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1. 发明授权

US4329986A Treatment of an extracorporeal stream of blood with a dialyzable chemotherapeutic and a fluorescable tracer 失效
标题翻译：用可透析化学治疗剂和可荧光示踪剂治疗体外血液流
公开(公告)号：US4329986A
公开(公告)日：1982-05-18
申请号：US48334
申请日：1979-06-14
申请人： Albert L. Babb
发明人： Albert L. Babb
IPC分类号： A61K33/00 , G01N33/487 , A61K49/00 , A61M5/00 , G01N31/00 , G01N33/48 , G01N33/52 , G01N33/84 , G01N35/00
CPC分类号： A61K33/00
摘要： A therapeutic composition suitable for extracorporeal treatment of whole blood comprises a dialyzable chemotherapeutic agent and a dialyzable fluorescable tracer means. The removal rate of the fluorescable tracer compound from treated blood during hemodialysis is a function of the removal rate of unreacted chemotherapeutic agent present. The residual chemotherapeutic agent concentration after hemodialysis is ascertained by measuring the concentration of the fluorescable tracer compound in a dialysate using fluorometric techniques.
摘要翻译：适用于全血的体外治疗的治疗组合物包括可透析的化学治疗剂和可透析的可荧光示踪剂装置。在血液透析期间，来自处理血液的可荧光示踪剂化合物的去除率是存在的未反应化学治疗剂的去除率的函数。通过使用荧光测定技术测量透析液中的可荧光示踪剂化合物的浓度来确定血液透析后的残留化学治疗剂浓度。

2. 发明授权

US4399036A Proportioning system for bicarbonate dialysate 失效
标题翻译：碳酸氢盐透析液比例系统
公开(公告)号：US4399036A
公开(公告)日：1983-08-16
申请号：US096865
申请日：1979-11-23
申请人： Albert L. Babb , Belding H. Scribner
发明人： Albert L. Babb , Belding H. Scribner
IPC分类号： A61M1/16 , B01F5/02 , C01D7/10 , B01D31/00 , B01D13/00
CPC分类号： C01D7/10 , A61M1/1656 , B01F5/02
摘要： A proportioning system for compounding a bicarbonate-containing dialysate suitable for hemodialysis of human blood is disclosed. An aqueous alkali metal carbonate solution and an aqueous hydrochloric acid-containing solution are combined at a predetermined volumetric rate, and the conductivity as well as the hydrogen ion activity of the resulting bicarbonate-containing dialysate is monitored.
摘要翻译：公开了一种用于混合适用于人血液透析的含碳酸氢盐透析液的配比系统。将碱金属碳酸盐水溶液和含盐酸水溶液以预定的体积比组合，并监测所得含碳酸氢盐透析液的电导率以及氢离子活性。

3. 发明授权

US5197464A Carbon dioxide detection 失效
标题翻译：二氧化碳检测
公开(公告)号：US5197464A
公开(公告)日：1993-03-30
申请号：US629055
申请日：1990-12-14
申请人： Albert L. Babb , Michael P. Hlastala , Gary L. Tarbox
发明人： Albert L. Babb , Michael P. Hlastala , Gary L. Tarbox
IPC分类号： A61B5/083 , A61M16/04 , G01N31/22
CPC分类号： A61M16/0488 , G01N31/223 , A61B5/0836 , A61M2016/0413
摘要： Methods and apparatus for ascertaining whether there is at least a threshold concentration of carbon dioxide in gases being monitored. Reversible hydration of the carbon dioxide to generate excess hydrogen ions and trigger a color change in a pH sensitive indicator is employed in represenative embodiments of the invention to provide a indication that the threshold concentration of carbon dioxide is present in the gases. The methods and apparatus may be used to distinguish between tracheal and esophageal intubation of human and other nammalian patients.
摘要翻译：确定在被监测的气体中是否存在至少二氧化碳的阈值浓度的方法和装置。在本发明的代表性实施方案中使用二氧化碳的可逆水合以产生过量氢离子并引发pH敏感指示剂的颜色变化，以提供二氧化碳的阈值浓度存在于气体中的指示。方法和装置可用于区分人和其他nammalian患者的气管和食管插管。

4. 发明授权

US4528178A Chemotherapeutic agent and tracer composition and use thereof 失效
标题翻译：化疗剂和示踪剂组合物及其用途
公开(公告)号：US4528178A
公开(公告)日：1985-07-09
申请号：US377383
申请日：1982-05-12
申请人： Albert L. Babb
发明人： Albert L. Babb
IPC分类号： A61K33/00 , G01N33/487 , G01N33/48 , G01N31/00
CPC分类号： A61K33/00 , Y10S436/80 , Y10S436/805 , Y10S436/811 , Y10S436/815
摘要： A therapeutic composition suitable for extracorporeal treatment of whole blood comprises a dialyzable chemotherapeutic agent and a dialyzable fluorescable tracer means. The removal rate of the fluorescable tracer compound from treated blood during hemodialysis is a function of the removal rate of unreacted chemotherapeutic agent present. The residual chemotherapeutic agent concentration after hemodialysis is ascertained by measuring the concentration of the fluorescable tracer compound in a dialysate using fluorometric techniques.
摘要翻译：适用于全血的体外治疗的治疗组合物包括可透析的化学治疗剂和可透析的可荧光示踪剂装置。在血液透析期间，来自处理血液的可荧光示踪剂化合物的去除率是存在的未反应化学治疗剂的去除率的函数。通过使用荧光测定技术测量透析液中的可荧光示踪剂化合物的浓度来确定血液透析后的残留化学治疗剂浓度。

5. 发明授权

US4411792A Lymph filtration system 失效
标题翻译：淋巴滤过系统
公开(公告)号：US4411792A
公开(公告)日：1983-10-25
申请号：US291175
申请日：1981-08-10
申请人： Albert L. Babb
发明人： Albert L. Babb
IPC分类号： A61M1/34 , A61M1/36 , B01D63/08 , B01D31/00 , B01D13/00
CPC分类号： B01D63/087 , A61M1/3496 , A61M1/3603 , A61M2202/0405 , A61M2202/0407 , A61M2205/7554 , A61M2206/12
摘要： A lymphapheresis or lymph filtration system is disclosed for removing lymph from a patient, separating the lymph into a liquid fraction and a cellular component fraction and returning the liquid fraction to the patient. The system includes an input pump to pump lymph from the patient into a filtration cell having a membrane which filters the lymph into fractions. The liquid fraction is removed from the cell by a reversible pump and is returned to the patient. As the membrane becomes plugged the reversible pump is reversed to backflush the membrane to return it to a high filtration rate. The cellular component fraction which includes lymphocytes is disposed of.
摘要翻译：公开了一种用于从患者中除去淋巴液的淋巴细胞过滤或淋巴过滤系统，将淋巴液分离成液体部分和细胞组分级分并将液体馏分返回给患者。该系统包括一个输入泵，将来自患者的淋巴液泵入具有将淋巴过滤成部分的膜的过滤细胞。液体部分通过可逆泵从细胞中除去并返回到患者体内。当膜被堵塞时，可逆泵被反向以反冲膜以将其返回到高过滤速率。处理包括淋巴细胞的细胞组分级分。

6. 发明授权

US4381004A Extracorporeal system for treatment of infectious and parasitic diseases 失效
标题翻译：用于治疗感染和寄生虫病的体外系统
公开(公告)号：US4381004A
公开(公告)日：1983-04-26
申请号：US225309
申请日：1981-01-15
申请人： Albert L. Babb
发明人： Albert L. Babb
IPC分类号： A61M1/36 , A61M1/03
CPC分类号： A61M1/3687 , Y10S128/03
摘要： An extracorporeal method is provided for the treatment of a disease caused by pathogenic microorganisms in the bloodstream in which blood is withdrawn from a patient and at least a fraction thereof is treated with a microorganism inactivator. Then, the inactivator and any endotoxins that may be present are removed from the blood or blood fraction, and the treated blood is returned to the patient. The method may also be used to prevent the transmission of pathogenic organisms from a blood donor to a transfusion recipient.
摘要翻译：提供了一种体外方法，用于治疗血液中的病原微生物引起的疾病，其中血液从患者中排出，并且至少一部分用微生物灭活剂治疗。然后，可以从血液或血液部分除去可能存在的灭活剂和任何内毒素，并将处理过的血液返回给患者。该方法还可用于防止致病生物从献血者传播至输血接受者。

7. 发明授权

US4326955A Hemodialysis with sodium bicarbonate dialysate prepared in plural stages 失效
标题翻译：用多级制备的碳酸氢钠透析液进行血液透析
公开(公告)号：US4326955A
公开(公告)日：1982-04-27
申请号：US209742
申请日：1980-11-24
申请人： Albert L. Babb , Belding H. Scribner
发明人： Albert L. Babb , Belding H. Scribner
IPC分类号： C01D7/10 , B01D13/00
CPC分类号： C01D7/10
摘要： A dialysate solution containing sodium bicarbonate is provided in which the sodium bicarbonate is generated just prior to dialysis by combining an aqueous sodium carbonate-containing stream with an aqueous stream containing hydrochloric acid, acetic acid or a mixture of these acids in at least two stages with an excess of acid in the first stage.
摘要翻译：提供了含有碳酸氢钠的透析液，其中在渗透之前产生碳酸氢钠，其中将含碳酸钠水溶液流与含有盐酸，乙酸或这些酸的混合物的水流在至少两个阶段中混合，第一阶段酸过多。

8. 发明授权

US5291879A Carbon dioxide detection (II) 失效
标题翻译：二氧化碳检测（二）
公开(公告)号：US5291879A
公开(公告)日：1994-03-08
申请号：US918372
申请日：1992-07-23
申请人： Albert L. Babb , Michael P. Hlastala , Gary L. Tarbox
发明人： Albert L. Babb , Michael P. Hlastala , Gary L. Tarbox
IPC分类号： A61B5/083 , A61M16/04 , G01N31/22 , A61M16/00
CPC分类号： A61M16/0488 , G01N31/223 , A61B5/0836 , A61M2016/0413
摘要： Methods and apparatus for ascertaining whether there is at least a threshold concentration of carbon dioxide in gases being monitored. Reversible hydration of the carbon dioxide to generate excess hydrogen ions and trigger a color change in a pH sensitive indicator is employed in representative embodiments of the invention to provide an indication that the threshold concentration of carbon dioxide is present in the gases. The methods and apparatus may be used to distinguish between tracheal and esophageal intubation of human and other mammalian patients.
摘要翻译：确定在被监测的气体中是否存在至少二氧化碳的阈值浓度的方法和装置。在本发明的代表性实施例中采用二氧化碳的可逆水合以产生过量的氢离子并引发pH敏感指示剂的颜色变化，以提供二氧化碳的阈值浓度存在于气体中的指示。方法和装置可以用于区分人和其他哺乳动物患者的气管和食管插管。

9. 发明授权

US4671298A Isothermal rebreathing apparatus and method 失效
标题翻译：等温再呼吸装置及方法
公开(公告)号：US4671298A
公开(公告)日：1987-06-09
申请号：US674941
申请日：1984-11-26
申请人： Albert L. Babb , Michael P. Hlastala
发明人： Albert L. Babb , Michael P. Hlastala
IPC分类号： G01N33/497 , A61B5/00
CPC分类号： G01N33/4972 , Y10S436/90 , Y10T436/204165
摘要： A isothermal rebreathing apparatus and method for collecting human breath samples for chemical analysis of the ethyl alcohol content wherein the breath samples are obtained from a subject repetitively exhaling into the inhaling from an enclosed, flexible, variable volume, bag-like collection receptacle which is heated to maintain the breath sample enclosed therein at a prescribed temperature, preferably at or near the subject's body temperature, before extracting the breath sample for subsequent chemical analysis. The collection receptacle may be enclosed by an airtight chamber including heaters therein to warm the air around the collection receptacle in order to regulate the temperature of the breath sample therein. A bellows section in fluid communication with the heating chamber allows for inflation and deflation of the flexible collection receptacle while located in an airtight environment.
摘要翻译：一种用于收集用于乙醇含量化学分析的人呼吸样本的等温再呼吸装置和方法，其中从受试者获得的呼吸样本从封闭的，柔性的，可变体积的袋状收集容器中重复地呼出吸入，该收集容器被加热在提取呼吸样品以进行后续化学分析之前，将呼吸样品包封在规定的温度下，优选地在受试者的体温附近或附近。收集容器可以由其中包括加热器的气密室包围以加热收集容器周围的空气，以便调节其中的呼吸样品的温度。与加热室流体连通的波纹管部分允许位于气密环境中的柔性收集容器的充气和放气。

10. 发明授权

US4336881A Aqueous acid concentrate for hemodialysis dialysate 失效
标题翻译：用于血液透析透析液的酸性浓缩酸水溶液
公开(公告)号：US4336881A
公开(公告)日：1982-06-29
申请号：US132866
申请日：1980-03-24
申请人： Albert L. Babb , Belding H. Scribner
发明人： Albert L. Babb , Belding H. Scribner
IPC分类号： A61M1/16 , B65D85/00
CPC分类号： A61M1/1654
摘要： An aqueous acid concentrate in unit dosage form, suitable for use in compounding a hemodialysis dialysate, is disclosed. The concentrate contains water, chloride ion in a concentration of about 3.5 Molar to about 4.7 Molar, sodium ion in a concentration of about 1.9 Molar to about 2.7 Molar, and dextrose in a concentration of about 0 Molar to about 0.4 Molar. Additionally, the concentrate may contain acetate group in a concentration of up to about 0.525 Molar, calcium ion in a concentration of up to about 0.125 Molar, potassium ion in a concentration of up to about 0.14 Molar, and magnesium ion in a concentration of up to about 0.09 Molar.
摘要翻译：公开了适用于混合血液透析透析液的单位剂量浓度的浓缩酸水溶液。浓缩物含有约3.5摩尔浓度至约4.7摩尔浓度的水，氯离子，约1.9摩尔浓度至约2.7摩尔浓度的钠离子和约0摩尔浓度至约0.4摩尔浓度的葡萄糖。此外，浓缩物可以含有浓度高达约0.525摩尔浓度的乙酸盐，浓度高达约0.125摩尔的钙离子，浓度高达约0.14摩尔的钾离子，浓度高达约0.14摩尔浓度的镁离子至约0.09摩尔。

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