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1. 发明申请

US20050158732A1 Novel purified polypeptides from Streptococcus pneumoniae 审中-公开
标题翻译：来自肺炎链球菌的新型纯化多肽
公开(公告)号：US20050158732A1
公开(公告)日：2005-07-21
申请号：US10871369
申请日：2004-06-18
申请人： Aled Edwards , Akil Dharamsi , Masoud Vedadi , Muhammad Alam , Simon Houston , Matthew Kimber , Robert Lam , Ivy Ng , Benjamin Pinder
发明人： Aled Edwards , Akil Dharamsi , Masoud Vedadi , Muhammad Alam , Simon Houston , Matthew Kimber , Robert Lam , Ivy Ng , Benjamin Pinder
IPC分类号： C12N9/00 , C12Q1/68 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： C12N9/93 , C07K2299/00
摘要： The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified proteins comprising amino acid sequences set forth within. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.
摘要翻译：本发明涉及病原菌的新型药物靶标。因此，本发明提供了包含在其内的氨基酸序列的纯化蛋白质。本发明还提供本发明多肽的生物化学和生物物理学特征。

2. 发明申请

US20050214773A1 Novel purified polypeptides from bacteria 审中-公开
标题翻译：来自细菌的新型纯化多肽
公开(公告)号：US20050214773A1
公开(公告)日：2005-09-29
申请号：US10806062
申请日：2004-03-22
申请人： Aled Edwards , Akil Dharamsi , Masoud Vedadi , Muhammad Alam , Megan Domagala , Simon Houston , Robert Lam , Qin Li , Kathleen Nethery-Brokx , Ivy Ng , Benjamin Pinder , Cristina Viola , Olga Wrezel , Dhushy Kanagarajah , Kamran Mansoury , Sasha Necakov , Francois Vallee , Merry-Lynn McDonald
发明人： Aled Edwards , Akil Dharamsi , Masoud Vedadi , Muhammad Alam , Megan Domagala , Simon Houston , Robert Lam , Qin Li , Kathleen Nethery-Brokx , Ivy Ng , Benjamin Pinder , Cristina Viola , Olga Wrezel , Dhushy Kanagarajah , Kamran Mansoury , Sasha Necakov , Francois Vallee , Merry-Lynn McDonald
IPC分类号： A61K38/00 , C07K14/205 , C07K14/21 , C07K14/245 , C07K14/31 , C07K14/315 , C12N9/00 , C12N9/04 , C12N9/10 , C12N9/12 , C12N9/80 , G01N33/569 , C12Q1/68 , C07H21/04 , C12N1/21 , C12N15/74
CPC分类号： C07K14/205 , A61K38/00 , C07K14/21 , C07K14/245 , C07K14/31 , C07K14/3156 , C07K2299/00 , C07K2319/00 , C12N9/0006 , C12N9/1077 , C12N9/1085 , C12N9/1205 , C12N9/1217 , C12N9/1229 , C12N9/1241 , C12N9/80 , C12N9/93 , C12Y207/01026 , C12Y207/01069 , C12Y207/02003 , C12Y207/07003 , C12Y601/01001 , C12Y601/0101 , C12Y601/01021 , G01N33/56911 , G01N33/56938 , G01N33/56944
摘要： The present invention relates to polypeptide targets for pathogenic bacteria. The invention also provides biochemical and biophysical characteristics of those polypeptides.
摘要翻译：本发明涉及致病细菌的多肽靶标。本发明还提供那些多肽的生物化学和生物物理学特征。

3. 发明申请

US20070004020A1 Crystal structures of aspartate semialdehyde dehydrogenases 审中-公开
标题翻译：天冬氨酸半醛脱氢酶的晶体结构
公开(公告)号：US20070004020A1
公开(公告)日：2007-01-04
申请号：US11172433
申请日：2005-06-30
申请人： Aled Edwards , Akil Dharamsi , Masoud Vedadi , Matthew Kimber , Robert Lam
发明人： Aled Edwards , Akil Dharamsi , Masoud Vedadi , Matthew Kimber , Robert Lam
IPC分类号： C12N9/02 , G06F19/00
CPC分类号： C12N9/0008 , C07K2299/00 , Y02A90/26
摘要： The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.
摘要翻译：本发明涉及病原菌的新型药物靶标。因此，本发明提供了包含SEQ ID NO：4所示氨基酸序列的纯化蛋白质。本发明还提供本发明多肽的生物化学和生物物理学特征。

4. 发明申请

US20060079669A1 Crystal structures of NH3-dependent NAD synthetases 审中-公开
标题翻译： NH3依赖性NAD合成酶的晶体结构
公开(公告)号：US20060079669A1
公开(公告)日：2006-04-13
申请号：US11171495
申请日：2005-06-30
申请人： Aled Edwards , Akil Dharamsi , Masoud Vedadi , Matthew Kimber , Robert Lam
发明人： Aled Edwards , Akil Dharamsi , Masoud Vedadi , Matthew Kimber , Robert Lam
IPC分类号： G06F19/00 , C07K14/21
CPC分类号： C12N9/93 , C07K2299/00 , G16B15/00 , Y02A90/26
摘要： The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.
摘要翻译：本发明涉及病原菌的新型药物靶标。因此，本发明提供了包含SEQ ID NO：4所示氨基酸序列的纯化蛋白质。本发明还提供本发明多肽的生物化学和生物物理学特征。

5. 发明申请

US20060078974A1 Novel purified hydroxymethylglutaryl-CoA reductases and structures thereof 审中-公开
标题翻译：新型纯化羟甲基戊二酰辅酶A还原酶及其结构
公开(公告)号：US20060078974A1
公开(公告)日：2006-04-13
申请号：US11229484
申请日：2005-09-16
申请人： Aled Edwards , Akil Dharamsi , Klaus Fiebig , Robert Lam
发明人： Aled Edwards , Akil Dharamsi , Klaus Fiebig , Robert Lam
IPC分类号： C12N9/02 , G06F19/00
CPC分类号： C12N9/0006 , C07K2299/00 , C12Y101/01034 , Y02A90/26
摘要： The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.
摘要翻译：本发明涉及病原菌的新型药物靶标。因此，本发明提供了包含SEQ ID NO：4所示氨基酸序列的纯化蛋白质。本发明还提供本发明多肽的生物化学和生物物理学特征。

6. 发明申请

US20060078922A1 Novel purified polypeptides from haemophilus influenzae 审中-公开
标题翻译：来自流感嗜血杆菌的新型纯化多肽
公开(公告)号：US20060078922A1
公开(公告)日：2006-04-13
申请号：US11224737
申请日：2005-09-12
申请人： Aled Edwards , Akil Dharamsi , Robert Lam
发明人： Aled Edwards , Akil Dharamsi , Robert Lam
IPC分类号： C12Q1/68 , G06F19/00 , C12P21/06 , C12N9/10 , C12N15/74
CPC分类号： C12N9/1241 , C07K14/285 , C07K2299/00 , G01N2333/285 , G01N2500/04
摘要： The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.
摘要翻译：本发明涉及病原菌的新型药物靶标。因此，本发明提供了包含SEQ ID NO：4所示氨基酸序列的纯化蛋白质。本发明还提供本发明多肽的生物化学和生物物理学特征。

7. 发明申请

US20110046022A1 CRYSTALLIZATION DEVICE FOR HIGH-THROUGHPUT VISUAL INSPECTION AND X-RAY DIFFRACTION ANALYSIS 审中-公开
标题翻译：用于高通量视觉检测和X射线衍射分析的结晶器件
公开(公告)号：US20110046022A1
公开(公告)日：2011-02-24
申请号：US12747029
申请日：2008-12-11
申请人： Nickolay Chirgadze , Joseph Miller , Robert Lam , Kathy Johns
发明人： Nickolay Chirgadze , Joseph Miller , Robert Lam , Kathy Johns
IPC分类号： C40B60/12
CPC分类号： G01N23/2005 , C30B7/04 , C30B29/58 , C30B35/00 , G01N2223/612
摘要： A crystallization chip has a two-dimensional substrate surface with modified wetting properties convenient for the evaluation of the crystallization experiment results by optical microscope and by X-ray diffraction. A crystallization chip mount comprises a base and a support structure that is connected to the base. The support structure provides a first channel that receives a portion of the crystallization chip. A crystallization chip holder comprises a body defining at least one slot to slidably receive the crystallization chip described herein. The at least one slot extends from an upper surface to a lower surface of the body. The crystallization chip holder further includes at least one support surface for each slot. For a given slot the at least one support surface is disposed on an edge of at least two surfaces of portions of the body that define the given slot. During use, the at least one support surface supports the crystallization chip prior to, during or after the formation of crystals.
摘要翻译：结晶芯片具有改性润湿性能的二维基材表面，便于通过光学显微镜和X射线衍射评价结晶实验结果。结晶芯片安装架包括底座和连接到基座的支撑结构。支撑结构提供接收结晶芯片的一部分的第一通道。结晶芯片保持器包括限定至少一个狭槽的主体以可滑动地容纳本文所述的结晶芯片。至少一个狭槽从主体的上表面延伸到下表面。结晶芯片保持架还包括用于每个槽的至少一个支撑表面。对于给定的槽，至少一个支撑表面设置在限定给定槽的主体部分的至少两个表面的边缘上。在使用期间，至少一个支撑表面在形成晶体之前，之中或之后支撑结晶芯片。

8. 发明申请

US20100305309A1 NANODIAMOND PARTICLE COMPLEXES 审中-公开
标题翻译：纳米颗粒复合物
公开(公告)号：US20100305309A1
公开(公告)日：2010-12-02
申请号：US12789966
申请日：2010-05-28
申请人： Dean Ho , Mark Chen , Erik Pierstorff , Erik Robinson , Robert Lam , Rafael Shimkunas , Xueqing Zhang
发明人： Dean Ho , Mark Chen , Erik Pierstorff , Erik Robinson , Robert Lam , Rafael Shimkunas , Xueqing Zhang
IPC分类号： C07K17/14 , C07H21/00 , C07C237/26
CPC分类号： C07K17/14 , A61K47/6921 , A61K47/6929 , B82Y5/00
摘要： The present invention provides various functionalized nanodiamond particles. In particular, the present invention provides soluble complexes of nanodiamond particles and therapeutic agents, for example insoluble therapeutics, anthracycline and/or tetracycline compounds, nucleic acids, proteins, etc.
摘要翻译：本发明提供了各种官能化纳米金刚石颗粒。特别地，本发明提供了纳米金刚石颗粒和治疗剂的可溶性复合物，例如不溶性治疗剂，蒽环类抗生素和/或四环素化合物，核酸，蛋白质等。

9. 发明授权

US06484478B1 System and method for packaging oriented containers 有权
标题翻译：面向包装的容器的系统和方法
公开(公告)号：US06484478B1
公开(公告)日：2002-11-26
申请号：US09490212
申请日：2000-01-24
申请人： Craig W. Arends , Lonnie R. Seymour , Robert Lam
发明人： Craig W. Arends , Lonnie R. Seymour , Robert Lam
IPC分类号： B65B3556
CPC分类号： B65C9/067 , B65B21/04 , B65B35/58 , B65G47/244 , B65G47/847 , B65G2201/0244 , B65G2207/42
摘要： A system and method for packaging oriented containers in a container carrier wherein a plurality of containers are fed into an orientation wheel including one or more chucks. Each chuck engages one end of the container and rotates the container into an oriented position. A transfer belt having a plurality of tactile fingers is operatively connected to the orientation wheel and transfers an oriented container nested within the tactile fingers in a fixed rotational position from the orientation wheel to a packaging machine. In a method of packaging containers according to this invention, multiple containers are positioned within the carrier in one or more rotational positions based upon the desired appearance of the package.
摘要翻译：一种用于在容器载体中包装定向容器的系统和方法，其中多个容器被馈送到包括一个或多个卡盘的定向轮中。每个卡盘啮合容器的一端并将容器旋转到取向位置。具有多个触觉指状物的转移带可操作地连接到定向轮，并将固定的旋转位置内的定向容器从定向轮传送到包装机。在根据本发明的包装容器的方法中，基于包装的期望外观，多个容器位于载体内的一个或多个旋转位置。

10. 发明申请

US20100040672A1 DELIVERY OF THERAPEUTICS 审中-公开
标题翻译：交付治疗
公开(公告)号：US20100040672A1
公开(公告)日：2010-02-18
申请号：US12481400
申请日：2009-06-09
申请人： Dean Ho , Robert Lam , Mark Chen , Houjin Huang , Erik Pierstorff , Erik Robinson
发明人： Dean Ho , Robert Lam , Mark Chen , Houjin Huang , Erik Pierstorff , Erik Robinson
IPC分类号： A61K9/70 , A61K31/56 , A61K31/351
CPC分类号： A61K31/573 , A61K9/0024 , A61K9/5115 , A61K9/7007 , A61K31/704 , A61K47/6957 , A61L27/34 , A61L27/54 , A61L2300/222 , A61L2300/41 , A61L2300/416 , A61L2300/602 , A61L2300/608 , A61L2300/624 , A61L2420/08 , C08L65/04
摘要： The present invention provides materials and devices for the controlled release of therapeutics, and methods for uses thereof.
摘要翻译：本发明提供用于控制释放治疗剂的材料和装置及其用途的方法。

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