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1. 发明授权

US08178519B2 Pharmaceutical manufacturing process for heat sterilized glucocorticoid suspensions 有权
标题翻译：热灭菌糖皮质激素悬浮液的制药工艺
公开(公告)号：US08178519B2
公开(公告)日：2012-05-15
申请号：US11667872
申请日：2005-11-16
申请人： John Miller , Paul Ronald , Adrian Ashley , Paul Lamb , Donald MacDonald , Martin Oliver , Matthew Pollard
发明人： John Miller , Paul Ronald , Adrian Ashley , Paul Lamb , Donald MacDonald , Martin Oliver , Matthew Pollard
IPC分类号： A61K31/58 , A61K31/56
CPC分类号： A61K9/0073 , A61K9/10 , A61K31/573 , A61K47/26
摘要： The present invention provides a method for preparing a sterile suspension of a glucocorticosteroid. The glucocorticosteroids used in the invention are preferably antiinflammatory glucocorticosteroids. By making the last stage of product preparation be the sterilization process, the potential for contamination during manufacture and heat degradation of products is greatly reduced.
摘要翻译：本发明提供了制备糖皮质激素无菌悬浮液的方法。本发明中使用的糖皮质激素优选为抗炎糖皮质激素。通过使产品制备的最后阶段成为灭菌过程，产品制造和热降解过程中污染的可能性大大降低。

2. 发明申请

US20080269178A1 Pharmaceutical Manufacturing Process For Heat Sterilized Glucocorticoid Suspensions 有权
标题翻译：热灭菌糖皮质激素悬浮液的制药工艺
公开(公告)号：US20080269178A1
公开(公告)日：2008-10-30
申请号：US11667872
申请日：2005-11-16
申请人： John Miller , Paul Ronald , Adrian Ashley , Paul Lamb , Donald MacDonald , Martin Oliver , Matthew Pollard
发明人： John Miller , Paul Ronald , Adrian Ashley , Paul Lamb , Donald MacDonald , Martin Oliver , Matthew Pollard
IPC分类号： A61K31/56 , A61P43/00
CPC分类号： A61K9/0073 , A61K9/10 , A61K31/573 , A61K47/26
摘要： The present invention provides a method for preparing a sterile suspension of a glucocorticosteroid. The glucocorticosteroids used in the invention are preferably antiinflammatory glucocorticosteroids. By making the last stage of product preparation be the sterilization process, the potential for contamination during manufacture and heat degradation of products is greatly reduced.
摘要翻译：本发明提供了制备糖皮质激素无菌悬浮液的方法。本发明中使用的糖皮质激素优选为抗炎糖皮质激素。通过使产品制备的最后阶段成为灭菌过程，产品制造和热降解过程中污染的可能性大大降低。

3. 发明申请

US20120258939A1 PHARMACEUTICAL MANUFACTURING PROCESS 审中-公开
标题翻译：药物制造工艺
公开(公告)号：US20120258939A1
公开(公告)日：2012-10-11
申请号：US13447468
申请日：2012-04-16
申请人： John Miller , Donald MacDonald , Martin Oliver , Matthew Pollard , Paul Ronald , Adrian Ashley , Paul Lamb
发明人： John Miller , Donald MacDonald , Martin Oliver , Matthew Pollard , Paul Ronald , Adrian Ashley , Paul Lamb
IPC分类号： A61K31/56
CPC分类号： A61K9/0073 , A61K9/10 , A61K31/573 , A61K47/26
摘要： The present invention provides a method for preparing a sterile suspension of a glucocorticosteroid. The glucocorticosteroids used in the invention are preferably antiinflammatory glucocorticosteroids. By making the last stage of product preparation be the sterilization process, the potential for contamination during manufacture and heat degradation of products is greatly reduced.
摘要翻译：本发明提供了制备糖皮质激素无菌悬浮液的方法。本发明中使用的糖皮质激素优选为抗炎糖皮质激素。通过使产品制备的最后阶段成为灭菌过程，产品制造和热降解过程中污染的可能性大大降低。

4. 发明授权

US07560688B2 Mass analysis of mobility selected ion populations 有权
标题翻译：迁移选择离子群体的质量分析
公开(公告)号：US07560688B2
公开(公告)日：2009-07-14
申请号：US11582198
申请日：2006-10-16
申请人： Brian H. Clowers , Herbert H. Hill, Jr. , Prabha Dwivedi , Matthew Pollard
发明人： Brian H. Clowers , Herbert H. Hill, Jr. , Prabha Dwivedi , Matthew Pollard
IPC分类号： H01J49/00
CPC分类号： H01J49/02 , G01N27/622 , H01J49/004
摘要： Particular aspects provide novel methods for analysis of ion populations, the methods comprising filtering and selecting an ion population using a low-field dual-gate ion mobility spectrometer comprising a drift tube, the spectrometer operating at a pressure of at least 100 Torr, to provide mobility-selected ions. Certain aspects comprise: (i) subsequently accumulating the low-field selected ions in an ion trap (e.g., an MS ion trap) and mass spectrometry analysis; (ii) introducing the low-field selected ions into a high-field ion mobility spectrometer for separating thereby (optionally followed by mass spectrometry); and (iii) introducing the low-field selected ions into an ion trap mass spectrometer, and subsequently into a second low-field ion mobility spectrometer (e.g., a non-dual gate spectrometer operating at less than about 100 Torr). Additional aspects provide novel apparatus and combination thereof for performing the disclosed methods.
摘要翻译：具体方面提供用于分析离子群体的新方法，所述方法包括使用包含漂移管的低场双栅离子迁移谱仪来过滤和选择离子群，所述漂移管在至少100托的压力下操作，以提供迁移率选择离子某些方面包括：（i）随后在离子阱（例如，MS离子阱）中积聚低场选择的离子和质谱分析; （ii）将低场选择的离子引入用于分离的高场离子迁移谱仪（任选地随后进行质谱）; 和（iii）将低场选择的离子引入离子阱质谱仪中，随后进入第二低场离子迁移谱仪（例如，操作在小于约100托的非双栅光谱仪）。另外的方面提供了用于执行所公开的方法的新颖的装置及其组合。

5. 发明授权

US09127057B2 Anti-IL-23 heterodimer specific antibodies 有权
标题翻译：抗IL-23异二聚体特异性抗体
公开(公告)号：US09127057B2
公开(公告)日：2015-09-08
申请号：US13810474
申请日：2011-07-20
申请人： Adam William Clarke , Anthony G. Doyle , Matthew Pollard , Stephen Tran
发明人： Adam William Clarke , Anthony G. Doyle , Matthew Pollard , Stephen Tran
IPC分类号： A61K39/395 , C07K16/24 , A61K39/00
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/32 , C07K2317/33 , C07K2317/55 , C07K2317/76 , C07K2317/92
摘要： The present disclosure provides an isolated or recombinant IL-23-binding protein comprising an antigen binding domain of an antibody, wherein the antigen binding domain specifically binds to IL-23 but does not significantly bind to an IL-12p40 subunit and does not significantly bind to an IL-23p19 subunit when they are not components of IL-23. The present disclosure also provides uses of the IL-23-binding protein.
摘要翻译：本公开提供了包含抗体的抗原结合结构域的分离或重组的IL-23结合蛋白，其中所述抗原结合结构域特异性结合IL-23，但不显着结合IL-12p40亚基并且不显着结合到IL-23p19亚基，当它们不是IL-23的成分时。本公开还提供了IL-23结合蛋白的用途。

6. 发明申请

US20130115166A1 ANTI-IL-23 HETERODIMER SPECIFIC ANTIBODIES 有权
标题翻译：抗IL-23 HETERBRER特异性抗体
公开(公告)号：US20130115166A1
公开(公告)日：2013-05-09
申请号：US13810474
申请日：2011-07-20
申请人： Adam William Clarke , Anthony G. Doyle , Matthew Pollard , Stephen Tran
发明人： Adam William Clarke , Anthony G. Doyle , Matthew Pollard , Stephen Tran
IPC分类号： C07K16/24
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/32 , C07K2317/33 , C07K2317/55 , C07K2317/76 , C07K2317/92
摘要： The present disclosure provides an isolated or recombinant IL-23-binding protein comprising an antigen binding domain of an antibody, wherein the antigen binding domain specifically binds to IL-23 but does not significantly bind to an IL-12p40 subunit and does not significantly bind to an IL-23p19 subunit when they are not components of IL-23. The present disclosure also provides uses of the IL-23-binding protein.
摘要翻译：本公开提供了包含抗体的抗原结合结构域的分离或重组的IL-23结合蛋白，其中所述抗原结合结构域特异性结合IL-23，但不显着结合IL-12p40亚基并且不显着结合到IL-23p19亚基，当它们不是IL-23的成分时。本公开还提供了IL-23结合蛋白的用途。

7. 发明申请

US20070158543A1 Mass analysis of mobility selected ion populations 有权
标题翻译：迁移选择离子群体的质量分析
公开(公告)号：US20070158543A1
公开(公告)日：2007-07-12
申请号：US11582198
申请日：2006-10-16
申请人： Brian Clowers , Herbert Hill , Prabha Dwivedi , Matthew Pollard
发明人： Brian Clowers , Herbert Hill , Prabha Dwivedi , Matthew Pollard
IPC分类号： B01D59/44
CPC分类号： H01J49/02 , G01N27/622 , H01J49/004
摘要： Particular aspects provide novel methods for analysis of ion populations, the methods comprising filtering and selecting an ion population using a low-field dual-gate ion mobility spectrometer comprising a drift tube, the spectrometer operating at a pressure of at least 100 Torr, to provide mobility-selected ions. Certain aspects comprise: (i) subsequently accumulating the low-field selected ions in an ion trap (e.g., an MS ion trap) and mass spectrometry analysis; (ii) introducing the low-field selected ions into a high-field ion mobility spectrometer for separating thereby (optionally followed by mass spectrometry); and (iii) introducing the low-field selected ions into an ion trap mass spectrometer, and subsequently into a second low-field ion mobility spectrometer (e.g., a non-dual gate spectrometer operating at less than about 100 Torr). Additional aspects provide novel apparatus and combination thereof for performing the disclosed methods.
摘要翻译：具体方面提供用于分析离子群体的新方法，所述方法包括使用包含漂移管的低场双栅离子迁移谱仪来过滤和选择离子群，所述漂移管在至少100托的压力下操作，以提供迁移率选择离子某些方面包括：（i）随后在离子阱（例如，MS离子阱）中积聚低场选择的离子和质谱分析; （ii）将低场选择的离子引入用于分离的高场离子迁移谱仪（任选地随后进行质谱）; 和（iii）将低场选择的离子引入离子阱质谱仪中，随后进入第二低场离子迁移谱仪（例如，操作在小于约100托的非双栅光谱仪）。另外的方面提供了用于执行所公开的方法的新颖的装置及其组合。

8. 发明授权

US08470320B2 Humanised antibodies with anti-tumour activity 失效
标题翻译：人源化抗体具有抗肿瘤活性
公开(公告)号：US08470320B2
公开(公告)日：2013-06-25
申请号：US12725192
申请日：2010-03-16
申请人： Adam W. Clarke , Anthony G. Doyle , Philip A. Jennings , Norbert Kienzle , Matthew Pollard
发明人： Adam W. Clarke , Anthony G. Doyle , Philip A. Jennings , Norbert Kienzle , Matthew Pollard
IPC分类号： A61K39/395
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/3076 , C07K16/464 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/567 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/734 , G01N33/57419 , G01N33/57423 , G01N33/57438 , G01N33/57449
摘要： The present invention provides humanized antibodies and binding domains thereof with anti-tumor activity. In particular the humanized antibodies have specific binding to and direct killing of human colon tumor cells and display potent immune-mediated cytotoxic activity against human colon cancer cells in vitro using antibody-dependent cell-mediated cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC) assays and in vivo using mouse tumor models.
摘要翻译：本发明提供具有抗肿瘤活性的人源化抗体及其结合结构域。特别地，人源化抗体具有与人结肠肿瘤细胞的特异性结合和直接杀伤，并且使用抗体依赖性细胞介导的细胞毒性（ADCC）和补体依赖性细胞毒性（CDC）在体外显示针对人结肠癌细胞的有效免疫介导的细胞毒活性测定和体内使用小鼠肿瘤模型。

9. 发明申请

US20100297134A1 HUMANISED ANTIBODIES WITH ANTI-TUMOUR ACTIVITY 失效
标题翻译：具有抗肿瘤活性的人类抗体
公开(公告)号：US20100297134A1
公开(公告)日：2010-11-25
申请号：US12725192
申请日：2010-03-16
申请人： Adam W. Clarke , Anthony G. Doyle , Philip A. Jennings , Norbert Kienzle , Matthew Pollard
发明人： Adam W. Clarke , Anthony G. Doyle , Philip A. Jennings , Norbert Kienzle , Matthew Pollard
IPC分类号： A61K39/395 , C07K16/18 , A61P35/00 , G01N33/574
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/3076 , C07K16/464 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/567 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/734 , G01N33/57419 , G01N33/57423 , G01N33/57438 , G01N33/57449
摘要： The present invention provides humanised antibodies and binding domains thereof with anti-tumour activity. In particular the humanised antibodies have specific binding to and direct killing of human colon tumour cells and display potent immune-mediated cytotoxic activity against human colon cancer cells in vitro using antibody-dependent cell-mediated cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC) assays and in vivo using mouse tumour models.
摘要翻译：本发明提供具有抗肿瘤活性的人源化抗体及其结合结构域。特别地，人源化抗体具有与人结肠肿瘤细胞的特异性结合和直接杀伤，并且使用抗体依赖性细胞介导的细胞毒性（ADCC）和补体依赖性细胞毒性（CDC）在体外显示针对人结肠癌细胞的有效免疫介导的细胞毒性活性测定和体内使用小鼠肿瘤模型。

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