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1. 发明申请

US20070105864A1 Methods for inhibiting protein kinases 审中-公开
标题翻译：抑制蛋白激酶的方法
公开(公告)号：US20070105864A1
公开(公告)日：2007-05-10
申请号：US11598188
申请日：2006-11-08
申请人： Timothy Guzi , Kamil Paruch , Michael Dwyer , David Parry , Lianyun Zhao , Patrick Curran , David Belanger , Blake Hamann , Panduranga Reddy , M. Siddiqui , Praveen Tadikonda
发明人： Timothy Guzi , Kamil Paruch , Michael Dwyer , David Parry , Lianyun Zhao , Patrick Curran , David Belanger , Blake Hamann , Panduranga Reddy , M. Siddiqui , Praveen Tadikonda
IPC分类号： A61K31/498
CPC分类号： A61K31/4985 , A61K31/498
摘要： The present invention provides methods for inhibiting protein kinases selected from the group consisting of AKT, Checkpoint kinase, Aurora kinase, Pim-1 kinase, and tyrosine kinase using imidazo[1,2-a]pyrazine compounds and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with protein kinases using such compounds.
摘要翻译：本发明提供使用咪唑并[1,2-a]吡嗪化合物抑制选自AKT，检查点激酶，极光激酶，Pim-1激酶和酪氨酸激酶的蛋白激酶的方法以及治疗，预防，抑制，或使用这些化合物改善与蛋白激酶相关的一种或多种疾病。

2. 发明申请

US20070043045A1 Novel high affinity thiophene-based and furan-based kinase ligands 失效
标题翻译：新型高亲和力噻吩类和呋喃类激酶配体
公开(公告)号：US20070043045A1
公开(公告)日：2007-02-22
申请号：US11505263
申请日：2006-08-16
申请人： Yongqi Deng , Lianyun Zhao , Gerald Shipps , Patrick Curran , M. Siddiqui , Rumin Zhang , Charles McNemar , Todd Mayhood , William Windsor , Emma Lees , David Parry
发明人： Yongqi Deng , Lianyun Zhao , Gerald Shipps , Patrick Curran , M. Siddiqui , Rumin Zhang , Charles McNemar , Todd Mayhood , William Windsor , Emma Lees , David Parry
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/496 , A61K31/4439 , A61K31/4709 , A61K31/428 , A61K31/42 , A61K31/4196 , A61K31/4178 , A61K31/4025 , A61K31/416 , C07D413/02 , C07D405/02 , C07D409/02 , C07D417/02
CPC分类号： C07D405/12 , C07D333/40 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： Inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provides for methods of making CDK-2 inhibitor compounds, methods of inhibiting CDK-2, and methods for treating disease or disease symptoms.
摘要翻译：描述了细胞周期蛋白依赖性激酶2的抑制剂，包括抑制剂的组合物，以及使用抑制剂和抑制剂组合物的方法。包括它们的抑制剂和组合物可用于治疗疾病或疾病症状。本发明还提供了制备CDK-2抑制剂化合物的方法，抑制CDK-2的方法以及治疗疾病或疾病症状的方法。

3. 发明申请

US20060111411A1 Substituted 5-carboxyamide pyrazoles and [1,2,4]triazoles as antiviral agents 失效
标题翻译：取代的5-羧酰胺吡唑和[1,2,4]三唑作为抗病毒剂
公开(公告)号：US20060111411A1
公开(公告)日：2006-05-25
申请号：US11259399
申请日：2005-10-26
申请人： Alan Cooper , Hugh Zhu , James Wang , Jagdish Desai , Gerald Shipps , Patrick Curran , D. Allen Annis , Huw Nash , Viyyoor Girijavallabhan
发明人： Alan Cooper , Hugh Zhu , James Wang , Jagdish Desai , Gerald Shipps , Patrick Curran , D. Allen Annis , Huw Nash , Viyyoor Girijavallabhan
IPC分类号： A61K31/4152 , A61K31/416 , C07D403/02
CPC分类号： C07D249/10 , C07D231/14 , C07D231/40 , C07D231/42 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The present invention provides compounds of formula I wherein X, Y, R1-R7 are as defined herein. Compositions containing these compounds, and methods for inhibiting HCV RNA-dependent RNA polymerase and treating hepatitis C and related disorders using these compounds and compositions are also provided.
摘要翻译：本发明提供式I化合物，其中X，Y，R 1 -R 7如本文所定义。还提供了含有这些化合物的组合物，以及用于抑制HCV RNA依赖性RNA聚合酶和使用这些化合物和组合物治疗丙型肝炎和相关病症的方法。

4. 发明申请

US20060106023A1 Novel imidazopyrazines as cyclin dependent kinase inhibitors 失效
标题翻译：新型咪唑并吡嗪作为细胞周期蛋白依赖性激酶抑制剂
公开(公告)号：US20060106023A1
公开(公告)日：2006-05-18
申请号：US11272392
申请日：2005-11-10
申请人： Timothy Guzi , Kamil Paruch , Michael Dwyer , Lianyun Zhao , Patrick Curran , David Belanger , Blake Hamann , Panduranga Reddy , M. Siddiqui
发明人： Timothy Guzi , Kamil Paruch , Michael Dwyer , Lianyun Zhao , Patrick Curran , David Belanger , Blake Hamann , Panduranga Reddy , M. Siddiqui
IPC分类号： A61K31/506 , A61K31/498 , C07D487/02
CPC分类号： C07D487/04
摘要： In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyrazine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
摘要翻译：在其许多实施方案中，本发明提供了一类新颖的咪唑并[1,2-a]吡嗪化合物作为细胞周期蛋白依赖性激酶的抑制剂，制备此类化合物的方法，含有一种或多种此类化合物的药物组合物，制备药物制剂的方法包括一种或多种这样的化合物，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与CDK相关的一种或多种疾病的方法。

5. 发明申请

US20050151420A1 Hybrid electric vehicle powertrain with regenerative braking 审中-公开
标题翻译：混合电动汽车动力总成与再生制动
公开(公告)号：US20050151420A1
公开(公告)日：2005-07-14
申请号：US11050183
申请日：2005-02-03
申请人： Dale Crombez , Patrick Curran , Steven Napier
发明人： Dale Crombez , Patrick Curran , Steven Napier
IPC分类号： B60K6/44 , B60K6/46 , B60K6/52 , B60L7/24 , B60T1/10 , B60T8/26 , B60W10/18 , F16D61/00 , B60K1/00
CPC分类号： B60L7/24 , B60K6/44 , B60K6/46 , B60K6/52 , B60T1/10 , B60T8/26 , B60W10/18 , F16D61/00 , Y02T10/6217 , Y02T10/623 , Y02T10/6265
摘要： A powertrain control method and strategy for a hybrid electric vehicle is disclosed including establishing electric motor-generator regenerative braking on a first driving axle and engine compression braking for a second driving axle when the vehicle is in a deceleration mode and friction braking the first driving axle when regenerative braking, the friction braking complementing regenerative braking to satisfy a given total braking request.
摘要翻译：公开了一种用于混合动力电动车辆的动力总成控制方法和策略，其包括在车辆处于减速模式时，在第一驱动轴上建立电动发电机再生制动和用于第二驱动轴的发动机压缩制动，并且摩擦制动第一驱动轴当再生制动时，摩擦制动补充再生制动以满足给定的总制动要求。

6. 发明申请

US20050042513A1 Carbon electrode for use in aqueous electrochemical devices and method of preparationo 失效
标题翻译：用于水电化学装置的碳电极及其制备方法
公开(公告)号：US20050042513A1
公开(公告)日：2005-02-24
申请号：US10921673
申请日：2004-08-18
申请人： Patrick Curran , Robert Atlas
发明人： Patrick Curran , Robert Atlas
IPC分类号： A61F2/06 , H01G9/00 , H01G9/155 , H01M4/58 , H01M4/583 , H01M4/62 , H01M4/96 , H01M4/02
CPC分类号： H01G9/155 , H01M4/583 , H01M4/625 , H01M4/96 , Y02E60/13 , Y10T29/49108 , Y10T428/249921
摘要： A high tensile strength, highly conductive flexible composite sheet consisting of fibrillated PTFE polymers, performance enhancing dopants, and carbon particles useful in electrochemical devices such as flow through capacitors, capacitive deionization, electronic water purification, fuel cells, capacitors, super-capacitors and a method of preparation. The method consists of mixing the materials and calendering to the desired thickness and strength all at room temperature and leaving the material in a wet state without further drying.
摘要翻译：由原纤化PTFE聚合物，性能增强掺杂剂和用于电化学装置（例如流过电容器，电容去离子，电子水净化，燃料电池，电容器，超级电容器）和电化学装置的碳颗粒组成的高拉伸强度的高导电性柔性复合片材制备方法该方法包括将材料和压延混合到室温下所需的厚度和强度，并将材料留在湿态而不进一步干燥。

7. 发明授权

US07214819B2 Fluorous triphasic reaction and separation processes for the generation of enantioenriched alcohols, amines, carboxylic acids and related compounds 失效
标题翻译：用于产生对映体富含醇，胺，羧酸和相关化合物的氟三相反应和分离方法
公开(公告)号：US07214819B2
公开(公告)日：2007-05-08
申请号：US10442664
申请日：2003-05-21
申请人： Dennis Patrick Curran , Zhiyong Luo
发明人： Dennis Patrick Curran , Zhiyong Luo
IPC分类号： C07B57/00
CPC分类号： C07D207/333 , C07B37/04 , C07B61/00 , C07B63/00 , C07C1/325 , C07C17/02 , C07C45/46 , C07D307/46 , C07D333/22 , C07C15/52 , C07C23/10 , C07C22/04 , C07C49/84
摘要： A method of obtaining an enantioenriched organic compound comprising the steps of: 1) generating from a starting racemic, non-enantiopure or achiral compound a first mixture comprising at least one fluorous-tagged compound and at least one other non-fluorous tagged compound, at least one of these two compounds being enantioenriched relative to the starting compound; 2) contacting a first non-fluorous phase including the first mixture with a fluorous phase at a first phase interface, the fluorous-tagged compound distributing between the first non-fluorous phase and the fluorous phase; and 3) contacting the fluorous phase with a second non-fluorous phase at a second phase interface. The method further includes the step of having a third compound in the second non-fluorous phase that reacts with the fluorous-tagged compound to produce a second compound and the step of generating the first mixture by chemical or enzymatic kinetic resolution of a racemic or non-enantiopure compound.
摘要翻译：一种获得对映体有机化合物的方法，包括以下步骤：1）从起始外消旋非对映体纯或非手性化合物产生包含至少一种含氟标记化合物和至少一种其它非氟标记化合物的第一混合物，这两种化合物中的至少一种相对于起始化合物具有对映体; 2）在第一相界面处将包含第一混合物的第一非氟相与氟相接触，分配在第一非氟相和氟相之间的含氟标记化合物; 和3）在第二相界面处将氟相与第二非氟相接触。所述方法还包括使所述第二非氟相中的第三化合物与所述含氟标记的化合物反应以产生第二化合物的步骤，以及通过化学或酶动力学拆分外消旋或非 - - 昂贵化合物。

8. 发明申请

US20060191065A1 Portable toilet 有权
标题翻译：便携式厕所
公开(公告)号：US20060191065A1
公开(公告)日：2006-08-31
申请号：US11269425
申请日：2005-11-08
申请人： Miguel Martinez , Patrick Curran , Edward McKiernan , Otto Erbacher , Robert Krieder
发明人： Miguel Martinez , Patrick Curran , Edward McKiernan , Otto Erbacher , Robert Krieder
IPC分类号： E03D1/24
CPC分类号： E03D5/01
摘要： A portable toilet is provided comprising a bowl provided with an outlet and at least one spout. A flush tank is adapted to store a fluid, wherein the flush tank is adapted to be pressurized. A manually-actuated pump is in sealed communication with the flush tank, wherein the pump is adapted to cause the flush tank to become pressurized. A pressure relief valve adapted to release pressure from the flush tank. A manually-actuated flush valve is in sealed communication with the flush tank and is normally biased to a closed position. The flush valve includes a fluid outlet connected to the at least one spout and a fluid inlet. A flush valve actuator is disposed outside of the flush tank and is adapted to actuate the flush valve, wherein actuation of the flush valve actuator causes the flush valve to open to permit pressurized fluid contained within the flush tank to be delivered through the at least one spout.
摘要翻译：提供了一种便携式马桶，其包括设置有出口和至少一个喷口的碗。冲洗槽适于储存流体，其中冲洗罐适于加压。手动泵与冲洗水箱密封连通，其中泵适于使冲水箱加压。适于从冲洗槽释放压力的减压阀。手动冲洗阀与冲洗槽密封连通，通常被偏压到关闭位置。冲洗阀包括连接到至少一个喷口的流体出口和流体入口。冲洗阀致动器设置在冲洗槽的外部并且适于致动冲洗阀，其中冲洗阀致动器的致动导致冲洗阀打开以允许包含在冲洗罐内的加压流体通过至少一个喷口。

9. 发明授权

US11630624B1 Concurrent event detection for distributed rasterization processing in a printing environment 有权
公开(公告)号：US11630624B1
公开(公告)日：2023-04-18
申请号：US17693681
申请日：2022-03-14
申请人： Walter F. Kailey , Patrick Curran
发明人： Walter F. Kailey , Patrick Curran
IPC分类号： G06F3/12
摘要： Systems and methods are provided for event detection. One embodiment includes an interface that acquires logs, and a controller that is able to identify events recited in the logs, to include the events within a list sorted based on at least one of start times or end times indicated by the timing data, and to determine a longest duration of the events. The controller receives a requested time, calculates a prior time separated by the longest duration from the requested time, and processes the list by: identifying a first index of the list for a first event in time having a start time on or after the prior time, and identifying a last index of the list for a last event in time having a start time on or before the requested time. The controller generates a set of events bounded by the first index and the last index.

10. 发明申请

US20070075300A1 Carbon Electrode for use in aqueous electrochemical devices and method of preparation 审中-公开
标题翻译：用于水电化学装置的碳电极及其制备方法
公开(公告)号：US20070075300A1
公开(公告)日：2007-04-05
申请号：US11602614
申请日：2006-11-20
申请人： Patrick Curran , Robert Atlas
发明人： Patrick Curran , Robert Atlas
IPC分类号： H01B1/24
CPC分类号： H01G9/155 , H01M4/583 , H01M4/625 , H01M4/96 , Y02E60/13 , Y10T29/49108 , Y10T428/249921
摘要： A high tensile strength, highly conductive flexible composite sheet consisting of fibrillated PTFE polymers, performance enhancing dopants, and carbon particles useful in electrochemical devices such as flow through capacitors, capacitive deionization, electronic water purification, fuel cells, capacitors, super-capacitors and a method of preparation. The method consists of mixing the materials and calendering to the desired thickness and strength all at room temperature and leaving the material in a wet state without further drying.
摘要翻译：由原纤化PTFE聚合物，性能增强掺杂剂和用于电化学装置（例如流过电容器，电容去离子，电子水净化，燃料电池，电容器，超级电容器）和电化学装置的碳颗粒组成的高拉伸强度的高导电性柔性复合片材制备方法该方法包括将材料和压延混合到室温下所需的厚度和强度，并将材料留在湿态而不进一步干燥。

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