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1. 发明授权

US08791096B2 Heat sterilization of glucocorticosteroids 有权
标题翻译：糖皮质激素加热灭菌
公开(公告)号：US08791096B2
公开(公告)日：2014-07-29
申请号：US10594861
申请日：2005-05-17
申请人： Adrian Ashley , Paul Lamb , Donald MacDonald , John Miller , Martin J. Oliver , Mathew Pollard
发明人： Adrian Ashley , Paul Lamb , Donald MacDonald , John Miller , Martin J. Oliver , Mathew Pollard
IPC分类号： A61K31/56 , A61L2/00 , C07J5/00
CPC分类号： A61K9/1682 , A61K31/56 , A61K31/573 , A61K31/58 , A61L2/0011 , A61L2/0023 , C07J5/00
摘要： The present invention provides a method for the sterilization of a labile glucocorticosteroid, which method comprises heat-treating by moist heat the labile glucocorticosteroid in the form of a suspension for a sterilizing-effective time. The methods and compositions according to the invention are useful as therapeutic tools to prevent, reverse, and/or reduce the symptoms of allergic and/or inflammatory conditions in a mammalian patient. The invention also provides methods and compositions, which may be manipulated and fine-tuned to fit the condition(s) to be treated while producing fewer side effects.
摘要翻译：本发明提供了一种灭活不稳定糖皮质激素的方法，该方法包括以悬浮液的形式将不稳定的糖皮质激素通过湿热加热灭菌有效时间。根据本发明的方法和组合物可用作预防，逆转和/或减少哺乳动物患者的过敏和/或炎症状况的治疗工具。本发明还提供方法和组合物，其可以被操纵和微调以适应待治疗的状况，同时产生更少的副作用。

2. 发明申请

US20080139519A1 Heat Sterilization of Glucocorticosteroids 有权
标题翻译：糖皮质激素的热灭菌
公开(公告)号：US20080139519A1
公开(公告)日：2008-06-12
申请号：US10594861
申请日：2005-05-17
申请人： Adrian Ashley , Paul Lamb , Donald MacDonald , John Miller , Martin J. Oliver , Mathew Pollard
发明人： Adrian Ashley , Paul Lamb , Donald MacDonald , John Miller , Martin J. Oliver , Mathew Pollard
IPC分类号： A61K31/575 , C07D317/70 , C07J1/00 , A61K31/58
CPC分类号： A61K9/1682 , A61K31/56 , A61K31/573 , A61K31/58 , A61L2/0011 , A61L2/0023 , C07J5/00
摘要： The present invention provides a method for the sterilization of a labile glucocorticosteroid, which method comprises heat-treating by moist heat the labile glucocorticosteroid in the form of a suspension for a sterilizing-effective time. The methods and compositions according to the invention are useful as therapeutic tools to prevent, reverse, and/or reduce the symptoms of allergic and/or inflammatory conditions in a mammalian patient. The invention also provides methods and compositions, which may be manipulated and fine-tuned to fit the condition(s) to be treated while producing fewer side effects.
摘要翻译：本发明提供了一种灭活不稳定糖皮质激素的方法，该方法包括以悬浮液的形式将不稳定的糖皮质激素通过湿热加热灭菌有效时间。根据本发明的方法和组合物可用作预防，逆转和/或减少哺乳动物患者的过敏和/或炎症状况的治疗工具。本发明还提供方法和组合物，其可以被操纵和微调以适应待治疗的状况，同时产生更少的副作用。

3. 发明申请

US20120258939A1 PHARMACEUTICAL MANUFACTURING PROCESS 审中-公开
标题翻译：药物制造工艺
公开(公告)号：US20120258939A1
公开(公告)日：2012-10-11
申请号：US13447468
申请日：2012-04-16
申请人： John Miller , Donald MacDonald , Martin Oliver , Matthew Pollard , Paul Ronald , Adrian Ashley , Paul Lamb
发明人： John Miller , Donald MacDonald , Martin Oliver , Matthew Pollard , Paul Ronald , Adrian Ashley , Paul Lamb
IPC分类号： A61K31/56
CPC分类号： A61K9/0073 , A61K9/10 , A61K31/573 , A61K47/26
摘要： The present invention provides a method for preparing a sterile suspension of a glucocorticosteroid. The glucocorticosteroids used in the invention are preferably antiinflammatory glucocorticosteroids. By making the last stage of product preparation be the sterilization process, the potential for contamination during manufacture and heat degradation of products is greatly reduced.
摘要翻译：本发明提供了制备糖皮质激素无菌悬浮液的方法。本发明中使用的糖皮质激素优选为抗炎糖皮质激素。通过使产品制备的最后阶段成为灭菌过程，产品制造和热降解过程中污染的可能性大大降低。

4. 发明申请

US20080269178A1 Pharmaceutical Manufacturing Process For Heat Sterilized Glucocorticoid Suspensions 有权
标题翻译：热灭菌糖皮质激素悬浮液的制药工艺
公开(公告)号：US20080269178A1
公开(公告)日：2008-10-30
申请号：US11667872
申请日：2005-11-16
申请人： John Miller , Paul Ronald , Adrian Ashley , Paul Lamb , Donald MacDonald , Martin Oliver , Matthew Pollard
发明人： John Miller , Paul Ronald , Adrian Ashley , Paul Lamb , Donald MacDonald , Martin Oliver , Matthew Pollard
IPC分类号： A61K31/56 , A61P43/00
CPC分类号： A61K9/0073 , A61K9/10 , A61K31/573 , A61K47/26
摘要： The present invention provides a method for preparing a sterile suspension of a glucocorticosteroid. The glucocorticosteroids used in the invention are preferably antiinflammatory glucocorticosteroids. By making the last stage of product preparation be the sterilization process, the potential for contamination during manufacture and heat degradation of products is greatly reduced.
摘要翻译：本发明提供了制备糖皮质激素无菌悬浮液的方法。本发明中使用的糖皮质激素优选为抗炎糖皮质激素。通过使产品制备的最后阶段成为灭菌过程，产品制造和热降解过程中污染的可能性大大降低。

5. 发明授权

US08178519B2 Pharmaceutical manufacturing process for heat sterilized glucocorticoid suspensions 有权
标题翻译：热灭菌糖皮质激素悬浮液的制药工艺
公开(公告)号：US08178519B2
公开(公告)日：2012-05-15
申请号：US11667872
申请日：2005-11-16
申请人： John Miller , Paul Ronald , Adrian Ashley , Paul Lamb , Donald MacDonald , Martin Oliver , Matthew Pollard
发明人： John Miller , Paul Ronald , Adrian Ashley , Paul Lamb , Donald MacDonald , Martin Oliver , Matthew Pollard
IPC分类号： A61K31/58 , A61K31/56
CPC分类号： A61K9/0073 , A61K9/10 , A61K31/573 , A61K47/26
摘要： The present invention provides a method for preparing a sterile suspension of a glucocorticosteroid. The glucocorticosteroids used in the invention are preferably antiinflammatory glucocorticosteroids. By making the last stage of product preparation be the sterilization process, the potential for contamination during manufacture and heat degradation of products is greatly reduced.
摘要翻译：本发明提供了制备糖皮质激素无菌悬浮液的方法。本发明中使用的糖皮质激素优选为抗炎糖皮质激素。通过使产品制备的最后阶段成为灭菌过程，产品制造和热降解过程中污染的可能性大大降低。

6. 发明授权

US09403400B2 Modular portable writing and projection system having variable curvature 有权
标题翻译：具有可变曲率的模块化便携式写入和投影系统
公开(公告)号：US09403400B2
公开(公告)日：2016-08-02
申请号：US12860037
申请日：2010-08-20
申请人： Michael McManus , Stephen Spencer , Donald MacDonald , John Crowley , Joseph Ballay
发明人： Michael McManus , Stephen Spencer , Donald MacDonald , John Crowley , Joseph Ballay
IPC分类号： B43L1/00 , A47B97/04 , B43L1/08 , B43L1/10
CPC分类号： B43L1/00 , A47B97/04 , B43L1/08 , B43L1/10
摘要： A modular, portable writing and projection system having a variable curvature is disclosed. The system uses dry erase boards, chalk or black boards, or other flexible panels having at least one writing surface. The panels have edges for joining to posts. The system combines panels to form a large, modular system for use at meetings, gatherings or other assemblies. The system allows a large number of users to contribute to a presentation, and also allows users to view the presentation. Because the panels are flexible, the system may be curved, allowing more panels to be mounted, used, written on and viewed, within limited space. The panels may be used in either a convex or concave manner, i.e., curved in or curved out, as desired. The resistance of the panels to remaining in a curved state is overcome by feet on the posts and braking or holding devices on the feet.
摘要翻译：公开了具有可变曲率的模块化便携式书写和投影系统。该系统使用干擦板，白垩或黑板或具有至少一个书写表面的其它柔性板。面板具有用于连接到柱的边缘。该系统将面板组合成一个大型的模块化系统，用于会议，集会或其他组件。该系统允许大量用户贡献一个演示文稿，并允许用户查看演示文稿。因为面板是柔性的，所以系统可以是弯曲的，允许在有限的空间内安装，使用，写入和查看更多的面板。面板可以以凸或凹的方式使用，即根据需要弯曲或弯曲出来。通过脚上的脚和脚上的制动或保持装置来克服面板保持在弯曲状态的阻力。

7. 发明申请

US20110042541A1 COLLABORATIVE PANEL SYSTEM 有权
标题翻译：协同面板系统
公开(公告)号：US20110042541A1
公开(公告)日：2011-02-24
申请号：US12860022
申请日：2010-08-20
申请人： Stephen Spencer , Joseph Ballay , David Bishop , Donald MacDonald , John Crowley
发明人： Stephen Spencer , Joseph Ballay , David Bishop , Donald MacDonald , John Crowley
IPC分类号： B43L1/00 , B23P19/00
CPC分类号： B43L1/00 , A47B97/001 , B43L1/04 , B43L1/10 , E04F13/0883 , E04F2201/0505 , F16B5/0635 , Y10T29/49826
摘要： A modular collaborative panel system intended for use on walls, frames and stands is disclosed. The system uses dry erase boards, chalk or black boards, or other panels having at least one writing surface. The panels have notches or cut-outs on each side so the panels can be mounted to a wall or a frame using pegs. The system combines panels in rows or columns, or both, to form a large, modular system for use at meetings, gatherings or other assemblies. The system allows a large number of users to contribute to a presentation, and also allows users to view the presentation.
摘要翻译：公开了一种旨在用于墙壁，框架和支架上的模块化协作面板系统。该系统使用干擦板，白垩或黑板或具有至少一个书写面的其他面板。这些面板在每侧都有凹口或切口，因此面板可以使用钉子安装到墙壁或框架上。该系统将行或列或两者的面板组合在一起，形成一个用于会议，聚会或其他组件的大型模块化系统。该系统允许大量用户贡献一个演示文稿，并允许用户查看演示文稿。

8. 发明授权

US08596600B2 Collaborative panel system 有权
标题翻译：协作面板系统
公开(公告)号：US08596600B2
公开(公告)日：2013-12-03
申请号：US12860022
申请日：2010-08-20
申请人： Stephen Spencer , Joseph Ballay , David Bishop , Donald MacDonald , John Crowley
发明人： Stephen Spencer , Joseph Ballay , David Bishop , Donald MacDonald , John Crowley
IPC分类号： A47B23/04
CPC分类号： B43L1/00 , A47B97/001 , B43L1/04 , B43L1/10 , E04F13/0883 , E04F2201/0505 , F16B5/0635 , Y10T29/49826
摘要： A modular collaborative panel system intended for use on walls, frames and stands is disclosed. The system uses dry erase boards, chalk or black boards, or other panels having at least one writing surface. The panels have notches or cut-outs on each side so the panels can be mounted to a wall or a frame using pegs. The system combines panels in rows or columns, or both, to form a large, modular system for use at meetings, gatherings or other assemblies. The system allows a large number of users to contribute to a presentation, and also allows users to view the presentation.
摘要翻译：公开了一种旨在用于墙壁，框架和支架上的模块化协作面板系统。该系统使用干擦板，白垩或黑板或具有至少一个书写面的其他面板。这些面板在每侧都有凹口或切口，因此面板可以使用钉子安装到墙壁或框架上。该系统将行或列或两者的面板组合在一起，形成一个用于会议，聚会或其他组件的大型模块化系统。该系统允许大量用户贡献一个演示文稿，并允许用户查看演示文稿。

9. 发明授权

US4541212A Adjustable width frame member for wall openings 失效
标题翻译：用于墙壁开口的可调节宽度框架构件
公开(公告)号：US4541212A
公开(公告)日：1985-09-17
申请号：US607508
申请日：1984-05-07
申请人： Donald MacDonald
发明人： Donald MacDonald
IPC分类号： E06B1/10 , E04C3/38 , E06B1/04
CPC分类号： E06B1/10
摘要： This invention is an adjustable frame member or jamb for a wall opening and a method for making it. It consists of two side-by-side jamb members, a spring and a stop. The stop is attached to one jamb member in an overhanging or step-like relationship. The spring is inserted into the back of this member so that an elongated portion defines a slot with the overhanging portion of the stop. Narrow kerfs are appropriately let into the back of the jamb and the door stop for anchoring the arm portions of the spring. The second jamb member is slid into the slot defined by the stop and spring, where it is firmly gripped by the spring. By forming one mounting point for the spring in the back of the stop, a short lever arm is maintained to better resist any prying or dislodging forces applied against the spring caused by the other jamb member. The artical can conveniently be made by first attaching one edge of the stop to a jamb of the narrowest width expected in use. The jamb is severed into two pieces and the kerfs are simultaneously cut. An inlet zone into the jamb members in the area of the spring enables the assembly to have a flat back for rigid mounting against a framing stud.
摘要翻译：本发明是用于墙壁开口的可调节框架构件或侧柱及其制造方法。它由两个并排的侧面成员组成，一个春天和一个停止。站在一个悬挂或阶梯式的关系附加到一个jamb成员。弹簧被插入该构件的后部，使得细长部分限定了具有止动件的伸出部分的狭槽。狭窄的缝隙适当地放入侧柱的后部和用于锚定弹簧的臂部的门挡块。第二侧柱构件滑入由止动件和弹簧限定的槽中，其中弹簧被牢固地夹紧。通过在止挡件的后部形成用于弹簧的一个安装点，保持短的杠杆臂以更好地抵抗由另一个侧柱构件引起的施加在弹簧上的任何撬动或移动力。可以方便地通过首先将停止物的一个边缘附接到预期使用的最窄宽度的侧栏来进行。侧腿被切断成两片，同时切断缝。在弹簧区域中进入侧壁构件的入口区域使得组件能够具有平坦的背面，用于刚性地安装在框架螺柱上。

10. 发明授权

US08061427B2 Well product recovery process 有权
标题翻译：产品回收过程良好
公开(公告)号：US08061427B2
公开(公告)日：2011-11-22
申请号：US11421034
申请日：2006-05-30
申请人： Robert A. Jackson , Donald MacDonald
发明人： Robert A. Jackson , Donald MacDonald
IPC分类号： E21B43/267
CPC分类号： E21B43/006 , E21B43/267
摘要： A process for fracturing a selected region of a formation including: introducing a supply of fracturing fluid to the region of the formation until a first threshold is reached, adjusting the flow of the fracturing fluid to the region of the formation to reach a second threshold, adjusting the flow of the fracturing fluid to the region of the formation to reach a third threshold and ceasing flow of the fracturing fluid to region of the formation, the fracturing fluid being a non-participating gas and including a proppant in at least one of the stages of flow of the fracturing fluid.
摘要翻译：一种用于压裂地层的选定区域的方法，包括：将压裂液供应到地层的区域，直到达到第一阈值，调节压裂流体到地层的区域达到第二阈值，将压裂流体的流量调节到地层的区域以达到第三阈值并停止压裂流体到地层的区域的流动，压裂流体是不参与气体，并且包括在至少一个压裂液流动阶段。

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