专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20070129573A1 Process for the synthesis of eneamide derivatives 有权
标题翻译：合成烯酰胺衍生物的方法
公开(公告)号：US20070129573A1
公开(公告)日：2007-06-07
申请号：US10583902
申请日：2004-12-22
申请人： Alain Burgos , Blandine Bertrand , Sonia Roussiasse , Jean-Francois Pluvie , Sylvie Blanchet , Juliette Martin , Florence Perrin , Francoise Bourdeau
发明人： Alain Burgos , Blandine Bertrand , Sonia Roussiasse , Jean-Francois Pluvie , Sylvie Blanchet , Juliette Martin , Florence Perrin , Francoise Bourdeau
IPC分类号： C07C233/06
CPC分类号： C07C231/10 , C07C233/06 , C07C2602/08 , C07C2602/10
摘要： A process for the production of ene-amide derivatives represented by the formula (I) wherein R1 and R2 and R3 are independently a hydrogen atom, an alkyl, a cycloalkyl, a cycloalkylalkyl, an alkylaryl, an aryl, a heterocycle, a cyano, an alkoxy, an aryloxy, a carboxyl, a carbamoyl, —CONR5R6 (in which R5 and R6 are independently an alkyl, arylalkyl or aryl group said ring being substituted being substituted or not with a functional group or with R5) or —COOR5 group (in which R5 is an alkyl, alkylaryl or aryl group), said alkyl, cycloalkyl, cycloalkylalkyl, alkylaryl and aryl groups being substituted or not with a functional group or with R5; or R1 and R2 taken together, may form a ring (which terms includes mono-, di- and higher polycyclic ring systems); R4 is a hydrogen atom, an alkyl, an aryl, an alkylaryl, said groups substituted or not with a halogen atom as Cl, Br, or F; X is an oxygen atom or a leaving group and m is an integer 1 or 2; when m is 1 then X is a leaving group; when m is 2 then X is a oxygen atom, which comprise: a hydrogenation/isomerization reaction in presence of a heterogeneous catalyst, of an oxime derivatives of formula (II) where R1, R2 and R3 are as defined above with an acyl derivative of formula (III) (R4CO)mX wherein R4, m and X are as defined above.
摘要翻译：制备由式（I）表示的烯 - 酰胺衍生物的方法，其中R 1和R 2和R 3独立地为氢原子，烷基，环烷基，环烷基烷基，烷基芳基，芳基，杂环，氰基，烷氧基，芳氧基，羧基，氨基甲酰基，-CONR 5 R 6（其中R 5和R 6独立地为所述被取代的环的烷基，芳基烷基或芳基被取代或不被官能团取代或与R5）或-COOR5基团其中R5是烷基，烷基芳基或芳基），所述烷基，环烷基，环烷基烷基，烷基芳基和芳基被官能团取代或不与R5取代; 或R 1和R 2一起形成环（该术语包括单环，二和更高多环系统）; R4是氢原子，烷基，芳基，烷基芳基，所述基团被卤素原子取代或不与Cl，Br或F取代; X是氧原子或离去基团，m是整数1或2; 当m为1时，X为离去基团; 当m为2时，X为氧原子，其包括：在非均相催化剂存在下的式（II）的肟衍生物，其中R 1，R 2和R 3如上所定义的肟衍生物与氢化/异构化反应，其中酰基衍生物为式（III）（R4CO）m X其中R4，m和X如上定义。

2. 发明授权

US07884243B2 Process for the synthesis of eneamide derivatives 有权
标题翻译：合成烯酰胺衍生物的方法
公开(公告)号：US07884243B2
公开(公告)日：2011-02-08
申请号：US10583902
申请日：2004-12-22
申请人： Alain Burgos , Blandine Bertrand , Sonia Roussiasse , Jean-François Pluvie , Sylvie Blanchet , Juliette Martin , Florence Perrin , Françoise Bourdeau
发明人： Alain Burgos , Blandine Bertrand , Sonia Roussiasse , Jean-François Pluvie , Sylvie Blanchet , Juliette Martin , Florence Perrin , Françoise Bourdeau
IPC分类号： C07C233/00
CPC分类号： C07C231/10 , C07C233/06 , C07C2602/08 , C07C2602/10
摘要： A process for the production of ene-amide derivatives represented by the formula (I) wherein R1 and R2 and R3 are independently a hydrogen atom, an alkyl, a cycloalkyl, a cycloalkylalkyl, an alkylaryl, an aryl, a heterocycle, a cyano, an alkoxy, an aryloxy, a carboxyl, a carbamoyl, —CONR5R6 (in which R5 and R6 are independently an alkyl, arylalkyl or aryl group said ring being substituted or not with a functional group or with R5) or —COOR5 group (in which R5 is an alkyl, alkylaryl or aryl group), said alkyl, cycloalkyl, cycloalkylalkyl, alkylaryl and aryl groups being substituted or not with a functional group or with R5; or R1 and R2 taken together, may form a ring (which terms includes mono-, di- and higher polycyclic ring systems); R4 is a hydrogen atom, an alkyl, an aryl, an alkylaryl, said groups are substituted or not with a halogen atom as Cl, Br, or F; X is an oxygen atom or a leaving group and m is an integer 1 or 2; when m is 1 then X is a leaving group; when m is 2 then X is a oxygen atom, which comprise: a hydrogenation/isomerization reaction in presence of a heterogeneous catalyst, of an oxime derivatives of formula (II) wherein R1, R2 and R3 are as defined above with an acyl derivative of formula (III) (R4CO)mX wherein R4, m and X are as defined above.
摘要翻译：制备由式（I）表示的烯 - 酰胺衍生物的方法，其中R 1和R 2和R 3独立地为氢原子，烷基，环烷基，环烷基烷基，烷基芳基，芳基，杂环，氰基，烷氧基，芳氧基，羧基，氨基甲酰基-CONR 5 R 6（其中R 5和R 6独立地是烷基，芳基烷基或芳基，所述环被取代或不被官能团或与R5）或-COOR5基团（其中 R5是烷基，烷基芳基或芳基），所述烷基，环烷基，环烷基烷基，烷基芳基和芳基被官能团取代或不与R5取代; 或R 1和R 2一起形成环（该术语包括单环，二和更高多环系）; R4是氢原子，烷基，芳基，烷基芳基，所述基团被卤素原子取代或未被取代为Cl，Br或F; X是氧原子或离去基团，m是整数1或2; 当m为1时，X为离去基团; 当m为2时，X为氧原子，其包括：在非均相催化剂存在下的氢化/异构化反应，式（II）的肟衍生物，其中R 1，R 2和R 3如上定义，与酰基衍生物式（III）（R4CO）mX其中R4，m和X如上所定义。

3. 发明授权

US07456320B2 Process for the synthesis of substituted alpha-aminoindan derivatives 有权
标题翻译：用于合成取代的α-氨基茚满衍生物的方法
公开(公告)号：US07456320B2
公开(公告)日：2008-11-25
申请号：US10589529
申请日：2005-02-21
申请人： Blandine Bertrand , Sylvie Blanchet , Alain Burgos , Juliette Martin , Florence Perrin , Sonia Roussiasse , Yvon Derrien
发明人： Blandine Bertrand , Sylvie Blanchet , Alain Burgos , Juliette Martin , Florence Perrin , Sonia Roussiasse , Yvon Derrien
IPC分类号： C07C209/62
CPC分类号： C07C213/02 , C07C217/54 , C07C233/25 , C07C2602/08
摘要： A process for the preparation of optically active substituted alpha-amino-indane derivatives of formula (I), which include: an asymmetric hydrogenation reaction of an en-amide derivative of formula (III) in presence of hydrogen and an optically active catalyst, in order to obtain an amide derivative of formula (II), a hydrolysis reaction of the amide derivative of formula (II) obtained in the previous step,in order to obtain optically active substituted alpha-amino-indane derivatives of formula (I).
摘要翻译：一种制备式（I）的光学活性取代的α-氨基 - 二氢化茚衍生物的方法，其包括：式（III）的酰胺衍生物在氢和光学活性催化剂存在下的不对称氢化反应，为了获得式（I）的光学活性取代的α-氨基 - 二氢茚衍生物，得到上述步骤中得到的式（II）的酰胺衍生物的水解反应，得到式（II）的酰胺衍生物。

4. 发明申请

US20070191640A1 Process for the synthesis of substituted alpha-aminoindan derivatives 有权
标题翻译：用于合成取代的α-氨基茚满衍生物的方法
公开(公告)号：US20070191640A1
公开(公告)日：2007-08-16
申请号：US10589529
申请日：2005-02-21
申请人： Blandine Bertrand , Sylvie Blanchet , Alain Burgos , Juliette Martin , Florence Perrin , Sonia Roussiasse , Yvon Derrien
发明人： Blandine Bertrand , Sylvie Blanchet , Alain Burgos , Juliette Martin , Florence Perrin , Sonia Roussiasse , Yvon Derrien
IPC分类号： C07C213/02
CPC分类号： C07C213/02 , C07C217/54 , C07C233/25 , C07C2602/08
摘要： A process is for the preparation of optically active substituted alpha-indanyl amide derivatives of formula (I), which include: an asymmetric hydrogenation reaction of an en-amide derivative of formula (III) in presence of hydrogen and an optically active catalyst, in order to obtain an amide derivative of formula (II), a hydrolysis reaction of the amide derivative of formula (II) obtained in the previous step, in order to obtain optically active-substituted alpha-indanyl amide derivatives of formula (I).
摘要翻译：一种制备式（I）的光学活性取代的α-茚满基酰胺衍生物的方法，其包括：式（III）的酰胺衍生物在氢和光学活性催化剂存在下的不对称氢化反应，为了获得式（I）的光学活性取代的α-茚满基酰胺衍生物，得到上述步骤中得到的式（II）的酰胺衍生物的水解反应，得到式（II）的酰胺衍生物。

5. 发明申请

US20100029985A1 Process 审中-公开
标题翻译：处理
公开(公告)号：US20100029985A1
公开(公告)日：2010-02-04
申请号：US11722454
申请日：2005-12-14
申请人： George Robert Hodges , Juliette Martin , Noel Anthony Hammil , Ian Nicholas Houson
发明人： George Robert Hodges , Juliette Martin , Noel Anthony Hammil , Ian Nicholas Houson
IPC分类号： C07C211/27 , C07C37/00
CPC分类号： C07C211/29 , C07C29/143 , C07C209/16 , C07C33/46
摘要： A process for the preparation of a compound of Formula (1) wherein Ar represents an optionally substituted hydrocarbyl or an optionally substituted heterocyclyl group comprising an aromatic moiety; and R1 and R2 each independently represent an optionally substituted hydrocarbyl or an optionally substituted heterocyclyl group; said process comprising: a) reducing a compound of Formula (2) to form a compound of Formula (3): b) activating the compound of Formula (3) to form a compound of Formula (4): wherein OX represents a leaving group; and c) coupling the compound of Formula (4) to a compound of Formula (5): to form a compound of Formula (1). A stereoselective reduction of ketones to alcohols is also disclosed.
摘要翻译：制备式（1）化合物的方法，其中Ar表示任选取代的烃基或任选取代的包含芳族部分的杂环基; 并且R 1和R 2各自独立地表示任选取代的烃基或任选取代的杂环基; 所述方法包括：a）还原式（2）的化合物以形成式（3）的化合物：b）活化式（3）的化合物以形成式（4）的化合物：其中OX表示离去基团 ; 和c）将式（4）的化合物与式（5）的化合物偶合：形成式（1）的化合物。还公开了酮对醇的立体选择性还原。

6. 发明授权

US09145570B2 Enzymatic acylation method using an acylphosphonate donor 有权
标题翻译：使用酰基膦酸盐供体的酶酰化方法
公开(公告)号：US09145570B2
公开(公告)日：2015-09-29
申请号：US13812978
申请日：2011-07-29
申请人： Juliette Martin , Gerard Guillamot , Laurent Fourage , Denis Wahler
发明人： Juliette Martin , Gerard Guillamot , Laurent Fourage , Denis Wahler
IPC分类号： C12P7/62 , C12P9/00 , C12P11/00 , C12P13/02 , C12P17/06
CPC分类号： C12P7/62 , C12P9/00 , C12P11/00 , C12P13/02 , C12P17/06
摘要： The invention relates to an enzymatic acylation method including at least the following steps of: contacting at least one compound having at least one function selected from among the amine, alcohol, or thiol functions, at least one microorganism having an acyl transfer activity and/or an acyl transfer enzyme, and at least one acylphosphonate donor of formula (I), where: R is an alkyl, alkene, alkyne, aryl, or aralkyl radical, or is —ORa, —SRa, —NRaRb, where Ra and Rb are identical or different and are H, an alkyl, alkene, alkyne, aryl or aralkyl radical, the alkyl, alkene, alkyne, aryl or aralkyl radicals being optionally substituted; X is O or S; Y and Z, which are identical or different, are —OR1, —OR2, —SR1, —SR2, —NR′1R″1, —NR′2R″2; R1, R2, R′1, R′2, R″1 and R″2, which are identical or different, are an alkyl, alkene, alkyne, aryl or aralkyl radical, said alkyl, alkene, alkyne, aryl or aralkyl radicals being optionally substituted; and recovering the compound including at least one acyl function, said function being selected from among the amine, alcohol, or thiol functions.
摘要翻译：本发明涉及酶促酰化方法，其包括至少以下步骤：使至少一种具有至少一种选自胺，醇或硫醇官能团的官能团的化合物，至少一种具有酰基转移活性的微生物和/或酰基转移酶和至少一种式（I）的酰基膦酸盐供体，其中：R是烷基，烯烃，炔烃，芳基或芳烷基，或是-OR a，-SR a，-NR a R b，其中R a和R b是烷基，烯烃，炔烃，芳基或芳烷基，烷基，烯烃，炔烃，芳基或芳烷基任选被取代; X是O或S; Y和Z相同或不同，为-OR1，-OR2，-SR1，-SR2，-NR'1R“1，-NR'2R”2; 所述烷基，烯烃，炔烃，芳基或芳烷基，R 1，R 2，R'1，R'2，R“1和R”2是相同或不同的，所述烷基，烯烃，炔，芳基或芳烷基任选取代; 并回收包含至少一个酰基官能团的化合物，所述官能团选自胺，醇或巯基官能团。

7. 发明申请

US20130130337A1 Enzymatic Acylation Method Using an Acylphosphonate Donor 有权
标题翻译：使用酰基膦酸盐供体的酶法酰化方法
公开(公告)号：US20130130337A1
公开(公告)日：2013-05-23
申请号：US13812978
申请日：2011-07-29
申请人： Juliette Martin , Gerard Guillamot , Laurent Fourage , Denis Wahler
发明人： Juliette Martin , Gerard Guillamot , Laurent Fourage , Denis Wahler
IPC分类号： C12P7/62 , C12P9/00
CPC分类号： C12P7/62 , C12P9/00 , C12P11/00 , C12P13/02 , C12P17/06
摘要： The invention relates to an enzymatic acylation method including at least the following steps of: contacting at least one compound having at least one function selected from among the amine, alcohol, or thiol functions, at least one microorganism having an acyl transfer activity and/or an acyl transfer enzyme, and at least one acylphosphonate donor of formula (I), where: R is an alkyl, alkene, uikyne, aryl, or aralkyl radical, or is —ORa, —SRa, —NRaRb, where Ra and Rb are identical or different and are H, an alkyl, alkene, alkyne, aryl or aralkyl radical, the alkyl, alkene, alkyne, aryl or aralkyl radicals being optionally substituted; X is O or S; Y and Z, which are identical or different, are —OR1, —OR2, —SR1, —SR2, —NR′1R″1, —NR′2R″2; R1, R2, R′1, R′2, R″1 and R″2, which are identical or different, are an alkyl, alkene, alkyne, aryl or aralkyl radical, said alkyl, alkene, alkyne, aryl or aralkyl radicals being optionally substituted; and recovering the compound including at least one acyl function, said function being selected from among the amine, alcohol, or thiol functions.
摘要翻译：本发明涉及酶促酰化方法，其包括至少以下步骤：使至少一种具有至少一种选自胺，醇或硫醇官能团的官能团的化合物，至少一种具有酰基转移活性的微生物和/或酰基转移酶和至少一种式（I）的酰基膦酸盐供体，其中：R是烷基，烯烃，乙炔基，芳基或芳烷基，或是-OR a，-SR a，-NR a R b，其中R a和R b是烷基，烯烃，炔烃，芳基或芳烷基，烷基，烯烃，炔烃，芳基或芳烷基任选被取代; X是O或S; Y和Z相同或不同，为-OR1，-OR2，-SR1，-SR2，-NR'1R'1，-NR'2R'2; R1，R2，R'1，R'2，R'1和R'2相同或不同，是烷基，烯烃，炔，芳基或芳烷基，所述烷基，烯烃，炔烃，芳基或芳烷基任选被取代; 并回收包含至少一个酰基官能团的化合物，所述官能团选自胺，醇或巯基官能团。

8. 发明申请

US20060252964A1 Process for the preparation of aromatic amines 审中-公开
标题翻译：芳香胺的制备方法
公开(公告)号：US20060252964A1
公开(公告)日：2006-11-09
申请号：US10560305
申请日：2004-06-09
申请人： Andrew Blacker , Juliette Martin
发明人： Andrew Blacker , Juliette Martin
IPC分类号： C07C209/14
CPC分类号： C07C309/66 , C07B2200/07 , C07C29/143 , C07C209/14 , C07C209/16 , C07C209/88 , C07C303/28 , C07C211/30 , C07C33/18
摘要： There is provided a process for the preparation of aromatic amines of Formula (1): where Rx is optionally substituted aryl and Ry is optionally substituted hydrocarbyl, which comprises: (a) reducing a compound of Formula (2): to give a compound of Formula (3): then, (b) reacting a compound of Formula (3) with a leaving group donor, to give a compound of Formula (4); and, (c) reacting a compound of Formula (4) with ammonia to give the compound of Formula (1).
摘要翻译：提供了制备式（1）的芳族胺的方法：其中R x为任选取代的芳基，R y为任选取代的烃基，其包含：（ a）还原式（2）的化合物：得到式（3）的化合物：然后，（b）使式（3）的化合物与离去基团供体反应，得到式（4）的化合物; 和（c）使式（4）的化合物与氨反应得到式（1）的化合物。

9. 发明授权

US06696608B1 Transfer hydrogenation process 失效
标题翻译：转移氢化工艺
公开(公告)号：US06696608B1
公开(公告)日：2004-02-24
申请号：US10049611
申请日：2002-02-14
申请人： Juliette Martin , Lynne Alison Campbell
发明人： Juliette Martin , Lynne Alison Campbell
IPC分类号： C07C21103
CPC分类号： C07B43/04 , C07B53/00 , C07C209/26 , C07C209/62 , C07F9/36 , C07C211/08 , C07C211/27 , C07C211/30
摘要： A catalytic transfer hydrogenation process is provided. The process can be employed to transfer hydrogenate N-substituted imines and iminium salts, which are preferably prochiral. The catalyst employed in the process is preferably a metal complex with one hydrocarbyl or cyclopentadienyl ligand and which is also coordinated to defined bidentate ligands. Preferred metals include rhodium, ruthenium and iridium. Preferred bidentate ligands are diamines and aminoalcohols, particularly those comprising chiral centres. The hydrogen donor is advantageously a mixture of triethylamine and formic acid. A process for the production of primary and secondary amines using the catalytic transfer hydrogenation of the N-substituted imines and iminium salts is also provided.
摘要翻译：提供催化转移氢化方法。该方法可用于转移氢化N-取代的亚胺和亚胺盐，其优选是前置手性的。在该方法中使用的催化剂优选是具有一个烃基或环戊二烯基配体的金属络合物，并且还与定义的二齿配位体配位。优选的金属包括铑，钌和铱。优选的二齿配体是二胺和氨基醇，特别是包含手性中心的那些。氢供体有利地是三乙胺和甲酸的混合物。还提供了使用N-取代亚胺和亚胺鎓盐的催化转移氢化生产伯胺和仲胺的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式