wherein peripheral borders, edges or convex shapes of the conducting layer adjoin free regions of the substrate. According to the invention, a dielectric layer is provided on transitions from the conducting layer to the adjoining free regions of the substrate such that at least some of the peripheral borders, edges or convex shapes of the conducting layer are covered.
摘要翻译：一种用于影响质谱仪中的离子运动的电极，其具有介电衬底和在衬底的部分上的导电层，其中导电层的周边边界，边缘或凸形形状与衬底的自由区域相邻。根据本发明，在从导电层到基板的相邻自由区的过渡处提供介电层，使得覆盖导电层的周边边界，边缘或凸形的至少一些。

8. 发明申请

US20070138386A1 Method and apparatus for ion fragmentation by electron capture 有权
标题翻译：通过电子捕获离子碎裂的方法和装置
公开(公告)号：US20070138386A1
公开(公告)日：2007-06-21
申请号：US10592744
申请日：2005-03-29
申请人： Alexander Makarov , Eduard Denisov , Gerhard Jung
发明人： Alexander Makarov , Eduard Denisov , Gerhard Jung
IPC分类号： H01J49/00
CPC分类号： H01J49/0054
摘要： The present invention relates to a method and apparatus for ion fragmentation by electron capture. The present invention provides a method of generating fragment ions by electron capture, comprising; directing ions to be fragmented into a fragmentation chamber of a mass spectrometer into a fragmentation chamber of a mass spectrometer arrangement; trapping at least some of the ions to be fragmented in at least one direction of the fragmentation chamber by using a magnetic field, the ions being trapped within a volume V; generating an electron beam using an electron source located away from the volume V; irradiating the trapped ions in the volume V with the electrons generated by the electron source in the presence of the said magnetic field, so as to cause dissociation; and ejecting the resultant fragment ions from the fragmentation chamber for subsequent analysis at a different location away from the fragmentation chamber.
摘要翻译：本发明涉及一种通过电子捕获离子破碎的方法和装置。本发明提供了一种通过电子捕获产生碎片离子的方法，包括：将离子分散成质谱仪的碎裂室进入质谱仪布置的碎裂室; 通过使用磁场捕获在碎裂室的至少一个方向上被分段的至少一些离子，离子被捕获在体积V内; 使用远离体积V的电子源产生电子束; 在存在所述磁场的情况下用电子源产生的电子照射体积V中的被俘获的离子，从而导致解离; 并将所得的碎片离子从碎裂室排出，以便在远离碎裂室的不同位置进行后续分析。

9. 发明授权

US08916819B2 Method and apparatus for improving the throughput of a charged particle analysis system 有权
标题翻译：用于提高带电粒子分析系统的通过量的方法和装置
公开(公告)号：US08916819B2
公开(公告)日：2014-12-23
申请号：US13876794
申请日：2011-09-29
申请人： Alexander Makarov , Anastassios Giannakopulos
发明人： Alexander Makarov , Anastassios Giannakopulos
IPC分类号： B01D59/44 , H01J49/06 , H01J49/00
CPC分类号： H01J49/0027 , H01J49/0031 , H01J49/06 , H01J49/062
摘要： A method of increasing ion throughput within an accumulator, an energy lift and a pulsed ion extractor, operated in that order upon a batch of ions, comprising the steps of: firstly loading a batch of ions into the accumulator; secondly changing the electrical potential of the energy lift to raise the energy of the batch of ions contained therein; and thirdly ejecting the batch of ions from the pulsed ion extractor; and wherein: the energy lift is a separate device from the accumulator and the pulsed ion extractor, and whilst changing the electrical potential in the second step a fresh batch of ions is loaded into the accumulator and/or a previous batch of ions is prepared for ejection in the pulsed ion extractor; or the energy lift is incorporated into the pulsed ion extractor and whilst changing the electrical potential in the second step a fresh batch of ions is loaded into the accumulator; or the energy lift is incorporated into the accumulator and whilst changing the electrical potential in the second step a previous batch of ions is prepared for ejection in the pulsed ion extractor. A charged particle analyzer system is also provided.
摘要翻译：一种增加蓄电池内的离子通量的方法，能量提升和脉冲离子提取器，其以一批离子的顺序操作，包括以下步骤：首先将一批离子加载到蓄电池中; 二次改变能量升高的电位，以提高其中所含的一批离子的能量; 第三次从脉冲离子提取器中排出一批离子; 并且其中：所述能量提升是与所述蓄能器和所述脉冲离子提取器分离的装置，并且在第二步骤中改变电势的同时，将新批次的离子加载到所述储存器中和/或先前批次的离子准备在脉冲离子提取器中喷射; 或者能量提升被并入到脉冲离子提取器中，并且在第二步骤中改变电势的同时，将新批次的离子加载到蓄能器中; 或者能量提升被并入蓄能器中，并且在第二步骤中改变电位的同时，准备先前的一批离子以在脉冲离子提取器中喷射。还提供带电粒子分析仪系统。

10. 发明授权

US07425699B2 Mass spectrometry method and apparatus 有权
标题翻译：质谱法和仪器
公开(公告)号：US07425699B2
公开(公告)日：2008-09-16
申请号：US11832596
申请日：2007-08-01
申请人： Alexander Makarov , Mark E Hardman , Jae C. Schwartz , Michael W. Senko
发明人： Alexander Makarov , Mark E Hardman , Jae C. Schwartz , Michael W. Senko
IPC分类号： G01N27/62 , H01J49/00 , B01D59/44
CPC分类号： H01J49/4225 , G01N27/62 , H01J49/425
摘要： A mass spectrometer 10 comprises an ion source 12 which generates nebulized ions which enter an ion cooler 20 via an ion source block 16. Ions within a window of m/z of interest are extracted via a quadrupole mass filter 24 and passed to a linear trap 30. Ions are trapped in a potential well in the linear trap 30 and are bunched at the bottom of the potential well adjacent an exit segment 50. Ions are gated out of the linear trap 30 into an electrostatic ion trap 130 and are detected by a secondary electron multiplier 10. By bunching the ions in the linear trap 30 prior to ejection, and by focussing the ions in time of flight (TOF) upon the entrance of the electrostatic trap 130, the ions arrive at the electrostatic trap 130 as a convolution of short, energetic packets of similar m/z. Such packets are particularly suited to an electrostatic trap because the FWHM of each packet's TOF distribution is less than the period of oscillation of those ions in the electrostatic trap.
摘要翻译：质谱仪10包括产生经由离子源块16进入离子冷却器20的雾化离子的离子源12。通过四极质量过滤器24提取感兴趣的m / z窗口内的离子，并将其传递到线性阱30中。离子被捕获在线性阱30中的势阱中，并且在与潜在井相邻的势阱的底部聚集离子区域从线性阱30门控进入静电离子阱130中，并由二次电子倍增器10检测。通过在排出之前聚集线性阱30中的离子，并且通过在飞行（TOF）在静电捕获器130的入口处，离子以类似m / z的短能量分组的卷积到达静电捕获器130。由于每个分组的TOF分布的FWHM小于静电阱中的那些离子的振荡周期，所以这样的分组特别适用于静电阱。

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