专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5623074A Substituted tetrahydroisoquinoline compounds, and process for producing them, and composition containing them 失效
标题翻译：取代的四氢异喹啉化合物及其制备方法和含有它们的组合物
公开(公告)号：US5623074A
公开(公告)日：1997-04-22
申请号：US269733
申请日：1994-06-30
申请人： Akihiro Tanaka , Takashi Fujikura , Ryuji Tsuzuki , Masaki Yokota , Takeyuki Yatsu
发明人： Akihiro Tanaka , Takashi Fujikura , Ryuji Tsuzuki , Masaki Yokota , Takeyuki Yatsu
IPC分类号： C07D217/16 , C07D495/04 , C07D513/04
CPC分类号： C07D495/04 , C07D217/16 , C07D513/04
摘要： A compound of the formula (I) or its salt and a process for producing the compounds; The compounds have the effect to dilate neophrovascular tracts; ##STR1## Wherein ##STR2## represents the formula ##STR3## (wherein R.sup.4 is a hydrogen atom or lower alkylsulfonyl); R.sup.1 is hydrogen, lower alkyl, hydroxyl, halogen, amino, or lower acylamino;R.sup.2 is hydrogen, lower alkyl, hydroxyl, amino, or lower alkylsulfonylamino;R.sup.3 is hydrogen, lower alkyl, or hydroxyl;R is hydrogen or halogen;with the proviso that when R.sup.1 is hydroxyl, there is no case that all of R.sup.2, R.sup.3 and R are hydrogens, and further with the proviso that when R is hydrogen, A excludes ##STR4## or a salt thereof.
摘要翻译：式（I）化合物或其盐及其制备方法; 该化合物具有扩张新生血管束的作用; 式（IMA）（其中R4是氢原子或低级烷基磺酰基）; R1是氢，低级烷基，羟基，卤素，氨基或低级酰基氨基; R2是氢，低级烷基，羟基，氨基或低级烷基磺酰基氨基; R3是氢，低级烷基或羟基; R是氢或卤素; 条件是当R 1是羟基时，不存在所有的R 2，R 3和R都是氢的情况，并且进一步条件是当R是氢时，A不包括它们或其盐。

2. 发明授权

US5077406A Production of 2-amino-7-(6-fluoro-3,4-hydroxyphenyl)-4,5,6,7-tetrahydrothiazolo[4,5-c] pyridine dihydrobromide 失效
标题翻译： 2-氨基-7-（6-氟-3,4-羟基苯基）-4,5,6,7-四氢吡唑并（4,5-C）吡啶二酮
公开(公告)号：US5077406A
公开(公告)日：1991-12-31
申请号：US518579
申请日：1990-05-03
申请人： Akihiro Tanaka , Takashi Fujikura , Ryuji Tsuzuki , Masaki Yokota , Takeyuki Yatsu
发明人： Akihiro Tanaka , Takashi Fujikura , Ryuji Tsuzuki , Masaki Yokota , Takeyuki Yatsu
IPC分类号： C07D217/16 , C07D277/44 , C07D495/04 , C07D513/04
CPC分类号： C07D495/04 , C07D217/16 , C07D513/04
摘要： A compound of the formula (I) or its salt and a process for producing the compounds; The compounds have the effect to dilate neophrovascular tracts; ##STR1## wherein ##STR2## represents the formula ##STR3## (wherein R.sup.4 is a hydrogen atom or lower alkylsulfonyl); R.sup.1 is hydrogen, lower alkyl, hydroxyl, halogen, amino, or lower acylamino;R.sup.2 is hydrogen, lower alkyl, hydroxyl, amino, or lower alkysulfonylamino;R.sup.3 is hydrogen, lower alkyl, or hydroxyl;R is hydrogen or halogen;with the proviso that when R.sup.1 is hydroxyl, there is no case that all of R.sup.2, R.sup.3 and R are hydrogens, and further with the proviso that when R is hydrogen. A excludes ##STR4## or a salt thereof.

3. 发明授权

US4876261A Substituted tetrahydroisoquinoline compounds and composition containing them 失效
标题翻译：取代的四氢异喹啉化合物和含有它们的组合物
公开(公告)号：US4876261A
公开(公告)日：1989-10-24
申请号：US173376
申请日：1988-03-25
申请人： Akihiro Tanaka , Takashi Fujikura , Ryuji Tsuzuki , Masaki Yokota , Takeyuki Yatsu
发明人： Akihiro Tanaka , Takashi Fujikura , Ryuji Tsuzuki , Masaki Yokota , Takeyuki Yatsu
IPC分类号： C07D217/16 , C07D277/44 , C07D495/04 , C07D513/04
CPC分类号： C07D495/04 , C07D217/16 , C07D513/04
摘要： A compound of the formula (I) or its salt and a process for producing the compounds; The compounds have the effect to dilate neophrovascular tracts; ##STR1## wherein ##STR2## represents the formula ##STR3## (wherein R.sup.4 is a hydrogen atom or lower alkylsulfonyl); R.sup.1 is hydrogen, lower alkyl, hydroxyl, halogen, amino, or lower acylamino;R.sup.2 is hydrogen, lower alkyl, hydroxyl, amino, or lower alkylsulfonylamino;R.sup.3 is hydrogen, lower, alkyl or hydroxyl;R is hydrogen or halogen;with the proviso that when R.sup.1 is hydroxyl, there is no case that all of R.sup.2, R.sup.3 and R are hydrogens, and further with the proviso that when R is hydrogen, A excludes ##STR4## or a salt thereof.

4. 发明授权

US4966904A Substituted tetrahydroisoquinoline compounds, and process for producing them, and composition containing them 失效
标题翻译：取代的四氢异喹啉化合物及其制备方法和含有它们的组合物
公开(公告)号：US4966904A
公开(公告)日：1990-10-30
申请号：US320975
申请日：1989-03-09
申请人： Akihiro Tanaka , Takashi Fujikura , Ryuji Tsuzuki , Masaki Yokota , Takeyuki Yatsu
发明人： Akihiro Tanaka , Takashi Fujikura , Ryuji Tsuzuki , Masaki Yokota , Takeyuki Yatsu
IPC分类号： C07D217/16 , C07D277/44 , C07D495/04 , C07D513/04
CPC分类号： C07D495/04 , C07D217/16 , C07D513/04
摘要： A compound of the formula (I) or its salt and a process for producing the compounds; The compounds have the effect to dilate neophrovascular tracts; ##STR1## Wherein ##STR2## represents the formula ##STR3## (wherein R.sup.4 is a hydrogen atom or lower alkylsulfonyl); R.sup.1 is hydrogen, lower alkyl, hydroxyl, halogen, amino, or lower acylamino;R.sup.2 is hydrogen, lower alkyl, hydroxyl, amino, or lower alkylsulfonylamino;R.sup.3 is hydrogen, lower alkyl, or hydroxyl;R is hydrogen or halogen;with the proviso that when R.sup.1 is hydroxyl, there is no case that all of R.sup.2, R.sup.3 and R are hydrogens, and further with the proviso that when R is hydrogen, A excludes ##STR4## or a salt therof.
摘要翻译：式（I）化合物或其盐及其制备方法; 该化合物具有扩张新生血管束的作用; （I）其中代表式（IMAGE）（其中R4是氢原子或低级烷基磺酰基）; R1是氢，低级烷基，羟基，卤素，氨基或低级酰基氨基; R2是氢，低级烷基，羟基，氨基或低级烷基磺酰基氨基; R3是氢，低级烷基或羟基; R是氢或卤素; 条件是当R 1是羟基时，不存在所有的R 2，R 3和R都是氢的情况，并且进一步条件是当R是氢时，A不包括囟素或盐。

5. 发明授权

US5204468A Substituted 4,5,6,7-tetrahydrothiens[2,3-C]pyridine compounds 失效
标题翻译：取代4,5,6,7-四氢噻吩（2,3-C）吡啶化合物
公开(公告)号：US5204468A
公开(公告)日：1993-04-20
申请号：US737883
申请日：1991-07-25
申请人： Akihiro Tanaka , Takashi Fujikura , Ryuji Tsuzuki , Masaki Yokota , Takeyuki Yatsu
发明人： Akihiro Tanaka , Takashi Fujikura , Ryuji Tsuzuki , Masaki Yokota , Takeyuki Yatsu
IPC分类号： C07D217/16 , C07D495/04 , C07D513/04
CPC分类号： C07D495/04 , C07D217/16 , C07D513/04
摘要： This invention provides the single species (-)-(S)-4-(3,4-dihydroxyphenyl)-7, 8-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydrochloride hydrate, which is useful as a nephrovascular dilator.
摘要翻译：本发明提供了可用作肾血管扩张剂的单一（ - ） - （S）-4-（3,4-二羟基苯基）-7,8-二羟基-1,2,3,4-四氢异喹啉盐酸盐水合物。

6. 发明授权

US5378849A Substituted tetrahydroisoquinoline compounds, and process for producing them, and composition containing them 失效
标题翻译：取代的四氢异喹啉化合物及其制备方法和含有它们的组合物
公开(公告)号：US5378849A
公开(公告)日：1995-01-03
申请号：US981137
申请日：1992-11-24
申请人： Akihiro Tanaka , Takashi Fujikura , Ryuji Tsuzuki , Masaki Yokota , Takeyuki Yatsu
发明人： Akihiro Tanaka , Takashi Fujikura , Ryuji Tsuzuki , Masaki Yokota , Takeyuki Yatsu
IPC分类号： C07D217/16 , C07D495/04 , C07D513/04 , C07D471/02 , C07D217/00
CPC分类号： C07D495/04 , C07D217/16 , C07D513/04
摘要： This invention provides certain novel substituted tetrahydroisoquinoline opticulisomers of the formula: ##STR1## wherein A represents the formula ##STR2## wherein R is hydrogen or halogen; R.sup.1 is hydrogen, lower alkyl, hydroxyl, halogen, amino, or lower acylamino;R.sup.2 is hydrogen, lower alkyl, hydroxyl, amino, or lower alkylsulfonylamino;R.sup.3 is hydrogen, lower alkyl, or hydroxyl;R.sup.4 is a hydrogen atom or a lower alkylsulfonyl;with the proviso that when R.sup.1 is hydroxyl, R.sup.2 and R.sup.3 are all not hydrogen, or salts thereof.
摘要翻译：本发明提供了一些具有下式的新型取代的四氢异喹啉视觉异构体：其中+ E，crc / A /代表式其中R是氢或卤素; R1是氢，低级烷基，羟基，卤素，氨基或低级酰基氨基; R2是氢，低级烷基，羟基，氨基或低级烷基磺酰基氨基; R3是氢，低级烷基或羟基; R4是氢原子或低级烷基磺酰基; 条件是当R 1是羟基时，R 2和R 3都不是氢或其盐。

7. 发明授权

US5079256A Substituted tetrahydroisoquinoline compounds and method containing them 失效
标题翻译：取代的四氢喹啉化合物和含有它们的方法
公开(公告)号：US5079256A
公开(公告)日：1992-01-07
申请号：US412840
申请日：1989-09-26
申请人： Akihiro Tanaka , Takashi Fujikura , Ryuji Tsuzuki , Masaki Yokota , Takeyuki Yatsu
发明人： Akihiro Tanaka , Takashi Fujikura , Ryuji Tsuzuki , Masaki Yokota , Takeyuki Yatsu
IPC分类号： C07D217/16 , C07D277/44 , C07D495/04 , C07D513/04
CPC分类号： C07D495/04 , C07D217/16 , C07D513/04
摘要： A compound of the formula (I) or its salt and a process for producing the compounds. The compounds have the effect of dilating neophrovascular tracts; ##STR1## wherein ##STR2## represents the formula ##STR3## wherein R.sup.4 is a hydrogen atom or lower alkylsulfonyl;R.sup.1 is hydrogen, lower alkyl, hydroxyl, halogen, amino, or lower acylamino;R.sup.2 is hydrogen, lower alkyl, hydroxyl, amino, or lower alkylsulfonylamino;R.sup.3 is hydrogen, lower alkyl, or hydroxyl;R is hydrogen or halogen;with the proviso that when R.sup.1 is hydroxyl, there is no case that all of R.sup.2, R.sup.3 and R are hydrogens, and further with the proviso that when R is hydrogen, A excludes ##STR4## or a salt thereof.

8. 发明授权

US08891799B2 Earphone 有权
标题翻译：耳机
公开(公告)号：US08891799B2
公开(公告)日：2014-11-18
申请号：US12478765
申请日：2009-06-04
申请人： Takashi Fujikura , Kazunori Ishizaka
发明人： Takashi Fujikura , Kazunori Ishizaka
IPC分类号： H04R25/00 , H04R1/10
CPC分类号： H04R1/1091
摘要： An earphone includes a cylindrical portion having an opening in one end and an audio output unit which outputs sound from one face. The audio output unit is fixed to the cylindrical portion such that another face is in contact with an end face of the one end of the cylindrical portion. The audio output unit and the cylindrical portion are insertable at least partially in the external auditory canal of a human being. The earphone further includes a thin-wall part provided in the cylindrical portion and a ring, made of a material of a greater specific gravity than the cylindrical portion, which is fixed to the inner surface. The ring is fixed in a position such that the ring overlaps in the axial direction of the cylindrical portion with respect to the thin-wall part.
摘要翻译：耳机包括在一端具有开口的圆柱形部分和从一个面输出声音的音频输出单元。音频输出单元固定到圆柱形部分，使得另一个面与圆柱形部分的一端的端面接触。音频输出单元和圆柱形部分至少部分地可插入人的外耳道中。耳机还包括设置在圆筒形部分中的薄壁部分和由比固定在内表面上的比圆柱形部分更大比重的材料制成的环。环被固定在使得环相对于薄壁部在圆筒部的轴向上重叠的位置。

9. 发明授权

US5447958A Sulfamoyl-substituted phenethylamine derivatives, their preparation, and pharmaceutical compositions, containing them 失效
标题翻译：磺酰胺取代的苯乙胺衍生物，它们的制备方法和含有它们的药物组合物
公开(公告)号：US5447958A
公开(公告)日：1995-09-05
申请号：US314322
申请日：1994-09-28
申请人： Kunihiro Niigata , Takashi Fujikura
发明人： Kunihiro Niigata , Takashi Fujikura
IPC分类号： A61K31/18 , C07C311/16 , C07C311/24 , C07C317/14 , C07D203/10 , A01N41/06 , C07C311/10
CPC分类号： C07D203/10 , C07C309/00
摘要： Pharmaceutical compositions are provided for the treatment of disorders in a subject, such as hypertension, congestive heart failure, angina pectoris, lower urinary tract dysfunction and prostatic hypertrophy. The compositions when administered to a subject produce an .alpha.-adrenergic blocking action and contain as an active ingredient sulfamoyl-substituted phenethylamine derivatives, such as optically active 5-2-[ 2-(2-ethoxyphenoxy)ethylamino] -2-methylethyl-2-methoxybenzenesulfonamide 2-methoxybenzenesulfonamide, and a pharmaceutically acceptable carrier.
摘要翻译：提供药物组合物用于治疗受试者中的疾病，例如高血压，充血性心力衰竭，心绞痛，下尿路功能障碍和前列腺肥大。给予受试者时的组合物产生α-肾上腺素能阻断作用并含有作为活性成分的氨磺酰基取代的苯乙胺衍生物，例如光学活性的5-2- [2-（2-乙氧基苯氧基）乙基氨基] -2-甲基乙基-2 - 甲氧基苯磺酰胺2-甲氧基苯磺酰胺和药学上可接受的载体。

10. 发明授权

US5063246A Phenethylamine derivative compositions and use 失效
标题翻译：苯乙烯衍生物组合物和用途
公开(公告)号：US5063246A
公开(公告)日：1991-11-05
申请号：US569780
申请日：1990-08-21
申请人： Kazuo Imai , Kunihiro Niigata , Takashi Fujikura , Shinichi Hashimoto , Toichi Takenaka , Kazuo Honda
发明人： Kazuo Imai , Kunihiro Niigata , Takashi Fujikura , Shinichi Hashimoto , Toichi Takenaka , Kazuo Honda
IPC分类号： A61K20060101 , A61K31/135 , A61K31/255
CPC分类号： A61K31/135 , A61K31/255
摘要： Phenethylamine derivatives shown by the general formula ##STR1## wherein Ro represents a lower alkyl group; R.sub.1 represents a lower alkyl group or a lower alkoxy group, R.sub.2 represents hydrogen atom or a hydroxyl group; R.sub.3 and R.sub.4 each represents hydrogen atom or a lower alkyl group; R.sub.5 represents hydrogen atom or a lower alkoxy group; X represents oxygen atom or a methylene group; m is an integer of 1-3; and n is an integer of 0-2and the acid addition salts thereof.These compounds exhibit a strong .alpha.-adrenergic blocking action and are useful as an antihypertensive agent.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式