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1. 发明授权

US09075065B2 Prostate cancer biomarker 有权
标题翻译：前列腺癌生物标志物
公开(公告)号：US09075065B2
公开(公告)日：2015-07-07
申请号：US13063320
申请日：2009-09-10
申请人： Zhiming Liao , Uffe Lovborg
发明人： Zhiming Liao , Uffe Lovborg
IPC分类号： C12Q1/00 , G01N33/53 , G01N33/574
CPC分类号： G01N33/57434
摘要： The present invention relates to the field of prostate cancer. Particularly the invention relates to villin as a novel prostate biomarker. The invention further relates to compositions comprising anti-villin antibodies and use of these compositions for an improved detection of prostate cancer in a subject.
摘要翻译：本发明涉及前列腺癌领域。特别地，本发明涉及作为新型前列腺生物标志物的维生素。本发明还涉及包含抗绒毛蛋白抗体的组合物和这些组合物用于改善受试者前列腺癌的检测。

2. 发明申请

US20080003669A1 HYBRID AERATION MEMBRANE BIOREACTOR 审中-公开
标题翻译：混合动力膜生物反应器
公开(公告)号：US20080003669A1
公开(公告)日：2008-01-03
申请号：US11769831
申请日：2007-06-28
申请人： Zhiming LIAO , Rong LI , Dejin JU , Jijun WU , Jingkui GUO , Yuhe HUANG , Dongsheng CAI , Aiguo WAN , Kun YU , Zhizhong LIU
发明人： Zhiming LIAO , Rong LI , Dejin JU , Jijun WU , Jingkui GUO , Yuhe HUANG , Dongsheng CAI , Aiguo WAN , Kun YU , Zhizhong LIU
IPC分类号： C12M1/04
CPC分类号： C02F3/1273 , C02F3/20 , C12M29/04 , Y02W10/15
摘要： The present invention teaches a hybrid aeration membrane bioreactor, comprising a bio-reaction tank; a plurality of membrane modules disposed within the bio-reaction tank; a macropore aeration apparatus comprising a first aeration pipe; a plurality of macropore heads having each a plurality of macropores, the macropore heads being disposed on the first aeration pipe; and a first gas pump; and a micropore aeration apparatus comprising a second aeration pipe; a plurality of micropore heads having each a plurality of micropores, the micropore heads being disposed on the second aeration pipe; and a second gas pump; wherein the first aeration pipe is connected to the first gas pump; the second aeration pipe is connected to the second gas pump; the macropore head is disposed below the membrane module; the micropore head is disposed near the bottom of the bio-reaction tank; and the micropores are smaller in diameter than the macropores. In accordance with the present invention, two aeration types, the macropore aeration and the micropore aeration, are combined, at the same aeration rate, the oxygen utilization rate of the membrane bioreactor is increased and thus the energy consumption for treating waste water is decreased. Therefore, the reactor is suitable for treating highly loaded organic waste water.
摘要翻译：本发明教导了混合曝气膜生物反应器，其包括生物反应罐; 设置在生物反应罐内的多个膜组件; 一种大孔曝气装置，包括第一曝气管; 多个具有多个大孔的大孔喷头，大孔喷头设置在第一曝气管上; 和第一气泵; 以及包括第二曝气管的微孔曝气装置; 具有多个微孔的多个微孔头，所述微孔头设置在所述第二曝气管上; 和第二气泵; 其中所述第一曝气管连接到所述第一气泵; 第二通气管连接到第二气泵; 大孔头设置在膜组件下方; 微孔头设置在生物反应罐底部附近; 并且微孔的直径比大孔小。根据本发明，通过两种通气类型，大孔曝气和微孔曝气，以相同的通气速率组合，膜生物反应器的氧气利用率增加，因此用于处理废水的能量消耗降低。因此，反应器适用于处理高负荷有机废水。

3. 发明申请

US20120003664A1 METHOD FOR EVALUATING PRE-TREATMENT 审中-公开
标题翻译：评估预处理方法
公开(公告)号：US20120003664A1
公开(公告)日：2012-01-05
申请号：US13133558
申请日：2009-12-09
申请人： Uffe Lovborg , Zhiming Liao , Clive R. Taylor
发明人： Uffe Lovborg , Zhiming Liao , Clive R. Taylor
IPC分类号： G01N33/53
CPC分类号： G01N1/31 , G01N35/00594
摘要： The present invention relates to methods for evaluating tissue pre-treatment such as ischemic time, fixation time and alcohol time in an immunohistochemical assay by using one or more internal controls. Said internal controls may be biomarker specific or tissue specific. Also included are uses and kits comprising said internal controls.
摘要翻译：本发明涉及通过使用一个或多个内部对照在免疫组织化学测定中评价组织预处理如缺血时间，固定时间和酒精时间的方法。所述内部对照可以是生物标记特异性或组织特异性。还包括包括所述内部控制的用途和试剂盒。

4. 发明授权

US09040667B2 Antibody cocktail 有权
标题翻译：抗体鸡尾酒
公开(公告)号：US09040667B2
公开(公告)日：2015-05-26
申请号：US13318215
申请日：2010-04-27
申请人： Zhiming Liao , Jeanette Musser
发明人： Zhiming Liao , Jeanette Musser
IPC分类号： C07K16/00 , G01N33/574
CPC分类号： G01N33/57434 , G01N2333/47 , G01N2333/4742 , G01N2333/99 , G01N2800/52
摘要： The present invention relates to a composition comprising at least three primary antibodies or fragments thereof, wherein the at least three antibodies or fragments thereof binds specifically to at least three different proteins, and wherein the at least three different proteins are AMCAR, CK 5/6, and HMWC. Methods for using the composition in diagnosis, prognosis, and assessing efficacy of treatment is further included as well as kits comprising said composition, and optionally, instructions of its use.
摘要翻译：本发明涉及包含至少三种一抗或其片段的组合物，其中所述至少三种抗体或其片段特异性结合至少三种不同的蛋白质，并且其中所述至少三种不同的蛋白质是AMCAR，CK5 / 6 ，和HMWC。进一步包括在组合物诊断，预后和评价治疗功效中使用该组合物的方法以及包含所述组合物和任选的其使用说明书的试剂盒。

5. 发明申请

US20120082999A1 NEW ANTIBODY COCKTAIL 有权
标题翻译：新抗体蛋白
公开(公告)号：US20120082999A1
公开(公告)日：2012-04-05
申请号：US13318215
申请日：2010-04-27
申请人： Zhiming Liao , Jeanette Musser
发明人： Zhiming Liao , Jeanette Musser
IPC分类号： G01N33/573
CPC分类号： G01N33/57434 , G01N2333/47 , G01N2333/4742 , G01N2333/99 , G01N2800/52
摘要： The present invention relates to a composition comprising at least three primary antibodies or fragments thereof, wherein the at least three antibodies or fragments thereof binds specifically to at least three different proteins, and wherein the at least three different proteins are AMCAR, CK 5/6, and HMWC. Methods for using the composition in diagnosis, prognosis, and assessing efficacy of treatment is further included as well as kits comprising said composition, and optionally, instructions of its use.
摘要翻译：本发明涉及包含至少三种一抗或其片段的组合物，其中所述至少三种抗体或其片段特异性结合至少三种不同的蛋白质，并且其中所述至少三种不同的蛋白质是AMCAR，CK5 / 6 ，和HMWC。进一步包括在组合物诊断，预后和评价治疗功效中使用该组合物的方法以及包含所述组合物和任选的其使用说明书的试剂盒。

6. 发明申请

US20110236910A1 PROSTATE CANCER BIOMARKER 有权
标题翻译：前列腺癌生物标志物
公开(公告)号：US20110236910A1
公开(公告)日：2011-09-29
申请号：US13063320
申请日：2009-09-10
申请人： Zhiming Liao , Uffe Lovborg
发明人： Zhiming Liao , Uffe Lovborg
IPC分类号： G01N33/574 , C07K14/47 , C07K16/18
CPC分类号： G01N33/57434
摘要： The present invention relates to the field of prostate cancer. Particularly the invention relates to villin as a novel prostate biomarker. The invention further relates to compositions comprising anti-villin antibodies and use of these compositions for an improved detection of prostate cancer in a subject.
摘要翻译：本发明涉及前列腺癌领域。特别地，本发明涉及作为新型前列腺生物标志物的维生素。本发明还涉及包含抗绒毛蛋白抗体的组合物和这些组合物用于改善受试者前列腺癌的检测。

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