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1. 发明授权

US08321030B2 Esophageal activity modulated obesity therapy 有权
标题翻译：食管活动调节肥胖症治疗
公开(公告)号：US08321030B2
公开(公告)日：2012-11-27
申请号：US12763980
申请日：2010-04-20
申请人： Jeremy Maniak , Johann Neisz
发明人： Jeremy Maniak , Johann Neisz
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61N1/0551
摘要： Methods and devices for delivering electrical stimulation to the sympathetic nervous system in response to the onset of eating. In some methods, swallowing is detected which then initiates a dose of stimulation which can vary in intensity, frequency, or both over the dose length. In some methods, the dose length is between about one quarter hour and one hour. The dose frequency may increase, hold steady, then decrease over the dose duration so as to mimic the response of the gut stretch and nutrient receptors to receiving food. The dose can drive biomarkers indicative of eating, for example glucagon, glucose, FFA or glycerol to at least about half of their normal post eating levels and then stop so as to retain stimulation effectiveness for subsequent doses and to prolong battery life.
摘要翻译：用于向交感神经系统递送电刺激以响应于进食的方法和装置。在一些方法中，检测吞咽，然后开始剂量的刺激，其可以在剂量长度上强度，频率或两者都变化。在一些方法中，剂量长度在约四分之一小时至一小时之间。剂量频率可能增加，保持稳定，然后在剂量持续时间内减少，以模拟肠道拉伸和营养受体对接受食物的反应。该剂量可以将指示进食的生物标志物（例如胰高血糖素，葡萄糖，FFA或甘油）驱动至其正常饮食水平的至少约一半，然后停止，以保持后续剂量的刺激效果并延长电池寿命。

2. 发明申请

US20100268306A1 ESOPHAGEAL ACTIVITY MODULATED OBESITY THERAPY 有权
标题翻译：食疗活性调节性肥胖治疗
公开(公告)号：US20100268306A1
公开(公告)日：2010-10-21
申请号：US12763980
申请日：2010-04-20
申请人： Jeremy Maniak , Johann Neisz
发明人： Jeremy Maniak , Johann Neisz
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61N1/0551
摘要： Methods and devices for delivering electrical stimulation to the sympathetic nervous system in response to the onset of eating. In some methods, swallowing is detected which then initiates a dose of stimulation which can vary in intensity, frequency, or both over the dose length. In some methods, the dose length is between about one quarter hour and one hour. The dose frequency may increase, hold steady, then decrease over the dose duration so as to mimic the response of the gut stretch and nutrient receptors to receiving food. The dose can drive biomarkers indicative of eating, for example glucagon, glucose, FFA or glycerol to at least about half of their normal post eating levels and then stop so as to retain stimulation effectiveness for subsequent doses and to prolong battery life.
摘要翻译：用于向交感神经系统递送电刺激以响应于进食的方法和装置。在一些方法中，检测吞咽，然后开始剂量的刺激，其可以在剂量长度上强度，频率或两者都变化。在一些方法中，剂量长度在约四分之一小时至一小时之间。剂量频率可能增加，保持稳定，然后在剂量持续时间内减少，以模拟肠道拉伸和营养受体对接受食物的反应。该剂量可以将指示进食的生物标志物（例如胰高血糖素，葡萄糖，FFA或甘油）驱动至其正常饮食水平的至少约一半，然后停止，以保持后续剂量的刺激效果并延长电池寿命。

3. 发明申请

US20100168820A1 AUTOMATIC THRESHOLD ASSESMENT UTILIZING PATIENT FEEDBACK 审中-公开
标题翻译：自动阈值评估应用患者反馈
公开(公告)号：US20100168820A1
公开(公告)日：2010-07-01
申请号：US12629823
申请日：2009-12-02
申请人： Jeremy Maniak , Ralph Cardinal , Hans Neisz , Jason John Skubitz , Henry DeMorett
发明人： Jeremy Maniak , Ralph Cardinal , Hans Neisz , Jason John Skubitz , Henry DeMorett
IPC分类号： A61N1/08
CPC分类号： A61N1/36007 , A61N1/37247
摘要： Methods, Implantable Pulse Generators (IPGs), and systems for stimulating a sympathetic nervous system nerve including automatically increasing the maximum stimulation current intensity over time. Some IPGS increase the current stimulation current maximum upon passage of an elapsed time or occurrence of a time of day. The current stimulation current maximum is the actual stimulation current in some methods and is a ramp maximum in other methods. The patient may interact with the IPG to indicate discomfort, resulting in a decrease in the current stimulation current maximum. In some methods, after receiving too many patient indications of discomfort, stimulation is stopped by the IPG.
摘要翻译：方法，植入式脉冲发生器（IPG）和用于刺激交感神经系统神经的系统，包括随时间自动增加最大刺激电流强度。一些IPGS在经过时间或一天的时间发生时增加当前刺激电流的最大值。目前的刺激电流最大值是一些方法中的实际刺激电流，而在其他方法中是最大的斜坡。患者可能与IPG相互作用以表示不适，导致当前刺激电流最大值的降低。在一些方法中，在接收到太多患者的不适指示之后，IPG停止刺激。

4. 发明申请

US20090192563A1 METHOD AND APPARATUS FOR ADJUSTING CARDIAC EVENT DETECTION THRESHOLD BASED ON DYNAMIC NOISE ESTIMATION 有权
标题翻译：基于动态噪声估计调整心脏事件检测阈值的方法和装置
公开(公告)号：US20090192563A1
公开(公告)日：2009-07-30
申请号：US12415619
申请日：2009-03-31
申请人： William J. Linder , Jeremy Maniak , Ron A. Balczewski
发明人： William J. Linder , Jeremy Maniak , Ron A. Balczewski
IPC分类号： A61N1/37
CPC分类号： A61B5/04017 , A61N1/3704 , A61N1/3925 , A61N1/3962 , Y10S128/901
摘要： An implantable cardiac rhythm management (CRM) device includes a sensing and detection circuit that senses at least one cardiac signal and detects cardiac electrical events from the sensed cardiac signal using a detection threshold that is adjusted based on a dynamic noise estimation. The sensed cardiac signal is filtered to produce a filtered cardiac signal having a signal frequency band and a noise signal having a noise frequency band. The noise frequency band is substantially different from the signal frequency band. A dynamic noise floor is produced based on the noise signal and used as the minimum value for the detection threshold. A cardiac electrical is detected when the amplitude of the filtered cardiac signal exceeds the detection threshold.
摘要翻译：可植入心律管理（CRM）装置包括感测和检测电路，其感测至少一个心脏信号并且使用基于动态噪声估计调整的检测阈值从所感测的心脏信号检测心脏电气事件。所感测的心脏信号被滤波以产生具有信号频带的滤波心脏信号和具有噪声频带的噪声信号。噪声频带与信号频带基本不同。基于噪声信号产生动态底噪，并将其用作检测阈值的最小值。当过滤的心脏信号的幅度超过检测阈值时，检测心电。

5. 发明授权

US07774064B2 Cardiac response classification using retriggerable classification windows 有权
标题翻译：使用可重新触发分类窗口的心脏反应分类
公开(公告)号：US07774064B2
公开(公告)日：2010-08-10
申请号：US10734599
申请日：2003-12-12
申请人： Scott A. Meyer , Yanting Dong , Jeremy Maniak , Doug Birholz , John Voegele
发明人： Scott A. Meyer , Yanting Dong , Jeremy Maniak , Doug Birholz , John Voegele
IPC分类号： A61N1/37
CPC分类号： A61B5/7264 , A61B5/04525 , A61B5/7217 , A61N1/371
摘要： Methods and devices for classifying a cardiac response to pacing involve establishing a retriggerable cardiac response classification window. A first cardiac response classification window is established subsequent to delivery of a pacing pulse. A cardiac signal following the pacing stimulation is sensed in the first classification window. A second cardiac response classification may be triggered if a trigger characteristic is detected in the first classification window. The cardiac signal is sensed in the second classification window if the second classification window is established. The cardiac response to the pacing stimulation is determined based on characteristics of the cardiac signal. The cardiac response may be determined to be one of a captured response, a non-captured response; a non-captured response added to an intrinsic beat, and a fusion/pseudofusion beat, for example.
摘要翻译：用于分类心脏起搏应答的方法和装置包括建立可再触发的心脏反应分类窗口。在递送起搏脉冲之后建立第一心脏响应分类窗口。起搏刺激后的心脏信号在第一分类窗口中被感测。如果在第一分类窗口中检测到触发特性，则可以触发第二心跳响应分类。如果建立第二分类窗口，则在第二分类窗口中感测到心脏信号。基于心脏信号的特征确定对起搏刺激的心脏反应。心脏反应可以被确定为捕获的应答，非捕获的响应之一; 例如，添加到固有节拍的非捕获响应以及融合/假融合节拍。

6. 发明授权

US07515955B2 Method and apparatus for adjusting cardiac event detection threshold based on dynamic noise estimation 有权
标题翻译：基于动态噪声估计调整心脏事件检测阈值的方法和装置
公开(公告)号：US07515955B2
公开(公告)日：2009-04-07
申请号：US11557318
申请日：2006-11-07
申请人： William J. Linder , Jeremy Maniak , Ron A. Balczewski
发明人： William J. Linder , Jeremy Maniak , Ron A. Balczewski
IPC分类号： A61B5/0402
CPC分类号： A61B5/04017 , A61N1/3704 , A61N1/3925 , A61N1/3962 , Y10S128/901
摘要： An implantable cardiac rhythm management (CRM) device includes a sensing and detection circuit that senses at least one cardiac signal and detects cardiac electrical events from the sensed cardiac signal using a detection threshold that is adjusted based on a dynamic noise estimation. The sensed cardiac signal is filtered to produce a filtered cardiac signal having a signal frequency band and a noise signal having a noise frequency band. The noise frequency band is substantially different from the signal frequency band. A dynamic noise floor is produced based on the noise signal and used as the minimum value for the detection threshold. A cardiac electrical is detected when the amplitude of the filtered cardiac signal exceeds the detection threshold.
摘要翻译：可植入心律管理（CRM）装置包括感测和检测电路，其感测至少一个心脏信号并且使用基于动态噪声估计调整的检测阈值从所感测的心脏信号检测心脏电气事件。所感测的心脏信号被滤波以产生具有信号频带的滤波心脏信号和具有噪声频带的噪声信号。噪声频带与信号频带基本不同。基于噪声信号产生动态底噪，并将其用作检测阈值的最小值。当过滤的心脏信号的幅度超过检测阈值时，检测心电。

7. 发明申请

US20070088399A1 METHOD AND APPARATUS FOR ADJUSTING CARDIAC EVENT DETECTION THRESHOLD BASED ON DYNAMIC NOISE ESTIMATION 有权
标题翻译：基于动态噪声估计调整心脏事件检测阈值的方法和装置
公开(公告)号：US20070088399A1
公开(公告)日：2007-04-19
申请号：US11557318
申请日：2006-11-07
申请人： William Linder , Jeremy Maniak , Ron Balczewski
发明人： William Linder , Jeremy Maniak , Ron Balczewski
IPC分类号： A61N1/00
CPC分类号： A61B5/04017 , A61N1/3704 , A61N1/3925 , A61N1/3962 , Y10S128/901
摘要： An implantable cardiac rhythm management (CRM) device includes a sensing and detection circuit that senses at least one cardiac signal and detects cardiac electrical events from the sensed cardiac signal using a detection threshold that is adjusted based on a dynamic noise estimation. The sensed cardiac signal is filtered to produce a filtered cardiac signal having a signal frequency band and a noise signal having a noise frequency band. The noise frequency band is substantially different from the signal frequency band. A dynamic noise floor is produced based on the noise signal and used as the minimum value for the detection threshold. A cardiac electrical is detected when the amplitude of the filtered cardiac signal exceeds the detection threshold.
摘要翻译：可植入心律管理（CRM）装置包括感测和检测电路，其感测至少一个心脏信号并且使用基于动态噪声估计调整的检测阈值从所感测的心脏信号检测心脏电气事件。所感测的心脏信号被滤波以产生具有信号频带的滤波心脏信号和具有噪声频带的噪声信号。噪声频带与信号频带基本不同。基于噪声信号产生动态底噪，并将其用作检测阈值的最小值。当过滤的心脏信号的幅度超过检测阈值时，检测心电。

8. 发明授权

US08798742B2 Method and apparatus for adjusting cardiac event detection threshold based on dynamic noise estimation 有权
标题翻译：基于动态噪声估计调整心脏事件检测阈值的方法和装置
公开(公告)号：US08798742B2
公开(公告)日：2014-08-05
申请号：US12415619
申请日：2009-03-31
申请人： William J. Linder , Jeremy Maniak , Ron A. Balczewski
发明人： William J. Linder , Jeremy Maniak , Ron A. Balczewski
IPC分类号： A61N1/39 , A61B5/0428
CPC分类号： A61B5/04017 , A61N1/3704 , A61N1/3925 , A61N1/3962 , Y10S128/901
摘要： An implantable cardiac rhythm management (CRM) device includes a sensing and detection circuit that senses at least one cardiac signal and detects cardiac electrical events from the sensed cardiac signal using a detection threshold that is adjusted based on a dynamic noise estimation. The sensed cardiac signal is filtered to produce a filtered cardiac signal having a signal frequency band and a noise signal having a noise frequency band. The noise frequency band is substantially different from the signal frequency band. A dynamic noise floor is produced based on the noise signal and used as the minimum value for the detection threshold. A cardiac electrical is detected when the amplitude of the filtered cardiac signal exceeds the detection threshold.
摘要翻译：可植入心律管理（CRM）装置包括感测和检测电路，其感测至少一个心脏信号并且使用基于动态噪声估计调整的检测阈值从所感测的心脏信号检测心脏电气事件。所感测的心脏信号被滤波以产生具有信号频带的滤波心脏信号和具有噪声频带的噪声信号。噪声频带与信号频带基本不同。基于噪声信号产生动态底噪，并将其用作检测阈值的最小值。当过滤的心脏信号的幅度超过检测阈值时，检测心电。

9. 发明申请

US20110172730A1 IMPLANTABLE MEDICAL DEVICE WITH EMBEDDED PROGRAMMABLE NON-VOLATILE MEMORY 有权
标题翻译：具有嵌入式可编程非易失性存储器的可植入医疗设备
公开(公告)号：US20110172730A1
公开(公告)日：2011-07-14
申请号：US13052231
申请日：2011-03-21
申请人： Jeremy Maniak , William L. Zimmer , Ron A. Balczewski , William J. Linder
发明人： Jeremy Maniak , William L. Zimmer , Ron A. Balczewski , William J. Linder
IPC分类号： A61N1/365 , A61N1/36 , A61N1/39
CPC分类号： A61B5/04
摘要： A method comprising providing a programmable non-volatile memory (PNVM) circuit fabricated together with a processor on an integrated circuit chip (IC) in an implantable medical device (IMD), partitioning the PNVM circuit into a plurality of portions based on how often that the processor accesses a portion, and selectively providing power or selectively restricting power to one or more of the portions according to how often that the processor accesses a portion.
摘要翻译：一种方法，包括提供与可植入医疗装置（IMD）中的集成电路芯片（IC）上的处理器一起制造的可编程非易失性存储器（PNVM）电路，基于所述多个部分，将PNVM电路分成多个部分，处理器访问一部分，并且根据处理器访问部分的频率，选择性地向一个或多个部分提供功率或选择性地限制功率。

10. 发明申请

US20070208261A1 IMPLANTABLE MEDICAL DEVICE WITH EMBEDDED PROGRAMMABLE NON-VOLATILE MEMORY 有权
标题翻译：具有嵌入式可编程非易失性存储器的可植入医疗设备
公开(公告)号：US20070208261A1
公开(公告)日：2007-09-06
申请号：US11276490
申请日：2006-03-02
申请人： Jeremy Maniak , William Zimmer , Ron Balczewski , William Linder
发明人： Jeremy Maniak , William Zimmer , Ron Balczewski , William Linder
IPC分类号： A61B5/04
CPC分类号： A61B5/04
摘要： A system comprising an implantable medical device (IMD). The IMD includes a processor fabricated on an integrated circuit chip (IC), a random access memory (RAM) circuit fabricated on the same IC, and a programmable non-volatile memory (PNVM) circuit also fabricated on the same IC.
摘要翻译：一种包括可植入医疗装置（IMD）的系统。 IMD包括在集成电路芯片（IC）上制造的处理器，在同一IC上制造的随机存取存储器（RAM）电路，以及也在同一IC上制造的可编程非易失性存储器（PNVM）电路。

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