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1. 发明申请

US20060035363A1 Novel acylase gene 失效
标题翻译：新型酰基转移酶基因
公开(公告)号：US20060035363A1
公开(公告)日：2006-02-16
申请号：US10516587
申请日：2003-05-30
申请人： Akiko Nishi , Takumi Mano , Shinichi Yokota , Masayuki Takano , Kazuyoshi Yajima
发明人： Akiko Nishi , Takumi Mano , Shinichi Yokota , Masayuki Takano , Kazuyoshi Yajima
IPC分类号： C12N9/80 , C07H21/04 , C12P21/06 , C12N15/74 , C12N1/21
CPC分类号： C12P37/04 , C12N9/80 , C12N9/84
摘要： The subject of the present invention is to provide a β-lactam acylase protein having high activity, a gene coding for said β-lactam acylase protein, a recombinant vector having said gene, a transformant containing said recombinant vector, and a method of producing a β-lactam antibiotic such as amoxycillin using said β-lactam acylase. A β-lactam acylase gene of Stenotrophomonas maltophilia was cloned, the DNA base sequence and the amino acid sequence expected therefrom was determined, and a Stenotrophomonas β-lactam acylase gene was obtained. This gene was found to code for a protein with a molecular weight of about 70 kDa and having β-lactam acylase activity, and could efficiently produce amoxycillin without being inhibited by phenylacetic acid, etc. Furthermore, by modification of the amino acid sequence, a protein which can more efficiently produce amoxycillin could be obtained.
摘要翻译：本发明的主题是提供具有高活性的β-内酰胺酰基转移酶蛋白，编码所述β-内酰胺酰基转移酶蛋白的基因，具有所述基因的重组载体，含有所述重组载体的转化体，以及制备 β-内酰胺抗生素如阿莫西林，使用所述β-内酰胺酰基转移酶。克隆了嗜麦芽寡养单胞菌的β-内酰胺酰基转移酶基因，测定了DNA碱基序列和预期的氨基酸序列，得到了嗜麦芽寡养单胞菌β-内酰胺酰基转移酶基因。发现该基因编码具有约70kDa分子量且具有β-内酰胺酰基转移酶活性的蛋白质，并且可以有效地产生阿莫西林而不被苯乙酸等抑制。此外，通过修饰氨基酸序列，a 可以获得更有效地产生阿莫西林的蛋白质。

2. 发明授权

US07195892B2 Acylase gene 失效
标题翻译：淀粉酶基因
公开(公告)号：US07195892B2
公开(公告)日：2007-03-27
申请号：US10516587
申请日：2003-05-30
申请人： Akiko Nishi , Takumi Mano , Shinichi Yokota , Masayuki Takano , Kazuyoshi Yajima
发明人： Akiko Nishi , Takumi Mano , Shinichi Yokota , Masayuki Takano , Kazuyoshi Yajima
IPC分类号： C12P35/00 , C12P21/00 , C12N9/84 , C12N1/20 , C07H21/04
CPC分类号： C12P37/04 , C12N9/80 , C12N9/84
摘要： The subject of the present invention is to provide a β-lactam acylase protein having high activity, a gene coding for said β-lactam acylase protein, a recombinant vector having said gene, a transformant containing said recombinant vector, and a method of producing a β-lactam antibiotic such as amoxycillin using said β-lactam acylase. A β-lactam acylase gene of Stenotrophomonas maltophilia was cloned, the DNA base sequence and the amino acid sequence expected therefrom was determined, and a Stenotrophomonas β-lactam acylase gene was obtained. This gene was found to code for a protein with a molecular weight of about 70 kDa and having β-lactam acylase activity, and could efficiently produce amoxycillin without being inhibited by phenylacetic acid, etc. Furthermore, by modification of the amino acid sequence, a protein which can more efficiently produce amoxycillin could be obtained.
摘要翻译：本发明的主题是提供具有高活性的β-内酰胺酰基转移酶蛋白，编码所述β-内酰胺酰基转移酶蛋白的基因，具有所述基因的重组载体，含有所述重组载体的转化体，以及制备 β-内酰胺抗生素如阿莫西林，使用所述β-内酰胺酰基转移酶。克隆了嗜麦芽寡养单胞菌的β-内酰胺酰基转移酶基因，测定了DNA碱基序列和预期的氨基酸序列，得到了嗜麦芽寡养单胞菌β-内酰胺酰基转移酶基因。发现该基因编码具有约70kDa分子量且具有β-内酰胺酰基转移酶活性的蛋白质，并且可以有效地产生阿莫西林而不被苯乙酸等抑制。此外，通过修饰氨基酸序列，a 可以获得更有效地产生阿莫西林的蛋白质。

3. 发明授权

US5902736A Process for the production of D-.alpha.-amino acids by hydrolysis of the corresponding N-carbamyl derivative 失效
标题翻译：通过水解相应的N-氨基甲酰基衍生物生产D-氨基酸的方法
公开(公告)号：US5902736A
公开(公告)日：1999-05-11
申请号：US244657
申请日：1994-06-06
申请人： Hideaki Yamada , Sakayu Shimizu , Yasuhiro Ikenaka , Kazuyoshi Yajima , Yukio Yamada , Hirokazu Nanba , Masayuki Takano , Satomi Takahashi
发明人： Hideaki Yamada , Sakayu Shimizu , Yasuhiro Ikenaka , Kazuyoshi Yajima , Yukio Yamada , Hirokazu Nanba , Masayuki Takano , Satomi Takahashi
IPC分类号： C12P13/04 , C12P41/00 , C07C1/04
CPC分类号： C12P13/04 , C12P41/009 , Y10S435/874 , Y10S435/911
摘要： In a process for the production of a D-.alpha.-amino acid, in which an N-carbamyl-D-.alpha.-amino acid corresponding to the general formula: ##STR1## wherein R represents phenyl, hydroxy-substituted phenyl, substituted or unsubstituted alkyl, or thienyl, is converted by a microbial enzyme in an aqueous medium to a D-.alpha.-amino acid corresponding to the general formula: ##STR2## wherein R is the same as defined above, decarbamylase produced by a microorganism of the genus Comamonas, Blastobacter, Alcaligenes, Sporosarcina, Rhizobium, Bradyrhizobium or Arthrobacter is used as the enzyme converting the N-carbamyl-D-.alpha.-amino acid to the D-.alpha.-amino acid.The conversion of the N-carbamyl-D-.alpha.-amino acids to the D-.alpha.-amino acids is carried out in a neutral to alkaline pH range.
摘要翻译： PCT No.PCT / JP93 / 01408 Sec。 371日期：1994年6月6日 102（e）日期1994年6月6日PCT提交1993年10月1日PCT公布。公开号WO94 / 08030 日期1994年4月14日在制备D-氨基酸的方法中，其中N-氨基甲酰基-D-α-氨基酸对应于通式：其中R表示苯基，羟基取代的苯基，取代的或未取代的烷基或噻吩基通过微生物酶在水性介质中转化成对应于以下通式的D-α-氨基酸：其中R与上述定义相同，由Comamonas属的微生物产生的脱氨基甲酰酶，使用喷杆菌属，产碱杆菌属，孢子体菌属，根瘤菌属，Bradyrhizobium或节杆菌作为将N-氨基甲酰基-D-α-氨基酸转化为D-氨基酸的酶。 N-氨基甲酰基-D-α-氨基酸向D-α-氨基酸的转化在中性至碱性pH范围内进行。

4. 发明授权

US6083752A DNA coding for decarbamylase improved in thermostability and use thereof 失效
标题翻译：编码脱氨基甲酰酶的DNA改善了热稳定性和使用
公开(公告)号：US6083752A
公开(公告)日：2000-07-04
申请号：US876398
申请日：1997-06-16
申请人： Yasuhiro Ikenaka , Hirokazu Nanba , Masayuki Takano , Kazuyoshi Yajima , Yukio Yamada , Satomi Takahashi
发明人： Yasuhiro Ikenaka , Hirokazu Nanba , Masayuki Takano , Kazuyoshi Yajima , Yukio Yamada , Satomi Takahashi
IPC分类号： C12N9/80 , C12N15/55 , C12N15/72 , C12P13/06 , C12P13/08 , C12P13/22 , C12N15/00 , C12N5/10 , C12N9/14
CPC分类号： C12N15/72 , C12N9/80 , C12P13/06 , C12P13/08 , C12P13/22
摘要： A DNA fragment coding for a decarbamylase protein improved in thermostability as the result of replacement of at least one base of a DNA fragment coding for a decarbamylase protein derived from a microorganism with another base and the resultant replacement of at least one of the corresponding amino acids, and its production process; a vector containing the DNA fragment; a transformant obtained by transformation with the vector; as well as a decarbamylase improved in thermostability and its production process. Also disclosed is a process for producing a D-.alpha.-amino acid, which comprises converting an N-carbamoyl-D-.alpha.-amino acid into the corresponding D-.alpha.-amino acid in an aqueous medium by the action of a decarbamylase having a thermostable temperature of 65.degree. C. or higher; and collecting the D-.alpha.-amino acid produced.
摘要翻译：由于将来自微生物的脱氨基甲酰酶蛋白质的至少一个碱基替换为另一碱基的氨基酸残基的至少一个碱基，所以替代了至少一个相应的氨基酸，及其生产工艺; 含有DNA片段的载体; 通过用载体转化获得的转化体; 以及改进了热稳定性的脱氨基甲酰酶及其制备方法。还公开了一种制备D-α-氨基酸的方法，该方法包括通过脱氨基甲酰酶的作用将N-氨基甲酰基-D-α-氨基酸转化成水性介质中的相应的D- 耐热温度在65℃以上; 并收集产生的D-α-氨基酸。

5. 发明授权

US5565344A Process for production of D-.alpha.-amino acids 失效
标题翻译：生产D-α-氨基酸的方法
公开(公告)号：US5565344A
公开(公告)日：1996-10-15
申请号：US917111
申请日：1992-08-07
申请人： Hirokazu Nanba , Yukio Yamada , Masayuki Takano , Yasuhiro Ikenaka , Satomi Takahashi , Kazuyoshi Yajima
发明人： Hirokazu Nanba , Yukio Yamada , Masayuki Takano , Yasuhiro Ikenaka , Satomi Takahashi , Kazuyoshi Yajima
IPC分类号： C12N1/21 , C12N9/80 , C12N15/55 , C12P13/04 , C12P41/00 , C07H19/00 , C12N1/12 , C12N9/14
CPC分类号： C12P41/009 , C12N9/80 , C12P13/04
摘要： The present invention is directed to a gene which is related to a D-N-carbamoyl-.alpha.-amino acid amidohydrolase which is an enzyme capable of converting D-N-carbamoyl-.alpha.-amino acids into D-.alpha.-amino acids; a recombinant plasmid in which a DNA fragment containing the gene is incorporated into a vector; a microorganism belonging to the genus Escherichia, Pseudomonas, Flavobacterium, Bacillus, Serratia, Corynebacterium, or Brevibacterium, which is transformed by incorporating the recombinant plasmid thereinto; a process for the production of D-N-carbamoyl-.alpha.-amino acid amidohydrolases, comprising the steps of cultivating the transformed microorganism and collecting the desired product therefrom; a D-N-carbamoyl-.alpha.-amino acid amidohydrolase obtained by the method; and a process for the production of D-.alpha.-amino acids with the aid of an action of the enzyme.The D-N-carbamoyl-.alpha.-amino acid amidohydrolase can be fixed on a support for immobilization and used as an immobilized enzyme.
摘要翻译： PCT No.PCT / JP91 / 01696 Sec。 371日期：1992年8月7日 102（e）日期1992年8月7日PCT 1991年12月6日PCT PCT。出版物WO92 / 10579 日期1992年6月25日本发明涉及与能够将D-N-氨基甲酰基-α-氨基酸转化为D-氨基酸的酶的D-N-氨基甲酰基-α-氨基酸酰胺水解酶相关的基因。将含有该基因的DNA片段并入载体的重组质粒; 通过将重组质粒并入而转化的属于埃希氏杆菌属，假单胞菌属，黄杆菌属，芽孢杆菌属，沙雷氏菌属，棒状杆菌属或短杆菌属的微生物; 制备D-N-氨基甲酰基-α-氨基酸酰胺水解酶的方法，包括培养转化的微生物并从其中收集所需产物的步骤; 通过该方法获得的D-N-氨基甲酰基-α-氨基酸酰胺水解酶; 以及借助于酶的作用生产D-氨基酸的方法。 D-N-氨基甲酰基-α-氨基酸酰胺水解酶可以固定在用于固定的载体上并用作固定化酶。

6. 发明授权

US5824522A Recombinant decarbamylases for producing D-.alpha.-amino acids 失效
标题翻译：用于产生D-α-氨基酸的重组脱氨基甲酰酶
公开(公告)号：US5824522A
公开(公告)日：1998-10-20
申请号：US294871
申请日：1994-08-22
申请人： Yasuhiro Ikenaka , Hirokazu Nanba , Masayuki Takano , Kazuyoshi Yajima , Yukio Yamada , Satomi Takahashi , Kazuma Okubo , Kazuhiko Yamada , Yoshiro Hiraishi
发明人： Yasuhiro Ikenaka , Hirokazu Nanba , Masayuki Takano , Kazuyoshi Yajima , Yukio Yamada , Satomi Takahashi , Kazuma Okubo , Kazuhiko Yamada , Yoshiro Hiraishi
IPC分类号： C12N9/80 , C12N9/96 , C12N11/02 , C12N11/08 , C12P13/04 , C12P13/06 , C12P13/08 , C12P13/22 , C12P41/00 , C12N1/20 , C12N9/14 , C12N11/00
CPC分类号： C12N11/02 , C12N11/08 , C12N9/80 , C12N9/96 , C12P13/04 , C12P13/06 , C12P13/08 , C12P13/22 , C12P41/009 , Y10S435/849 , Y10S435/874
摘要： Decarbamylases are provided capable of producing D-.alpha.-amino acids by hydrolysis of N-carbamyl-D-.alpha.-amino acids. A source of the decarbamylases is recombinant microorganisms produced by gene manipulation methods. Decarbamylases having improved thermostability can be obtained in which amino acids at a thermostability-related site of a natural decarbamylase have been replaced with other amino acids by mutating a DNA fragment encoding the natural decarbamylase. Recombinant DNA is obtained from a vector DNA and a DNA fragment encoding a natural decarbamylase where the nucleic acid sequence encoding an amino acid at a thermostability-related site is replaced with a nucleic acid sequence encoding another amino acid. The recombinant DNA is used to produce transformants that produce thermostable decarbamylases. The decarbamylases may be immobilized in purified, partially-purified or crude form or in the form of decarbamylase-containing microbial cells on a support such as a polymer having ion exchange groups or covalent bonding groups. The presence of an antioxidant such as dithiothreitol results in an immobilized decarbamylase preparation that can be repeatedly used 30 times or more.
摘要翻译：提供的脱甲酰氨基酶能够通过N-氨基甲酰基-D-α-氨基酸的水解产生D-氨基酸。脱氨基甲酰酶的来源是通过基因操作方法产生的重组微生物。通过突变编码天然脱氨基甲酰酶的DNA片段，可以得到具有改善的热稳定性的脱甲酰氨基磷酸酶，其中天然脱氨基甲酰酶的热稳定性相关部位的氨基酸已被其它氨基酸替代。从载体DNA和编码天然脱氨基甲酰酶的DNA片段获得重组DNA，其中将编码热稳定性相关部位的氨基酸的核酸序列替换为编码另一氨基酸的核酸序列。重组DNA用于产生产生热稳定性脱氨基甲酰酶的转化体。脱氨基甲酰酶可以固定在纯化的，部分纯化的或粗制的形式中，或以含脱氨基甲酰酶的微生物细胞的形式固定在载体上，例如具有离子交换基团或共价键合基团的聚合物。抗氧化剂如二硫苏糖醇的存在导致可重复使用30次以上的固定化脱氨基甲酰酶制剂。

7. 发明授权

US5695968A Process for production of D-.alpha.-amino acids 失效
标题翻译：生产D-α-氨基酸的方法
公开(公告)号：US5695968A
公开(公告)日：1997-12-09
申请号：US479638
申请日：1995-06-07
申请人： Hirokazu Nanba , Yukio Yamada , Masayuki Takano , Yasuhiro Ikenaka , Satomi Takahashi , Kazuyoshi Yajima
发明人： Hirokazu Nanba , Yukio Yamada , Masayuki Takano , Yasuhiro Ikenaka , Satomi Takahashi , Kazuyoshi Yajima
IPC分类号： C12N1/21 , C12N9/80 , C12N15/55 , C12P13/04 , C12P41/00 , C07H19/00 , C12N1/20 , C12P21/06
CPC分类号： C12P41/009 , C12N9/80 , C12P13/04
摘要： The present invention is directed to a gene which is related to a D-N-carbamoyl-.alpha.-amino acid amidohydrolase which is an enzyme capable of converting D-N-carbamoyl-.alpha.-amino acids into D-.alpha.-amino acids; a recombinant plasmid in which a DNA fragment containing the gene is incorporated into a vector; a microorganism belonging to the genus Escherichia, Pseudomonas, Flavobacterium, Bacillus, Serratia, Corynebacterium, or Brevibacterium, which is transformed by incorporating the recombinant plasmid thereinto; a process for the production of D-N-carbamoyl-.alpha.-amino acid amidohydrolases, comprising the steps of cultivating the transformed microorganism and collecting the desired product therefrom; a D-N-carbamoyl-.alpha.-amino acid amidohydrolase obtained by the method; and a process for the production of D-.alpha.-amino acids with the aid of an action of the enzyme. The D-N-carbamoyl-.alpha.-amino acid amidohydrolase can be fixed on a support for immobilization and used as an immobilized enzyme.
摘要翻译：本发明涉及与D-N-氨基甲酰基-α-氨基酸酰胺水解酶相关的基因，其是能够将D-N-氨基甲酰基-α-氨基酸转化为D-α-氨基酸的酶; 将含有该基因的DNA片段并入载体的重组质粒; 通过将重组质粒并入而转化的属于埃希氏杆菌属，假单胞菌属，黄杆菌属，芽孢杆菌属，沙雷氏菌属，棒状杆菌属或短杆菌属的微生物; 制备D-N-氨基甲酰基-α-氨基酸酰胺水解酶的方法，包括培养转化的微生物并从其中收集所需产物的步骤; 通过该方法获得的D-N-氨基甲酰基-α-氨基酸酰胺水解酶; 以及借助于酶的作用生产D-氨基酸的方法。 D-N-氨基甲酰基-α-氨基酸酰胺水解酶可以固定在用于固定的载体上并用作固定化酶。

8. 发明授权

US5962279A Process for producing D-amino acids with composite immobilized enzyme preparation 失效
标题翻译：用复合固定化酶制剂生产D-氨基酸的方法
公开(公告)号：US5962279A
公开(公告)日：1999-10-05
申请号：US596144
申请日：1996-08-16
申请人： Hirokazu Nanba , Yukio Yamada , Kazuyoshi Yajima , Masayuki Takano , Yasuhiro Ikenaka , Satomi Takahashi , Takehisa Ohashi
发明人： Hirokazu Nanba , Yukio Yamada , Kazuyoshi Yajima , Masayuki Takano , Yasuhiro Ikenaka , Satomi Takahashi , Takehisa Ohashi
IPC分类号： C12P13/04 , C12P41/00 , C12N11/00
CPC分类号： C12P13/04 , C12P41/009
摘要： A process for the efficient production of a D-amino acid from the corresponding DL-5-substituted hydantoin by one-step reaction which comprises using a composite immobilized enzyme at a pH about neutrality, said composite immobilized enzyme being obtained by immobilizing a hydantoinase having its optimal pH within an alkaline range and a D-N-carbamyl-.alpha.-amino acid amidohydrolase having its optimal pH about neutrality in a coexisting state on an immobilizing support, simultaneously, is disclosed.
摘要翻译： PCT No.PCT / JP95 / 01257第 371日期：1996年8月16日 102（e）日期1996年8月16日PCT提交1995年6月23日PCT公布。公开号WO96 / 00296 日期1996年1月4日一种通过一步反应从相应的DL-5-取代的乙内酰脲有效生产D-氨基酸的方法，其包括在pH约为中性的情况下使用复合固定化酶，所述复合固定化酶得到通过将其最佳pH在碱性范围内的乙内酰脲固定化，并且同时具有在共存状态下具有最佳pH约中性的DN-氨基甲酰-α-氨基酸酰胺水解酶。

9. 发明授权

US5863785A Decarbamylase isolated from comamonas or blastobacter 失效
标题翻译：从comamonas或blastobacter分离的脱氨基甲酰酶
公开(公告)号：US5863785A
公开(公告)日：1999-01-26
申请号：US479639
申请日：1995-06-07
申请人： Hideaki Yamada , Sakayu Shimizu , Yasuhiro Ikenaka , Kazuyoshi Yajima , Yukio Yamada , Hirokazu Nanba , Masayuki Takano , Satomi Takahashi
发明人： Hideaki Yamada , Sakayu Shimizu , Yasuhiro Ikenaka , Kazuyoshi Yajima , Yukio Yamada , Hirokazu Nanba , Masayuki Takano , Satomi Takahashi
IPC分类号： C12P13/04 , C12P41/00 , C12N9/78 , C12N9/80
CPC分类号： C12P13/04 , C12P41/009 , Y10S435/874 , Y10S435/911
摘要： In a process for the production of a D-.alpha.-amino acid, in which an N-carbamyl-D-.alpha.-amino acid corresponding to the general formula: ##STR1## wherein R represents phenyl, hydroxy-substituted phenyl, substituted or unsubstituted alkyl, or thienyl, is converted by a microbial enzyme in an aqueous medium to a D-.alpha.-amino acid corresponding to the general formula: ##STR2## wherein R is the same as defined above, decarbamylase produced by a microorganism of the genus Comamonas, Blastobacter, Alcaligenes, Sporosarcina, Rhizobium, Bradyrhizobium or Arthrobacter is used as the enzyme converting the N-carbamyl-D-.alpha.-amino acid to the D-.alpha.-amino acid.The conversion of the N-carbamyl-D-.alpha.-amino acids to the D-.alpha.-amino acids is carried out in a neutral to alkaline pH range.
摘要翻译：在制备D-α-氨基酸的方法中，其中相应于通式为：苯基，取代或未取代的烷基或噻吩基的N-氨基甲酰基-D-α-氨基酸被转化通过微生物酶在水性介质中与对应于以下通式的D-α-氨基酸反应：其中R与上述定义相同，由Comamonas属，Blastobacter，Alcaligenes，Sporosarcina属的微生物产生的脱氨基甲酰酶，使用根瘤菌，Bradyrhizobium或节杆菌作为将N-氨基甲酰基-D-α-氨基酸转化为D-α-氨基酸的酶。 N-氨基甲酰基-D-α-氨基酸向D-α-氨基酸的转化在中性至碱性pH范围内进行。

10. 发明申请

US20080171373A1 Processes for producing coenzyme Q10 有权
标题翻译：生产辅酶Q10的方法
公开(公告)号：US20080171373A1
公开(公告)日：2008-07-17
申请号：US11981181
申请日：2007-10-31
申请人： Kazuyoshi Yajima , Takahisa Kato , Akihisa Kanda , Shiro Kitamura , Yasuyoshi Ueda
发明人： Kazuyoshi Yajima , Takahisa Kato , Akihisa Kanda , Shiro Kitamura , Yasuyoshi Ueda
IPC分类号： C12N9/00
CPC分类号： C12P7/66 , C12P7/22
摘要： The present invention relates to a process for producing reduced coenzyme Q10 which comprises obtaining microbial cells containing reduced coenzyme Q10 at a ratio of not less than 70 mole % among the entire coenzymes Q10, optionally disrupting the cells and recovering thus-produced reduced coenzyme Q10. The present invention also relates to a process for producing oxidized coenzyme Q10 which comprises either recovering oxidized coenzyme Q10 after oxidizing the above-mentioned microbial cells or disrupted product thereof, or recovering reduced coenzyme Q10 from the above-mentioned microbial cells or disrupted product thereof to oxidize thus-obtained reduced coenzyme Q10 thereafter. According to the processes of the present invention, reduced coenzyme Q10 and oxidized coenzyme Q10 can be produced simply on the industrial scale.
摘要翻译：本发明涉及一种还原型辅酶Q 10的制备方法，该方法包括：将全部还原型辅酶Q 10的比例不小于70摩尔％的还原型辅酶Q 10 辅酶Q 10，任选地破坏细胞并回收如此生产的还原型辅酶Q 10。本发明还涉及一种生产氧化型辅酶Q 10的方法，其包括在氧化上述微生物细胞或其破坏的产物之后回收氧化型辅酶Q 10，或从上述微生物细胞中回收还原型辅酶Q 10 N或其破坏产物，从而氧化由此得到的还原型辅酶Q 10。根据本发明的方法，可以简单地在工业规模上制备还原型辅酶Q 10和氧化型辅酶Q 10。

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