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1. 发明申请

US20120165782A1 PHARMACEUTICAL COMPOSITION OF AN IONTOPHORESIS 有权
标题翻译：药物的药物组合物
公开(公告)号：US20120165782A1
公开(公告)日：2012-06-28
申请号：US13388295
申请日：2010-07-28
申请人： Akihiro Hasui , Takamitsu Miyagi
发明人： Akihiro Hasui , Takamitsu Miyagi
IPC分类号： A61K31/661 , A61P29/00 , A61N1/30 , A61P21/00 , A61P15/02 , A61K9/00 , A61P19/02
CPC分类号： A61K31/573 , A61K9/0009 , A61K47/18 , A61K47/32 , A61N1/0428 , A61N1/0432 , A61N1/0448 , A61N1/30
摘要： It is an object of the present inventions to produce a pharmaceutical composition for the iontophoresis wherein a drug stability is excellent, and it is easy to blend and fill up when manufactured and it is possible to manufacture at low cost. A pharmaceutical composition for an iontophoresis according to the present invention, is characterized in that the composition contains a nonionic synthetic polymer, betamethasone sodium phosphate and solvent. Furthermore, in a preferred embodiment of a pharmaceutical composition for an iontophoresis according to the present invention, the composition is characterized in that the nonionic synthetic polymer is polyvinyl alcohol (PVA). Furthermore, in a preferred embodiment of a pharmaceutical composition for an iontophoresis according to the present invention, the composition is characterized in that the mixing amount of the polyvinyl alcohol (PVA) is 0.5 to 30.0 percent by weight.
摘要翻译：本发明的目的是制备用于离子电渗疗法的药物组合物，其中药物稳定性优异，并且在制造时容易混合和填充，并且可以以低成本制造。根据本发明的用于离子电渗疗法的药物组合物的特征在于，所述组合物含有非离子合成聚合物，倍他米松磷酸钠和溶剂。此外，在本发明的离子电渗疗法用药物组合物的优选实施方式中，所述组合物的特征在于，所述非离子型合成聚合物为聚乙烯醇（PVA）。此外，在本发明的离子电渗用药物组合物的优选实施方式中，所述组合物的特征在于，所述聚乙烯醇（PVA）的混合量为0.5〜30.0重量％。

2. 发明授权

US08652522B2 Pharmaceutical composition of an iontophoresis 有权
标题翻译：离子电渗疗法的药物组成
公开(公告)号：US08652522B2
公开(公告)日：2014-02-18
申请号：US13388295
申请日：2010-07-28
申请人： Akihiro Hasui , Takamitsu Miyagi
发明人： Akihiro Hasui , Takamitsu Miyagi
IPC分类号： A61K9/14 , A61N1/30
CPC分类号： A61K31/573 , A61K9/0009 , A61K47/18 , A61K47/32 , A61N1/0428 , A61N1/0432 , A61N1/0448 , A61N1/30
摘要： It is an object of the present inventions to produce a pharmaceutical composition for the iontophoresis wherein a drug stability is excellent, and it is easy to blend and fill up when manufactured and it is possible to manufacture at low cost. A pharmaceutical composition for an iontophoresis according to the present invention, is characterized in that the composition contains a nonionic synthetic polymer, betamethasone sodium phosphate and solvent. Furthermore, in a preferred embodiment of a pharmaceutical composition for an iontophoresis according to the present invention, the composition is characterized in that the nonionic synthetic polymer is polyvinyl alcohol (PVA). Furthermore, in a preferred embodiment of a pharmaceutical composition for an iontophoresis according to the present invention, the composition is characterized in that the mixing amount of the polyvinyl alcohol (PVA) is 0.5 to 30.0 percent by weight.
摘要翻译：本发明的目的是制备用于离子电渗疗法的药物组合物，其中药物稳定性优异，并且在制造时容易混合和填充，并且可以以低成本制造。根据本发明的用于离子电渗疗法的药物组合物的特征在于，所述组合物含有非离子合成聚合物，倍他米松磷酸钠和溶剂。此外，在本发明的离子电渗疗法用药物组合物的优选实施方式中，所述组合物的特征在于，所述非离子型合成聚合物为聚乙烯醇（PVA）。此外，在本发明的离子电渗用药物组合物的优选实施方式中，所述组合物的特征在于，所述聚乙烯醇（PVA）的混合量为0.5〜30.0重量％。

3. 发明授权

US09517331B2 Iontophoresis patch 有权
标题翻译：离子电渗贴片
公开(公告)号：US09517331B2
公开(公告)日：2016-12-13
申请号：US13578168
申请日：2011-02-09
申请人： Mitsutoshi Yaegashi , Akihiro Hasui , Hiroyuki Kubo
发明人： Mitsutoshi Yaegashi , Akihiro Hasui , Hiroyuki Kubo
IPC分类号： A61N1/30 , A61N1/04
CPC分类号： A61N1/0428
摘要： An iontophoresis patch is equipped with a donor gel and a reference gel which are disposed to contact an external conductor, for example, the skin of a patient and thereby output current from a current-carrying device to the external conductor. The iontophoresis patch includes: a donor portion having the donor gel containing a medical agent to be penetrated into the external conductor; a reference portion having a reference gel, mounted with the current-carrying device on the surface on the side opposite to the reference gel, and disposed on the external conductor apart from the donor portion; and an electrode film for supplying current from the current-carrying device to the donor gel and the reference gel.
摘要翻译：离子电渗贴片配备有供体凝胶和参考凝胶，其被设置为接触外部导体，例如患者的皮肤，从而将电流从载流装置输出到外部导体。离子电渗贴片包括：供体部分，其具有供体凝胶，其含有要渗入外导体的药剂; 具有参考凝胶的参考部分，其在与参考凝胶相反的一侧的表面上安装有载流装置，并且设置在远离供体部分的外部导体上; 以及用于从载流装置向供体凝胶和参考凝胶提供电流的电极膜。

4. 发明申请

US20120310143A1 IONTOPHORESIS PATCH 有权
标题翻译： IOPOPHORESIS PATCH
公开(公告)号：US20120310143A1
公开(公告)日：2012-12-06
申请号：US13578168
申请日：2011-02-09
申请人： Mitsutoshi Yaegashi , Akihiro Hasui , Hiroyuki Kubo
发明人： Mitsutoshi Yaegashi , Akihiro Hasui , Hiroyuki Kubo
IPC分类号： A61N1/30
CPC分类号： A61N1/0428
摘要： An iontophoresis patch is equipped with a donor gel and a reference gel which are disposed to contact an external conductor, for example, the skin of a patient and thereby output current from a current-carrying device to the external conductor. The iontophoresis patch includes: a donor portion having the donor gel containing a medical agent to be penetrated into the external conductor; a reference portion having a reference gel, mounted with the current-carrying device on the surface on the side opposite to the reference gel, and disposed on the external conductor apart from the donor portion; and an electrode film for supplying current from the current-carrying device to the donor gel and the reference gel.
摘要翻译：离子电渗贴片配备有供体凝胶和参考凝胶，其被设置为接触外部导体，例如患者的皮肤，从而将电流从载流装置输出到外部导体。离子电渗贴片包括：供体部分，其具有供体凝胶，其含有要渗入外导体的药剂; 具有参考凝胶的参考部分，其在与参考凝胶相反的一侧的表面上安装有载流装置，并且设置在远离供体部分的外部导体上; 以及用于从载流装置向供体凝胶和参考凝胶提供电流的电极膜。

5. 发明申请

US20130310733A1 ELECTRODE PAD USED FOR IONTOPHORESIS TREATMENT 审中-公开
标题翻译：电极垫用于静电治疗
公开(公告)号：US20130310733A1
公开(公告)日：2013-11-21
申请号：US13995720
申请日：2011-12-21
申请人： Akihiro Hasui , Atsuhiko Shiraishi , Ken-ichi Hattori , Shinji Tanaka , Hirokazu Takahashi , Makoto Takahashi
发明人： Akihiro Hasui , Atsuhiko Shiraishi , Ken-ichi Hattori , Shinji Tanaka , Hirokazu Takahashi , Makoto Takahashi
IPC分类号： A61N1/04
CPC分类号： A61N1/0448 , A61M2037/0007 , A61N1/0428 , A61N1/30 , A61N1/325
摘要： The present invention verifies a method of reducing skin irritation (particularly, cumulative skin irritation) caused by transdermal administration of a local anesthetic using iontophoresis, and provides an electrode pad for relief from a puncture pain which is safe not only at single administration but also at repeated administrations. The electrode pad comprises a base sheet; an electrode placed on the base sheet; an adhesive sheet placed on the base sheet and having an opening, within which the electrode being exposed; and a medicament reservoir containing a local anesthetic and placed in the opening of the adhesive sheet while being in contact with the electrode. An inner peripheral surface of the opening of the adhesive sheet and an outer peripheral surface of the medicament reservoir are prevented from coming into contact with human skin while contacting with each other, and thereby skin irritation is reduced.
摘要翻译：本发明验证了使用离子渗透电泳法减少透皮给药局部麻醉剂引起的皮肤刺激（特别是累积性皮肤刺激）的方法，并且提供了用于缓解穿刺疼痛的电极垫，其不仅在单次给药时也是安全的，重复行政。电极垫包括基片; 放置在基片上的电极; 粘合片放置在基片上并具有开口，电极被露出; 以及含有局部麻醉剂并放置在与电极接触的粘合片的开口中的药物容器。防止粘合片的开口的内周面和药剂容器的外周面与人的皮肤接触，同时彼此接触，从而减少皮肤刺激。

6. 发明授权

US10342968B2 Electrode pad used for iontophoresis treatment 有权
公开(公告)号：US10342968B2
公开(公告)日：2019-07-09
申请号：US13995720
申请日：2011-12-21
申请人： Akihiro Hasui , Atsuhiko Shiraishi , Ken-ichi Hattori , Shinji Tanaka , Hirokazu Takahashi , Makoto Takahashi
发明人： Akihiro Hasui , Atsuhiko Shiraishi , Ken-ichi Hattori , Shinji Tanaka , Hirokazu Takahashi , Makoto Takahashi
IPC分类号： A61N1/04 , A61N1/32 , A61N1/30 , A61M37/00
摘要： The present invention verifies a method of reducing skin irritation (particularly, cumulative skin irritation) caused by transdermal administration of a local anesthetic using iontophoresis, and provides an electrode pad for relief from a puncture pain which is safe not only at single administration but also at repeated administrations. The electrode pad comprises a base sheet; an electrode placed on the base sheet; an adhesive sheet placed on the base sheet and having an opening, within which the electrode being exposed; and a medicament reservoir containing a local anesthetic and placed in the opening of the adhesive sheet while being in contact with the electrode. An inner peripheral surface of the opening of the adhesive sheet and an outer peripheral surface of the medicament reservoir are prevented from coming into contact with human skin while contacting with each other, and thereby skin irritation is reduced.

7. 发明授权

US08658625B2 External preparation for treating painful skin wound 有权
标题翻译：治疗疼痛皮肤伤口的外用剂
公开(公告)号：US08658625B2
公开(公告)日：2014-02-25
申请号：US10589462
申请日：2004-02-16
申请人： Yukiko Inamoto , Mitsuhiro Kawada , Akihiro Hasui , Kenichi Hattori
发明人： Yukiko Inamoto , Mitsuhiro Kawada , Akihiro Hasui , Kenichi Hattori
IPC分类号： A61K31/616
CPC分类号： A61K31/616
摘要： External preparations for treatment of painful skin wound having an analgesic activity which comprises acetylsalicylic acid or its pharmacologically acceptable salt as an active ingredient.
摘要翻译：用于治疗具有止痛活性的疼痛皮肤伤口的外用制剂，其包含乙酰水杨酸或其药理学上可接受的盐作为活性成分。

8. 发明授权

US09433772B2 Electrode device used in iontophoresis treatment 有权
标题翻译：用于离子电渗疗法的电极装置
公开(公告)号：US09433772B2
公开(公告)日：2016-09-06
申请号：US13518343
申请日：2010-12-17
申请人： Akihiro Hasui
发明人： Akihiro Hasui
IPC分类号： A61N1/30 , A61N1/04
CPC分类号： A61N1/0448 , A61N1/0432
摘要： The present invention provides an electrode device used in iontophoresis treatment, in which an electrode layer used for introduction of medication can be contacted to a medication reservoir layer with a simple manner, and in which the medication reservoir layer can be reliably held when the medication is introduced into a skin. A main-electrode layer 3 and a sub-electrode layer 1 are secured on a substrate 6 while both the layers are being insulated from each other. The main-electrode layer 3 is intended for introduction of the medication, and the sub-electrode layer 1 is provided to hold the medication reservoir layer 5 on the substrate 6. The medication reservoir layer 5 is located on the substrate 6, so as to be in contact with the main-electrode layer 3 and the sub-electrode layer 1. The medication reservoir layer 5 is a gel containing halogen compound, and the sub-electrode layer 1 comprises a metal having a lower ionization tendency than hydrogen. The medication reservoir layer 5 and the sub-electrode layer 1 are bonded to each other by applying an electric current to both layers. In this way, the medication reservoir layer 5 can be firmly held on the substrate 6, while being kept in contact with the main-electrode layer 3.
摘要翻译：本发明提供一种用于离子电渗处理的电极装置，其中用于引入药物的电极层可以以简单的方式与药物储存层接触，并且其中当药物是药物储存层时可以可靠地保持药物储存层引入皮肤。主电极层3和副电极层1固定在基板6上，同时两层彼此绝缘。主电极层3用于引入药物，并且设置副电极层1以将药物储存层5保持在基板6上。药物储存层5位于基板6上，以便与主电极层3和副电极层1接触。药物储存层5是含有卤素化合物的凝胶，副电极层1具有比氢更低的电离倾向的金属。药物储存层5和副电极层1通过向两层施加电流而彼此接合。以这种方式，药物储存层5能够牢固地保持在基板6上，同时与主电极层3保持接触。

9. 发明申请

US20120330217A1 ELECTRODE DEVICE USED IN IONTOPHORESIS TREATMENT 有权
标题翻译：电极设备用于静电治疗
公开(公告)号：US20120330217A1
公开(公告)日：2012-12-27
申请号：US13518343
申请日：2010-12-17
申请人： Akihiro Hasui
发明人： Akihiro Hasui
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/0432
摘要： The present invention provides an electrode device used in iontophoresis treatment, in which an electrode layer used for introduction of medication can be contacted to a medication reservoir layer with a simple manner, and in which the medication reservoir layer can be reliably held when the medication is introduced into a skin. A main-electrode layer 3 and a sub-electrode layer 1 are secured on a substrate 6 while both the layers are being insulated from each other. The main-electrode layer 3 is intended for introduction of the medication, and the sub-electrode layer 1 is provided to hold the medication reservoir layer 5 on the substrate 6. The medication reservoir layer 5 is located on the substrate 6, so as to be in contact with the main-electrode layer 3 and the sub-electrode layer 1. The medication reservoir layer 5 is a gel containing halogen compound, and the sub-electrode layer 1 comprises a metal having a lower ionization tendency than hydrogen. The medication reservoir layer 5 and the sub-electrode layer 1 are bonded to each other by applying an electric current to both layers. In this way, the medication reservoir layer 5 can be firmly held on the substrate 6, while being kept in contact with the main-electrode layer 3.
摘要翻译：本发明提供一种用于离子电渗处理的电极装置，其中用于引入药物的电极层可以以简单的方式接触药物储存层，并且其中当药物是药物储存层时可以可靠地保持药物储存层引入皮肤。主电极层3和副电极层1固定在基板6上，同时两层彼此绝缘。主电极层3用于引入药物，并且设置副电极层1以将药物储存层5保持在基板6上。药物储存层5位于基板6上，以便与主电极层3和副电极层1接触。药物储存层5是含有卤素化合物的凝胶，副电极层1具有比氢更低的电离倾向的金属。药物储存层5和副电极层1通过向两层施加电流而彼此接合。以这种方式，药物储存层5能够牢固地保持在基板6上，同时与主电极层3保持接触。

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