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1. 发明申请

US20060205639A1 Pro-nanodispersion for the delivery of cyclosporin 失效
标题翻译：用于递送环孢菌素的准纳米分散体
公开(公告)号：US20060205639A1
公开(公告)日：2006-09-14
申请号：US11363379
申请日：2006-02-28
申请人： Abraham Domb , Avi Avramoff , Victor Pevzner
发明人： Abraham Domb , Avi Avramoff , Victor Pevzner
IPC分类号： A61K38/13
CPC分类号： A61K9/0048 , A61K9/1075 , A61K9/4808 , A61K9/4858 , A61K9/4866 , A61K38/13
摘要： A novel cyclosporine formulation, which is a pro-nanodispersion at room temperature, featuring solid particles of a relatively large particle size (at least about 150 nm) and yet which is a nanodispersion at body temperature.
摘要翻译：一种新颖的环孢菌素制剂，其在室温下是原分散体，其特征在于具有相对较大粒度（至少约150nm）的固体颗粒，并且其在体温下是纳米分散体。

2. 发明申请

US20070043434A1 Biodegradable endovascular stent using stereocomplexation of polymers 审中-公开
标题翻译：使用聚合物立体络合的可生物降解的血管内支架
公开(公告)号：US20070043434A1
公开(公告)日：2007-02-22
申请号：US11206161
申请日：2005-08-18
申请人： David Meerkin , Abraham Domb , Chaim Lotan
发明人： David Meerkin , Abraham Domb , Chaim Lotan
IPC分类号： A61F2/06
CPC分类号： A61F2/82 , A61F2210/0004 , A61L31/06 , A61L31/14 , A61L31/148
摘要： A biodegradable stent is comprised of a stereocomplex of polylactide enantiomers. The unique characteristics of stereocomplex polymers allows for the stent to have variable material characteristics along its length, while retaining uniform geometry. Thus, the stent is designed to be flexible upon insertion through the blood vessels while still retaining its rigidity and support upon expansion within the vessel. Furthermore, the material characteristics can be manipulated such that high strengths are possible even with small thicknesses of struts within the stent.
摘要翻译：可生物降解的支架由聚丙交酯对映体的立体络合物组成。立体络合物聚合物的独特特征允许支架沿其长度具有可变的材料特性，同时保持均匀的几何形状。因此，支架被设计成在插入通过血管时是柔性的，同时在容器内膨胀时仍然保持其刚性和支撑。此外，可以操纵材料特性，使得即使在支架内具有小厚度的支柱也可以实现高强度。

3. 发明申请

US20070036855A1 Soft polylactides 失效
标题翻译：柔性聚交酯
公开(公告)号：US20070036855A1
公开(公告)日：2007-02-15
申请号：US11335138
申请日：2006-01-19
申请人： Abraham Domb , Robert Langer
发明人： Abraham Domb , Robert Langer
IPC分类号： A61K9/22 , A61K9/14
CPC分类号： A61K9/0024 , A61K9/0019 , A61K47/34 , C08G63/06
摘要： Biodegradable polymeric compositions that are liquids or pastes at temperatures below 37° C. are described. Immersion of the compositions in aqueous medium, such as body fluids, increases the viscosity of the composition resulting in the formation of a semisolid material. The polymeric material is a hydroxyalkanoic acid polyester derived from the copolymerization of at least one unsaturated hydroxy fatty acid copolymerized with hydroxyalkanoic acids of 2-6 carbons.
摘要翻译：描述了在37℃以下的液体或糊状物的可生物分解的聚合物组合物。组合物在水性介质（例如体液）中的浸渍增加了组合物的粘度，从而形成半固体材料。聚合物材料是由至少一种与2-6个碳原子的羟基链烷酸共聚的不饱和羟基脂肪酸的共聚得到的羟基链烷酸聚酯。

4. 发明申请

US20060013850A1 Electropolymerizable monomers and polymeric coatings on implantable devices prepared therefrom 审中-公开
标题翻译：由其制备的可植入装置上的电聚合单体和聚合物涂层
公开(公告)号：US20060013850A1
公开(公告)日：2006-01-19
申请号：US11183850
申请日：2005-07-19
申请人： Abraham Domb
发明人： Abraham Domb
IPC分类号： A61K9/14 , A61F13/00
CPC分类号： C07D207/327 , A61L27/042 , A61L27/34 , A61L31/022 , A61L31/10 , A61L31/16 , A61L33/0088 , A61L2300/80 , A61L2400/12 , A61L2420/02 , C08F2/58 , C08F226/06 , C09D5/4476 , C08L39/06
摘要： Conductive surfaces of e.g., implantable devices, coated with electropolymerized polymers having active substances attached thereto are disclosed. Electropolymerizable monomers designed and used for obtaining such conductive surfaces and processes, devices and methods for attaching the electropolymerized polymers to conductive surfaces are also disclosed. The polymers, processes and devices presented herein can be beneficially used in the preparation of implantable medical devices.
摘要翻译：公开了涂覆有附着有活性物质的电聚合聚合物的例如可植入装置的导电表面。还公开了设计和用于获得这种导电表面的电聚合单体和用于将电聚合聚合物附着到导电表面的方法，装置和方法。本文提出的聚合物，方法和装置可有利地用于可植入医疗装置的制备。

5. 发明授权

US5356630A Delivery system for controlled release of bioactive factors 失效
标题翻译：用于控制释放生物活性因子的递送系统
公开(公告)号：US5356630A
公开(公告)日：1994-10-18
申请号：US59516
申请日：1993-05-07
申请人： Cato T. Laurencin , Paul A. Lucas , Glenn T. Syftestad , Abraham Domb , Julianne Glowacki , Robert S. Langer
发明人： Cato T. Laurencin , Paul A. Lucas , Glenn T. Syftestad , Abraham Domb , Julianne Glowacki , Robert S. Langer
IPC分类号： A61K9/00 , A61K9/20 , A61L27/18 , A61L27/22 , A61L27/54 , A61L27/58 , C08G67/04 , A61F2/28 , A61K37/12 , C07K15/20 , C07K17/08
CPC分类号： A61K9/0024 , A61K9/2031 , A61K9/204 , A61L27/18 , A61L27/227 , A61L27/54 , A61L27/58 , C08G67/04 , A61L2300/252 , A61L2300/414 , A61L2300/604 , Y10S530/84
摘要： A composition and method for controlled release of water-soluble proteins comprising a surface-eroding polymer matrix and water-soluble bioactive factors is described. The composition bioerodes in the biological environment of the subject at a controlled rate, thereby releasing the water soluble proteins at a rate which allows them to interact with local cell populations.
摘要翻译：描述了包含表面侵蚀聚合物基质和水溶性生物活性因子的水溶性蛋白质的控制释放组合物和方法。组合物以受控的速率在受试者的生物环境中生物反应，从而以允许其与局部细胞群体相互作用的速率释放水溶性蛋白质。

6. 发明授权

US08540722B2 Methods, materials and apparatus for treating bone and other tissue 有权
公开(公告)号：US08540722B2
公开(公告)日：2013-09-24
申请号：US12485098
申请日：2009-06-16
申请人： Mordechay Beyar , Oren Globerman , Abraham Domb , Ronen Shavit , Hila Wachsler-Avrahami
发明人： Mordechay Beyar , Oren Globerman , Abraham Domb , Ronen Shavit , Hila Wachsler-Avrahami
IPC分类号： A61B17/58 , A61B17/60 , A61F2/00
CPC分类号： A61B17/8852 , A61B17/7095 , A61B17/8805 , A61B17/8811 , A61B17/8816 , A61B17/8819 , A61B17/8822 , A61B17/8833 , A61B2017/00539 , A61B2017/00734 , A61L24/06 , A61L27/16 , A61L2400/06 , A61L2430/38 , B01F7/00416 , B01F15/00006 , B01F15/00058 , B01F15/00883 , B01F15/0279 , C08L33/10
摘要： A method of treating a vertebra, comprising: (a) accessing an interior of a vertebra; and (b) introducing a sufficient amount of artificial biocompatible material which does not set to a hardened condition in storage, into said bone, with sufficient force to move apart fractured portions of said bone.

7. 发明申请

US20090264892A1 Methods, Materials and Apparatus for Treating Bone or Other Tissue 有权
标题翻译：方法，治疗骨或其他组织的材料和装置
公开(公告)号：US20090264892A1
公开(公告)日：2009-10-22
申请号：US12485101
申请日：2009-06-16
申请人： Mordechay Beyar , Oren Globerman , Abraham Domb , Ronen Shavit , Hila Wachsler-Avrahami
发明人： Mordechay Beyar , Oren Globerman , Abraham Domb , Ronen Shavit , Hila Wachsler-Avrahami
IPC分类号： A61B17/56
CPC分类号： A61B17/8852 , A61B17/7095 , A61B17/8805 , A61B17/8811 , A61B17/8816 , A61B17/8819 , A61B17/8822 , A61B17/8833 , A61B2017/00539 , A61B2017/00734 , A61L24/06 , A61L27/16 , A61L2400/06 , A61L2430/38 , B01F7/00416 , B01F15/00006 , B01F15/00058 , B01F15/00883 , B01F15/0279 , C08L33/10
摘要： A method of treating a vertebra, comprising: (a) accessing an interior of a vertebra; and (b) introducing a sufficient amount of artificial biocompatible material which does not set to a hardened condition in storage, into said bone, with sufficient force to move apart fractured portions of said bone.
摘要翻译：一种治疗椎骨的方法，包括：（a）进入椎骨内部; 和（b）以足够的力将足量的人造生物相容性材料引入到所述骨中，所述人造生物相容性材料不会被固定在所述骨中，所述人造生物相容性材料不会被硬化。

8. 发明授权

US5629009A Delivery system for controlled release of bioactive factors 失效
标题翻译：用于控制释放生物活性因子的递送系统
公开(公告)号：US5629009A
公开(公告)日：1997-05-13
申请号：US693466
申请日：1996-08-07
申请人： Cato T. Laurencin , Paul A. Lucas , Glenn T. Syftestad , Abraham Domb , Julie Glowacki , Robert S. Langer
发明人： Cato T. Laurencin , Paul A. Lucas , Glenn T. Syftestad , Abraham Domb , Julie Glowacki , Robert S. Langer
IPC分类号： A61K9/00 , A61K9/20 , A61L27/18 , A61L27/22 , A61L27/54 , A61L27/58 , C08G67/04 , A61F2/28 , A61K38/39 , C07K14/485 , C07K14/51
CPC分类号： A61K9/0024 , A61K9/2031 , A61K9/204 , A61L27/18 , A61L27/227 , A61L27/54 , A61L27/58 , C08G67/04 , A61L2300/252 , A61L2300/414 , A61L2300/604 , Y10S530/84
摘要： A composition and method for controlled release of water-soluble proteins comprising a surface-eroding polymer matrix and water-soluble bioactive factors is described. The composition bioerodes in the biological environment of the subject at a controlled rate, thereby releasing the water soluble proteins at a rate which allows them to interact with local cell populations.
摘要翻译：描述了包含表面侵蚀聚合物基质和水溶性生物活性因子的水溶性蛋白质的控制释放组合物和方法。组合物以受控的速率在受试者的生物环境中生物反应，从而以允许其与局部细胞群体相互作用的速率释放水溶性蛋白质。

9. 发明申请

US20080035569A1 Water Treatment Device and Method Therefor 审中-公开
标题翻译：水处理装置及其方法
公开(公告)号：US20080035569A1
公开(公告)日：2008-02-14
申请号：US10598545
申请日：2004-10-15
申请人： Haim Wilder , Abraham Domb
发明人： Haim Wilder , Abraham Domb
IPC分类号： C02F1/28 , C02F1/42 , C02F9/00
CPC分类号： C02F1/003 , C02F1/283 , C02F1/68 , C02F1/688 , C02F2001/422 , C02F2001/425 , C02F2307/02
摘要： A system for upgrading raw water using a filter, for eliminating intrinsic factors of such water. Optionally the system includes a device for facilitating sustained release of extrinsic factors supplied by one or more capsules. Optionally the system includes also a dosing device for prolonging the constant supply of extrinsic factors to the drinking water to a period of time beyond that which is facilitated by one capsule laden with the factors. The filter of the system forces the gravitationally trickling raw water to meander through a path in which it reacts with a set of reactants. Upgraded after having passed through the filter, the water is collected and made available for dispensing through a spout. Optionally, one or more capsules laden with health promoting, nutritive, remedies or other beneficial factors are added to the upgraded water. A number of techniques for facilitating a substantially constant addition of vitamins, minerals, and other beneficial chemicals is described.
摘要翻译：一种使用过滤器升级原水的系统，用于消除这种水的内在因素。可选地，该系统包括用于促进由一个或多个胶囊供应的外在因素的持续释放的装置。可选地，该系统还包括用于将外部因素恒定供应给饮用水的计量装置，其时间超过由一个因素影响的胶囊促成的时间。系统的过滤器迫使重力涓流的原水曲折通过与一组反应物反应的路径。在通过过滤器之后升级，收集水并通过喷口进行分配。任选地，将含有健康促进，营养，补救或其它有益因子的一种或多种胶囊加入升级的水中。描述了用于促进维生素，矿物质和其它有益化学物质基本上恒定添加的许多技术。

10. 发明申请

US20060079905A1 Methods, materials and apparatus for treating bone and other tissue 审中-公开
公开(公告)号：US20060079905A1
公开(公告)日：2006-04-13
申请号：US11194411
申请日：2005-08-01
申请人： Mordechay Beyar , Oren Globerman , Abraham Domb , Ronen Shavit , Hila Wachsler-Avrahami
发明人： Mordechay Beyar , Oren Globerman , Abraham Domb , Ronen Shavit , Hila Wachsler-Avrahami
IPC分类号： A61F2/28
CPC分类号： A61B17/8852 , A61B17/7095 , A61B17/8805 , A61B17/8811 , A61B17/8816 , A61B17/8819 , A61B17/8822 , A61B17/8833 , A61B2017/00539 , A61B2017/00734 , A61L24/06 , A61L27/16 , A61L2400/06 , A61L2430/38 , B01F7/00416 , B01F15/00006 , B01F15/00058 , B01F15/00883 , B01F15/0279 , C08L33/10
摘要： A method of treating a vertebra, comprising: (a) accessing an interior of a vertebra; and (b) introducing a sufficient amount of artificial biocompatible material which does not set to a hardened condition in storage, into said bone, with sufficient force to move apart fractured portions of said bone.

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