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    • 1. 发明申请
    • Enzymatic Acylation Method Using an Acylphosphonate Donor
    • 使用酰基膦酸盐供体的酶法酰化方法
    • US20130130337A1
    • 2013-05-23
    • US13812978
    • 2011-07-29
    • Juliette MartinGerard GuillamotLaurent FourageDenis Wahler
    • Juliette MartinGerard GuillamotLaurent FourageDenis Wahler
    • C12P7/62C12P9/00
    • C12P7/62C12P9/00C12P11/00C12P13/02C12P17/06
    • The invention relates to an enzymatic acylation method including at least the following steps of: contacting at least one compound having at least one function selected from among the amine, alcohol, or thiol functions, at least one microorganism having an acyl transfer activity and/or an acyl transfer enzyme, and at least one acylphosphonate donor of formula (I), where: R is an alkyl, alkene, uikyne, aryl, or aralkyl radical, or is —ORa, —SRa, —NRaRb, where Ra and Rb are identical or different and are H, an alkyl, alkene, alkyne, aryl or aralkyl radical, the alkyl, alkene, alkyne, aryl or aralkyl radicals being optionally substituted; X is O or S; Y and Z, which are identical or different, are —OR1, —OR2, —SR1, —SR2, —NR′1R″1, —NR′2R″2; R1, R2, R′1, R′2, R″1 and R″2, which are identical or different, are an alkyl, alkene, alkyne, aryl or aralkyl radical, said alkyl, alkene, alkyne, aryl or aralkyl radicals being optionally substituted; and recovering the compound including at least one acyl function, said function being selected from among the amine, alcohol, or thiol functions.
    • 本发明涉及酶促酰化方法,其包括至少以下步骤:使至少一种具有至少一种选自胺,醇或硫醇官能团的官能团的化合物,至少一种具有酰基转移活性的微生物和/或 酰基转移酶和至少一种式(I)的酰基膦酸盐供体,其中:R是烷基,烯烃,乙炔基,芳基或芳烷基,或是-OR a,-SR a,-NR a R b,其中R a和R b是 烷基,烯烃,炔烃,芳基或芳烷基,烷基,烯烃,炔烃,芳基或芳烷基任选被取代; X是O或S; Y和Z相同或不同,为-OR1,-OR2,-SR1,-SR2,-NR'1R'1,-NR'2R'2; R1,R2,R'1,R'2,R'1和R'2相同或不同,是烷基,烯烃,炔,芳基或芳烷基,所述烷基,烯烃,炔烃,芳基或 芳烷基任选被取代; 并回收包含至少一个酰基官能团的化合物,所述官能团选自胺,醇或巯基官能团。
    • 2. 发明授权
    • Enzymatic acylation method using an acylphosphonate donor
    • 使用酰基膦酸盐供体的酶酰化方法
    • US09145570B2
    • 2015-09-29
    • US13812978
    • 2011-07-29
    • Juliette MartinGerard GuillamotLaurent FourageDenis Wahler
    • Juliette MartinGerard GuillamotLaurent FourageDenis Wahler
    • C12P7/62C12P9/00C12P11/00C12P13/02C12P17/06
    • C12P7/62C12P9/00C12P11/00C12P13/02C12P17/06
    • The invention relates to an enzymatic acylation method including at least the following steps of: contacting at least one compound having at least one function selected from among the amine, alcohol, or thiol functions, at least one microorganism having an acyl transfer activity and/or an acyl transfer enzyme, and at least one acylphosphonate donor of formula (I), where: R is an alkyl, alkene, alkyne, aryl, or aralkyl radical, or is —ORa, —SRa, —NRaRb, where Ra and Rb are identical or different and are H, an alkyl, alkene, alkyne, aryl or aralkyl radical, the alkyl, alkene, alkyne, aryl or aralkyl radicals being optionally substituted; X is O or S; Y and Z, which are identical or different, are —OR1, —OR2, —SR1, —SR2, —NR′1R″1, —NR′2R″2; R1, R2, R′1, R′2, R″1 and R″2, which are identical or different, are an alkyl, alkene, alkyne, aryl or aralkyl radical, said alkyl, alkene, alkyne, aryl or aralkyl radicals being optionally substituted; and recovering the compound including at least one acyl function, said function being selected from among the amine, alcohol, or thiol functions.
    • 本发明涉及酶促酰化方法,其包括至少以下步骤:使至少一种具有至少一种选自胺,醇或硫醇官能团的官能团的化合物,至少一种具有酰基转移活性的微生物和/或 酰基转移酶和至少一种式(I)的酰基膦酸盐供体,其中:R是烷基,烯烃,炔烃,芳基或芳烷基,或是-OR a,-SR a,-NR a R b,其中R a和R b是 烷基,烯烃,炔烃,芳基或芳烷基,烷基,烯烃,炔烃,芳基或芳烷基任选被取代; X是O或S; Y和Z相同或不同,为-OR1,-OR2,-SR1,-SR2,-NR'1R“1,-NR'2R”2; 所述烷基,烯烃,炔烃,芳基或芳烷基,R 1,R 2,R'1,R'2,R“1和R”2是相同或不同的,所述烷基,烯烃,炔,芳基或芳烷基 任选取代; 并回收包含至少一个酰基官能团的化合物,所述官能团选自胺,醇或巯基官能团。