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    • 7. 发明授权
    • Biometric imaging using an optical adaptive interface
    • 使用光学自适应接口的生物统计学成像
    • US08570149B2
    • 2013-10-29
    • US13047597
    • 2011-03-14
    • Robert K. RoweStephen P. CorcoranPaul Butler
    • Robert K. RoweStephen P. CorcoranPaul Butler
    • G06F7/00
    • G06K9/0004A61B5/0075A61B5/1172A61B2562/146G07C9/00158
    • Embodiments of the invention provide for a biometric system with an optically adaptive interface. In some embodiments, an optically adaptive interface changes optical characteristics in response to the placement of a finger on the optically adaptive interface. In some embodiments, the optically adaptive interface can include an active layer and a surface layer. The active layer and the surface layer can have different optical properties. For example, one layer may be opaque and the other transparent, the two layers may have complementary colors, the two layers may have orthogonal polarization reflectors, one layer may be reflective and the other absorptive, etc. Moreover, the active layer can be a fluid with either high or low viscosity. For example, the viscosity can be such that the active layer fluid is either completely displaced or not displaced in locations corresponding to finger valleys.
    • 本发明的实施例提供具有光学适应接口的生物测定系统。 在一些实施例中,光学自适应接口响应于手指在光学自适应接口上的放置而改变光学特性。 在一些实施例中,光学自适应接口可以包括有源层和表面层。 有源层和表面层可以具有不同的光学性质。 例如,一层可以是不透明的,另一层可以具有互补色,两层可以具有正交的偏振反射器,一层可以是反射型的,另一层可以是其它的吸收性等。此外,有源层可以是 具有高或低粘度的流体。 例如,粘度可以使得活性层流体在对应于手指谷的位置中被完全移位或不被移位。
    • 8. 发明授权
    • Indole derivatives in the treatment of emesis
    • 吲哚衍生物治疗呕吐
    • US5618834A
    • 1997-04-08
    • US565425
    • 1995-11-30
    • Paul Butler
    • Paul Butler
    • C07D403/06A61K31/40A61K31/404A61P1/08A61K31/395A61K31/405A61K31/445
    • A61K31/404Y10S514/872
    • Compounds of formula I, ##STR1## wherein R.sup.1 represents hydrogen; R.sup.2 represents hydrogen, halogen, cyano, OR.sup.4, --(CH.sub.2).sub.m CONR.sup.5 R.sup.6, --(CH.sub.2).sub.m SO.sub.2 NR.sup.5 R.sup.6, --(CH.sub.2).sub.m NR.sup.7 COR.sup.8, --(CH.sub.2).sub.m S(O).sub.x R.sup.8, --(CH.sub.2).sub.m NR.sup.7 CONR.sup.5 R.sup.6, --(CH.sub.2).sub.m NR.sup.7 COOR.sup.9 or --CH.dbd.CH(CH.sub.2).sub.y R.sup.10 ; R.sup.3 represents hydrogen or C.sub.1-6 alkyl; R.sup.4 represents hydrogen, C.sub.1-6 alkyl or aryl; R.sup.5 and R.sup.6 are independently represent hydrogen, C.sub.1-6 alkyl, aryl or (C.sub.1-3 alkyl)aryl; or R.sup.5 and R.sup.6 taken together may form a 4-, 5- or 6-membered ring; R.sup.7 and R.sup.8 independently represent hydrogen, C.sub.1-6 alkyl, aryl or (C.sub.1-3 alkyl)aryl; R.sup.9 represents hydrogen, C.sub.1-6 alkyl, aryl or (C.sub.1-3 alkyl)aryl; R.sup.10 represents --CONR.sup.5 R.sup.6, --SO.sub.2 NR.sup.5 R.sup.6, --NR.sup.7 COR.sup.8, --NR.sup.7 SO.sub.2 R.sup.8, --NR.sup.7 CONR.sup.5 R.sup.6, --S(O).sub.x R.sup.8 or --NR.sup.7 COOR.sup.9 ; m is 0, 1, 2 or 3; n is 0, 1 or 2; y is 0, 1 or 2; x is 1 or 2; and pharmaceutically acceptable salts thereof; are useful in the treatment or prevention of emesis not associated with migraine.
    • 式I化合物,其中R 1表示氢; R 2表示氢,卤素,氰基,OR 4, - (CH 2)m CONR 5 R 6, - (CH 2)m SO 2 NR 5 R 6, - (CH 2)m NR 7 COR 8, - (CH 2)m S(O)x R 8, - (CH 2)m NR 7 CONR 5 R 6, - (CH 2)m NR 27 COOR 9或 -CH = CH(CH 2)y R 10; R3表示氢或C1-6烷基; R4表示氢,C1-6烷基或芳基; R5和R6独立地表示氢,C1-6烷基,芳基或(C1-3烷基)芳基; 或R 5和R 6一起可以形成4-,5-或6-元环; R 7和R 8独立地表示氢,C 1-6烷基,芳基或(C 1-3烷基)芳基; R 9表示氢,C 1-6烷基,芳基或(C 1-3烷基)芳基; R 10表示-CONR 5 R 6,-SO 2 NR 5 R 6,-NR 7 COR 8,-NR 7 SO 2 R 8,-NR 7 CONR 5 R 6,-S(O)x R 8或-NR 7 COOR 9; m为0,1,2或3; n为0,1或2; y为0,1或2; x为1或2; 及其药学上可接受的盐; 可用于治疗或预防与偏头痛无关的呕吐。