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1. 发明申请

US20060111411A1 Substituted 5-carboxyamide pyrazoles and [1,2,4]triazoles as antiviral agents 失效
标题翻译：取代的5-羧酰胺吡唑和[1,2,4]三唑作为抗病毒剂
公开(公告)号：US20060111411A1
公开(公告)日：2006-05-25
申请号：US11259399
申请日：2005-10-26
申请人： Alan Cooper , Hugh Zhu , James Wang , Jagdish Desai , Gerald Shipps , Patrick Curran , D. Allen Annis , Huw Nash , Viyyoor Girijavallabhan
发明人： Alan Cooper , Hugh Zhu , James Wang , Jagdish Desai , Gerald Shipps , Patrick Curran , D. Allen Annis , Huw Nash , Viyyoor Girijavallabhan
IPC分类号： A61K31/4152 , A61K31/416 , C07D403/02
CPC分类号： C07D249/10 , C07D231/14 , C07D231/40 , C07D231/42 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The present invention provides compounds of formula I wherein X, Y, R1-R7 are as defined herein. Compositions containing these compounds, and methods for inhibiting HCV RNA-dependent RNA polymerase and treating hepatitis C and related disorders using these compounds and compositions are also provided.
摘要翻译：本发明提供式I化合物，其中X，Y，R 1 -R 7如本文所定义。还提供了含有这些化合物的组合物，以及用于抑制HCV RNA依赖性RNA聚合酶和使用这些化合物和组合物治疗丙型肝炎和相关病症的方法。

2. 发明申请

US20050059672A1 Novel farnesyl protein transferase inhibitors as antitumor agents 失效
标题翻译：新型法呢基蛋白转移酶抑制剂作为抗肿瘤剂
公开(公告)号：US20050059672A1
公开(公告)日：2005-03-17
申请号：US10911340
申请日：2004-08-04
申请人： Hugh Zhu , Alan Cooper , Jagdish Desai , James Wang , Dinanath Rane , Ronald Doll , F. Njoroge , Viyyoor Girijavallabhan
发明人： Hugh Zhu , Alan Cooper , Jagdish Desai , James Wang , Dinanath Rane , Ronald Doll , F. Njoroge , Viyyoor Girijavallabhan
IPC分类号： A61P35/00 , C07D401/06 , A61K31/496 , C07D43/14
CPC分类号： C07D401/06
摘要： Disclosed are novel tricyclic compounds of the formula: and a pharmaceutically acceptable salts or solvates thereof. The compounds are useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising the compounds of formula (I). Also disclosed are uses of the compounds of formula (I) for the manufacture of a medicament for the treatment of cancer.
摘要翻译：公开了下式的新型三环化合物及其药学上可接受的盐或溶剂化物。该化合物可用于抑制法呢基蛋白转移酶。还公开了包含式（I）化合物的药物组合物。还公开了式（I）化合物在制备用于治疗癌症的药物中的用途。

3. 发明申请

US20070232610A1 Novel compounds that are ERK inhibitors 失效
公开(公告)号：US20070232610A1
公开(公告)日：2007-10-04
申请号：US11705709
申请日：2007-02-13
申请人： Yongqi Deng , Gerald Shipps , Alan Cooper , Yang Nan , Tong Wang , M. Siddiqui , Hugh Zhu , Robert Sun , Joseph Kelly , Ronald Doll , Jagdish Desai , James Wang , Youhao Dong , Vincent Madison , Li Xiao , Alan Hruza , Neng-Yang Shih
发明人： Yongqi Deng , Gerald Shipps , Alan Cooper , Yang Nan , Tong Wang , M. Siddiqui , Hugh Zhu , Robert Sun , Joseph Kelly , Ronald Doll , Jagdish Desai , James Wang , Youhao Dong , Vincent Madison , Li Xiao , Alan Hruza , Neng-Yang Shih
IPC分类号： A61K31/53 , A61K31/506 , A61K31/502 , A61K31/497 , A61K31/4439 , A61K31/407 , A61K31/401 , C07D403/02
CPC分类号： C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/08
摘要： Disclosed are the ERK inhibitors of formula 1.0: and the pharmaceutically acceptable salts and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.

4. 发明申请

US20070191604A1 Novel compounds that are ERK inhibitors 审中-公开
标题翻译： ERK抑制剂的新型化合物
公开(公告)号：US20070191604A1
公开(公告)日：2007-08-16
申请号：US11636954
申请日：2006-12-11
申请人： Alan Cooper , Yongqi Deng , Gerald Shipps , Neng-Yang Shih , Hugh Zhu , Robert Sun , Joseph Kelly , Ronald Doll , Yang Nan , Tong Wang , Jagdish Desai , James Wang , Youhao Dong , Vincent Madison , Li Xiao , Alan Hruza , M. Siddiqui , Ahmed Samatar , Sunil Paliwal , Hon-Chung Tsui , Azim Celebi , Yiji Wu , Sobhana Boga
发明人： Alan Cooper , Yongqi Deng , Gerald Shipps , Neng-Yang Shih , Hugh Zhu , Robert Sun , Joseph Kelly , Ronald Doll , Yang Nan , Tong Wang , Jagdish Desai , James Wang , Youhao Dong , Vincent Madison , Li Xiao , Alan Hruza , M. Siddiqui , Ahmed Samatar , Sunil Paliwal , Hon-Chung Tsui , Azim Celebi , Yiji Wu , Sobhana Boga
IPC分类号： C07D417/14 , C07D413/14 , C07D403/14
CPC分类号： C07D405/14 , C07D231/56 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/14
摘要： Disclosed are the ERK inhibitors of formula 1.0: and the pharmaceutically acceptable salts and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.
摘要翻译：公开了式1.0的ERK抑制剂及其药学上可接受的盐和溶剂化物。 Q是可以具有桥或稠合环的哌啶或哌嗪环。哌啶环可以在环中具有双键。所有其他取代基如本文所定义。还公开了使用式1.0化合物治疗癌症的方法。

5. 发明申请

US20060111412A1 Substituted 5-oxo pyrazoles and [1,2,4]triazoles as antiviral agents 失效
标题翻译：取代的5-氧代吡唑和[1,2,4]三唑作为抗病毒剂
公开(公告)号：US20060111412A1
公开(公告)日：2006-05-25
申请号：US11259397
申请日：2005-10-26
申请人： Gerald Shipps , Tong Wang , Kristin Rosner , Patrick Curran , Alan Cooper , Viyyoor Girijavallabhan
发明人： Gerald Shipps , Tong Wang , Kristin Rosner , Patrick Curran , Alan Cooper , Viyyoor Girijavallabhan
IPC分类号： A61K31/4196 , A61K31/4152 , C07D249/12 , C07D231/08
CPC分类号： C07D231/20 , C07D231/22 , C07D401/12 , C07D403/04 , C07D409/12 , C07D417/12
摘要： The present invention provides compounds of formula I wherein X and R1-R7 are as defined herein. Compositions containing these compounds, and methods for inhibiting HCV RNA-dependent RNA polymerase and treating hepatitis C and related disorders using these compounds and compositions are also provided.
摘要翻译：本发明提供式I化合物，其中X和R 1 -R 7如本文所定义。还提供了含有这些化合物的组合物，以及用于抑制HCV RNA依赖性RNA聚合酶和使用这些化合物和组合物治疗丙型肝炎和相关病症的方法。

6. 发明申请

US20060205755A1 Novel farnesyl protein transferase inhibitors as antitumor agents 审中-公开
标题翻译：新型法呢基蛋白转移酶抑制剂作为抗肿瘤剂
公开(公告)号：US20060205755A1
公开(公告)日：2006-09-14
申请号：US11311052
申请日：2005-12-19
申请人： Alan Cooper , Hugh Zhu , James Wang , Jagdish Desai
发明人： Alan Cooper , Hugh Zhu , James Wang , Jagdish Desai
IPC分类号： A61K31/473 , C07D401/14
CPC分类号： C07D401/14
摘要： Disclosed are novel tricyclic compounds of the formula: and the pharmaceutically acceptable salts thereof. Y is C or CH. When Y is C then Z is not present and the optional bond from Y to the C-11 carbon of the tricyclic nucleus is present. When Y is CH then Z is present and Z is H or —OH. The compounds are useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising the compounds of formula 1.0. Also disclosed are methods of treating cancer using the compounds of formula 1.0.
摘要翻译：公开了下式的新型三环化合物及其药学上可接受的盐。 Y是C或CH。当Y为C时，Z不存在，并且存在从三价核的Y到C-11碳的任意键。当Y为CH时，则存在Z，Z为H或-OH。该化合物可用于抑制法呢基蛋白转移酶。还公开了包含式1.0化合物的药物组合物。还公开了使用式1.0化合物治疗癌症的方法。

7. 发明授权

US07807672B2 Compounds that are ERK inhibitors 失效
标题翻译： ERK抑制剂的化合物
公开(公告)号：US07807672B2
公开(公告)日：2010-10-05
申请号：US11705709
申请日：2007-02-13
申请人： Yongqi Deng , Gerald W. Shipps, Jr. , Alan Cooper , Yang Nan , Tong Wang , M. Arshad Siddiqui , Hugh Zhu , Robert Sun , Joseph M. Kelly , Ronald Doll , Jagdish Desai , James J-S Wang , Youhao Dong , Vincent Madison , Li Xiao , Alan Hruza , Neng-Yang Shih
发明人： Yongqi Deng , Gerald W. Shipps, Jr. , Alan Cooper , Yang Nan , Tong Wang , M. Arshad Siddiqui , Hugh Zhu , Robert Sun , Joseph M. Kelly , Ronald Doll , Jagdish Desai , James J-S Wang , Youhao Dong , Vincent Madison , Li Xiao , Alan Hruza , Neng-Yang Shih
IPC分类号： A61K31/506 , A61K31/5377 , A61K31/4025 , A61K31/496 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/06 , C07D417/12
CPC分类号： C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/08
摘要： Disclosed are the ERK inhibitors of formula 1.0: and the pharmaceutically acceptable salts and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substituents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.
摘要翻译：公开了式1.0的ERK抑制剂及其药学上可接受的盐和溶剂化物。 Q是可以具有桥或稠合环的哌啶或哌嗪环。哌啶环可以在环中具有双键。所有其它取代基如本文所定义。还公开了使用式1.0化合物治疗癌症的方法。

8. 发明授权

US09584055B2 Voltage regulator system for a genset 有权
标题翻译：发电机组电压调节系统
公开(公告)号：US09584055B2
公开(公告)日：2017-02-28
申请号：US14414709
申请日：2012-07-17
申请人： Alan Cooper , Keith Chambers , David McGowan , John Morrow
发明人： Alan Cooper , Keith Chambers , David McGowan , John Morrow
IPC分类号： H02P9/00 , H02P9/44 , H02P9/30
CPC分类号： H02P9/44 , H02J9/08 , H02P9/008 , H02P9/30 , H02P9/48
摘要： A voltage regulator system for regulating an output voltage of a genset includes a voltage regulator for reducing terminal voltage in response to a reduction in terminal frequency. A plurality of under-frequency roll-off (UFRO) states is provided in the voltage regulator, with each UFRO state being configured to implement a UFRO characteristic. An operational signal indicative of an operating condition of the genset forms the basis for selection of the UFRO characteristic.
摘要翻译：用于调节发电机组的输出电压的电压调节器系统包括用于响应于终端频率的降低而降低端电压的电压调节器。在电压调节器中提供多个低频滚降（UFRO）状态，每个UFRO状态被配置为实现UFRO特性。指示发电机组的运行状态的操作信号构成了用于选择UFRO特性的基础。

9. 发明申请

US20100292449A1 WATER-STABLE COMPOUNDS, CATALYSTS AND CATALYSED REACTIONS 审中-公开
标题翻译：水稳定化合物，催化剂和催化反应
公开(公告)号：US20100292449A1
公开(公告)日：2010-11-18
申请号：US12665387
申请日：2008-06-16
申请人： Arran Alexander Dickon Tulloch , Alan Cooper , Robert Hume Duncan
发明人： Arran Alexander Dickon Tulloch , Alan Cooper , Robert Hume Duncan
IPC分类号： C07C291/08 , B01J31/12 , C07C69/80
CPC分类号： B01J31/2243 , B01J31/2247 , B01J2231/342 , B01J2231/42 , B01J2231/70 , B01J2531/31 , B01J2531/46 , B01J2531/48 , B01J2531/842 , B01J2531/96
摘要： The invention provides a method of carrying out a Lewis-acid catalysed organic reaction in the presence of a Lewis acid catalyst comprising a metal-organic compound having the following formula: M(HO(CR1R2)z)a(O(CR1R2)z)bY—(CR3R4)χ-Y((CR1R2)zO)c((CR1R2)zOH)d.nR5OH (Formula I) in which: M is a metal atom, preferably titanium, zirconium, hafnium or iron (III) Y is selected from P and N, but Ss very preferably N; each R1, R2, R3 and R4 is independently selected from H, alkyl, aryl, substituted alkyl or substituted aryl, R5 is hydrogen, an alkyl group, a hydroxy-functionalised alkyl group, a polyoxyalkylmoiety, R6O or R7COO where R6 and R7 may each represent H, alkyl, aryl or alkyl-aryl; d and a are each O or 1, b and c are each 1 or 2, b+c=the valency of M, a+b+c+d=4, each z is independently 1, 2, 3 or 4; x represents the least number of C atoms between the Y atoms and is 2 or 3 and n is a number in the range from 0 to 4. The metal-organic compound forms a stable hydrate in water which retains Lewis-acid catalytic properties.
摘要翻译：本发明提供一种在路易斯酸催化剂存在下进行路易斯酸催化的有机反应的方法，该路易斯酸催化剂包含具有下式的金属有机化合物：M（HO（CR 1 R 2）z）a（O（CR 1 R 2）z） bY-（CR3R4）χ-Y（（CR1R2）zO）c（（CR1R2）zOH）d.nR5OH（式I）其中：M是金属原子，优选钛，锆，铪或铁（III）Y是选自P和N，但S优选为N; 每个R 1，R 2，R 3和R 4独立地选自H，烷基，芳基，取代的烷基或取代的芳基，R 5是氢，烷基，羟基官能化的烷基，聚氧烷基摩尔，R6O或R7COO，其中R6和R7可以各自表示H，烷基，芳基或烷基 - 芳基; d和a各自为O或1，b和c各自为1或2，b + c = M的化合价，a + b + c + d = 4，每个z独立地为1,2,3或4; x表示Y原子之间的C原子数最少，为2或3，n为0至4的数。该金属有机化合物在水中形成稳定的水合物，保留路易斯酸催化性能。

10. 发明授权

US08829145B2 Water-stable catalysts for polyurethane manufacture 有权
标题翻译：用于聚氨酯制造的水稳定催化剂
公开(公告)号：US08829145B2
公开(公告)日：2014-09-09
申请号：US12665377
申请日：2008-06-16
申请人： Arran Alexander Dickon Tulloch , David Jenkins , Joseph Atkinson , Mark Alexander Kent , Alan Cooper
发明人： Arran Alexander Dickon Tulloch , David Jenkins , Joseph Atkinson , Mark Alexander Kent , Alan Cooper
IPC分类号： C08G18/22 , B01J31/12 , C07C215/14 , C07F7/00 , C08G18/10 , C08G18/12 , C08G18/08 , C08G101/00
CPC分类号： C07F7/003 , B01J2531/0238 , B01J2531/46 , C07C215/14 , C08G18/0885 , C08G18/10 , C08G18/12 , C08G18/222 , C08G2101/0083 , C08G18/6674
摘要： A method of manufacturing a polyurethane compound comprises mixing together a polyol, a polyisocyanate compound and a catalyst and allowing the mixture to cure to form a polyurethane, and is characterized in that the catalyst is a neutral complex of a metal selected from Ti, Zr, Hf, Al, Fe, Bi or Sn and a multidentate organic ligand having: a) a number of anionic donor sites=x; b) a number of neutral donor sites, capable of forming a co-ordinate bond with the metal, =y; c) where x+y=from 5 to 8; d) x is from 2 to 4; e) the ligand molecule is of a size and conformation to enable each of the anionic donor sites and neutral donor sites to form a bond with the same metal atom.
摘要翻译：制备聚氨酯化合物的方法包括将多元醇，多异氰酸酯化合物和催化剂混合在一起，并使混合物固化形成聚氨酯，其特征在于催化剂是选自Ti，Zr， Hf，Al，Fe，Bi或Sn和多齿有机配体，其具有：a）多个阴离子供体位点= x; b）能够与金属形成坐标键的许多中性供体位点= y; c）其中x + y = 5至8; d）x为2至4; e）配体分子的大小和构象使得阴离子供体位点和中间供体位点中的每一个能够与相同的金属原子形成键。

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