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1. 发明授权

US4861581A Detection of necrotic malignant tissue and associated therapy 失效
标题翻译：检测坏死性恶性组织及相关治疗
公开(公告)号：US4861581A
公开(公告)日：1989-08-29
申请号：US938425
申请日：1986-12-05
申请人： Alan L. Epstein , Clive R. Taylor
发明人： Alan L. Epstein , Clive R. Taylor
IPC分类号： A61K39/395 , A61K47/48 , A61K49/04 , A61K49/16 , A61K51/00 , A61K51/10 , C07K14/005 , C07K14/195 , C07K16/00 , C07K16/08 , C07K16/30 , C07K19/00 , C12P21/00 , C12P21/08 , G01N33/574 , G01N33/577
CPC分类号： C07K16/3061 , A61K47/48384 , A61K49/04 , A61K49/16 , A61K51/1018 , A61K51/1045 , C07K16/30 , G01N33/57496 , A61K2121/00 , A61K2123/00 , C07K2317/54
摘要： Disclosed is a method for measuring the effectiveness of therapy intended to kill malignant cells in vivo in a mammal, comprising the steps of obtaining monoclonal antibody that is specific to an internal cellular component of the mammal but not to external cellular components, wherein the monoclonal antibody is labeled; contacting the labeled antibody with tissue of a mammal that has received therapy to kill malignant cells in vivo, and determining the effectiveness of the therapy by measuring the binding of the labeled antibody to the internal cellular component. The internal cellular component is preferably insoluble intracellular antigen, and the label is preferably a radionuclide, a radiopaque material, or a magnetic resonance-enhancing material. Also disclosed is a method whereby the antibody to insoluble intracellular antigen is conjugated to an antineoplastic agent, so that upon administration of the antibody-antineoplastic agent conjugate, antineoplastic agent may be delivered to the tumor. Also disclosed are antibodies for use with the foregoing methods.
摘要翻译：公开了一种测量用于在哺乳动物体内杀死恶性细胞的治疗效果的方法，包括以下步骤：获得对哺乳动物的内部细胞成分特异但不与外部细胞成分特异的单克隆抗体，其中单克隆抗体被标记使标记的抗体与已经接受治疗以在体内杀死恶性细胞的哺乳动物的组织接触，并通过测量标记的抗体与内部细胞组分的结合来确定治疗的有效性。内部细胞组分优选为不溶性细胞内抗原，并且标记物优选为放射性核素，不透射线材料或磁共振增强材料。还公开了一种使不溶性细胞内抗原的抗体与抗肿瘤剂缀合的方法，使得在施用抗体 - 抗肿瘤剂缀合物时，可将抗肿瘤药递送至肿瘤。还公开了与上述方法一起使用的抗体。

2. 发明授权

US5019368A Detection of necrotic malignant tissue and associated therapy 失效
标题翻译：检测坏死性恶性组织及相关治疗
公开(公告)号：US5019368A
公开(公告)日：1991-05-28
申请号：US314437
申请日：1989-02-23
申请人： Alan L. Epstein , Clive R. Taylor
发明人： Alan L. Epstein , Clive R. Taylor
IPC分类号： A61K38/00 , A61K47/48 , A61K49/04 , A61K49/16 , A61K51/10 , C07K16/30 , G01N33/574
CPC分类号： G01N33/57496 , A61K47/48384 , A61K47/48569 , A61K49/04 , A61K49/16 , A61K51/1018 , A61K51/1045 , C07K16/30 , C07K16/3061 , A61K2121/00 , A61K2123/00 , A61K38/00 , C07K2317/54
摘要： Disclosed is a method for enhancing the effects of therapy that kills malignant cells in vivo comprising the steps of obtaining monoclonal antibody that is specific to an internal cellular component of a mammal but not to external cellular components, wherein the monoclonal antibody is attached to an antineoplastic agent; initiating therapy in a mammal to kill malignant cells in vivo, thereby causing some of the malignant cells to become necrotic; and administering the antibodies to the mammal. The antibodies bind to the necrotic malignant cells thereby delivering antineoplastic agent to surrounding cells. Also disclosed is a method of de novo therapy comprising administration of antibody-antineoplastic agent conjugate such that antineoplastic agent is delivered to the tumor. Also disclosed are antibodies for use with the foregoing methods and for use with diagnositc methods.
摘要翻译：公开了一种用于增强在体内杀死恶性细胞的治疗效果的方法，包括获得对哺乳动物的内部细胞成分特异但不与外部细胞成分特异的单克隆抗体的步骤，其中单克隆抗体连接于抗肿瘤代理人在哺乳动物中开始治疗以在体内杀死恶性细胞，从而导致一些恶性细胞变坏; 并向哺乳动物施用抗体。抗体结合坏死性恶性细胞，从而将抗肿瘤剂递送至周围细胞。还公开了一种从头治疗的方法，其包括施用抗 - 抗肿瘤剂缀合物，使得抗肿瘤剂递送至肿瘤。还公开了与上述方法一起使用并用于诊断方法的抗体。

3. 发明授权

US6071491A Detection of necrotic malignant tissue and associated therapy 失效
标题翻译：检测坏死性恶性组织及相关治疗
公开(公告)号：US6071491A
公开(公告)日：2000-06-06
申请号：US370367
申请日：1999-08-09
申请人： Alan L. Epstein , Clive R. Taylor
发明人： Alan L. Epstein , Clive R. Taylor
IPC分类号： A61K38/00 , A61K47/48 , A61K49/04 , A61K49/16 , A61K51/10 , C07K16/30 , G01N33/574 , A61K51/00 , A61M36/14
CPC分类号： G01N33/57496 , A61K47/48384 , A61K47/48569 , A61K49/04 , A61K49/16 , A61K51/1018 , A61K51/1045 , C07K16/30 , C07K16/3061 , A61K2121/00 , A61K2123/00 , A61K38/00 , C07K2317/54
摘要： Disclosed are methods for identifying the presence of a tumor in a mammal, comprising the steps of obtaining an antibody against cell ghosts, wherein the antibody is specific to an intracellular antigen not present on the cell surface of normal or neoplastic cells, and wherein the antibody is labeled with a label capable of being imaged; administering the antibody to the mammal, thereby permitting the antibody to bind preferentially to necrotic tissue; and imaging the binding of the antibody to the necrotic tissue, wherein a localized concentration of said antibody is indicative of the presence of a tumor. The antibodies used in these methods are preferably monoclonal antibodies, are also preferably specific for one or more nuclear proteins, and are also preferably labeled with one or more radionuclides. Also disclosed are antibodies for use with the foregoing methods.
摘要翻译：公开了用于鉴定哺乳动物肿瘤存在的方法，包括以下步骤：获得针对细胞重影的抗体，其中所述抗体对于不存在于正常或肿瘤细胞的细胞表面上的细胞内抗原是特异性的，并且其中所述抗体标有能够成像的标签; 向哺乳动物施用抗体，从而允许抗体优先结合坏死组织; 以及成像抗体与坏死组织的结合，其中所述抗体的局部浓度指示肿瘤的存在。这些方法中使用的抗体优选是单克隆抗体，也优选对一种或多种核蛋白是特异性的，并且还优选用一种或多种放射性核素标记。还公开了与上述方法一起使用的抗体。

4. 发明授权

US6017514A Detection of necrotic malignant tissue and associated therapy 失效
标题翻译：检测坏死性恶性组织及相关治疗
公开(公告)号：US6017514A
公开(公告)日：2000-01-25
申请号：US268543
申请日：1999-03-11
申请人： Alan L. Epstein , Clive R. Taylor
发明人： Alan L. Epstein , Clive R. Taylor
IPC分类号： A61K38/00 , A61K47/48 , A61K49/04 , A61K49/16 , A61K51/10 , C07K16/30 , G01N33/574 , A61K49/00 , G01N31/00 , G01N33/48
CPC分类号： G01N33/57496 , A61K47/48384 , A61K47/48569 , A61K49/04 , A61K49/16 , A61K51/1018 , A61K51/1045 , C07K16/30 , C07K16/3061 , A61K2121/00 , A61K2123/00 , A61K38/00 , C07K2317/54
摘要： Disclosed is a method for measuring the effectiveness of therapy intended to kill malignant cells in vivo in a mammal, comprising the steps of obtaining monoclonal antibody that is specific to an internal cellular component of the mammal but not to external cellular components, wherein the monoclonal antibody is labeled; contacting the labeled antibody with tissue of a mammal that has received therapy to kill malignant cells in vivo, and determining the effectiveness of the therapy by measuring the binding of the labeled antibody to the internal cellular component. The internal cellular component is preferably insoluble intracellular antigen, and the label is preferably a radionuclide, a radiopaque material, or a magnetic resonance-enhancing material. Also disclosed is a method whereby the antibody to insoluble intracellular antigen is conjugated to an antineoplastic agent, so that upon administration of the antibody-antineoplastic agent conjugate, antineoplastic agent may be delivered to the tumor. Also disclosed are antibodies for use with the foregoing methods.
摘要翻译：公开了一种测量用于在哺乳动物体内杀死恶性细胞的治疗效果的方法，包括以下步骤：获得对哺乳动物的内部细胞成分特异但不与外部细胞成分特异的单克隆抗体，其中单克隆抗体被标记使标记的抗体与已经接受治疗以在体内杀死恶性细胞的哺乳动物的组织接触，并通过测量标记的抗体与内部细胞组分的结合来确定治疗的有效性。内部细胞组分优选为不溶性细胞内抗原，并且标记物优选为放射性核素，不透射线材料或磁共振增强材料。还公开了一种使不溶性细胞内抗原的抗体与抗肿瘤剂缀合的方法，使得在施用抗体 - 抗肿瘤剂缀合物时，可将抗肿瘤药递送至肿瘤。还公开了与上述方法一起使用的抗体。

5. 发明授权

US5882626A Detection of necrotic malignant tissue and associated therapy 失效
公开(公告)号：US5882626A
公开(公告)日：1999-03-16
申请号：US668920
申请日：1991-03-13
申请人： Alan L. Epstein , Clive R. Taylor
发明人： Alan L. Epstein , Clive R. Taylor
IPC分类号： A61K38/00 , A61K47/48 , A61K49/04 , A61K49/16 , A61K51/10 , C07K16/30 , G01N33/574 , A61K51/00 , A61M36/14
CPC分类号： G01N33/57496 , A61K47/48384 , A61K47/48569 , A61K49/04 , A61K49/16 , A61K51/1018 , A61K51/1045 , C07K16/30 , C07K16/3061 , A61K2121/00 , A61K2123/00 , A61K38/00 , C07K2317/54
摘要： Disclosed is a method for measuring the effectiveness of therapy intended to kill malignant cells in vivo in a mammal, comprising the steps of obtaining monoclonal antibody that is specific to an internal cellular component of the mammal but not to external cellular components, wherein the monoclonal antibody is labeled; contacting the labeled antibody with tissue of a mammal that has received therapy to kill malignant cells in vivo, and determining the effectiveness of the therapy by measuring the binding of the labeled antibody to the internal cellular component. The internal cellular component is preferably insoluble intracellular antigen, and the label is preferably a radionuclide, a radiopaque material, or a magnetic resonance-enhancing material. Also disclosed is a method whereby the antibody to insoluble intracellular antigen is conjugated to an antineoplastic agent, so that upon administration of the antibody-antineoplastic agent conjugate, antineoplastic agent may be delivered to the tumor. Also disclosed are antibodies for use with the foregoing methods.

6. 发明申请

US20140113385A1 Compositions and Methods for Identifying Single Antigens or Other Molecules in Cell Preparations 审中-公开
标题翻译：在细胞制剂中鉴定单一抗原或其他分子的组合物和方法
公开(公告)号：US20140113385A1
公开(公告)日：2014-04-24
申请号：US13877436
申请日：2011-10-21
申请人： Clive R. Taylor
发明人： Clive R. Taylor
IPC分类号： G01N33/543
CPC分类号： G01N33/54313
摘要： Disclosed are compositions and methods for identifying and preferably quantifying single antigens/molecules in tissue sections and other cell preparations. The methods make use of specific antibodies or aptomers linked with beads or other micro-particles using bright field microscopy having the purpose to identify and quantify single antigens or other molecules.
摘要翻译：公开了用于鉴定和优选地定量组织切片和其它细胞制剂中的单个抗原/分子的组合物和方法。该方法利用具有目的来鉴定和定量单个抗原或其他分子的明视野显微镜，利用与珠粒或其他微粒子连接的特异性抗体或起始物。

7. 发明申请

US20100267162A1 METHODS FOR QUANTITATIVE TARGET DETECTION AND RELATED DEVICES AND SYSTEMS 有权
标题翻译：量化目标检测方法及相关设备和系统
公开(公告)号：US20100267162A1
公开(公告)日：2010-10-21
申请号：US12761299
申请日：2010-04-15
申请人： Emil P. KARTALOV , Axel Scherer , Clive R. Taylor
发明人： Emil P. KARTALOV , Axel Scherer , Clive R. Taylor
IPC分类号： G01N27/22 , G01N27/00
CPC分类号： B01L3/502753 , B01L2200/0647 , B01L2300/0645 , B01L2300/0816 , B01L2300/0864
摘要： Described herein are methods for quantitative target detection in a sample through use of microbeads and related devices and systems.
摘要翻译：本文描述了通过使用微珠和相关装置和系统在样品中进行定量目标检测的方法。

8. 发明申请

US20120003664A1 METHOD FOR EVALUATING PRE-TREATMENT 审中-公开
标题翻译：评估预处理方法
公开(公告)号：US20120003664A1
公开(公告)日：2012-01-05
申请号：US13133558
申请日：2009-12-09
申请人： Uffe Lovborg , Zhiming Liao , Clive R. Taylor
发明人： Uffe Lovborg , Zhiming Liao , Clive R. Taylor
IPC分类号： G01N33/53
CPC分类号： G01N1/31 , G01N35/00594
摘要： The present invention relates to methods for evaluating tissue pre-treatment such as ischemic time, fixation time and alcohol time in an immunohistochemical assay by using one or more internal controls. Said internal controls may be biomarker specific or tissue specific. Also included are uses and kits comprising said internal controls.
摘要翻译：本发明涉及通过使用一个或多个内部对照在免疫组织化学测定中评价组织预处理如缺血时间，固定时间和酒精时间的方法。所述内部对照可以是生物标记特异性或组织特异性。还包括包括所述内部控制的用途和试剂盒。

9. 发明授权

US09005987B2 Methods for quantitative target detection and related devices and systems 有权
标题翻译：定量目标检测方法及相关设备及系统
公开(公告)号：US09005987B2
公开(公告)日：2015-04-14
申请号：US12761299
申请日：2010-04-15
申请人： Emil P. Kartalov , Axel Scherer , Clive R. Taylor
发明人： Emil P. Kartalov , Axel Scherer , Clive R. Taylor
IPC分类号： G01N27/22 , B01L3/00 , G01N27/00
CPC分类号： B01L3/502753 , B01L2200/0647 , B01L2300/0645 , B01L2300/0816 , B01L2300/0864
摘要： Described herein are methods for quantitative target detection in a sample through use of microbeads and related devices and systems.
摘要翻译：本文描述了通过使用微珠和相关装置和系统在样品中进行定量目标检测的方法。

10. 发明授权

US5658743A Antibody to antigen specifically expressed on the surface of B cells and Hodgkin's cells 失效
标题翻译：在B细胞和霍奇金细胞表面上特异性表达的抗原抗体
公开(公告)号：US5658743A
公开(公告)日：1997-08-19
申请号：US229364
申请日：1994-04-18
申请人： Ashraf Imam , Clive R. Taylor
发明人： Ashraf Imam , Clive R. Taylor
IPC分类号： C07K14/705 , C07K16/28 , C07K16/30 , G01N33/53 , G01N33/574
CPC分类号： C07K14/705 , C07K16/28 , C07K16/3061 , C07K2317/73 , Y10S530/837
摘要： The invention relates to a new antigen termed BLA-36 specifically expressed on the surface of Hodgkin's cells, Reed-Sternberg cells and B lymphocytes, and to a new monoclonal antibody (anti-BLA-36) specific thereto. The antigen is characterized by the following properties:a molecular weight of about 36,000 D;the presence of an epitope recognized by antibody to said protein;specific expression by Hodgkin's cells and Reed-Sternberg cells in all subsets of Hodgkin's disease, and by activated and early proliferating B cells;no expression by T cells;capability of reacting with its antibody in both frozen and fixed/paraffin embedded tissues;a function associated with the growth of cells capable to express said antigen protein.
摘要翻译：本发明涉及在霍奇金细胞，Reed-Sternberg细胞和B淋巴细胞表面特异性表达的称为BLA-36的新抗原，以及与其特异性的新的单克隆抗体（抗BLA-36）。抗原的特征在于以下性质：分子量约36,000D; 存在抗体对所述蛋白质识别的表位; Hodgkin's细胞和Reed-Sternberg细胞在霍奇金病的所有亚型中的特异性表达，以及活化和早期增殖的B细胞; T细胞无表达; 在冷冻和固定/石蜡包埋组织中与其抗体反应的能力; 与能够表达所述抗原蛋白的细胞的生长相关的功能。

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