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1. 发明授权

US08340772B2 Brown adipose tissue utilization through neuromodulation 有权
标题翻译：棕色脂肪组织利用通过神经调节
公开(公告)号：US08340772B2
公开(公告)日：2012-12-25
申请号：US12774073
申请日：2010-05-05
申请人： Abhi Vase , Johann Neisz
发明人： Abhi Vase , Johann Neisz
IPC分类号： A61N1/34
CPC分类号： A61N1/0551
摘要： Methods and devices for improved neurostimulation to treat obesity. Some methods include measuring temperature increases in Brown Adipose Tissue (BAT) during intraoperative test stimulations to determine the proper nerve electrode placement for implantation. Methods can include determining the side of the patient having the most BAT, and stimulating preferentially on that right or left side. The BAT maybe used to burn fat by stimulating the sympathetic nervous system innervating the BAT deposits.
摘要翻译：改善神经刺激治疗肥胖症的方法和装置。一些方法包括在术中测试刺激期间测量棕色脂肪组织（BAT）中的温度升高，以确定用于植入的适当的神经电极放置。方法可以包括确定具有最多BAT的患者的侧面，并且优先地在该右侧或左侧刺激。 BAT可能通过刺激支配BAT沉积物的交感神经系统来燃烧脂肪。

2. 发明申请

US20100312295A1 BROWN ADIPOSE TISSUE UTILIZATION THROUGH NEUROMODULATION 有权
标题翻译：通过神经修复的棕色ADIPOSE组织利用
公开(公告)号：US20100312295A1
公开(公告)日：2010-12-09
申请号：US12774073
申请日：2010-05-05
申请人： Abhi Vase , Johann Neisz
发明人： Abhi Vase , Johann Neisz
IPC分类号： A61N1/36
CPC分类号： A61N1/0551
摘要： Methods and devices for improved neurostimulation to treat obesity. Some methods include measuring temperature increases in Brown Adipose Tissue (BAT) during intraoperative test stimulations to determine the proper nerve electrode placement for implantation. Methods can include determining the side of the patient having the most BAT, and stimulating preferentially on that right or left side. The BAT maybe used to burn fat by stimulating the sympathetic nervous system innervating the BAT deposits.
摘要翻译：改善神经刺激治疗肥胖症的方法和装置。一些方法包括在术中测试刺激期间测量棕色脂肪组织（BAT）中的温度升高，以确定用于植入的适当的神经电极放置。方法可以包括确定具有最多BAT的患者的侧面，并且优先地在该右侧或左侧刺激。 BAT可能通过刺激支配BAT沉积物的交感神经系统来燃烧脂肪。

3. 发明授权

US09039649B2 Devices and methods for gastrointestinal bypass 有权
标题翻译：胃肠旁路装置和方法
公开(公告)号：US09039649B2
公开(公告)日：2015-05-26
申请号：US13485893
申请日：2012-05-31
申请人： Johann Neisz , Cole Chen , Sean Miller , Josiah Verkaik
发明人： Johann Neisz , Cole Chen , Sean Miller , Josiah Verkaik
IPC分类号： A61M5/00 , A61B17/04 , A61B17/064 , A61B17/068 , A61B17/11 , A61B19/00 , A61F2/04 , A61F5/00 , A61B17/00 , A61B17/06
CPC分类号： A61F5/0076 , A61B17/0401 , A61B17/064 , A61B17/068 , A61B17/1114 , A61B90/39 , A61B2017/00818 , A61B2017/0404 , A61B2017/0409 , A61B2017/0419 , A61B2017/0464 , A61B2017/047 , A61B2017/06052 , A61B2017/0647 , A61B2090/3908 , A61B2090/395 , A61B2090/3966 , A61F2/04 , A61F5/0036 , A61F5/0079 , A61F5/0089 , A61F2002/045 , A61F2250/0097
摘要： Devices and methods for gastrointestinal bypass are described. A gastrointestinal bypass device includes a gastrointestinal cuff and a gastrointestinal sleeve. The cuff may be configured to be attached in the esophagus, and may be sufficiently flexible to expand and collapse to conform with the inside of the esophagus to allow the esophagus to function substantially normally. The sleeve is configured to be coupled to the cuff, and may be made of a material that is floppy or flaccid but does not substantially expand radially.
摘要翻译：描述了胃肠旁路的装置和方法。胃肠旁路装置包括胃肠套和胃肠套。袖带可以构造成附接在食道中，并且可以具有足够的柔性以膨胀和折叠以与食道内部一致以允许食道基本上正常地起作用。套筒被配置为联接到袖带，并且可以由软盘或松弛材料制成，但是基本上不会径向扩张。

4. 发明授权

US09050168B2 Devices and methods for gastrointestinal bypass 有权
公开(公告)号：US09050168B2
公开(公告)日：2015-06-09
申请号：US13485889
申请日：2012-05-31
申请人： Johann Neisz , Cole Chen , Sean Miller
发明人： Johann Neisz , Cole Chen , Sean Miller
IPC分类号： A61M5/00 , A61F5/00 , A61B17/11 , A61F2/04 , A61B17/064 , A61B17/068 , A61B19/00 , A61B17/04 , A61B17/00 , A61B17/06
CPC分类号： A61F5/0076 , A61B17/0401 , A61B17/064 , A61B17/068 , A61B17/1114 , A61B90/39 , A61B2017/00818 , A61B2017/0404 , A61B2017/0409 , A61B2017/0419 , A61B2017/0464 , A61B2017/047 , A61B2017/06052 , A61B2017/0647 , A61B2090/3908 , A61B2090/395 , A61B2090/3966 , A61F2/04 , A61F5/0036 , A61F5/0079 , A61F5/0089 , A61F2002/045 , A61F2250/0097
摘要： Devices and methods for gastrointestinal bypass are described. A gastrointestinal bypass device includes a gastrointestinal cuff and a gastrointestinal sleeve. The cuff may be configured to be attached in the esophagus, and may be sufficiently flexible to expand and collapse to conform with the inside of the esophagus to allow the esophagus to function substantially normally. The sleeve is configured to be coupled to the cuff, and may be made of a material that is floppy or flaccid but does not substantially expand radially.

5. 发明申请

US20070021650A1 Sling Assembly with Secure and Convenient Attachment 有权
标题翻译：安全和方便的附件的吊装装配
公开(公告)号：US20070021650A1
公开(公告)日：2007-01-25
申请号：US11535018
申请日：2006-09-25
申请人： Gary Rocheleau , Johann Neisz , Gary Nachreiner
发明人： Gary Rocheleau , Johann Neisz , Gary Nachreiner
IPC分类号： A61F2/02
CPC分类号： A61B17/06004 , A61B17/0401 , A61B17/0469 , A61B17/0482 , A61B17/0487 , A61B17/06066 , A61B17/06109 , A61B17/30 , A61B17/3211 , A61B17/42 , A61B50/30 , A61B90/02 , A61B2017/0046 , A61B2017/00464 , A61B2017/00805 , A61B2017/0458 , A61B2017/06009 , A61B2017/06014 , A61B2017/06042 , A61B2017/06085 , A61F2/0045
摘要： Surgical articles that are conveniently securely coupled are disclosed. Improved surgical procedures are also disclosed.
摘要翻译：公开了方便牢固连接的外科用品。还公开了改进的外科手术。

6. 发明申请

US20050080480A1 Retrievable stent and method of use thereof 审中-公开
标题翻译：可检索的支架及其使用方法
公开(公告)号：US20050080480A1
公开(公告)日：2005-04-14
申请号：US10960195
申请日：2004-10-06
申请人： Stephen Bolea , Robert Rykhus , Sidney Hauschild , Johann Neisz , Mark Polyak , Bradford Staehle
发明人： Stephen Bolea , Robert Rykhus , Sidney Hauschild , Johann Neisz , Mark Polyak , Bradford Staehle
IPC分类号： A61F2/90 , A61F2/06
CPC分类号： A61F2/90 , A61F2/848 , A61F2/95 , A61F2002/9511 , A61F2002/9528
摘要： A removable stent system and method for extraction of a removable stent from a target site is disclosed. The removable stent includes a removable stent having a collapsible end and a collapsing element configured for coupling with a removal tool. The collapsing element can be configured as a lasso or can be movable between two positions when deployed at a target site in vivo. The removable stent overcomes disadvantages and limitations of previous types of stents as well as overcoming complications during or following stent deployment in vivo. The removable stent further includes features that increase its ease of use and reduce the maneuvering required of devices or tools used to remove the stent. This then decreases the amount of effort required by the physician, the procedure time, and the level of discomfort experienced by a patient during the procedure.
摘要翻译：公开了一种用于从目标部位提取可移除支架的可移除支架系统和方法。可拆卸支架包括具有可折叠端部的可拆卸支架和被构造成与拆卸工具联接的塌缩元件。折叠元件可以被配置为套索，或者当在体内部署在目标部位时可以在两个位置之间移动。可移除的支架克服了先前支架类型的缺点和局限性，并克服了体内支架展开期间或之后的并发症。可拆卸支架还包括增加其易用性并减少用于移除支架的装置或工具所需的操纵的特征。这样就减少了医师所需的努力量，手术时间以及患者在手术过程中所遇到的不适程度。

7. 发明授权

US08321030B2 Esophageal activity modulated obesity therapy 有权
标题翻译：食管活动调节肥胖症治疗
公开(公告)号：US08321030B2
公开(公告)日：2012-11-27
申请号：US12763980
申请日：2010-04-20
申请人： Jeremy Maniak , Johann Neisz
发明人： Jeremy Maniak , Johann Neisz
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61N1/0551
摘要： Methods and devices for delivering electrical stimulation to the sympathetic nervous system in response to the onset of eating. In some methods, swallowing is detected which then initiates a dose of stimulation which can vary in intensity, frequency, or both over the dose length. In some methods, the dose length is between about one quarter hour and one hour. The dose frequency may increase, hold steady, then decrease over the dose duration so as to mimic the response of the gut stretch and nutrient receptors to receiving food. The dose can drive biomarkers indicative of eating, for example glucagon, glucose, FFA or glycerol to at least about half of their normal post eating levels and then stop so as to retain stimulation effectiveness for subsequent doses and to prolong battery life.
摘要翻译：用于向交感神经系统递送电刺激以响应于进食的方法和装置。在一些方法中，检测吞咽，然后开始剂量的刺激，其可以在剂量长度上强度，频率或两者都变化。在一些方法中，剂量长度在约四分之一小时至一小时之间。剂量频率可能增加，保持稳定，然后在剂量持续时间内减少，以模拟肠道拉伸和营养受体对接受食物的反应。该剂量可以将指示进食的生物标志物（例如胰高血糖素，葡萄糖，FFA或甘油）驱动至其正常饮食水平的至少约一半，然后停止，以保持后续剂量的刺激效果并延长电池寿命。

8. 发明申请

US20100268306A1 ESOPHAGEAL ACTIVITY MODULATED OBESITY THERAPY 有权
标题翻译：食疗活性调节性肥胖治疗
公开(公告)号：US20100268306A1
公开(公告)日：2010-10-21
申请号：US12763980
申请日：2010-04-20
申请人： Jeremy Maniak , Johann Neisz
发明人： Jeremy Maniak , Johann Neisz
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61N1/0551
摘要： Methods and devices for delivering electrical stimulation to the sympathetic nervous system in response to the onset of eating. In some methods, swallowing is detected which then initiates a dose of stimulation which can vary in intensity, frequency, or both over the dose length. In some methods, the dose length is between about one quarter hour and one hour. The dose frequency may increase, hold steady, then decrease over the dose duration so as to mimic the response of the gut stretch and nutrient receptors to receiving food. The dose can drive biomarkers indicative of eating, for example glucagon, glucose, FFA or glycerol to at least about half of their normal post eating levels and then stop so as to retain stimulation effectiveness for subsequent doses and to prolong battery life.
摘要翻译：用于向交感神经系统递送电刺激以响应于进食的方法和装置。在一些方法中，检测吞咽，然后开始剂量的刺激，其可以在剂量长度上强度，频率或两者都变化。在一些方法中，剂量长度在约四分之一小时至一小时之间。剂量频率可能增加，保持稳定，然后在剂量持续时间内减少，以模拟肠道拉伸和营养受体对接受食物的反应。该剂量可以将指示进食的生物标志物（例如胰高血糖素，葡萄糖，FFA或甘油）驱动至其正常饮食水平的至少约一半，然后停止，以保持后续剂量的刺激效果并延长电池寿命。

9. 发明申请

US20060199994A1 Surgical instruments 有权
公开(公告)号：US20060199994A1
公开(公告)日：2006-09-07
申请号：US11414484
申请日：2006-05-01
申请人： Mona Inman , John Westrum , Johannes Gaston , Douglas VanOrnum , Robert Lund , Brian Watschke , Johann Neisz , Vicki Vandersloot
发明人： Mona Inman , John Westrum , Johannes Gaston , Douglas VanOrnum , Robert Lund , Brian Watschke , Johann Neisz , Vicki Vandersloot
IPC分类号： A61F2/02
CPC分类号： A61B17/06109 , A61B17/0401 , A61B17/0469 , A61B17/0482 , A61B17/0487 , A61B17/06004 , A61B17/06066 , A61B17/42 , A61B50/30 , A61B90/02 , A61B2017/00424 , A61B2017/0046 , A61B2017/00464 , A61B2017/00805 , A61B2017/06009 , A61B2017/06014 , A61B2017/06042 , A61B2017/06085 , A61B2017/320044 , A61F2/0045
摘要： A novel surgical instrument is shown and described. The surgical instrument is useful in pelvic floor repair procedures such as sling procedures for treating incontinence. Also, a novel, ornamental design for a handle for a surgical instrument is shown and described.

10. 发明申请

US20050240076A1 Implantable article and method 有权
标题翻译：可植入物品及方法
公开(公告)号：US20050240076A1
公开(公告)日：2005-10-27
申请号：US11166277
申请日：2005-06-27
申请人： Johann Neisz , John Westrum , Christopher Porter
发明人： Johann Neisz , John Westrum , Christopher Porter
IPC分类号： A61B17/00 , A61B17/04 , A61B17/06 , A61B17/30 , A61B17/32 , A61B17/42 , A61B19/00 , A61B19/02 , A61F2/00 , A61F2/02 , A61F13/00
CPC分类号： A61B17/0482 , A61B17/04 , A61B17/0401 , A61B17/0469 , A61B17/0487 , A61B17/06004 , A61B17/06066 , A61B17/06109 , A61B17/30 , A61B17/3211 , A61B17/42 , A61B50/30 , A61B90/02 , A61B2017/0046 , A61B2017/00805 , A61B2017/06009 , A61B2017/06014 , A61B2017/06042 , A61B2017/06085 , A61F2/0045
摘要： An implantable article and method of use are disclosed to treat urological disorders. The biocompatible device includes a sling assembly configured to be minimally invasive and provide sufficient support to the target site. In addition, the configuration of the sling assembly also allows the position of the sling to be permanently changed during and/or after implantation.
摘要翻译：公开了可植入制品和使用方法来治疗泌尿系统疾病。生物相容性装置包括被配置为微创并且向目标部位提供足够支撑的吊索组件。此外，吊索组件的构造还允许吊索的位置在植入期间和/或之后永久地改变。

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