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1. 发明授权

US08318441B2 Fibrinogen alpha and hemoglobin polypeptides as cancer markers 有权
标题翻译：纤维蛋白原α和血红蛋白多肽作为癌症标志物
公开(公告)号：US08318441B2
公开(公告)日：2012-11-27
申请号：US12753527
申请日：2010-04-02
申请人： Alexander Miron , James Dirk Iglehart , Lyndsay N. Harris , Xin Lu , Qian Shi
发明人： Alexander Miron , James Dirk Iglehart , Lyndsay N. Harris , Xin Lu , Qian Shi
IPC分类号： G01N33/53
CPC分类号： G01N33/57407 , G01N2333/75 , G01N2333/805 , G01N2800/44
摘要： The present invention provides methods of detecting cancer using biomarkers.
摘要翻译：本发明提供使用生物标志物检测癌症的方法。

2. 发明授权

US08236852B2 Compounds with (substituted phenyl)-propenal moiety, their derivatives, biological activity, and use thereof 有权
公开(公告)号：US08236852B2
公开(公告)日：2012-08-07
申请号：US12008124
申请日：2008-01-08
申请人： Charles C. Y. Shih , Qian Shi , Hui-Kang Wang , Ching-Yuan Su
发明人： Charles C. Y. Shih , Qian Shi , Hui-Kang Wang , Ching-Yuan Su
IPC分类号： A61K31/24 , A61K31/135 , A61K31/12
CPC分类号： C07C49/255 , C07C45/00 , C07C45/30 , C07C45/673 , C07C45/68 , C07C45/73 , C07C45/74 , C07C47/277 , C07C49/248 , C07C49/753 , C07C69/007 , C07C69/738 , C07C69/96 , C07C225/16 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C49/12
摘要： The present invention includes compounds, pharmaceuticals and cosmetics having at least one (substituted phenyl)-propenal moiety. The compounds and compositions of the present invention are useful in the treatment or prevention of medical conditions including androgen associated conditions, androgen associated inflammation, acne, alopecia, hirsutism, a wound, prostate cancer, bladder cancer, liver cancer, breast cancer and Kennedy's disease.

3. 发明申请

US20120046247A1 1,5-DIPHENYL-PENTA-1,4-DIEN-3-ONE COMPOUNDS 有权
标题翻译： 1,5-二苯基-1,4-二烯-3-酮化合物
公开(公告)号：US20120046247A1
公开(公告)日：2012-02-23
申请号：US13210728
申请日：2011-08-16
申请人： Charles C-Y Shih , Toshio Kitamura , Qian Shi , Toshiyuki Kawashima , Hui-Kang Wang
发明人： Charles C-Y Shih , Toshio Kitamura , Qian Shi , Toshiyuki Kawashima , Hui-Kang Wang
IPC分类号： A61K31/6615 , C07C309/67 , C07D211/74 , C07C235/82 , C07F9/12 , C07F9/32 , C07C225/16 , C07C49/255 , C07C307/02 , C07D295/112 , A61K31/12 , A61K31/255 , A61K31/45 , A61K31/165 , A61K31/663 , A61K31/138 , A61K31/661 , A61K31/4453 , A61K31/5375 , A61P35/00 , A61P35/02 , C07C49/248
CPC分类号： C07C49/248 , C07C49/235 , C07C49/255 , C07C69/16 , C07C217/22 , C07C217/60 , C07C235/82 , C07C307/02 , C07C309/65 , C07C309/66 , C07C309/73 , C07C317/24 , C07C2601/14 , C07C2601/16 , C07D213/68 , C07D295/112 , C07D295/13 , C07F9/06 , C07F9/09 , C07F9/12 , C07F9/32 , C07F9/3282
摘要： This invention relates to compounds of Formula (I), (II), or (III) as shown in the specification, which contain a 1,5-diphenylpenta-1,4-dien-3-one backbone. These compounds can be used to treat cancer, inflammatory disease, or autoimmune disease.
摘要翻译：本发明涉及说明书中所示的含有1,5-二苯基戊-1,4-二烯-3-酮骨架的式（I），（II）或（III）的化合物。这些化合物可用于治疗癌症，炎性疾病或自身免疫性疾病。

4. 发明申请

US20060145776A1 High-speed VCO calibration technique for frequency synthesizers 审中-公开
标题翻译：用于频率合成器的高速VCO校准技术
公开(公告)号：US20060145776A1
公开(公告)日：2006-07-06
申请号：US11028693
申请日：2005-01-05
申请人： Qian Shi , Kevin Wang
发明人： Qian Shi , Kevin Wang
IPC分类号： H03L1/00
CPC分类号： H03L7/10 , H03L7/0891 , H03L7/18
摘要： The voltage-controlled oscillator (VCO) in a frequency synthesizer using a phase-locked loop (PLL) is calibrated digitally during power up. The VCO has a coarse frequency control and a fine frequency control. The coarse control is a digital phase-locked loop to quantize the broad frequency range into limited number of frequency steps with a clock frequency divided from the VCO frequency, and to hold the phase-locked dc control voltage for the fine control. By limiting the number of frequency steps and clocking at a divided frequency of the VCO, the coarse control is speeded up. The fine control is [connected to the charge pump output as in] a regular PLL. By searching for the optimal control setting, the center frequency of the VCO is trimmed close to the wanted frequency for the PLL to lock. This allows small VCO gain without losing the tolerance of process and temperature variations. As a result, the PLL phase noise performance is improved.
摘要翻译：在上电期间，使用锁相环（PLL）的频率合成器中的压控振荡器（VCO）进行数字校准。 VCO具有粗略的频率控制和精细的频率控制。粗略控制是数字锁相环，用于将宽频率范围量化为有限数量的频率步长，时钟频率与VCO频率分开，并保持用于精细控制的锁相直流控制电压。通过限制VCO的分频频率的频率步长和时钟频率，粗调控制被加速。精细的控制是[连接到常规PLL的电荷泵输出]。通过搜索最佳控制设置，VCO的中心频率被修剪成接近PLL的锁定频率。这允许小的VCO增益，而不会失去工艺和温度变化的公差。结果，提高了PLL相位噪声性能。

5. 发明申请

US20130338160A1 Compounds with (1E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof 有权
公开(公告)号：US20130338160A1
公开(公告)日：2013-12-19
申请号：US13920199
申请日：2013-06-18
申请人： Charles SHIH , Qian Shi , Hui-kang Wang
发明人： Charles SHIH , Qian Shi , Hui-kang Wang
IPC分类号： C07D295/192 , C07C49/255 , C07C69/618 , C07C235/78 , C07C309/65 , C07D277/46
CPC分类号： C07D295/16 , A61K31/12 , A61K31/165 , A61K31/255 , A61K31/426 , A61K31/5375 , C07C49/255 , C07C59/90 , C07C69/618 , C07C69/738 , C07C235/74 , C07C235/78 , C07C309/65 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D277/44 , C07D277/46 , C07D295/192 , Y10S514/884
摘要： The present invention includes compounds, pharmaceuticals and cosmetics having at least one (substituted phenyl)-propenal moiety. The compounds and compositions of the present invention are useful in the treatment or prevention of medical conditions including androgen associated conditions, androgen associated inflammation, a wound (the compounds assist with wound healing), acne, rheumatoid arthritis, psoriasis, rosacea, and alopecia; Kennedy's disease (spinal and bulbar muscular atrophy, or SBMA), polyglutamine-mediated motor neuron degeneration; cancers such as prostate cancer, bladder cancer, breast cancer, ovarian cancer, hepatocellular (liver) cancer, and pancreatic cancer; and other medical conditions described herein. Treatment of such medical conditions includes administering to an individual suffering from a medical condition describe herein, a therapeutically effective amount of any of the disclosed compounds, their derivatives, or pharmaceutical compositions thereof.

6. 发明申请

US20130261121A1 Compounds with (1E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof 有权
公开(公告)号：US20130261121A1
公开(公告)日：2013-10-03
申请号：US13525941
申请日：2012-06-18
申请人： Charles C.Y. SHIH , Qian Shi , Hui-Kang Wang , Ching-Yuan Su
发明人： Charles C.Y. SHIH , Qian Shi , Hui-Kang Wang , Ching-Yuan Su
IPC分类号： C07C49/255 , C07D277/46 , C07D295/192 , C07C235/78
CPC分类号： C07C49/255 , A61K31/12 , A61K31/135 , A61K31/165 , A61K31/216 , A61K31/426 , A61K31/5375 , C07C235/78 , C07D277/46 , C07D295/192
摘要： The present invention includes compounds, pharmaceuticals and cosmetics having at least one (substituted phenyl)-propenal moiety. The compounds and compositions of the present invention are useful in the treatment or prevention of medical conditions including androgen associated conditions, androgen associated inflammation, a wound (the compounds assist with wound healing), acne, rheumatoid arthritis, psoriasis, rosacea, and alopecia; Kennedy's disease (spinal and bulbar muscular atrophy, or SBMA), polyglutamine-mediated motor neuron degeneration; cancers such as prostate cancer, bladder cancer, breast cancer, ovarian cancer, hepatocellular (liver) cancer, and pancreatic cancer; and other medical conditions described herein. Treatment of such medical conditions includes administering to an individual suffering from a medical condition describe herein, a therapeutically effective amount of any of the disclosed compounds, their derivatives, or pharmaceutical compositions thereof.

7. 发明授权

US08276587B2 Automated qualitative mask fit tester 有权
标题翻译：自动定性面膜适合测试仪
公开(公告)号：US08276587B2
公开(公告)日：2012-10-02
申请号：US12372082
申请日：2009-02-17
申请人： Hai Zhang , Will Zanto , Qian Shi , Greg Olson , Phillip Poeschl , Vincent Majkowski , Stuart J. Olstad
发明人： Hai Zhang , Will Zanto , Qian Shi , Greg Olson , Phillip Poeschl , Vincent Majkowski , Stuart J. Olstad
IPC分类号： A61M16/00 , A61M16/14 , A61M15/00
CPC分类号： A61M11/06 , A61M2016/0027 , A61M2205/075 , A61M2205/50 , A61M2209/02
摘要： A hand-held, automated qualitative fit tester (QLFT) for establishing gas mask fit integrity. The automated QLFT may be configured to utilize a pressure source in combination with a cartridge and a nebulizer to generate aerosols having size distributions and concentrations that are substantially the same as OSHA-approved manual units. The QLFT may further include a cartridge that contains the aerosol solution used to test mask integrity. The cartridge may be configured to recapture solution that collects on the interior walls of the nebulizer. The automated QLFT may also be equipped with a microprocessor for executing sequences that are in substantive compliance with 29 CFR 1910.134 and for writing to a data storage device. The automated aspects of the invention can reduce or negate the need for operating personnel to repeatedly and manually actuate a squeeze ball and record results manually, as is required with present OSHA-approved hand-held aerosol generators.
摘要翻译：一种用于建立防毒面具配合完整性的手持式自动定性适合测试仪（QLFT）。自动化QLFT可以被配置为利用与筒和喷雾器组合的压力源来产生具有与OSHA认可的手动单元基本相同的尺寸分布和浓度的气溶胶。 QLFT还可以包括含有用于测试掩模完整性的气溶胶溶液的盒。墨盒可以被配置为重新捕获在雾化器的内壁上收集的溶液。自动化QLFT还可以配备微处理器，用于执行实质上符合29 CFR 1910.134的序列以及写入数据存储设备。本发明的自动化方面可以减少或否定操作人员重复和手动地致动挤压球并且手动记录结果的需要，如现在的OSHA认可的手持式气溶胶发生器所要求的。

8. 发明申请

US20050110550A1 DC offset cancellation in a direct-conversion receiver 审中-公开
标题翻译：直接转换接收机中的直流偏移消除
公开(公告)号：US20050110550A1
公开(公告)日：2005-05-26
申请号：US10719833
申请日：2003-11-24
申请人： Qian Shi , Liang Dai , Kevin Wang
发明人： Qian Shi , Liang Dai , Kevin Wang
IPC分类号： H03D3/00 , H03F3/45 , H03L5/00
CPC分类号： H03F3/45991 , H03D3/008 , H03F3/45973 , H03F2200/294 , H03F2200/372
摘要： The DCOC block is used in ZIF BB to form HPF function to cancel dc offset with a penalty of small silicon area and low power consumption. It is a LPF plus a voltage to current conversion (VIC) resistor, and can hook up with any BB opamp used in signal path, to form a feedback loop, with or without signal gain stages in the loop. The BB opamp is used as a summing point. The summing method is input current summing. The cutoff frequency of the HPF function is thus defined by the integrator, the VIC resistor, and the feedback resistor in the summing opamp. The presence of the VIC resistor can drastically reduce the integrator capacitor and resistor values and thus save silicon area or improve receiver performance.
摘要翻译：在ZIF BB中使用DCOC块形成HPF功能，以小的硅面积和低功耗的损失来消除直流偏移。它是一个LPF加上电压 - 电流转换（VIC）电阻，并且可以连接在信号通路中使用的任何BB运算放大器，形成一个反馈回路，在回路中有或没有信号增益级。 BB运算符用作求和点。求和方法为输入电流求和。因此，HPF功能的截止频率由积分器，VIC电阻和求和运算放大器中的反馈电阻器定义。 VIC电阻的存在可以显着降低积分器电容和电阻值，从而节省硅面积或提高接收机性能。

9. 发明授权

US06624317B1 Taxoid conjugates as antimitotic and antitumor agents 失效
标题翻译：紫杉烷类缀合物作为抗生素和抗肿瘤剂
公开(公告)号：US06624317B1
公开(公告)日：2003-09-23
申请号：US09669156
申请日：2000-09-25
申请人： Kuo-Hsiung Lee , Qian Shi , Kenneth F. Bastow , Hui-Kang Wang
发明人： Kuo-Hsiung Lee , Qian Shi , Kenneth F. Bastow , Hui-Kang Wang
IPC分类号： C07D30500
CPC分类号： C07D405/12 , A61K47/55 , A61K47/552 , A61K47/555 , C07D305/14 , C07D471/04 , C07D493/04 , C07H15/26 , C07H17/02
摘要： Compounds according to formula I: T1—L—T2 (I), wherein T1 is a taxoid group, preferably of Formula II: wherein R1 is C6H5; R2 is O; L is a linking group; and T2 is a substituent selected from the group consisting of epipodophyllotoxin, amsacrine, ellipticine, anthracycline antibiotic, mitoxantrone, and colchicine groups, and pharmaceutically acceptable salts thereof, are provided herein. The compounds are useful in, among other things, treating tumors or cancer in subjects in need thereof, inducing cellular differentiation, and inhibiting cellular mitosis.
摘要翻译：根据式I的化合物：其中T1是紫杉烷基，优选式II：其中R1是C6H5; R2是O; L是连接基团; 并且T2是选自表鬼臼毒素，amsacrine，玫瑰树碱，蒽环类抗生素，米托蒽醌和秋水仙素基团的取代基及其药学上可接受的盐。除其他外，该化合物可用于治疗有需要的受试者的肿瘤或癌症，诱导细胞分化和抑制细胞有丝分裂。

10. 发明授权

US09216977B2 Antofine and cryptopleurine derivatives as anticancer agents 有权
标题翻译：安托法和隐孢子虫衍生物作为抗癌剂
公开(公告)号：US09216977B2
公开(公告)日：2015-12-22
申请号：US13503113
申请日：2010-09-22
申请人： Kuo-Hsiung Lee , Xiaoming Yang , Qian Shi , Kenneth F. Bastow , Che-Ming Teng , Tse-Ming Hong , Pan-Chyr Yang , Shuenn-Chen Yang
发明人： Kuo-Hsiung Lee , Xiaoming Yang , Qian Shi , Kenneth F. Bastow , Che-Ming Teng , Tse-Ming Hong , Pan-Chyr Yang , Shuenn-Chen Yang
IPC分类号： A61K31/4355 , A61K31/436 , A61K31/4375 , C07D471/04 , C07D491/12 , C07D491/04
CPC分类号： C07D471/04 , C07D491/04
摘要： The present invention provides compounds of Formula (I-IV): compositions containing the same, and methods of use thereof such as for the treatment of cancer.
摘要翻译：本发明提供式（I-IV）化合物：含有该化合物的组合物及其使用方法，例如用于治疗癌症。

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