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1. 发明申请

US20050037462A1 GP75 as a tumor vaccine for melanoma 审中-公开
标题翻译： GP75作为黑色素瘤肿瘤疫苗
公开(公告)号：US20050037462A1
公开(公告)日：2005-02-17
申请号：US10877489
申请日：2004-06-25
申请人： Alan Houghton , Setaluri Vijayasaradhi
发明人： Alan Houghton , Setaluri Vijayasaradhi
IPC分类号： C12N15/11 , A61K31/65 , A61K35/36 , A61K38/00 , A61K39/00 , A61K48/00 , A61P35/00 , C07K14/47 , C12N9/02 , C12N15/09 , C12N15/12 , C12N15/53 , C12N15/63 , A61K38/27 , C07H21/04 , C07K7/08
CPC分类号： C12Y110/03001 , A61K38/00 , A61K39/00 , C07K14/47 , C12N9/0059 , C12N9/0071 , C12Y114/16002 , C12Y114/18001
摘要： The present invention provides an isolated nucleic acid molecule whose sequence encodes the amino acid sequence for gp75 or a fragment thereof. The present invention further provides an isolated cDNA molecule of the gp75 nucleic acid molecule or a fragment thereof and the amino acid sequence derived therefrom. This invention also provides vaccines for stimulating or enhancing in a subject to whom the vaccine is administered production of antibodies directed against gp75. This invention further provides methods using the vaccines of this invention for stimulating or enhancing production of antibodies against gp75 as well as for treating, preventing or delaying the recurrence of cancer.
摘要翻译：本发明提供了分离的核酸分子，其序列编码gp75的氨基酸序列或其片段。本发明还提供了gp75核酸分子或其片段的分离的cDNA分子和由其衍生的氨基酸序列。本发明还提供用于在施用疫苗的受试者中刺激或增强针对gp75的抗体产生的疫苗。本发明还提供了使用本发明的疫苗刺激或增强针对gp75的抗体的产生以及用于治疗，预防或延迟癌症复发的方法。

2. 发明授权

US06673348B2 Heat shock protein-based vaccines and immunotherapies 失效
公开(公告)号：US06673348B2
公开(公告)日：2004-01-06
申请号：US09794832
申请日：2001-02-27
申请人： James E. Rothman , F. Ulrich Hartl , Mee H. Hoe , Alan Houghton , Yoshizumi Takeuchi , Mark Mayhew
发明人： James E. Rothman , F. Ulrich Hartl , Mee H. Hoe , Alan Houghton , Yoshizumi Takeuchi , Mark Mayhew
IPC分类号： A61K3900
CPC分类号： C07K7/06 , A61K38/00 , A61K39/0005 , A61K39/0011 , A61K39/02 , A61K39/12 , A61K47/646 , A61K47/65 , A61K47/6901 , A61K48/00 , A61K2039/5152 , A61K2039/5156 , A61K2039/53 , A61K2039/6043 , A61K2039/622 , A61K2039/625 , C07K7/08 , C07K14/47 , C12N2710/20034 , Y10S530/828
摘要： The present invention relates to methods and compositions for inducing an immune response in a subject, wherein the subject is administered an effective amount of a heat shock protein complexed to a hybrid antigen comprising an antigenic domain and a heat shock protein-binding domain. These methods and compositions may be used in the treatment of infectious diseases and cancers.

3. 发明授权

US06331299B1 Method for treatment of cancer and infectious disease and compositions useful in same 失效
标题翻译：用于治疗癌症和感染性疾病的方法和可用于其的组合物
公开(公告)号：US06331299B1
公开(公告)日：2001-12-18
申请号：US09011648
申请日：1998-02-13
申请人： James E. Rothman , F. Ulrich Hartl , Mee H. Hoe , Alan Houghton , Yoshizumi Takeuchi , Mark Mayhew
发明人： James E. Rothman , F. Ulrich Hartl , Mee H. Hoe , Alan Houghton , Yoshizumi Takeuchi , Mark Mayhew
IPC分类号： A61K4800
CPC分类号： C07K7/06 , A61K38/00 , A61K39/0005 , A61K39/0011 , A61K47/646 , A61K47/65 , A61K47/6901 , A61K48/00 , A61K2039/5152 , A61K2039/5156 , A61K2039/53 , A61K2039/6043 , A61K2039/622 , A61K2039/625 , C07K7/08 , C07K14/47
摘要： Administration of expressible polynucleotides encoding eukaryotic heat shock proteins to mammalian cells leads to the stimulation of an immune response to antigens present in those cells. This makes it possible to stimulate an immune response to target antigens, including target tumor antigens or antigens associated with an infectious disease, without having to isolate a unique antigen or antigen-associated with an infectious disease, without having to isolate a unique antigen or antigen-associated heat shock protein for each target antigen by administering to a mammalian subject or to a group of mammalian cells containing the antigen, an expressible polynucleotide encoding a heat shock protein. The expressed heat shock protein may have the same structure as native heat shock proteins, or may have a modified form adapted to control the trafficking of the expressed heat shock protein within the cells.
摘要翻译：向哺乳动物细胞施用编码真核热休克蛋白的可表达多核苷酸导致对存在于这些细胞中的抗原的免疫应答的刺激。这使得可以刺激针对靶抗原（包括靶肿瘤抗原或与感染性疾病相关的抗原）的免疫应答，而不必分离独特的抗原或与感染性疾病相关的抗原，而不必分离独特的抗原或抗原通过向哺乳动物受试者或含有抗原的一组哺乳动物细胞施用与靶标抗原相关的热休克蛋白，即编码热休克蛋白的可表达多核苷酸。表达的热休克蛋白可以具有与天然热休克蛋白相同的结构，或者可以具有适于控制细胞内表达的热休克蛋白的运输的修饰形式。

4. 发明授权

US08600571B2 Energy optimization system 有权
标题翻译：能源优化系统
公开(公告)号：US08600571B2
公开(公告)日：2013-12-03
申请号：US12142528
申请日：2008-06-19
申请人： Jim Dillon , Ronald Blagus , Stephen Parr , Venkat Iyer , Alan Houghton
发明人： Jim Dillon , Ronald Blagus , Stephen Parr , Venkat Iyer , Alan Houghton
IPC分类号： G05D17/00 , G06F17/00
CPC分类号： G06Q50/06 , G06Q10/04 , Y02A30/12 , Y02E40/76 , Y04S10/545 , Y04S10/60
摘要： A system for optimizing a usage of energy based on cost, carbon footprint, and/or other criteria. The usage may be optimized for the next day or more. The optimization may deal with renewable energy, grid energy and stored energy. Various inputs may be considered for optimization, which could include energy costs, weather forecasts, characteristics of renewable energy, the load and storage, and other items. The optimizer may use equipment models with numerical transfer functions to take inputs and provide optimized estimates for the next day or so of energy usage. The outputs of the models may go to an optimization algorithms module for providing an output based on the inputs. The output may provide control information for the selection and amounts of the different types of energy in a scheduled manner.
摘要翻译：基于成本，碳足迹和/或其他标准来优化能量使用的系统。可能会为第二天或更长时间优化使用。优化可能涉及可再生能源，电网能量和储能。可以考虑各种投入进行优化，其中可能包括能源成本，天气预报，可再生能源的特性，负荷和储存等。优化器可以使用具有数字传递函数的设备模型来获取输入，并为第二天的能量使用提供优化的估计。模型的输出可以转到优化算法模块，以提供基于输入的输出。输出可以按计划的方式提供用于不同类型能量的选择和量的控制信息。

5. 发明授权

US06773707B1 Heat shock protein-based vaccines and immunotherapies 失效
公开(公告)号：US06773707B1
公开(公告)日：2004-08-10
申请号：US09636295
申请日：2000-08-10
申请人： James E. Rothman , Franz-Ulrich Hartl , Mee H. Hoe , Alan Houghton , Yoshizumi Takechi , Mark Mayhew
发明人： James E. Rothman , Franz-Ulrich Hartl , Mee H. Hoe , Alan Houghton , Yoshizumi Takechi , Mark Mayhew
IPC分类号： A61K39385
CPC分类号： C07K7/06 , A61K38/00 , A61K39/0011 , A61K39/02 , A61K39/12 , A61K47/646 , A61K47/65 , A61K47/6901 , A61K48/00 , A61K2039/53 , A61K2039/6043 , A61K2039/622 , A61K2039/625 , C07K7/08 , C07K14/47 , C12N2710/20034 , Y10S530/828
摘要： The present invention relates to methods and compositions for inducing an immune response in a subject, wherein the subject is administered an effective amount of a heat shock protein complexed to a hybrid antigen comprising an antigenic domain and a heat shock protein-binding domain. These methods and compositions may be used in the treatment of infectious diseases and cancers.

6. 发明授权

US06294378B1 Method and reagents for genetic immunization 失效
标题翻译：遗传免疫的方法和试剂
公开(公告)号：US06294378B1
公开(公告)日：2001-09-25
申请号：US09230199
申请日：1999-06-09
申请人： Alan Houghton , Shirley M. Bartido , Yiquing Xu , Siqun Wang
发明人： Alan Houghton , Shirley M. Bartido , Yiquing Xu , Siqun Wang
IPC分类号： C12N1563
CPC分类号： C12N9/0059 , A61K39/00 , C07K14/47 , C07K2319/04 , C07K2319/06 , C07K2319/40 , C12N9/0071 , C12N15/62
摘要： DNA vaccines which incorporate genetic sequences encoding sorting signals which direct an expressed antigen to a specific cellular organelle facilitate loading of the antigen onto a Class I or Class II MHC molecule for immune presentation. These vaccines are a nucleic acid construct of a genetic sequence encoding a protein or peptide antigen and a sorting signal which will direct expressed antigen to the ER or endosomal-lysosomal compartments within the cell. The resulting constructs can be used as naked DNA vaccines, packaged in liposomes, or coated onto colloidal gold particles. The construct might also be delivered in an expression vector which is expressed in cells of the organism being immunized.
摘要翻译：将编码将表达的抗原指导到特定细胞器的分选信号的遗传序列的DNA疫苗有助于将抗原加载到I类或II类MHC分子上用于免疫表达。这些疫苗是编码蛋白质或肽抗原的遗传序列的核酸构建体和将表达的抗原引导到细胞内的ER或内体 - 溶酶体区室的分选信号。所得构建体可用作裸DNA疫苗，包装在脂质体中，或涂覆在胶体金颗粒上。构建体也可以在表达载体中递送，所述表达载体在被免疫的生物体的细胞中表达。

7. 发明授权

US08021666B2 Method and compositions for stimulation of an immune response to CD20 using a xenogeneic CD20 antigen 有权
标题翻译：使用异种CD20抗原刺激对CD20的免疫应答的方法和组合物
公开(公告)号：US08021666B2
公开(公告)日：2011-09-20
申请号：US10285874
申请日：2002-10-31
申请人： Maria Lia Palomba , Alan Houghton , Jedd Wolchok , David A. Scheinberg , Wendy K. Roberts
发明人： Maria Lia Palomba , Alan Houghton , Jedd Wolchok , David A. Scheinberg , Wendy K. Roberts
IPC分类号： C07K14/705 , C07K14/435 , A61K39/00
CPC分类号： C07K14/705 , A61K39/00 , A61K39/0011
摘要： Tolerance of the immune system for endogenous CD20 can be overcome and an immune response stimulated by administration of xenogeneic or xenoexpressed CD20 antigen. For example, mouse CD20, or antigenically-effective portions thereof, can be used to stimulate an immune response to the corresponding differentiation antigen in a human subject. Administration of xenogeneic antigens in accordance with the invention results in an effective immunity against CD20 expressed by the cancer in the treated individual, thus providing a therapeutic approach to the treatment of lymphomas and leukemia expressing CD20.
摘要翻译：可以克服免疫系统对内源性CD20的耐受性，并通过施用异种或异种表达的CD20抗原刺激免疫应答。例如，可以使用小鼠CD20或其抗原性有效部分来刺激人受试者中对应的分化抗原的免疫应答。根据本发明的异种抗原的施用导致对治疗个体中由癌症表达的CD20的有效免疫，从而提供治疗表达CD20的淋巴瘤和白血病的治疗方法。

8. 发明授权

US07618637B2 Heat shock protein-based vaccines and immunotherapies 失效
标题翻译：基于热休克蛋白的疫苗和免疫治疗
公开(公告)号：US07618637B2
公开(公告)日：2009-11-17
申请号：US10170738
申请日：2002-06-13
申请人： James Rothman , F. Ulrich Hartl , Mee H. Hoe , Alan Houghton , Yoshizumi Takechi , Mark Mayhew
发明人： James Rothman , F. Ulrich Hartl , Mee H. Hoe , Alan Houghton , Yoshizumi Takechi , Mark Mayhew
IPC分类号： A61K39/385
CPC分类号： C07K7/06 , A61K38/00 , A61K39/0011 , A61K39/02 , A61K39/12 , A61K47/646 , A61K47/65 , A61K47/6901 , A61K48/00 , A61K2039/53 , A61K2039/6043 , A61K2039/622 , A61K2039/625 , C07K7/08 , C07K14/47 , C12N2710/20034 , Y02A50/414 , Y10S530/828
摘要： The present invention relates to methods and compositions for inducing an immune response in a subject, wherein the subject is administered an effective amount of at least one heat shock protein in combination with one or more defined target antigens. These methods and compositions may be used in the treatment of infectious eases and cancers.
摘要翻译：本发明涉及用于在受试者中诱导免疫应答的方法和组合物，其中所述受试者与一种或多种所定义的靶抗原组合施用有效量的至少一种热休克蛋白。这些方法和组合物可用于治疗感染性疾病和癌症。

9. 发明授权

US06663868B1 Heat shock protein-based vaccines and immunotherapies 失效
标题翻译：基于热休克蛋白的疫苗和免疫治疗
公开(公告)号：US06663868B1
公开(公告)日：2003-12-16
申请号：US09011645
申请日：1998-02-13
申请人： James E. Rothman , Franz Ulrich Hartl , Mee H. Hoe , Alan Houghton , Yoshizumi Takeuchi , Mark Mayhew
发明人： James E. Rothman , Franz Ulrich Hartl , Mee H. Hoe , Alan Houghton , Yoshizumi Takeuchi , Mark Mayhew
IPC分类号： A61K39385
CPC分类号： C07K7/06 , A61K38/00 , A61K39/0005 , A61K39/0011 , A61K39/02 , A61K39/12 , A61K47/646 , A61K47/65 , A61K47/6901 , A61K48/00 , A61K2039/5152 , A61K2039/5156 , A61K2039/53 , A61K2039/6043 , A61K2039/622 , A61K2039/625 , C07K7/08 , C07K14/47 , C12N2710/20034 , Y10S530/828
摘要： The present invention relates to methods and compositions for inducing an immune response in a subject, wherein the subject is administered an effective amount of a heat shock protein complexed to a hybrid antigen comprising an antigenic domain and a heat shock protein-binding domain. These methods and compositions may be used in the treatment of infectious diseases and cancers.
摘要翻译：本发明涉及用于在受试者中诱导免疫应答的方法和组合物，其中给予受试者有效量的与包含抗原结构域和热休克蛋白结合结构域的杂交抗原复合的热休克蛋白。这些方法和组合物可用于治疗感染性疾病和癌症。

10. 发明授权

US06641812B2 Heat shock protein-based vaccines and immunotherapies 失效
标题翻译：基于热休克蛋白的疫苗和免疫治疗
公开(公告)号：US06641812B2
公开(公告)日：2003-11-04
申请号：US09794529
申请日：2001-02-27
申请人： James E. Rothman , F. Ulrich Hartl , Mee H. Hoe , Alan Houghton , Yoshizumi Takeuchi , Mark Mayhew
发明人： James E. Rothman , F. Ulrich Hartl , Mee H. Hoe , Alan Houghton , Yoshizumi Takeuchi , Mark Mayhew
IPC分类号： A61K3900
CPC分类号： C07K7/06 , A61K38/00 , A61K39/0005 , A61K39/0011 , A61K39/02 , A61K39/12 , A61K47/646 , A61K47/65 , A61K47/6901 , A61K48/00 , A61K2039/5152 , A61K2039/5156 , A61K2039/53 , A61K2039/6043 , A61K2039/622 , A61K2039/625 , C07K7/08 , C07K14/47 , C12N2710/20034 , Y10S530/828
摘要： The present invention relates to methods and compositions for inducing an immune response in a subject, wherein the subject is administered an effective amount of at least one heat shock protein in combination with one or more defined target antigens. These methods and compositions may be used in the treatment of infectious diseases and cancers.
摘要翻译：本发明涉及用于在受试者中诱导免疫应答的方法和组合物，其中所述受试者与一种或多种所定义的靶抗原组合施用有效量的至少一种热休克蛋白。这些方法和组合物可用于治疗感染性疾病和癌症。

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