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1. 发明授权

US4601881A Liquid handling system 失效
公开(公告)号：US4601881A
公开(公告)日：1986-07-22
申请号：US667299
申请日：1984-11-01
申请人： Milo E. Webster
发明人： Milo E. Webster
IPC分类号： G01N33/483 , G01N1/00 , G01N35/08 , G01N21/00 , G01N31/00 , G01N33/00
CPC分类号： G01N35/08
摘要： A liquid handling system useful in apparatus for analyzing biological liquid specimens or the like includes a plurality of sample metering chambers, a distribution manifold connected between a sample inlet port and the sample metering chambers, and a corresponding plurality of auxiliary liquid metering chambers connected to corresponding auxiliary liquid reservoirs. Liquids are flowed from the sample inlet port through the distribution manifold to the sample metering chambers and from auxiliary liquid reservoirs to the auxiliary liquid metering chambers under the influence of reduced pressures which are selectively connected to the flow network through an integrated valve array and reduced pressure manifolds.

2. 发明授权

US5041181A Method of bonding plastics 失效
公开(公告)号：US5041181A
公开(公告)日：1991-08-20
申请号：US571937
申请日：1990-08-23
申请人： Tom S. Brackett , Milo E. Webster
发明人： Tom S. Brackett , Milo E. Webster
IPC分类号： B29C65/00 , B29C71/00 , B29D99/00 , F15C5/00 , B32B31/12
CPC分类号： B29C66/8264 , B29C65/02 , B29C66/02 , B29C66/341 , B29C66/71 , B29C66/7371 , F15C5/00 , B29C66/0344 , B29C71/00 , B29K2033/04 , B29K2995/0026 , B29L2031/7506 , Y10S264/71 , Y10T156/1064
摘要： A method of producing a fluidic module from two or more pieces (B.sub.1 B.sub.2) of plastic material having an intermolecular bonded interface, comprises forming an interface surface (2) on each piece, forming at least one fluidic passageway (4) in at least one of the interface surfaces, assembling the pieces with the interface surfaces in contact with each other and confining them against expansion. Heat is applied to the assembled pieces to induce their expansion against total or limited confinement to cause transmigration of molecules from one interface surface to the other to bond the pieces together.

3. 发明授权

US4283262A Analysis system 失效
标题翻译：分析系统
公开(公告)号：US4283262A
公开(公告)日：1981-08-11
申请号：US165051
申请日：1980-07-01
申请人： Alan D. Cormier , Milo E. Webster , John D. Czaban , Neil D. Silverman , Lynn W. Noble
发明人： Alan D. Cormier , Milo E. Webster , John D. Czaban , Neil D. Silverman , Lynn W. Noble
IPC分类号： G01N27/38 , G01N33/483 , G01N35/08 , G01N27/28
CPC分类号： G01N35/08 , G01N27/38
摘要： A system for analyzing a biological fluid specimen or the like includes an analysis chamber and an electrochemical electrode measuring system connected in sensing relation to the analysis chamber. A flow network connects a sample inlet port and an auxiliary fluid reservoir to the analysis chamber. The flow network includes a sample line connected between the sample inlet port and the analysis chamber and an auxiliary manifold connected to the auxiliary fluid reservoir. A positive displacement pump is connected in the sample line between the analysis chamber and a waste outlet port. A valved T-connection is provided between the sample line and the manifold; an inlet isolation valve is in the sample flow path between the sample inlet and the valved T-connection; an analysis chamber isolation valve is in the sample flow path between the valved T-connection and the analysis chamber; and both the sample line and the manifold have a vent valve, the sample line vent valve being connected between the inlet and chamber isolation valves and the manifold vent valve being connected upstream of the auxiliary fluid reservoir. Coordinated operation of the several valves permits the pump to selectively flow fluid from the auxiliary reservoir or a sample through the analysis chamber, together with imposition of nonlaminar flow conditions by concurrent operation of the vent valves to provide effective cleaning of flow surfaces and analysis chambers.
摘要翻译：用于分析生物流体样本等的系统包括分析室和连接到分析室的感测关系的电化学电极测量系统。流动网络将样品入口端口和辅助流体容器连接到分析室。流动网络包括连接在样品入口和分析室之间的样品管线和连接到辅助流体储存器的辅助歧管。容积式泵连接在分析室和废物出口之间的样品管线中。在样品管线和歧管之间提供带阀的T形连接件; 入口隔离阀位于样品入口与阀门T型连接件之间的样品流动路径中; 分析室隔离阀位于带阀T连接和分析室之间的样品流动路径中; 并且样品管线和歧管都具有通气阀，样品管线排气阀连接在入口和室隔离阀之间，并且歧管排放阀连接在辅助流体储存器的上游。多个阀的协调操作允许泵选择性地将流体从辅助储存器或样品通过分析室，同时通过排气阀的并行操作来施加非层流流动条件，以提供对流动表面和分析室的有效清洁。

4. 发明授权

US4858883A Valve with flexible sheet member 失效
公开(公告)号：US4858883A
公开(公告)日：1989-08-22
申请号：US281544
申请日：1988-12-08
申请人： Milo E. Webster
发明人： Milo E. Webster
IPC分类号： F16K7/17 , F16K11/02
CPC分类号： F16K7/17 , F16K11/022 , Y10T137/87885 , Y10T137/87893
摘要： A valve is disclosed comprising a first body portion (2) having a first surface (16), a second body portion (4) having a second surface (51) facing the first surface, a flexible sheet (8) positioned between the first and second surfaces, a void (4) in the first body portion created and defined by a concave surface (46) formed in the first surface and one side (18) of the flexible sheet. There are at least two fluid passageways (20) (22) in the first body portion communicating with the void at spaced locations, at least one of the fluid passageways being a channel formed in the first surface and terminating at the void. A source of pressure and vacuum (50) (54) is provided for flexing the sheet against and away from the first body portion in order that when the flexible sheet is flexed against the first body portion, the passageways are sealed from each other, and when the flexible sheet is flexed away from the first body portion the fluid passageways are placed in communication with each other by way of the void.

5. 发明授权

US4999069A Method of bonding plastics 失效
标题翻译：粘合塑料的方法
公开(公告)号：US4999069A
公开(公告)日：1991-03-12
申请号：US360267
申请日：1989-06-02
申请人： Tom S. Brackett , Milo E. Webster
发明人： Tom S. Brackett , Milo E. Webster
IPC分类号： B29C65/00 , B29C65/02 , B29C71/00 , B29D99/00 , B29K33/00 , C08J5/12 , F15C5/00 , F16C5/00
CPC分类号： B29C66/54 , B29C65/006 , B29C65/02 , B29C66/02 , B29C66/324 , B29C66/71 , B29C66/7371 , B29C66/8264 , B29C66/9141 , B29C66/91411 , B29C66/91445 , B29C66/919 , F15C5/00 , B29C66/02245 , B29C71/00 , B29K2033/00 , B29K2033/04 , B29K2995/0026 , B29L2031/7506 , Y10S264/71 , Y10T156/1064
摘要： A method of producing a fluidic module from two or more pieces (B.sub.1 B.sub.2) of plastic material having an intermolecular bonded interface, comprises forming an interface surface (2) on each piece, forming at least one fluidic passageway (4) in at least one of the interface surfaces, assembling the pieces with the interface surfaces in contact with each other and confining them against expansion. Heat is applied to the assembled pieces to induce their expansion against total or limited confinement to cause transmigration of molecules from one interface surface to the other to bond the pieces together.
摘要翻译：一种由具有分子间键合界面的塑料材料的两个或更多个片（B1 B2）生产流体模块的方法，包括在每个部件上形成界面（2），在至少一个流体通道（4）中形成至少一个流体通道的接口表面，将这些件与接口表面相互接触并将其限制在膨胀之中。将热量施加到组装的片上以引起其全面或有限限制的膨胀，从而使分子从一个界面表面向另一个界面表面转移到另一个界面。

6. 发明授权

US4859422A Analysis system 失效
标题翻译：分析系统
公开(公告)号：US4859422A
公开(公告)日：1989-08-22
申请号：US75052
申请日：1987-07-17
申请人： Humayun Qureshi , Stanley M. Liffmann , Milo E. Webster , Theodore S. Geiselman
发明人： Humayun Qureshi , Stanley M. Liffmann , Milo E. Webster , Theodore S. Geiselman
IPC分类号： B01J4/02 , G01N1/00 , G01N1/38 , G01N27/26 , G01N35/00 , G01N35/08 , G01N37/00
CPC分类号： G01N35/085 , G01N1/14 , G01N2001/382 , G01N2035/00237 , G01N35/1097 , Y10T436/117497
摘要： An analysis system includes sample insertion module structure with structure defining a reduced pressure reservoir, structure defining a sample region, and structure defining a reagent circuit that includes metering chamber structure in series with the reagent circuit. First transfer valve structure is arranged to couple the sample region to the reagent circuit on one side of the metering chamber structure, and second transfer valve structure is arranged to couple the reagent circuit to the reduced pressure reservoir structure on the side of the metering chamber structure remote from the first transfer valve structure for inserting an intact metered quantity of sample liquid into a reagent stream.

7. 发明授权

US4852851A Valve with flexible sheet member 失效
公开(公告)号：US4852851A
公开(公告)日：1989-08-01
申请号：US131751
申请日：1987-12-11
申请人： Milo E. Webster
发明人： Milo E. Webster
IPC分类号： F16K7/17 , F16K11/02
CPC分类号： F16K7/17 , F16K11/022 , Y10T137/87249 , Y10T137/87885
摘要： A valve is disclosed comprising a first body portion (2) having a first surface (16), a second body portion (4) having a second surface (51) facing the first surface, a flexible sheet (8) positioned between the first and second surfaces, a void (4) in the first body portion created and defined by a concave surface (46) formed in the first surface and one side (18) of the flexible sheet. There are at least two fluid passageways (20) (22) in the first body portion communicating with the void at spaced locations, at least one of the fluid passageways being a channel formed in the first surface and terminating at the void. A source of pressure and vacuum (50) (54) is provided for flexing the sheet against and away from the first body portion in order that when the flexible sheet is flexed against the first body portion, the passageways are sealed from each other, and when the flexible sheet is flexed away from the first body portion the fluid passageways are placed in communication with each other by way of the void.

8. 发明授权

US4848722A Valve with flexible sheet member 失效
标题翻译：带柔性片材的阀门
公开(公告)号：US4848722A
公开(公告)日：1989-07-18
申请号：US155038
申请日：1988-02-11
申请人： Milo E. Webster
发明人： Milo E. Webster
IPC分类号： F16K7/17 , F16K11/02
CPC分类号： F16K11/022 , F16K7/17 , Y10T137/87885 , Y10T137/87893 , Y10T137/87917
摘要： A valve is disclosed comprising a first body portion (2) having a first surface (16), a second body portion (4) having a second surface (51) facing the first surface, a flexible sheet (8) positioned between the first and second surfaces, a void (4) in the first body portion created and defined by a concave surface (46) formed in the first surface and one side (18) of the flexible sheet.There are at least two fluid passageways (20) (22) in the first body portion communicating with the void at spaced locations, at least one of the fluid passageways being a channel formed in the first surface and terminating at the void.A source of pressure and vacuum (50) (54) is provided for flexing the sheet against and away from the first body portion in order that when the flexible sheet is flexed against the first body portion, the passageways are sealed from each other, and when the flexible sheet is flexed away from the first body portion the fluid passageways are placed in communication with each other by way of the void.
摘要翻译：公开了一种阀，其包括具有第一表面（16）的第一主体部分（2），具有面向第一表面的第二表面（51）的第二主体部分（4），位于第一和第二表面之间的柔性片（8）第二表面是由形成在柔性片的第一表面和一侧（18）中的凹面（46）形成并限定的第一主体部分中的空隙（4）。在第一主体部分中至少有两个液体通道（20）（22）在间隔开的位置处与空隙连通，至少一个流体通道是形成在第一表面中并终止在空隙处的通道。提供压力和真空源（50）（54），用于使纸张抵靠和远离第一主体部分弯曲，以便当柔性片材抵靠第一主体部分弯曲时，通道彼此密封，并且当柔性片从第一主体部分弯曲时，流体通道通过空隙彼此连通。

9. 发明授权

US4268479A Fluid analyzer 失效
标题翻译：流体分析仪
公开(公告)号：US4268479A
公开(公告)日：1981-05-19
申请号：US111015
申请日：1980-01-10
申请人： Milo E. Webster
发明人： Milo E. Webster
IPC分类号： G01N1/00 , G01N1/10
CPC分类号： G01N35/1097
摘要： A portable fluid analyzer has a sampling section with flow passage structure for sealing engagement with a discharge port of a zwickel fitting or the like and retainer structure for engagement with the fitting. The retainer structure is urged by a spring towards a retaining position and is movable, by a manual operator towards a released position. When the retainer structure is engaged with the fitting and the manual operator is released, the sealing member is urged by the spring into engagement with the fitting's discharge port. The analyzer also includes an analysis chamber connected to the discharge end of the flow passage structure and monitoring means for providing an output as a function of a constituent of the fluid in the analysis chamber.
摘要翻译：便携式流体分析仪具有采样部分，该采样部分具有用于与zwickel配件等的排出口密封接合的流动通道结构和用于与配件接合的保持器结构。保持架结构被弹簧推向保持位置，并且可由手动操作者朝向释放位置移动。当保持器结构与配件接合并且手动操作器被释放时，密封构件被弹簧推动以与配件的排出口接合。分析器还包括连接到流路结构的排出端的分析室和用于提供作为分析室中的流体的组成的函数的输出的监测装置。

10. 发明授权

US5660370A Valve with flexible sheet member and two port non-flexing backer member 失效
标题翻译：阀带有柔性片材和两个端口不弯曲的支承件
公开(公告)号：US5660370A
公开(公告)日：1997-08-26
申请号：US612324
申请日：1996-03-07
申请人： Milo E. Webster
发明人： Milo E. Webster
IPC分类号： F16K7/17 , F16K7/12 , F16K31/06
CPC分类号： F16K7/17 , Y10T137/87885 , Y10T137/87893
摘要： A valve has a flexible sheet member which moves toward and away from a flat, non-flexing sheet member to cover and open two holes in the nonflexing sheet member to block or permit fluid flow between passageways in a second valve body portion member. The flexible sheet member is extendible into a recess formed in a first valve body portion member above the two holes so that fluid flows from one passageway through a chamber formed between the non-flexing sheet member surface and the faring surface of the flexible sheet member. The plunger head of a solenoid forces the flexible sheet member into contact with the non-flexing sheet member and when excited causes the plunger head to be moved out of contact with the flexible sheet member allowing the flexible sheet member to uncover the holes in the nonflexing sheet member. Vacuum is present at the valve site and draws the flexible sheet member away from the non-flexing sheet member substantially immediately as the plunger head is withdrawn from contact with the flexible sheet member. The solenoid is releasably engageable with a solenoid receiving opening in the first valve body portion at the valve site.
摘要翻译：阀具有柔性片状构件，其朝向和远离平坦的不弯曲片状构件移动以覆盖和打开非挠曲片构件中的两个孔，以阻挡或允许流体在第二阀体部件中的通道之间流动。柔性片材可延伸到形成在两个孔之上的第一阀体部分构件中的凹部中，使得流体从一个通道流过形成在非弯曲片构件表面和柔性片构件的制动表面之间的腔室。螺线管的柱塞头迫使柔性片构件与非弯曲片构件接触，并且当被激励时，使柱塞头移动离开与柔性片构件的接触，允许柔性片构件露出非挠性片中的孔片材成员。真空存在于阀位处，并且当柱塞头从与柔性片构件的接触退出时，基本上立即将柔性片构件拉离非挠性片构件。螺线管可释放地与阀位处的第一阀体部分中的螺线管接收开口接合。

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