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1. 发明授权

US06675033B1 Magnetic resonance imaging guidewire probe 有权
标题翻译：磁共振成像导丝探针
公开(公告)号：US06675033B1
公开(公告)日：2004-01-06
申请号：US09536090
申请日：2000-03-24
申请人： Albert C. Lardo , Xiaoming Yang , Ergin Atalar , Parag Karmarkar , Elliott R. McVeigh , Henry R. Halperin , Christine Enger McNamara , Paul A. Bottomley
发明人： Albert C. Lardo , Xiaoming Yang , Ergin Atalar , Parag Karmarkar , Elliott R. McVeigh , Henry R. Halperin , Christine Enger McNamara , Paul A. Bottomley
IPC分类号： A61B5055
CPC分类号： G01R33/287 , G01R33/34084
摘要： The invention describes a system, method, and means for an MRI guidewire that can be visible on an MRI, can act as an antenna and receive MRI signals from surrounding subject matter, and can allow the use of multiple interventional tools without removal of the guidewire from a subject.
摘要翻译：本发明描述了可以在MRI上可见的用于MRI导丝的系统，方法和装置，可用作天线并从周围主题接收MRI信号，并且可以允许使用多个介入工具而不去除导丝从一个主题。

2. 发明授权

US07848788B2 Magnetic resonance imaging probe 有权
标题翻译：磁共振成像探头
公开(公告)号：US07848788B2
公开(公告)日：2010-12-07
申请号：US10123065
申请日：2002-04-11
申请人： Steve Tulley , Albert C. Lardo , Parag Karmarkar , Elliot McVeigh , Henry R. Halperin , Christine Enger McNamara , Paul A. Bottomley , Ergin Atalar , Xiaoming Yang
发明人： Steve Tulley , Albert C. Lardo , Parag Karmarkar , Elliot McVeigh , Henry R. Halperin , Christine Enger McNamara , Paul A. Bottomley , Ergin Atalar , Xiaoming Yang
IPC分类号： A61B5/055
CPC分类号： G01R33/34084 , A61M25/09 , G01R33/287 , G01R33/34053 , G01R33/3657 , H01Q1/36 , H01Q1/362 , H01Q1/40 , H01Q1/42 , H01Q1/44 , H01Q11/08
摘要： Herein is disclosed a magnetic resonance imaging probe, having a probe shaft including a magnetic resonance antenna, and a spring tip attached to a distal end of the antenna.
摘要翻译：本文公开了一种磁共振成像探头，其具有包括磁共振天线的探针轴以及连接到天线远端的弹簧尖端。

3. 发明授权

US07422568B2 Device, systems and methods for localized heating of a vessel and/or in combination with MR/NMR imaging of the vessel and surrounding tissue 失效
标题翻译：用于容器局部加热和/或与容器和周围组织的MR / NMR成像组合的装置，系统和方法
公开(公告)号：US07422568B2
公开(公告)日：2008-09-09
申请号：US10404903
申请日：2003-04-01
申请人： Xiaoming Yang , Ergin Atalar , Christopher Yeung
发明人： Xiaoming Yang , Ergin Atalar , Christopher Yeung
IPC分类号： A61M31/00
CPC分类号： A61B18/1492 , A61B2018/00404 , A61B2018/144 , A61B2090/374 , A61B2218/002
摘要： Featured are devices, systems and methods for localized heating of a vessel as well as devices, systems and methods for MR/NMR imaging of a vessel while locally heating a portion of the vessel. More particularly featured are such devices, systems and methods for use when administering or delivering therapeutic agents including genes and/or drugs to the tissues of the vessel. Such a method includes positioning a thermal energy delivery device proximal a target site with the vessel of a body and activating the thermal energy delivery device so as to heat the target site thereby locally increasing a temperature of tissue at the target site. In further embodiments, the method includes introducing a therapeutic medium to the target site over a predetermined time period, and wherein said activating occurs at least one of before, during or after said step of introducing.
摘要翻译：特征是用于容器的局部加热的装置，系统和方法以及用于容器的MR / NMR成像的装置，系统和方法，同时局部加热容器的一部分。更特别的特征是这样的装置，系统和方法，用于在向血管的组织施用或递送包括基因和/或药物的治疗剂时使用。这种方法包括将靶区域近端的热能输送装置与身体的容器定位，并激活热能递送装置，以便加热靶部位，从而局部增加靶部位的组织温度。在另外的实施方案中，该方法包括在预定时间段内将治疗介质引入目标部位，并且其中所述激活发生在引入步骤之前，期间或之后的至少之一。

4. 发明申请

US20080208034A1 Device, systems and methods for localized heating of a vessel and/or in combination with mr/nmr imaging of the vessel and surrounding tissue 审中-公开
标题翻译：用于容器的局部加热和/或与容器和周围组织的mr / nmr成像组合的装置，系统和方法
公开(公告)号：US20080208034A1
公开(公告)日：2008-08-28
申请号：US12069865
申请日：2008-02-13
申请人： Xiaoming Yang , Ergin Atalar , Christopher Yeung
发明人： Xiaoming Yang , Ergin Atalar , Christopher Yeung
IPC分类号： A61B5/055 , A61B18/18 , A61M25/10
CPC分类号： A61B18/1492 , A61B2018/00404 , A61B2018/144 , A61B2090/374 , A61B2218/002
摘要： Featured are devices, systems and methods for localized heating of a vessel as well as devices, systems and methods for MR/NMR imaging of a vessel while locally heating a portion of the vessel. More particularly featured are such devices, systems and methods for use when administering or delivering therapeutic agents including genes and/or drugs to the tissues of the vessel. Such a method includes positioning a thermal energy delivery device proximal a target site within the vessel of a body and activating the thermal energy delivery device so as to heat the target site thereby locally increasing a temperature of tissue at the target site. In further embodiments, the method includes introducing a therapeutic medium to the target site over a predetermined time period, and wherein said activating occurs at least one of before, during or after said step of introducing.
摘要翻译：特征是用于容器的局部加热的装置，系统和方法以及用于容器的MR / NMR成像的装置，系统和方法，同时局部加热容器的一部分。更特别的特征是这样的装置，系统和方法，用于在向血管的组织施用或递送包括基因和/或药物的治疗剂时使用。这种方法包括将热能输送装置定位在身体的容器内的靶部位附近，并激活热能递送装置，以便加热靶部位，从而局部增加靶部位的组织温度。在另外的实施方案中，该方法包括在预定时间段内将治疗介质引入目标部位，并且其中所述激活发生在引入步骤之前，期间或之后的至少之一。

5. 发明授权

US09216977B2 Antofine and cryptopleurine derivatives as anticancer agents 有权
标题翻译：安托法和隐孢子虫衍生物作为抗癌剂
公开(公告)号：US09216977B2
公开(公告)日：2015-12-22
申请号：US13503113
申请日：2010-09-22
申请人： Kuo-Hsiung Lee , Xiaoming Yang , Qian Shi , Kenneth F. Bastow , Che-Ming Teng , Tse-Ming Hong , Pan-Chyr Yang , Shuenn-Chen Yang
发明人： Kuo-Hsiung Lee , Xiaoming Yang , Qian Shi , Kenneth F. Bastow , Che-Ming Teng , Tse-Ming Hong , Pan-Chyr Yang , Shuenn-Chen Yang
IPC分类号： A61K31/4355 , A61K31/436 , A61K31/4375 , C07D471/04 , C07D491/12 , C07D491/04
CPC分类号： C07D471/04 , C07D491/04
摘要： The present invention provides compounds of Formula (I-IV): compositions containing the same, and methods of use thereof such as for the treatment of cancer.
摘要翻译：本发明提供式（I-IV）化合物：含有该化合物的组合物及其使用方法，例如用于治疗癌症。

6. 发明申请

US20140153251A1 LED LAMP WITH OMNIDIRECTIONAL BEAM ANGLE 审中-公开
标题翻译： LED灯具带OMNIDIRECECECANG BEAM ANGLE
公开(公告)号：US20140153251A1
公开(公告)日：2014-06-05
申请号：US14235796
申请日：2012-03-20
申请人： Xiaoming Yang , Fuwen Li
发明人： Xiaoming Yang , Fuwen Li
IPC分类号： F21K99/00 , F21V13/02 , F21V29/00 , F21V7/00
CPC分类号： F21V29/71 , F21K9/232 , F21K9/60 , F21V3/02 , F21V7/0008 , F21V7/0016 , F21V7/0058 , F21V7/041 , F21V13/02 , F21Y2103/33 , F21Y2115/10 , Y02B20/30
摘要： A LED lamp with omnidirectional beam angle, comprises a lamp bulb shell and a light emitting unit. The lamp bulb shell covers the light emitting unit. The LED lamp with omnidirectional beam angle also comprises a reflecting unit. The reflecting unit comprises a reflecting member, and the reflecting member is fixed on the lamp bulb shell. The reflecting member is provided with an annular reflecting surface, and the annular reflecting surface of the reflecting member is arranged corresponding to the light emitting unit in order to reflect the light emitted from the light emitting unit to the bottom of the lamp bulb shell. The LED lamp with omnidirectional beam angle has the advantage of simple structure.
摘要翻译：具有全向光束角的LED灯，包括灯泡壳和发光单元。灯泡壳覆盖发光单元。具有全向光束角的LED灯还包括反射单元。反射单元包括反射构件，反射构件固定在灯泡壳上。反射构件设置有环形反射面，反射构件的环形反射面相对于发光单元配置，以便将从发光单元发射的光反射到灯泡壳的底部。具有全向光束角度的LED灯具有结构简单的优点。

7. 发明申请

US20120029018A1 9-SUBSTITUTED PHENANTHRENE BASED TYLOPHORINE DERIVATIVES 审中-公开
标题翻译： 9-取代的基于苯基的衍生物衍生物
公开(公告)号：US20120029018A1
公开(公告)日：2012-02-02
申请号：US13059426
申请日：2009-08-25
申请人： Kuo-Hsiung Lee , Qian Shi , Xiaoming Yang , Kenneth F. Bastow , Jau-Chen Lin , Pan-Chyr Yang
发明人： Kuo-Hsiung Lee , Qian Shi , Xiaoming Yang , Kenneth F. Bastow , Jau-Chen Lin , Pan-Chyr Yang
IPC分类号： A61K31/4525 , A61P35/00 , A61P35/02 , C07D405/10
CPC分类号： C07D405/06
摘要： The present invention provides compounds of Formula I: compositions containing the same, and methods of use thereof such as for the treatment of cancer.
摘要翻译：本发明提供式I化合物：含有该化合物的组合物及其使用方法，例如治疗癌症。

8. 发明授权

US07101558B2 High yield pertussis vaccine production strain and method for making same 有权
标题翻译：高产率百日咳疫苗生产菌株及其制备方法
公开(公告)号：US07101558B2
公开(公告)日：2006-09-05
申请号：US10312272
申请日：2001-06-26
申请人： Tod J. Merkel , Jerry M. Keith , Xiaoming Yang
发明人： Tod J. Merkel , Jerry M. Keith , Xiaoming Yang
IPC分类号： A61K39/02 , A01N63/00
CPC分类号： C12N1/20 , C07K14/235 , C12N15/74
摘要： The present invention provides a vaccine production strain of Bordetella bronchiseptica that produces a pertussis toxin in high yield. The present invention provides a method for creating a Bordetella bronchiseptica cell line which produces a Bordetella pertussis toxin comprising the steps of introducing a plasmid containing a DNA encoding antibiotic resistance into a Bordetella bronchiseptica strain, selecting for isolates in which the DNA encoding antibiotic resistance is recombinantly incorporated into the chromosome in place of the Bordetella bronchiseptica toxin gene, introducing a plasmid containing DNA encoding subunits of the Bordetella pertussis toxins into the Bordetella bronchiseptica isolates; and, selecting for isolates in which DNA encoding Bordetella pertussis toxin subunit is recombinantly incorporated into the chromosome, the resulting cells producing the Bordetella pertussis toxin. The present invention further provides a method for creating a Bordetella bronchiseptica cell line which produces a Bordetella pertussis toxin and does not express filamentous hemagglutinin.
摘要翻译：本发明提供了以高产率产生百日咳毒素的支气管炎博德特氏菌疫苗生产菌株。本发明提供了一种产生博德特氏菌百日咳杆菌毒素的博德特氏菌细胞系的方法，包括将含有编码抗生素抗性的DNA的质粒导入支气管炎博德特氏菌菌株，选择其中编码抗生素抗性的DNA重组的分离株引入染色体以代替支气管炎博德特氏菌毒素基因，将含有编码百日咳杆菌毒素的亚基的DNA的质粒引入支气管炎博德特菌分离株; 并且选择其中编码百日咳博德特氏菌毒素亚基的DNA重组并入染色体的分离物，所得细胞产生百日咳博德特氏菌毒素。本发明还提供一种产生支气管炎博德特氏菌细胞系的方法，其产生百日咳杆菌毒素并且不表达丝状血凝素。

9. 发明授权

US06008281A Powder and binder systems for use in metal and ceramic powder injection molding 有权
标题翻译：用于金属和陶瓷粉末注射成型的粉末和粘合剂体系
公开(公告)号：US06008281A
公开(公告)日：1999-12-28
申请号：US265106
申请日：1999-03-09
申请人： Xiaoming Yang , Robert J. Petcavich
发明人： Xiaoming Yang , Robert J. Petcavich
IPC分类号： B29C45/00 , B22F1/00 , B22F3/02 , B22F3/10 , B22F3/22 , B28B1/24 , C04B35/634 , C04B35/638 , C08K3/00 , C08K5/053 , C08K5/103 , C08L23/06 , C08L23/12 , C08L29/04
CPC分类号： B22F3/225 , B22F1/0059 , B22F3/1025 , C04B35/634 , C04B35/63408 , C04B35/63416 , C04B35/638 , C08K5/053 , C08L29/04 , B22F2998/00 , C08L23/06 , C08L23/12
摘要： A powder injection molding composition or feedstock is made of 70% or more by weight of a powdered metal or ceramic and 30% or less by weight of a binder system. The binder system contains a sufficient amount of polypropylene or polyethylene to hold the so-called brown preform of the molded metal or ceramic powder together for the sintering step of the injection molding process and a sufficient amount of partially hydrolyzed cold water soluble polyvinyl alcohol water and plasticizer to facilitate molding of the composition into the so- called green preform of the article to be manufactured. The debinding step of the injection molding process for transforming the green preform into the brown preform consists simply of immersing the green preform in water at ambient temperature to dissolve the polyvinyl alcohol. The binder system is nonhazardous, safe, harmless and fully degradable.
摘要翻译：粉末注射成型组合物或原料由70重量％或更多的粉末金属或陶瓷制成，30重量％或更少的粘合剂体系制成。粘合剂体系含有足量的聚丙烯或聚乙烯以将模制的金属或陶瓷粉末的所谓棕色预成型件保持在一起用于注射成型过程的烧结步骤和足量的部分水解的冷水可溶性聚乙烯醇水和增塑剂以便于将组合物模塑成待制造的制品的所谓的绿色预制件。用于将生坯预成型体转变成棕色预制件的注射成型方法的脱胶步骤仅在于将生坯预成型体在环境温度下浸入水中以溶解聚乙烯醇。粘合剂系统是非危险的，安全的，无害的和完全可降解的。

10. 发明申请

US20060154354A1 HIGH YIELD PERTUSSIS VACCINE PRODUCTION STRAIN AND METHOD FOR MAKING SAME 有权
标题翻译：高产量PERTUSSIS VACCINE生产菌株及其制备方法
公开(公告)号：US20060154354A1
公开(公告)日：2006-07-13
申请号：US10312272
申请日：2001-06-26
申请人： Tod Merkel , Jerry Keith , Xiaoming Yang
发明人： Tod Merkel , Jerry Keith , Xiaoming Yang
IPC分类号： C12N1/21
CPC分类号： C12N1/20 , C07K14/235 , C12N15/74
摘要： The present invention provides a vaccine production strain of Bordetella bronchiseptica that produces a pertussis toxin in high yield. The present invention provides a method for creating a Bordetella bronchiseptica cell line which produces a Bordetella pertussis toxin comprising the steps of introducing a plasmid containing a DNA encoding antibiotic resistance into a Bordetella bronchiseptica strain, selecting for isolates in which the DNA encoding antibiotic resistance is recombinantly incorporated into the chromosome in place of the Bordetella bronchiseptica toxin gene, introducing a plasmid containing DNA encoding subunits of the Bordetella pertussis toxins into the Bordetella bronchiseptica isolates; and, selecting for isolates in which DNA encoding Bordetella pertussis toxin subunit is recombinantly incorporated into the chromosome, the resulting cells producing the Bordetella pertussis toxin. The present invention further provides a method for creating a Bordetella bronchiseptica cell line which produces a Bordetella pertussis toxin and does not express filamentous hemagglutinin.
摘要翻译：本发明提供了以高产率产生百日咳毒素的支气管炎博德特氏菌疫苗生产菌株。本发明提供了一种产生博德特氏菌百日咳杆菌毒素的博德特氏菌细胞系的方法，包括将含有编码抗生素抗性的DNA的质粒导入支气管炎博德特氏菌菌株，选择其中编码抗生素抗性的DNA重组的分离株引入染色体以代替支气管炎博德特氏菌毒素基因，将含有编码百日咳杆菌毒素的亚基的DNA的质粒引入支气管炎博德特菌分离株; 并且选择其中编码百日咳博德特氏菌毒素亚基的DNA重组并入染色体的分离物，所得细胞产生百日咳博德特氏菌毒素。本发明还提供一种产生支气管炎博德特氏菌细胞系的方法，其产生百日咳杆菌毒素并且不表达丝状血凝素。

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