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1. 发明授权

US07670834B2 Gas thermal cycler 有权
标题翻译：气体热循环仪
公开(公告)号：US07670834B2
公开(公告)日：2010-03-02
申请号：US11166958
申请日：2005-06-23
申请人： Adrian Fawcett , Mark T. Reed
发明人： Adrian Fawcett , Mark T. Reed
IPC分类号： C12M1/00 , C12M3/00
CPC分类号： B01L3/50855 , B01L3/50851 , B01L7/52 , B01L2300/0654 , B01L2300/1827 , B01L2300/1838 , B01L2300/1844 , B01L2300/1894 , F28F1/16
摘要： The present application relates to an apparatus and method for thermal cycling using a source of cooling gas.
摘要翻译：本申请涉及一种使用冷却气体源的热循环的装置和方法。

2. 发明授权

US09776187B2 Thermal cycler for PCR 有权
公开(公告)号：US09776187B2
公开(公告)日：2017-10-03
申请号：US12229404
申请日：2008-08-22
申请人： John G. Atwood , Adrian Fawcett , Keith S. Ferrara , Paul M. Hetherington , Richard W. Noreiks , Douglas E. Olsen , John R. Widomski , Charles M. Wittmer
发明人： John G. Atwood , Adrian Fawcett , Keith S. Ferrara , Paul M. Hetherington , Richard W. Noreiks , Douglas E. Olsen , John R. Widomski , Charles M. Wittmer
IPC分类号： B01L7/00 , C12Q1/68 , F25B21/04 , G01R27/20 , G05D23/19 , H01L35/30 , B01L3/00
CPC分类号： B01L7/52 , B01L3/50853 , B01L2300/0829 , B01L2300/1822 , B01L2300/1827 , C12Q1/686 , F25B21/04 , F25B2321/021 , G01R27/205 , G05D23/1919 , H01L35/30 , Y10T137/1516
摘要： An instrument for performing highly accurate PCR employing an assembly, a heated cover, and an internal computer, is provided. The assembly is made up of a sample block, a number of Peltier thermal electric devices, and a heat sink, clamped together. A control algorithm manipulates the current supplied to thermoelectric coolers such that the dynamic thermal performance of a block can be controlled so that pre-defined thermal profiles of sample temperature can be executed. The sample temperature is calculated instead of measured using a design specific model and equations. The control software includes calibration diagnostics which permit variation in the performance of thermoelectric coolers from instrument to instrument to be compensated for such that all instruments perform identically. The block/heat sink assembly can be changed to another of the same or different design. The assembly carries the necessary information required to characterize its own performance in an on-board memory device, allowing the assembly to be interchangeable among instruments while retaining its precision operating characteristics.

3. 发明申请

US20150226672A1 OPTICAL SYSTEM FOR MULTIPLE REACTIONS 审中-公开
标题翻译：多种反应的光学系统
公开(公告)号：US20150226672A1
公开(公告)日：2015-08-13
申请号：US14620998
申请日：2015-02-12
申请人： Adrian Fawcett , David Tracy , Kevin Daley Simmons
发明人： Adrian Fawcett , David Tracy , Kevin Daley Simmons
IPC分类号： G01N21/64 , B01L7/00 , G01N21/03
CPC分类号： G01N21/6486 , B01L7/52 , B01L2300/046 , B01L2300/0829 , B01L2300/1805 , G01N21/0332 , G01N21/6452 , G01N2021/0367 , G01N2021/6421 , G01N2021/6471 , G01N2021/6478 , G01N2201/02 , G01N2201/062 , G01N2201/0626 , G01N2201/0627 , G01N2201/0636
摘要： Optical systems, and corresponding methods, for multiple reactions are provided. The optical systems are in a fixed position relative to a thermal assembly and include at least one array of excitation sources (e.g., light emitting diodes (LEDs)) configured to output excitation energy along an excitation optical path. In addition, a detector configured to receive emission energy along a detection optical path in the same plane as the excitation optical path is also provided.
摘要翻译：提供了多种反应的光学系统和相应的方法。光学系统相对于热组件处于固定位置，并且包括被配置为沿着激发光路输出激发能量的至少一组激励源（例如，发光二极管（LED））。此外，还提供了被配置为沿着与激励光路相同的平面中的检测光路接收发射能量的检测器。

4. 发明授权

US08987685B2 Optical system for multiple reactions 有权
标题翻译：光学系统多反应
公开(公告)号：US08987685B2
公开(公告)日：2015-03-24
申请号：US12841725
申请日：2010-07-22
申请人： Adrian Fawcett , David Tracy , Kevin Daley Simmons
发明人： Adrian Fawcett , David Tracy , Kevin Daley Simmons
IPC分类号： G01J1/58 , G01N21/64 , B01L7/00
CPC分类号： G01N21/6486 , B01L7/52 , B01L2300/046 , B01L2300/0829 , B01L2300/1805 , G01N21/0332 , G01N21/6452 , G01N2021/0367 , G01N2021/6421 , G01N2021/6471 , G01N2021/6478 , G01N2201/02 , G01N2201/062 , G01N2201/0626 , G01N2201/0627 , G01N2201/0636
摘要： Optical systems, and corresponding methods, for multiple reactions are provided. The optical systems are in a fixed position relative to a thermal assembly and include at least one array of excitation sources (e.g., light emitting diodes (LEDs)) configured to output excitation energy along an excitation optical path. In addition, a detector configured to receive emission energy along a detection optical path in the same plane as the excitation optical path is also provided.
摘要翻译：提供了多种反应的光学系统和相应的方法。光学系统相对于热组件处于固定位置，并且包括被配置为沿着激发光路输出激发能量的至少一组激励源（例如，发光二极管（LED））。此外，还提供了被配置为沿着与激励光路相同的平面中的检测光路接收发射能量的检测器。

5. 发明授权

US07452712B2 Sample block apparatus and method of maintaining a microcard on a sample block 有权
标题翻译：样品块装置和在样品块上维持微卡的方法
公开(公告)号：US07452712B2
公开(公告)日：2008-11-18
申请号：US10207263
申请日：2002-07-30
申请人： Adrian Fawcett
发明人： Adrian Fawcett
IPC分类号： C12M1/34 , C12M1/38
CPC分类号： C12Q1/686 , B01L7/52 , B01L9/523 , B01L2200/025 , B01L2300/0609 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , B01L2300/1805 , Y10S435/809
摘要： A thermal cycling device for thermally cycling samples of biological material contained in a microcard having a top and bottom surface. The thermal cycling device can include a sample block having an upper surface configured for engaging the bottom surface of a microcard, a vacuum device, and a temperature control system operatively connected with the sample block. The upper surface of the sample block may include a plurality of channels, the channels defining spaces between the sample block and the bottom surface of a microcard that may be positioned thereon. The vacuum device may be in fluid communication with the sample block for drawing gas out of the spaces defined by the channels in the sample block. The vacuum device may be configured for substantially maintaining a vacuum between the sample block and microcard so that a retention force is imparted on the microcard to urge the microcard toward the sample block. Methods of maintaining a microcard on a sample block of a thermal cycling device are also provided.
摘要翻译：一种用于热循环包含在具有顶表面和底表面的微卡中的生物材料样品的热循环装置。热循环装置可以包括具有被配置为接合微卡的底表面的上表面的样品块，真空装置和与样品块可操作地连接的温度控制系统。样品块的上表面可以包括多个通道，通道限定样品块和可以定位在其上的微卡的底表面之间的空间。真空装置可以与样品块流体连通，用于将气体从样品块中的通道限定的空间中排出。真空装置可以被配置为基本上保持样品块和微卡之间的真空，使得在微卡上施加保持力以将微卡推向样品块。还提供了在热循环装置的样品块上维持微卡的方法。

6. 发明申请

US20070230535A1 Thermal cycler for PCR 有权
标题翻译：热循环仪用于PCR
公开(公告)号：US20070230535A1
公开(公告)日：2007-10-04
申请号：US11804298
申请日：2007-05-17
申请人： John Atwood , Adrian Fawcett , Keith Ferrara , Paul Hetherington , Richard Noreiks , Douglas Olsen , John Widomski , Charles Wittmer
发明人： John Atwood , Adrian Fawcett , Keith Ferrara , Paul Hetherington , Richard Noreiks , Douglas Olsen , John Widomski , Charles Wittmer
IPC分类号： G01D18/00
CPC分类号： B01L7/52 , B01L3/50853 , B01L2300/0829 , B01L2300/1822 , B01L2300/1827 , C12Q1/686 , F25B21/04 , F25B2321/021 , G01R27/205 , G05D23/1919 , H01L35/30 , Y10T137/1516
摘要： An instrument for performing highly accurate PCR employing an assembly, a heated cover, and an internal computer, is provided. The assembly is made up of a sample block, a number of Peltier thermal electric devices, and a heat sink, clamped together. A control algorithm manipulates the current supplied to thermoelectric coolers such that the dynamic thermal performance of a block can be controlled so that pre-defined thermal profiles of sample temperature can be executed. The sample temperature is calculated instead of measured using a design specific model and equations. The control software includes calibration diagnostics which permit variation in the performance of thermoelectric coolers from instrument to instrument to be compensated for such that all instruments perform identically. The block/heat sink assembly can be changed to another of the same or different design. The assembly carries the necessary information required to characterize its own performance in an on-board memory device, allowing the assembly to be interchangeable among instruments while retaining its precision operating characteristics.
摘要翻译：提供了一种使用组件，加热盖和内部计算机执行高精度PCR的仪器。组件由样品块，多个珀耳帖热电器件和散热器组成，夹在一起。控制算法控制提供给热电冷却器的电流，使得可以控制块的动态热性能，从而可以执行样本温度的预定义热分布。计算样品温度，而不是使用设计特定的模型和方程来测量。控制软件包括校准诊断，其允许从仪器到仪器的热电冷却器的性能的变化被补偿，使得所有仪器执行相同的操作。块/散热器组件可以改变为相同或不同设计的另一个。该组件携带在板载存储器件中表征其自身性能所需的必要信息，允许组件在仪器之间可互换，同时保持其精密操作特性。

7. 发明申请

US20070117200A1 Thermal cycler for PCR 有权
公开(公告)号：US20070117200A1
公开(公告)日：2007-05-24
申请号：US11654238
申请日：2007-01-17
申请人： John Atwood , Adrian Fawcett , Keith Ferrara , Paul Hetherington , Richard Noreiks , Douglas Olsen , John Widomski , Charles Wittmer
发明人： John Atwood , Adrian Fawcett , Keith Ferrara , Paul Hetherington , Richard Noreiks , Douglas Olsen , John Widomski , Charles Wittmer
IPC分类号： C12M1/34
CPC分类号： B01L7/52 , B01L3/50853 , B01L2300/0829 , B01L2300/1822 , B01L2300/1827 , C12Q1/686 , F25B21/04 , F25B2321/021 , G01R27/205 , G05D23/1919 , H01L35/30 , Y10T137/1516
摘要： An instrument for performing highly accurate PCR employing an assembly, a heated cover and an internal computer. The assembly is made up of a sample block, a number of Peltier thermal electric devices and heat sink, clamped together. The sample block temperature is changed exclusively by the thermoelectric devices controlled by the computer. The sample block is of low thermal mass and is constructed of silver. The Peltier devices are designed to provide fast temperature excursions over a wide range. The heat sink has a perimeter trench to minimize edge losses and is adjacent to a continuously variable fan. A perimeter heater is used to improve the thermal uniformity across the sample block to approximately ±0.2° C. A heated platen pushes down onto the tube caps to apply a minimum acceptable force for seating the tubes into the block, ensuring good thermal contact with the block. The force is applied about the periphery of the tube caps to prevent distortion of the caps during thermal cycling. The platen is heated to provided thermal isolation from ambient conditions and to prevent evaporation from the surface of the sample into the upper portion of the sample tube. A control algorithm manipulates the current supplied to the thermoelectric coolers such that the dynamic thermal performance of the block can be controlled so that pre-defined thermal profiles for the sample temperature can be executed. The sample temperature is calculated instead of measured using a design specific model and equations. The control software includes calibration diagnostics which permit variation in the performance of thermoelectric coolers from instrument to instrument to be compensated for such that all instruments perform identically. The block/heat sink assembly can be changed to another of the same or different design. The assembly carries the necessary information required to characterize its own performance in an on-board memory device, allowing the assembly to be interchangeable among instruments while retaining its precision operating characteristics. The instrument has a graphical user interface. The instrument monitors the thermoelectric devices and warns of changes in resistance that may result in failure.

8. 发明申请

US20060024816A1 Gas thermal cycler 有权
标题翻译：气体热循环仪
公开(公告)号：US20060024816A1
公开(公告)日：2006-02-02
申请号：US11166958
申请日：2005-06-23
申请人： Adrian Fawcett , Mark Reed
发明人： Adrian Fawcett , Mark Reed
IPC分类号： C12M1/34
CPC分类号： B01L3/50855 , B01L3/50851 , B01L7/52 , B01L2300/0654 , B01L2300/1827 , B01L2300/1838 , B01L2300/1844 , B01L2300/1894 , F28F1/16
摘要： The present application relates to an apparatus and method for thermal cycling using a source of cooling gas.
摘要翻译：本申请涉及一种使用冷却气体源的热循环的装置和方法。

9. 发明申请

US20060011305A1 Automated seal applicator 审中-公开
标题翻译：自动封口机
公开(公告)号：US20060011305A1
公开(公告)日：2006-01-19
申请号：US11086263
申请日：2005-03-22
申请人： Donald Sandell , Albert Carrillo , Adrian Fawcett , Ian Harding , Gary Lim
发明人： Donald Sandell , Albert Carrillo , Adrian Fawcett , Ian Harding , Gary Lim
IPC分类号： B29C65/00 , B29C65/10 , B32B37/00
CPC分类号： G01N35/028 , B01L3/0293 , B01L3/5025 , B01L3/5027 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L9/50 , B01L9/523 , B01L2200/021 , B01L2200/025 , B01L2200/0605 , B01L2200/0642 , B01L2300/022 , B01L2300/044 , B01L2300/046 , B01L2300/0829 , B01L2300/0851 , B01L2300/0864 , B01L2300/1805 , B01L2400/0406 , B01L2400/0409 , B01L2400/0487 , B32B33/00 , B32B38/10 , B32B2038/047 , G01N21/274 , G01N21/553 , G01N21/6452 , G01N35/04 , G01N2035/00366 , G01N2035/0405 , Y10T156/171 , Y10T156/1744
摘要： An automated seal applicator for applying a sealing cover to a microplate. The microplate can comprise a plurality of wells for receiving an assay. The automated seal applicator can comprise a housing and a removable sealing cover cassette containing a sealing cover roll. The sealing cover roll can comprise an elongated carrier liner and a plurality of individual sealing covers releasably carried on the elongated carrier liner. The sealing cover cassette can be selectively engagable with the housing. A sealing cover drive system can engage the sealing cover roll and maintain a predetermined alignment of each of the plurality of individual sealing covers relative to the microplate.
摘要翻译：一种用于将密封盖施加到微孔板的自动密封施加器。微孔板可以包括用于接收测定的多个孔。自动密封施加器可以包括容纳密封盖辊的壳体和可移除的密封盖盒。密封盖辊可以包括细长的载体衬里和可释放地承载在细长载体衬垫上的多个单独的密封盖。密封盖盒可以选择性地与壳体接合。密封盖驱动系统可以接合密封盖辊并且保持多个单个密封盖中的每一个相对于微板的预定对准。

10. 发明授权

US09068947B2 Optical system for multiple reactions 有权
标题翻译：光学系统多反应
公开(公告)号：US09068947B2
公开(公告)日：2015-06-30
申请号：US13132315
申请日：2009-12-03
申请人： Adrian Fawcett , David Tracy
发明人： Adrian Fawcett , David Tracy
IPC分类号： G01N21/03 , G02B5/04 , C12Q1/68 , G01N21/64 , B01L3/00
CPC分类号： G01N21/6452 , B01L3/50851 , C12Q1/686 , G01N21/0303 , G01N21/0332 , G01N2021/6417 , G01N2021/6463 , G02B5/04 , G02B5/045
摘要： The invention relates to optical systems and methods for measurement of samples in multiple sample vessels using an array of light sources where the light from the light sources is divided into multiple light beams, and each beam is directed to a sample vessel.
摘要翻译：本发明涉及用于使用光源阵列测量多个样品容器中的样品的光学系统和方法，其中来自光源的光被分成多个光束，并且每个光束被引导到样品容器。

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