专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07807426B2 Processes for producing optically active 1-substituted 2-methylpyrrolidine 失效
标题翻译：光学活性1-取代2-甲基吡咯烷的制备方法
公开(公告)号：US07807426B2
公开(公告)日：2010-10-05
申请号：US10586337
申请日：2005-01-19
申请人： Akira Nishiyama , Naoaki Taoka , Narumi Kishimoto , Nobuo Nagashima
发明人： Akira Nishiyama , Naoaki Taoka , Narumi Kishimoto , Nobuo Nagashima
IPC分类号： C12P7/18 , C12P7/00
CPC分类号： C12P17/10 , C07C303/28 , C12P7/18 , C12P11/00 , C07C309/66
摘要： The present invention relates to a process for producing an optically active 1,4-pentanediol by asymmetrically reducing 5-hydroxy-2-pentanone, which is easily available at low cost. The present invention also relates to a process for producing an optically active 1-substituted 2-methylpyrrolidine including sulfonylating the optically active 1,4-pentanediol to convert it to an optically active sulfonate compound, and reacting the compound with an amine. According to the processes of the present invention, an optically active 1,4-pentanediol and an optically active 1-substituted 2-methylpyrrolidine, which are useful as an intermediate for medicines and an intermediate for agricultural chemicals, can be simply produced from an inexpensive starting material.
摘要翻译：本发明涉及通过不对称地还原5-羟基-2-戊酮来制备光学活性的1,4-戊二醇的方法，该方法容易以低成本获得。本发明还涉及一种光学活性1-取代的2-甲基吡咯烷的制备方法，其包括使光学活性的1,4-戊二醇磺酰化以将其转化成光学活性的磺酸盐化合物，并使该化合物与胺反应。根据本发明的方法，用作药物中间体和农药中间体的光学活性的1,4-丁二醇和光学活性的1-取代的2-甲基吡咯烷可以简便地从廉价的起始材料

2. 发明授权

US07408084B2 Process for producing optically active β-amino alcohol 失效
标题翻译：光学活性β-氨基醇的制备方法
公开(公告)号：US07408084B2
公开(公告)日：2008-08-05
申请号：US10516469
申请日：2003-06-02
申请人： Akira Nishiyama , Narumi Kishimoto , Nobuo Nagashima
发明人： Akira Nishiyama , Narumi Kishimoto , Nobuo Nagashima
IPC分类号： C07C211/05 , C07C213/08
CPC分类号： C07C49/84 , C07B2200/07 , C07C45/63 , C07C213/00 , C07C215/28 , C07C221/00 , C07C215/30 , C07C225/16
摘要： A process for easily producing an optically active β-amino alcohol useful as a pharmaceutical intermediate from an inexpensive, readily available starting material is provided. A readily available α-substituted ketone is reacted with an optically active amine to yield a diastereomer mixture of an optically active α-substituted aminoketone. One of the diastereomers is isolated optionally after the diastereomers are converted to salts with an acid. The optically active α-substituted aminoketone or a salt thereof thus isolated was stereoselectively reduced to yield an optically active β-substituted amino alcohol. The optically active β-substituted amino alcohol is subjected to hydrogenolysis to produce an optically active β-amino alcohol or a salt thereof.
摘要翻译：提供了一种从便宜的，容易获得的起始材料中容易地生产用作药物中间体的光学活性β-氨基醇的方法。将容易获得的α-取代的酮与光学活性胺反应，得到光学活性的α-取代的氨基酮的非对映异构体混合物。在非对映异构体与酸转化成盐之后，任选地分离非对映异构体之一。将如此分离的光学活性α-取代的氨基酮或其盐立体选择性地还原，得到光学活性的β-取代的氨基醇。将光学活性的β-取代氨基醇进行氢解以产生光学活性的β-氨基醇或其盐。

3. 发明申请

US20050277791A1 Process for producing optically active beta-amino alcohol 失效
标题翻译：光学活性β-氨基醇的制备方法
公开(公告)号：US20050277791A1
公开(公告)日：2005-12-15
申请号：US10516469
申请日：2003-06-02
申请人： Akira Nishiyama , Narumi Kishimoto , Nobuo Nagashima
发明人： Akira Nishiyama , Narumi Kishimoto , Nobuo Nagashima
IPC分类号： C07C45/63 , C07C49/84 , C07C213/00 , C07C215/28 , C07C215/30 , C07C221/00 , C07C225/16 , C07C29/06
CPC分类号： C07C49/84 , C07B2200/07 , C07C45/63 , C07C213/00 , C07C215/28 , C07C221/00 , C07C215/30 , C07C225/16
摘要： A process for easily producing an optically active β-amino alcohol useful as a pharmaceutical intermediate from an inexpensive, readily available starting material is provided. A readily available α-substituted ketone is reacted with an optically active amine to yield a diastereomer mixture of an optically active α-substituted aminoketone. One of the diastereomers is isolated optionally after the diastereomers are converted to salts with an acid. The optically active α-substituted aminoketone or a salt thereof thus isolated was stereoselectively reduced to yield an optically active β-substituted amino alcohol. The optically active β-substituted amino alcohol is subjected to hydrogenolysis to produce an optically active β-amino alcohol or a salt thereof.
摘要翻译：提供了一种从便宜的，容易获得的起始材料中容易地生产用作药物中间体的光学活性β-氨基醇的方法。将容易获得的α-取代的酮与光学活性胺反应，得到光学活性的α-取代的氨基酮的非对映异构体混合物。在非对映异构体与酸转化成盐之后，任选地分离非对映异构体之一。将如此分离的光学活性α-取代的氨基酮或其盐立体选择性地还原，得到光学活性的β-取代的氨基醇。将光学活性的β-取代氨基醇进行氢解以产生光学活性的β-氨基醇或其盐。

4. 发明申请

US20070292926A1 Processes for Producing Optically Active 1-Substituted 2-Methylpyrrolidine and Intermediate Therefor 失效
标题翻译：用于生产光学活性1-取代的2-甲基吡咯烷及其中间体的方法
公开(公告)号：US20070292926A1
公开(公告)日：2007-12-20
申请号：US10586337
申请日：2005-01-19
申请人： Akira Nishiyama , Naoaki Taoka , Narumi Kishimoto , Nobuo Nagashima
发明人： Akira Nishiyama , Naoaki Taoka , Narumi Kishimoto , Nobuo Nagashima
IPC分类号： C12P7/18 , C07C31/20 , C07D207/04
CPC分类号： C12P17/10 , C07C303/28 , C12P7/18 , C12P11/00 , C07C309/66
摘要： The present invention relates to a process for producing an optically active 1,4-pentanediol by asymmetrically reducing 5-hydroxy-2-pentanone, which is easily available at low cost. The present invention also relates to a process for producing an optically active 1-substituted 2-methylpyrrolidine including sulfonylating the optically active 1,4-pentanediol to convert it to an optically active sulfonate compound, and reacting the compound with an amine. According to the processes of the present invention, an optically active 1,4-pentanediol and an optically active 1-substituted 2-methylpyrrolidine, which are useful as an intermediate for medicines and an intermediate for agricultural chemicals, can be simply produced from an inexpensive starting material.
摘要翻译：本发明涉及通过不对称地还原5-羟基-2-戊酮来制备光学活性的1,4-戊二醇的方法，该方法容易以低成本获得。本发明还涉及一种光学活性1-取代的2-甲基吡咯烷的制备方法，其包括使光学活性的1,4-戊二醇磺酰化以将其转化成光学活性的磺酸盐化合物，并使该化合物与胺反应。根据本发明的方法，用作药物中间体和农药中间体的光学活性的1,4-丁二醇和光学活性的1-取代的2-甲基吡咯烷可以简便地从廉价的起始材料

5. 发明授权

US07834190B2 Process for production of optically active-3-amino-2-hydroxypropionic cyclopropylamide derivatives and salts thereof 有权
标题翻译：光学活性-3-氨基-2-羟基丙基丙烯酰胺衍生物及其盐的制备方法
公开(公告)号：US07834190B2
公开(公告)日：2010-11-16
申请号：US12227788
申请日：2007-05-22
申请人： Kohei Mori , Akira Nishiyama , Naoaki Taoka , Daisuke Moriyama , Nobuo Nagashima
发明人： Kohei Mori , Akira Nishiyama , Naoaki Taoka , Daisuke Moriyama , Nobuo Nagashima
IPC分类号： C07D263/08 , C07D303/02
CPC分类号： C07B53/00 , C07B2200/07 , C07C67/31 , C07C231/18 , C07C237/04 , C07C237/22 , C07C2601/02 , C07D263/16 , C07D301/24 , C07D303/16 , C07D303/48 , C12P7/42 , C12P13/02 , C12P41/002 , C07C69/675
摘要： An objective of the present application is to provide an industrially practicable method for producing an optically-active 3-amino-2-hydroxypropionic cyclopropylamide derivative or salt thereof from an inexpensive easily-available starting material. The derivative or salt thereof is useful as an intermediate for a medicine. It is also intended by the present application to provide a useful intermediate of the derivative. The objective is attained by the following method. First, an easily-available 2-halo-3-oxopropionic acid derivative is asymmetrically reduced, and then epoxidated to produce an optically-active epoxycarboxylic acid derivative. Next, the derivative is converted into an optically-active epoxyamide derivative by reaction with cyclopropylamine, and then reacted with a nitrile to obtain an optically-active oxazolinamide derivative. Subsequently, selective acid solvolysis of the oxazoline skeleton gives the optically-active 3-amino-2-hydroxypropionic cyclopropylamide derivative or salt thereof.
摘要翻译：本申请的目的是提供从便宜的廉价起始材料制备光学活性3-氨基-2-羟基丙基环丙基酰胺衍生物或其盐的工业上可行的方法。其衍生物或其盐可用作药物的中间体。本申请还希望提供衍生物的有用中间体。目的是通过以下方法实现。首先，容易获得的2-卤代-3-氧代丙酸衍生物被不对称地还原，然后环氧化以产生光学活性的环氧羧酸衍生物。接下来，通过与环丙胺反应将衍生物转化为光学活性的环氧酰胺衍生物，然后与腈反应，得到光学活性的恶唑啉酰胺衍生物。随后，恶唑啉骨架的选择性酸溶剂解产生光学活性3-氨基-2-羟基丙基丙烯酰胺衍生物或其盐。

6. 发明申请

US20100048909A1 Process for production of optically active-3-amino-2-hydroxypropionic cyclopropylamide derivatives and salts thereof 有权
公开(公告)号：US20100048909A1
公开(公告)日：2010-02-25
申请号：US12227788
申请日：2007-05-22
申请人： Kohei Mori , Akira Nishiyama , Naoaki Taoka , Daisuke Moriyama , Nobuo Nagashima
发明人： Kohei Mori , Akira Nishiyama , Naoaki Taoka , Daisuke Moriyama , Nobuo Nagashima
IPC分类号： C07D263/12 , C07D303/38 , C07C237/06
CPC分类号： C07B53/00 , C07B2200/07 , C07C67/31 , C07C231/18 , C07C237/04 , C07C237/22 , C07C2601/02 , C07D263/16 , C07D301/24 , C07D303/16 , C07D303/48 , C12P7/42 , C12P13/02 , C12P41/002 , C07C69/675
摘要： An objective of the present application is to provide an industrially practicable method for producing an optically-active 3-amino-2-hydroxypropionic cyclopropylamide derivative or salt thereof from an inexpensive easily-available starting material. The derivative or salt thereof is useful as an intermediate for a medicine. It is also intended by the present application to provide a useful intermediate of the derivative. The objective is attained by the following method. First, an easily-available 2-halo-3-oxopropionic acid derivative is asymmetrically reduced, and then epoxidated to produce an optically-active epoxycarboxylic acid derivative. Next, the derivative is converted into an optically-active epoxyamide derivative by reaction with cyclopropylamine, and then reacted with a nitrile to obtain an optically-active oxazolinamide derivative. Subsequently, selective acid solvolysis of the oxazoline skeleton gives the optically-active 3-amino-2-hydroxypropionic cyclopropylamide derivative or salt thereof.

7. 发明授权

US07223859B2 Method for producing (R)-3-[4-(trifluoromethyl) phenylamino]-pentanoic acid amide derivative 失效
标题翻译：（R）-3- [4-（三氟甲基）苯基氨基] - 戊酸酰胺衍生物的制备方法
公开(公告)号：US07223859B2
公开(公告)日：2007-05-29
申请号：US10801141
申请日：2004-03-16
申请人： Tatsuyoshi Tanaka , Masanobu Sugawara , Hirofumi Maeda , Akira Nishiyama , Yoshihiko Yasohara , Nobuo Nagashima
发明人： Tatsuyoshi Tanaka , Masanobu Sugawara , Hirofumi Maeda , Akira Nishiyama , Yoshihiko Yasohara , Nobuo Nagashima
IPC分类号： C07D205/02 , C07C233/00
CPC分类号： C07D205/08 , C07C231/02 , C07C309/66 , C07C309/73
摘要： The present invention provides a method for easily producing an (R)-3-[4-(trifluoromethyl)phenylamino]-pentanoic acid amide derivative useful for an intermediate for pharmaceutical products, particularly an inhibitor of a cholesteryl ester transfer protein (CETP) from easily available raw materials. In the present invention, (S)-N-[4-(trifluoromethyl)phenyl]-3-hydroxypentanoic acid amide prepared from easily available raw materials leads a production of (R)-4-ethyl-1-[4-(trifluoromethyl)phenyl]-2-azetidinone to give (R)-3-[4-(trifluoromethyl)phenylamino]-pentanoic acid amide. Furthermore, (R)-4-ethyl-1-[4-(trifluoromethyl)phenyl]-2-azetidinone is reacted with a carbamic acid ester to give an (R)-3-[4-(trifluoromethyl)phenylamino]-pentanoic acid amide derivative.
摘要翻译：本发明提供了一种容易地制备用于药物产品中间体（特别是胆固醇酯转移蛋白（CETP）抑制剂）的（R）-3- [4-（三氟甲基）苯基氨基] - 戊酸酰胺衍生物的方法，容易获得的原料。在本发明中，由容易获得的原料制备的（S）-N- [4-（三氟甲基）苯基] -3-羟基戊酸酰胺导致（R）-4-乙基-1- [4-（三氟甲基））苯基] -2-氮杂环丁酮，得到（R）-3- [4-（三氟甲基）苯基氨基] - 戊酸酰胺。此外，将（R）-4-乙基-1- [4-（三氟甲基）苯基] -2-氮杂环丁酮与氨基甲酸酯反应，得到（R）-3- [4-（三氟甲基）苯基氨基] - 戊酸酰胺衍生物。

8. 发明授权

US07986014B2 Semiconductor device 有权
公开(公告)号：US07986014B2
公开(公告)日：2011-07-26
申请号：US12654490
申请日：2009-12-22
申请人： Reika Ichihara , Yoshinori Tsuchiya , Masato Koyama , Akira Nishiyama
发明人： Reika Ichihara , Yoshinori Tsuchiya , Masato Koyama , Akira Nishiyama
IPC分类号： H01L29/76 , H01L29/94 , H01L31/062 , H01L31/113 , H01L31/119
CPC分类号： H01L21/823857 , H01L21/823462
摘要： A semiconductor device includes a semiconductor substrate, an nMISFET formed on the substrate, the nMISFET including a first dielectric formed on the substrate and a first metal gate electrode formed on the first dielectric and formed of one metal element selected from Ti, Zr, Hf, Ta, Sc, Y, a lanthanoide and actinide series and of one selected from boride, silicide and germanide compounds of the one metal element, and a pMISFET formed on the substrate, the pMISFET including a second dielectric formed on the substrate and a second metal gate electrode formed on the second dielectric and made of the same material as that of the first metal gate electrode, at least a portion of the second dielectric facing the second metal gate electrode being made of an insulating material different from that of at least a portion of the first dielectric facing the first metal gate electrode.

9. 发明申请

US20100087643A1 METHOD FOR PRODUCING OPTICALLY ACTIVE 2-ARYLPIPERAZINE DERIVATIVE 失效
标题翻译：用于生产光学活性2-亚氨基吡啶衍生物的方法
公开(公告)号：US20100087643A1
公开(公告)日：2010-04-08
申请号：US12449460
申请日：2008-02-05
申请人： Masatoshi Ohnuki , Akira Nishiyama , Masaru Mitsuda
发明人： Masatoshi Ohnuki , Akira Nishiyama , Masaru Mitsuda
IPC分类号： C07D241/04
CPC分类号： C07B53/00 , C07D241/04
摘要： The objective of the present invention is to produce an optically active 2-arylpiperazine derivative useful as a synthetic intermediate for pharmaceutical products and agricultural chemicals from inexpensive and readily available starting material by an industrially practicable method. The objective can be accomplished by treating an optically active substituted aminodiol derivative produced from an optically active styrene oxide derivative with a sulfonating agent in the presence of a base, and then reacting an amine compound to obtain the 2-arylpiperazine derivative. Especially, an optically active 1-unsubstituted-2-arylpiperazine derivative can be produced by treating an optically active 1-allyl-2-arylpiperazine derivative with water in the presence of a transition metal catalyst for deallylation.
摘要翻译：本发明的目的是通过工业上可行的方法从便宜且容易获得的原料制备用作药物产品和农药的合成中间体的光学活性2-芳基哌嗪衍生物。该目的可以通过在碱的存在下用磺化剂处理由光学活性苯乙烯氧化物衍生物产生的光学活性取代的氨基二醇衍生物，然后使胺化合物反应得到2-芳基哌嗪衍生物来实现。特别地，光学活性的1-未取代-2-芳基哌嗪衍生物可以通过在过渡金属催化剂的存在下用水处理光学活性的1-烯丙基-2-芳基哌嗪衍生物来进行脱气。

10. 发明申请

US20100052035A1 NONVOLATILE SEMICONDUCTOR MEMORY APPARATUS 有权
标题翻译：非易失性半导体存储器件
公开(公告)号：US20100052035A1
公开(公告)日：2010-03-04
申请号：US12403493
申请日：2009-03-13
申请人： Masahiro KOIKE , Yuichiro Mitani , Tatsuo Shimizu , Naoki Yasuda , Yasushi Nakasaki , Akira Nishiyama
发明人： Masahiro KOIKE , Yuichiro Mitani , Tatsuo Shimizu , Naoki Yasuda , Yasushi Nakasaki , Akira Nishiyama
IPC分类号： H01L29/788 , H01L29/792
CPC分类号： H01L29/7881 , H01L21/28273 , H01L21/28282 , H01L27/11521 , H01L29/513
摘要： A nonvolatile semiconductor memory apparatus includes: a source and drain regions formed at a distance from each other in a semiconductor layer; a first insulating film formed on the semiconductor layer located between the source region and the drain region, the first insulating film including a first insulating layer and a second insulating layer formed on the first insulating layer and having a higher dielectric constant than the first insulating layer, the second insulating layer having a first site performing hole trapping and releasing, the first site being formed by adding an element different from a base material to the second insulating film, the first site being located at a lower level than a Fermi level of a material forming the semiconductor layer; a charge storage film formed on the first insulating film; a second insulating film formed on the charge storage film; and a control gate electrode formed on the second insulating film.
摘要翻译：一种非易失性半导体存储器件，包括：在半导体层中形成为彼此间隔一定距离的源区和漏区; 形成在位于源极区域和漏极区域之间的半导体层上的第一绝缘膜，所述第一绝缘膜包括形成在所述第一绝缘层上并具有比所述第一绝缘层高的介电常数的第一绝缘层和第二绝缘层所述第二绝缘层具有进行孔捕获和释放的第一部位，所述第一部位通过将不同于基材的元素添加到所述第二绝缘膜而形成，所述第一部位位于比所述第二绝缘膜的费米能级更低的水平形成半导体层的材料; 形成在所述第一绝缘膜上的电荷存储膜; 形成在电荷存储膜上的第二绝缘膜; 以及形成在所述第二绝缘膜上的控制栅电极。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式